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Volumn 221, Issue 1, 2012, Pages 268-274

The removal from plasma of chylomicrons and remnants is reduced in heterozygous familial hypercholesterolemia subjects with identified LDL receptor mutations: Study with artificial emulsions

Author keywords

Chylomicrons; Emulsions; Familial hypercholesterolemia; LDL receptor mutations; Triglyceride rich lipoproteins

Indexed keywords

CARBON 14; CHOLESTEROL; CHOLESTEROL ESTER; CHYLOMICRON REMNANT; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; TRIOLEIN; TRITIUM;

EID: 84857029783     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.12.033     Document Type: Article
Times cited : (10)

References (39)
  • 1
    • 10744233618 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia
    • Civeira F. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia. Atherosclerosis 2004, 173:55-68.
    • (2004) Atherosclerosis , vol.173 , pp. 55-68
    • Civeira, F.1
  • 2
    • 0030661590 scopus 로고    scopus 로고
    • Hepatic uptake of chylomicron remnants
    • Cooper A.D. Hepatic uptake of chylomicron remnants. J Lipid Res 1997, 38:2173-2192.
    • (1997) J Lipid Res , vol.38 , pp. 2173-2192
    • Cooper, A.D.1
  • 3
    • 0031743318 scopus 로고    scopus 로고
    • Retention of chylomicron remnants by arterial tissue; importance of an efficient clearance mechanism from plasma
    • Mamo J.C., Proctor S.D., Smith D. Retention of chylomicron remnants by arterial tissue; importance of an efficient clearance mechanism from plasma. Atherosclerosis 1998, 141(Suppl. 1):S63-S69.
    • (1998) Atherosclerosis , vol.141 , Issue.SUPPL. 1
    • Mamo, J.C.1    Proctor, S.D.2    Smith, D.3
  • 4
    • 0031814147 scopus 로고    scopus 로고
    • Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall - evidence that plaque cholesterol may be derived from post-prandial lipoproteins
    • Proctor S.D., Mamo J.C. Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall - evidence that plaque cholesterol may be derived from post-prandial lipoproteins. Eur J Clin Invest 1998, 28:497-503.
    • (1998) Eur J Clin Invest , vol.28 , pp. 497-503
    • Proctor, S.D.1    Mamo, J.C.2
  • 5
    • 0025095799 scopus 로고
    • Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects
    • Rubinsztein D.C., Cohen J.C., Berger G.M., van der Westhuyzen D.R., Coetzee G.A., Gevers W. Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects. J Clin Invest 1990, 86:1306-1312.
    • (1990) J Clin Invest , vol.86 , pp. 1306-1312
    • Rubinsztein, D.C.1    Cohen, J.C.2    Berger, G.M.3    van der Westhuyzen, D.R.4    Coetzee, G.A.5    Gevers, W.6
  • 6
    • 0348038758 scopus 로고
    • Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor
    • Kita T., Goldstein J.L., Brown M.S., Watanabe Y., Hornick C.A., Havel R.J. Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor. Proc Natl Acad Sci U S A 1982, 79:3623-3627.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 3623-3627
    • Kita, T.1    Goldstein, J.L.2    Brown, M.S.3    Watanabe, Y.4    Hornick, C.A.5    Havel, R.J.6
  • 7
    • 0025860543 scopus 로고
    • Chylomicron-remnant clearance in homozygote and heterozygote Watanabe-heritable-hyperslipidaemic rabbits is defective. Lack of evidence for an independent chylomicron-remnant receptor
    • Bowler A., Redgrave T.G., Mamo J.C. Chylomicron-remnant clearance in homozygote and heterozygote Watanabe-heritable-hyperslipidaemic rabbits is defective. Lack of evidence for an independent chylomicron-remnant receptor. Biochem J 1991, 276(Pt 2):381-386.
    • (1991) Biochem J , vol.276 , Issue.PART 2 , pp. 381-386
    • Bowler, A.1    Redgrave, T.G.2    Mamo, J.C.3
  • 8
    • 0031683495 scopus 로고    scopus 로고
    • Delayed chylomicron remnant clearance in subjects with heterozygous familial hypercholesterolaemia
    • Cabezas M.C., de Bruin T.W., Westerveld H.E., Meijer E., Erkelens D.W. Delayed chylomicron remnant clearance in subjects with heterozygous familial hypercholesterolaemia. J Intern Med 1998, 244:299-307.
    • (1998) J Intern Med , vol.244 , pp. 299-307
    • Cabezas, M.C.1    de Bruin, T.W.2    Westerveld, H.E.3    Meijer, E.4    Erkelens, D.W.5
  • 9
    • 0034905141 scopus 로고    scopus 로고
    • Chylomicron remnant metabolism in familial hypercholesterolaemia studied with a stable isotope breath test
    • Watts G.F., Barrett P.H., Marais A.D., et al. Chylomicron remnant metabolism in familial hypercholesterolaemia studied with a stable isotope breath test. Atherosclerosis 2001, 157:519-523.
    • (2001) Atherosclerosis , vol.157 , pp. 519-523
    • Watts, G.F.1    Barrett, P.H.2    Marais, A.D.3
  • 10
    • 0842281358 scopus 로고    scopus 로고
    • Lack of evidence for reduced plasma apo B48 catabolism in patients with heterozygous familial hypercholesterolemia carrying the same null LDL receptor gene mutation
    • Tremblay A.J., Lamarche B., Ruel I., et al. Lack of evidence for reduced plasma apo B48 catabolism in patients with heterozygous familial hypercholesterolemia carrying the same null LDL receptor gene mutation. Atherosclerosis 2004, 172:367-373.
    • (2004) Atherosclerosis , vol.172 , pp. 367-373
    • Tremblay, A.J.1    Lamarche, B.2    Ruel, I.3
  • 11
    • 0022257996 scopus 로고
    • Metabolism of protein-free lipid emulsion models of chylomicrons in rats
    • Redgrave T.G., Maranhao R.C. Metabolism of protein-free lipid emulsion models of chylomicrons in rats. Biochim Biophys Acta 1985, 835:104-112.
    • (1985) Biochim Biophys Acta , vol.835 , pp. 104-112
    • Redgrave, T.G.1    Maranhao, R.C.2
  • 12
    • 0030603980 scopus 로고    scopus 로고
    • Plasma kinetics of a chylomicron-like emulsion in patients with coronary artery disease
    • Maranhão R.C., Feres M.C., Martins M.T., et al. Plasma kinetics of a chylomicron-like emulsion in patients with coronary artery disease. Atherosclerosis 1996, 126:15-25.
    • (1996) Atherosclerosis , vol.126 , pp. 15-25
    • Maranhão, R.C.1    Feres, M.C.2    Martins, M.T.3
  • 13
    • 0034657652 scopus 로고    scopus 로고
    • Effect of pravastatin on plasma removal of a chylomicron-like emulsion in men with coronary artery disease
    • Santos R.D., Sposito A.C., Ventura L.I., Cesar L.A., Ramires J.A., Maranhão R.C. Effect of pravastatin on plasma removal of a chylomicron-like emulsion in men with coronary artery disease. Am J Cardiol 2000, 85:1163-1166.
    • (2000) Am J Cardiol , vol.85 , pp. 1163-1166
    • Santos, R.D.1    Sposito, A.C.2    Ventura, L.I.3    Cesar, L.A.4    Ramires, J.A.5    Maranhão, R.C.6
  • 14
    • 0036121117 scopus 로고    scopus 로고
    • LDL concentration is correlated with the removal from the plasma of a chylomicron-like emulsion in subjects with coronary artery disease
    • Sposito A.C., Santos R.D., Hueb W., et al. LDL concentration is correlated with the removal from the plasma of a chylomicron-like emulsion in subjects with coronary artery disease. Atherosclerosis 2002, 161:447-453.
    • (2002) Atherosclerosis , vol.161 , pp. 447-453
    • Sposito, A.C.1    Santos, R.D.2    Hueb, W.3
  • 15
    • 0037298362 scopus 로고    scopus 로고
    • Atorvastatin enhances the plasma clearance of chylomicron-like emulsions in subjects with atherogenic dyslipidemia: relevance to the in vivo metabolism of triglyceride-rich lipoproteins
    • Sposito A.C., Santos R.D., Amâncio R.F., Ramires J.A., Chapman M.J., Maranhão R.C. Atorvastatin enhances the plasma clearance of chylomicron-like emulsions in subjects with atherogenic dyslipidemia: relevance to the in vivo metabolism of triglyceride-rich lipoproteins. Atherosclerosis 2003, 166:311-321.
    • (2003) Atherosclerosis , vol.166 , pp. 311-321
    • Sposito, A.C.1    Santos, R.D.2    Amâncio, R.F.3    Ramires, J.A.4    Chapman, M.J.5    Maranhão, R.C.6
  • 16
    • 5644272884 scopus 로고    scopus 로고
    • Delayed intravascular catabolism of chylomicron-like emulsions is an independent predictor of coronary artery disease
    • Sposito A.C., Ventura L.I., Vinagre C.G., et al. Delayed intravascular catabolism of chylomicron-like emulsions is an independent predictor of coronary artery disease. Atherosclerosis 2004, 176:397-403.
    • (2004) Atherosclerosis , vol.176 , pp. 397-403
    • Sposito, A.C.1    Ventura, L.I.2    Vinagre, C.G.3
  • 17
    • 2942518215 scopus 로고    scopus 로고
    • Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome in patients with stable angina undergoing secondary prevention treatment: a long-term follow-up study
    • Sposito A.C., Lemos P.A., Santos R.D., et al. Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome in patients with stable angina undergoing secondary prevention treatment: a long-term follow-up study. J Am Coll Cardiol 2004, 43:2225-2232.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 2225-2232
    • Sposito, A.C.1    Lemos, P.A.2    Santos, R.D.3
  • 18
    • 0027301629 scopus 로고
    • Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics
    • Williams R.R., Hunt S.C., Schumacher M.C., et al. Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics. Am J Cardiol 1993, 72:171-176.
    • (1993) Am J Cardiol , vol.72 , pp. 171-176
    • Williams, R.R.1    Hunt, S.C.2    Schumacher, M.C.3
  • 19
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988, 16:1215.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 20
    • 0016850021 scopus 로고
    • Separation of plasma lipoprotein by density-gradient ultracentrifugation
    • Redgrave T.G., Roberts D.C.K., West C.E. Separation of plasma lipoprotein by density-gradient ultracentrifugation. Anal Biochem 1975, 65:42-49.
    • (1975) Anal Biochem , vol.65 , pp. 42-49
    • Redgrave, T.G.1    Roberts, D.C.K.2    West, C.E.3
  • 21
    • 0023333174 scopus 로고
    • A kinetic model of chylomicron core lipid metabolism in rats: the effect of a single meal
    • Redgrave T.G., Zech L.A. A kinetic model of chylomicron core lipid metabolism in rats: the effect of a single meal. J Lipid Res 1987, 28:473-482.
    • (1987) J Lipid Res , vol.28 , pp. 473-482
    • Redgrave, T.G.1    Zech, L.A.2
  • 23
    • 33645515465 scopus 로고    scopus 로고
    • High cholesterol intake modifies chylomicron metabolism in normolipidemic young men
    • César T.B., Oliveira M.R., Mesquita C.H., Maranhão R.C. High cholesterol intake modifies chylomicron metabolism in normolipidemic young men. J Nutr 2006, 136:971-976.
    • (2006) J Nutr , vol.136 , pp. 971-976
    • César, T.B.1    Oliveira, M.R.2    Mesquita, C.H.3    Maranhão, R.C.4
  • 24
    • 0031889498 scopus 로고    scopus 로고
    • Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations
    • Dietschy J.M. Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations. J Nutr 1998, 128:444S-448S.
    • (1998) J Nutr , vol.128
    • Dietschy, J.M.1
  • 25
    • 0025345124 scopus 로고
    • Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol
    • Reihnér E., Rudling M., Stalberg D., et al. Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol. N Engl J Med 1990, 323:224-228.
    • (1990) N Engl J Med , vol.323 , pp. 224-228
    • Reihnér, E.1    Rudling, M.2    Stalberg, D.3
  • 26
    • 0035253792 scopus 로고    scopus 로고
    • The effects of gemfibrozil upon the metabolism of chylomicron-like emulsions in patients with endogenous hypertriglyceridemia
    • Santos R.D., Ventura L.I., Spósito A.C., Schreiber R., Ramires J.A., Maranhão R.C. The effects of gemfibrozil upon the metabolism of chylomicron-like emulsions in patients with endogenous hypertriglyceridemia. Cardiovasc Res 2001, 49:456-465.
    • (2001) Cardiovasc Res , vol.49 , pp. 456-465
    • Santos, R.D.1    Ventura, L.I.2    Spósito, A.C.3    Schreiber, R.4    Ramires, J.A.5    Maranhão, R.C.6
  • 27
    • 0035129158 scopus 로고    scopus 로고
    • Effects of etofibrate upon the metabolism of chylomicron-like emulsions in patients with coronary artery disease
    • Sposito A.C., Maranhão R.C., Vinagre C.G., Santos R.D., Ramires J.A. Effects of etofibrate upon the metabolism of chylomicron-like emulsions in patients with coronary artery disease. Atherosclerosis 2001, 154:455-461.
    • (2001) Atherosclerosis , vol.154 , pp. 455-461
    • Sposito, A.C.1    Maranhão, R.C.2    Vinagre, C.G.3    Santos, R.D.4    Ramires, J.A.5
  • 28
    • 79955014999 scopus 로고    scopus 로고
    • HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: data from the MedPed CZ database and the Czech population
    • Soskaa V., Freibergerb T., Cifkovac R., et al. HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: data from the MedPed CZ database and the Czech population. Clin Chim Acta 2011, 412:920-924.
    • (2011) Clin Chim Acta , vol.412 , pp. 920-924
    • Soskaa, V.1    Freibergerb, T.2    Cifkovac, R.3
  • 29
    • 0028819191 scopus 로고
    • Increased hepatic secretion of VLDL apolipoprotein B-100 in heterozygous familial hypercholesterolemia: a stable isotope study
    • Cummings M.H., Watts G.F., Umpleby M., Hennessy T.R., Quiney J.R., Sonksen P.H. Increased hepatic secretion of VLDL apolipoprotein B-100 in heterozygous familial hypercholesterolemia: a stable isotope study. Atherosclerosis 1995, 113:79-89.
    • (1995) Atherosclerosis , vol.113 , pp. 79-89
    • Cummings, M.H.1    Watts, G.F.2    Umpleby, M.3    Hennessy, T.R.4    Quiney, J.R.5    Sonksen, P.H.6
  • 30
    • 20044387775 scopus 로고    scopus 로고
    • Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production
    • Millar J.S., Maugeais C., Ikewaki K., et al. Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production. Arterioscler Thromb Vasc Biol 2005, 25:560-565.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 560-565
    • Millar, J.S.1    Maugeais, C.2    Ikewaki, K.3
  • 31
    • 0028933044 scopus 로고
    • Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidaemic rabbits. Saturation of the sequestration step of the remnant clearance pathway
    • Hussain M.M., Innerarity T.L., Brecht W.J., Mahley R.W. Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidaemic rabbits. Saturation of the sequestration step of the remnant clearance pathway. J Biol Chem 1995, 270:8578-8587.
    • (1995) J Biol Chem , vol.270 , pp. 8578-8587
    • Hussain, M.M.1    Innerarity, T.L.2    Brecht, W.J.3    Mahley, R.W.4
  • 32
    • 0025991653 scopus 로고
    • Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo
    • Choi S.Y., Fong L.G., Kirven M.J., Cooper A.D. Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo. J Clin Invest 1991, 88:1173-1181.
    • (1991) J Clin Invest , vol.88 , pp. 1173-1181
    • Choi, S.Y.1    Fong, L.G.2    Kirven, M.J.3    Cooper, A.D.4
  • 33
    • 0029076825 scopus 로고
    • Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor
    • Herz J., Qiu S.Q., Oesterle A., DeSilva H.V., Shafi S., Havel R.J. Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1995, 92:4611-4615.
    • (1995) Proc Natl Acad Sci U S A. , vol.92 , pp. 4611-4615
    • Herz, J.1    Qiu, S.Q.2    Oesterle, A.3    DeSilva, H.V.4    Shafi, S.5    Havel, R.J.6
  • 34
    • 0025738198 scopus 로고
    • Metabolism of lipoprotein remnants in humans. Studies during intestinal infusion of fat and cholesterol in subjects with varying expression of the low density lipoprotein receptor
    • Eriksson M., Angelin B., Henriksson P., Ericsson S., Vitols S., Berglund L. Metabolism of lipoprotein remnants in humans. Studies during intestinal infusion of fat and cholesterol in subjects with varying expression of the low density lipoprotein receptor. Arterioscler Thromb 1991, 11:827-837.
    • (1991) Arterioscler Thromb , vol.11 , pp. 827-837
    • Eriksson, M.1    Angelin, B.2    Henriksson, P.3    Ericsson, S.4    Vitols, S.5    Berglund, L.6
  • 35
    • 0031864303 scopus 로고    scopus 로고
    • Accumulation of chylomicron remnants in homozygous subjects with familial hypercholesterolaemia
    • Mamo J.C., Smith D., Yu K.C., et al. Accumulation of chylomicron remnants in homozygous subjects with familial hypercholesterolaemia. Eur J Clin Invest 1998, 28:379-384.
    • (1998) Eur J Clin Invest , vol.28 , pp. 379-384
    • Mamo, J.C.1    Smith, D.2    Yu, K.C.3
  • 36
    • 0031010389 scopus 로고    scopus 로고
    • Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo
    • Rensen P.C., Herijgers N., Netscher M.H., Meskers S.C., van Eck M., van Berkel T.J. Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo. J Lipid Res 1997, 38:1070-1084.
    • (1997) J Lipid Res , vol.38 , pp. 1070-1084
    • Rensen, P.C.1    Herijgers, N.2    Netscher, M.H.3    Meskers, S.C.4    van Eck, M.5    van Berkel, T.J.6
  • 37
    • 0014441380 scopus 로고
    • Particle size and protein content of six fractions of the S, >20 plasma lipoproteins isolated by density gradient centrifugation
    • Lossow W.J., Lindgren F.T., Murchio J.C., Stevens G.K. Particle size and protein content of six fractions of the S, >20 plasma lipoproteins isolated by density gradient centrifugation. J Lipid Res 1969, 10:68-76.
    • (1969) J Lipid Res , vol.10 , pp. 68-76
    • Lossow, W.J.1    Lindgren, F.T.2    Murchio, J.C.3    Stevens, G.K.4
  • 38
    • 0025149320 scopus 로고
    • Fat feeding increases size, but not number, of chylomicrons produced by the small intestine
    • Hayashi H., Fujimoto K., Cardelli J.A., Nutting D.F., Bergsted S., Tso P. Fat feeding increases size, but not number, of chylomicrons produced by the small intestine. Am J Physiol 1990, 259:G709-G719.
    • (1990) Am J Physiol , vol.259
    • Hayashi, H.1    Fujimoto, K.2    Cardelli, J.A.3    Nutting, D.F.4    Bergsted, S.5    Tso, P.6
  • 39
    • 0033759134 scopus 로고    scopus 로고
    • High dose of simvastatin normalizes postprandial remnant-like particle response in patients with heterozygous familial hypercholesterolemia
    • Twickler T.B., Dallinga-Thie G.M., de Valk H.W., Schreuder P.C., Jansen H., Cabezas M.C. High dose of simvastatin normalizes postprandial remnant-like particle response in patients with heterozygous familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2000, 20:2422-2427.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2422-2427
    • Twickler, T.B.1    Dallinga-Thie, G.M.2    de Valk, H.W.3    Schreuder, P.C.4    Jansen, H.5    Cabezas, M.C.6


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