Prostaglandin E2 signals monocyte/macrophage survival to peroxynitrite via protein kinase A converging in bad phosphorylation with the protein kinase Cα-dependent pathway driven by 5-hydroxyeicosatetraenoic acid

Journal of Immunology

Volumn 181, Issue 8, 2008, Pages 5637-5645

  Tommasini, Ilaria ^a   Cerioni, Liana ^a   Palomba, Letizia ^a   Cantoni, Orazio ^a  

^a UNIVERSITY OF URBINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYICOSATETRAENOIC ACID; ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PEROXYNITRITE; PHOSPHODIESTERASE INHIBITOR; PROSTAGLANDIN E2; PROTEIN BAD; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; 5-HYDROXY-6,8,11,14-EICOSATETRAENOIC ACID; BAD PROTEIN, HUMAN; BAD PROTEIN, RAT; HYDROXYICOSATETRAENOIC ACID; MITOCHONDRIAL PROTEIN; PEROXYNITROUS ACID; PHOSPHOLIPASE A2; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN EP2 RECEPTOR;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CELL LINEAGE; CELL PROTECTION; CELL STRAIN U937; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MITOCHONDRION; MONOCYTE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL DEATH; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ADENYLATE CYCLASE; ANIMALS; BCL-ASSOCIATED DEATH PROTEIN; CELL DEATH; CELL SURVIVAL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; ENZYME ACTIVATION; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; INFLAMMATION; MACROPHAGES, PERITONEAL; MITOCHONDRIAL PROTEINS; MONOCYTES; PEROXYNITROUS ACID; PHOSPHOLIPASES A2; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E; SIGNAL TRANSDUCTION; U937 CELLS;

EID: 54049091510     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.8.5637     Document Type: Article

References (37)

1. Patel, R. P., J. McAndrew, H. Sellak, C. R. White, H. Jo, B. A. Freeman, and V. M. Darley-Usmar. 1999. Biological aspects of reactive nitrogen species. Biochim. Biophys. Acta 1411: 385-400. (Pubitemid 29221963)
2. Guidarelli, A., C. Sciorati, E. Clementi, and O. Cantoni. 2006. Peroxynitrite mobilizes calcium ions from ryanodine-sensitive stores, a process associated with the mitochondrial accumulation of the cation and the enforced formation of species mediating cleavage of genomic DNA. Free Radic. Biol. Med. 41: 154-164. (Pubitemid 43866459)
3. Moncada, S., R. M. Palmer, and E. A. Higgs. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142.
4. Tommasini, I., P. Sestili, A. Guidarelli, and O. Cantoni. 2002. Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death. Cell Death Differ. 9: 1368-1376. (Pubitemid 36097707)
5. Tommasini, I., P. Sestili, A. Guidarelli, and O. Cantoni. 2004. Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cells death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2. Cell Death Differ. 11: 974-984. (Pubitemid 39232357)
6. 2-dependent protective signalling mediated by peroxynitrite in U937 cells. Biochem. Pharmacol. 69: 1275-1286.
7. Guidarelli, A., L. Cerioni, I. Tommasini, M. Fiorani, B. Brüne, and O. Cantoni. 2005. Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite. Free Radic. Biol. Med. 39: 1638-1649. (Pubitemid 41642595)
8. Cerioni, L., L. Palomba, B. Brüne, and O. Cantoni. 2006. Peroxynitrite-induced mitochondrial translocation of PKCα causes U937 cell survival. Biochem. Biophys. Res. Commun. 339: 126-131. (Pubitemid 41697524)
9. Tommasini, I., L. Palomba, A. Guidarelli, L. Cerioni, and O. Cantoni. 2006. 5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. J. Leukocyte Biol. 80: 929-938. (Pubitemid 44835911)
10. Cerioni, L., and O. Cantoni. 2007. ERK1/2 regulates two sequential steps promoting monocyte survival to peroxynitrite. J. Cell. Physiol. 210: 177-182. (Pubitemid 44904713)
11. Cerioni, L., and O. Cantoni. 2008. Mitochondrial H2O2 limits U937 cell survival to peroxynitrite by promoting ERK1/2 dephosphorylation. Biochim. Biophys. Acta 1783: 492-502.
12. Chao, D. T., and S. J. Korsmeyer. 1998. BCL-2 family: regulators of cell death. Annu. Rev. Immunol. 16: 395-419. (Pubitemid 28183370)
13. Knudson, C. M., K. S. Tung, W. G. Tourtellotte, G. A. Brown, and S. J. Korsmeyer. 1995. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270: 96-99.
14. Bertolotto, C., L. Maulon, N. Filippa, G. Baier, and P. Auberger. 2000. Protein kinase C θ and ε promote T-cell survival by a Rsk-dependent phosphorylation and inactivation of BAD. J. Biol. Chem. 275: 37246-37250. (Pubitemid 32002146)
15. Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241.
16. Klotz, L. O., S. M. Schieke, H. Sies, and N. J. Holbrook. 2000. Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts. Biochem. J. 352: 219-225.
17. Kang, K. W., S. H. Choi, and S. G. Kim. 2002. Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-transferase A2 induction. Nitric Oxide 7: 244-253.
18. Nomiyama, T., Y. Igarashi, H. Taka, R. Mineki, T. Uchida, T. Ogihara, J. Choi, B. H. Uchino, Y. Tanaka, H. Maegawa, et al. 2004. Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1. Biochem. Biophys. Res. Commun. 320: 639-647. (Pubitemid 38887192)
19. Estévez, A. G., R. Radi, L. Barbeito, J. T. Shin, J. A. Thompson, and J. S. Beckman. 1995. Peroxynitrite-induced cytotoxicity in PC12 cells: evidence for an apoptotic mechanism differentially modulated by neurotrophic factors. J. Neurochem. 65: 1543-1550.
20. El-Remessy, A. B., M. Bartoli, D. H. Platt, D. Fulton, and R. B. Caldwell. 2005. Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration. J. Cell Sci. 118: 243-252.
21. Zou, M. H., X. Y. Hou, C. M. Shi, D. Nagata, K. Walsh, and R. A. Cohen. 2002. Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. J. Biol. Chem. 277: 32552-32557.
22. Hellberg, C. B., S. E. Boggs, and E. G. Lapetina. 1998. Phosphatidylinositol 3-kinase is a target for protein tyrosine nitration. Biochem. Biophys. Res. Commun. 252: 313-317. (Pubitemid 28542883)
23. Rocca, B., and G. A. FitzGerald. 2002. Cyclooxygenases and prostaglandins: shaping up the immune response. Int. Immunopharmacol. 2: 603-630. (Pubitemid 34246363)
24. Radi, R., J. S. Beckman, K. M. Bush, and B. A. Freeman. 1991. Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266: 4244-4250. (Pubitemid 21909347)
25. Borutaite, V., H. Hope, and G. C. Brown. 2006. Arachidonate and NADPH oxidase synergise with iNOS to induce death in macrophages: mechanisms of inflammatory degeneration. Pharmacol. Rep. 58: 96-102.
26. Yu, W., B. G. Sanders, and K. Kline. 2003. RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. Cancer Res. 63: 2483-2491. (Pubitemid 36605187)
27. Peters-Golden, M., and T. G. Brock. 2000. Intracellular compartmentalization of leukotriene biosynthesis. Am. J. Respir. Crit. Care Med. 161: S36-S40.
28. Dixon, R. A., R. E. Diehl, E. Opas, E. Rands, P. J. Vickers, J. F. Evans, J. W. Gillard, and D. K. Miller. 1990. Requirement of a 5-lipoxygenase- activating protein for leukotriene synthesis. Nature 343: 282-284. (Pubitemid 20030648)
29. Watabe, A., Y. Sugimoto, A. Honda, A. Irie, T. Namba, M. Negishi, S. Ito, S. Narumiya, and A. Ichikawa. 1993. Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor. J. Biol. Chem. 268: 20175-20178. (Pubitemid 23278918)
30. Breyer, R. M., C. K. Bagdassarian, S. A. Myers, and M. D. Breyer. 2001. Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41: 661-690.
31. Coleman, R. A., W. L. Smith, and S. Narumiya. 1994. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46: 205-229.
32. Dennis, E. A. 1994. Diversity of group types, regulation, and function of phospholipase A2. J. Biol. Chem. 269: 13057-13060. (Pubitemid 24206060)
33. 2. J. Biol. Chem. 277: 2614-2619.
34. 2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases. J. Biol. Chem. 278: 12151-12156.
35. Harada, H., B. Becknell, M. Wilm, M. Mann, L. J. Huang, S. S. Taylor, J. D. Scott, and S. J. Korsmeyer. 1999. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol. Cell 3: 413-422. (Pubitemid 29292598)
36. Lizcano, J. M., N. Morrice, and P. Cohen. 2000. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem. J. 349: 547-557.
37. Pacher, P., J. S. Beckman, and L. Liaudet. 2007. Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 87: 315-424. (Pubitemid 46217686)