A moderate decline in U937 cell GSH levels triggers PI3 kinase/Akt-dependent Bad phosphorylation, thereby preventing an otherwise prompt apoptotic response

Pharmacological Research

Volumn 65, Issue 3, 2012, Pages 379-386

  Cerioni, Liana ^a   Fiorani, Mara ^a   Azzolini, Catia ^a   Cantoni, Orazio ^a  

^a UNIVERSITY OF URBINO   (Italy)

Author keywords

Akt; Apoptosis; Bad; GSH; Mitochondrial permeability transition

Indexed keywords

BUTHIONINE SULFOXIMINE; DIAMIDE; GLUTATHIONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BAX; PROTEIN KINASE B; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL STRAIN U937; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

EID: 84857037675     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.12.006     Document Type: Article

References (30)

1. J.C. Fernandez-Checa, N. Kaplowitz, C. Garcia-Ruiz, A. Colell, M. Miranda, and M. Mari GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect Am J Physiol 273 1997 G7 G17
2. J.C. Fernandez-Checa, C. Garcia-Ruiz, A. Colell, A. Morales, M. Mari, and M. Miranda Oxidative stress: role of mitochondria and protection by glutathione Biofactors 8 1998 7 11 (Pubitemid 28332777)
3. H.J. Forman, J.M. Fukuto, and M. Torres Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers Am J Physiol Cell Physiol 287 2004 C246 C256
4. P. Klatt, and S. Lamas Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress Eur J Biochem 267 2000 4928 4944 (Pubitemid 30641289)
5. X.Q. Shan, T.Y. Aw, and D.P. Jones Glutathione-dependent protection against oxidative injury Pharmacol Ther 47 1990 61 71 (Pubitemid 20183308)
6. G. Giordano, C.C. White, L.A. McConnachie, C. Fernandez, T.J. Kavanagh, and L.G. Costa Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione deficiency Mol Pharmacol 70 2006 2116 2126 (Pubitemid 44771927)
7. L. Ghibelli, C. Fanelli, G. Rotilio, E. Lafavia, S. Coppola, and C. Colussi Rescue of cells from apoptosis by inhibition of active GSH extrusion FASEB J 12 1998 479 486 (Pubitemid 28146527)
8. D.J. van den Dobbelsteen, C.S. Nobel, J. Schlegel, I.A. Cotgreave, S. Orrenius, and A.F. Slater Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody J Biol Chem 271 1996 15420 15427 (Pubitemid 26225311)
9. S. Orrenius Reactive oxygen species in mitochondria-mediated cell death Drug Metab Rev 39 2007 443 455 (Pubitemid 47355728)
10. H. Kamata, and H. Hirata Redox regulation of cellular signalling Cell Signal 11 1999 1 14 (Pubitemid 28546635)
11. H.H. Bailey l-S,R-buthionine sulfoximine: historical development and clinical issues Chem Biol Interact 111-112 1998 239 254 (Pubitemid 28271948)
12. M. D'Alessio, C. Cerella, C. Amici, C. Pesce, S. Coppola, and C. Fanelli Glutathione depletion up-regulates Bcl-2 in BSO-resistant cells FASEB J 18 2004 1609 1611 (Pubitemid 39561649)
13. L. Ghibelli, S. Coppola, C. Fanelli, G. Rotilio, P. Civitareale, and A.I. Scovassi Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis FASEB J 13 1999 2031 2036 (Pubitemid 29517633)
14. J.M. Adams, and S. Cory The Bcl-2 protein family: arbiters of cell survival Science 281 1998 1322 1326 (Pubitemid 28406819)
15. G. Kroemer, and J.C. Reed Mitochondrial control of cell death Nat Med 6 2000 513 519 (Pubitemid 30305900)
16. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309 1312 (Pubitemid 28406816)
17. L. Cerioni, L. Palomba, B. Brüne, and O. Cantoni Peroxynitrite-induced mitochondrial translocation of PKCalpha causes U937 cell survival Biochem Biophys Res Commun 339 2006 126 131 (Pubitemid 41697524)
18. A. Guidarelli, L. Cerioni, I. Tommasini, M. Fiorani, B. Brüne, and O. Cantoni Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite Free Radic Biol Med 39 2005 1638 1649 (Pubitemid 41642595)
19. N. Zamzami, S.A. Susin, P. Marchetti, T. Hirsch, I. Gomez-Monterrey, and M. Castedo Mitochondrial control of nuclear apoptosis J Exp Med 183 1996 1533 1544 (Pubitemid 26134296)
20. 2 signals monocyte/macrophage survival to peroxynitrite via protein kinase A converging in bad phosphorylation with the protein kinase C alpha-dependent pathway driven by 5-hydroxyeicosatetraenoic acid J Immunol 181 2008 5637 5645
21. 2-dependent protective signalling mediated by peroxynitrite in U937 cells Biochem Pharmacol 69 2005 1275 1286 (Pubitemid 40417499)
22. O. Cantoni, I. Tommasini, and L. Cerioni The arachidonate-dependent survival signaling preventing toxicity in monocytes/macrophages exposed to peroxynitrite Methods Enzymol 441 2008 73 82
23. E. Beutler Red cell metabolism A manual of biochemical methods 1984 Grune & Stratton New York p. 131-4
24. G. Song, G. Ouyang, and S. Bao The activation of Akt/PKB signaling pathway and cell survival J Cell Mol Med 9 2005 59 71
25. J. Liu, J.D. Farmer Jr., W.S. Lane, J. Friedman, I. Weissman, and S.L. Schreiber Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes Cell 66 1991 807 815 (Pubitemid 121001714)
26. W. Henke, and K. Jung Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria Biochem Pharmacol 46 1993 829 832 (Pubitemid 23272763)
27. R. Franco, and J.A. Cidlowski Apoptosis and glutathione: beyond an antioxidant Cell Death Differ 16 2009 1303 1314
28. A.G. Hall Review: the role of glutathione in the regulation of apoptosis Eur J Clin Invest 29 1999 238 245 (Pubitemid 29106315)
29. I. Tommasini, A. Guidarelli, and O. Cantoni Non-toxic concentrations of peroxynitrite commit U937 cells to mitochondrial permeability transition-dependent necrosis that is however prevented by endogenous arachidonic acid Biochem Pharmacol 67 2004 1077 1087 (Pubitemid 38296787)
30. I. Tommasini, A. Guidarelli, L. Palomba, L. Cerioni, and O. Cantoni 5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate- dependent protective signaling in monocytes/macrophages exposed to peroxynitrite J Leukoc Biol 80 2006 929 938 (Pubitemid 44835911)