In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation

European Journal of Pharmacology

Volumn 678, Issue 1-3, 2012, Pages 61-70

  Ibrahim Abdelwahab, Siddig ^a   Syaed Koko, Waleed ^b   Mohamed Elhassan Taha, Manal ^a   Mohan, Syam ^a   Achoui, Mouna ^a   Ameen Abdulla, Mahmood ^a   Rais Mustafa, Mohd ^a   Ahmad, Syahida ^c   Ibrahim Noordin, Mohamed ^c   Lip Yong, Chung ^a   Roslan Sulaiman, Mohd ^c   Othman, Rozana ^a   Amir Hassan, Asfarina ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b National Center for Research Sudan   (Sudan)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Columbin; Cyclooxygenase enzyme: docking; Mouse paw oedema; Nitric oxide; Tinspora bakis

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; ARGININE; CARRAGEENAN; COLUMBIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DITERPENOID; GAMMA INTERFERON; HYDROGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL NUCLEUS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MACROPHAGE; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PAW EDEMA; PLANT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TINSPORA BAKIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EDEMA; LACTONES; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; NITRIC OXIDE; PROTEIN BINDING;

EID: 84857050687     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.12.024     Document Type: Article

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