S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors

Biochimie

Volumn 94, Issue 3, 2012, Pages 704-710

  Poreba, Marcin ^a   Gajda, Anna ^a   Picha, Jan ^b   Jiracek, Jiri ^b   Marschner, Aline ^c   Klein, Christian D ^c   Salvesen, Guy S ^d   Drag, Marcin ^a,d  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Aminopeptidase; Enzyme; Inhibitor; Protease; Substrate library; Substrate specificity

Indexed keywords

AMINO ACID; BACTERIAL ENZYME; METHIONINE; METHIONYL AMINOPEPTIDASE; PEPTIDE HYDROLASE INHIBITOR; PHOSPHINATE DERIVATIVE; PHOSPHINE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORUS; UNCLASSIFIED DRUG;

ARTICLE; ENZYME INHIBITION; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENETIC CONSERVATION; HYDROLYSIS; IC 50; MOLECULAR LIBRARY; SCREENING; SEQUENCE ALIGNMENT;

AMINOPEPTIDASES; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; HUMANS; METALLOENDOPEPTIDASES; PHOSPHORUS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HOMO SAPIENS;

EID: 84857038589     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.10.014     Document Type: Article

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