Expression of p75NTR, a marker for basal forebrain cholinergic neurons, in young and aged dogs with or without cognitive dysfunction syndrome

Journal of Alzheimer's Disease

Volumn 28, Issue 2, 2012, Pages 291-296

  Insua, Daniel ^a,b   Corredoira, Angélica ^a   González Martínez, Ángela ^a   Suárez, María Luisa ^a   Santamarina, Germán ^a   Sarasa, Manuel ^b   Pesini, Pedro ^b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b Araclon Biotech Ltd   (Spain)

Author keywords

Aging; Alzheimer's disease; basal forebrain cholinergic neurons (BFCN); unbiased stereology

Indexed keywords

NEUROTROPHIN RECEPTOR P75;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; ARTICLE; BRAIN NERVE CELL; CHOLINERGIC NERVE; COGNITIVE DEFECT; DOG; FOREBRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUESTIONNAIRE;

EID: 84856998253     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110905     Document Type: Article

References (42)

1. Ferreira G, Meurisse M, Tillet Y, Levy F (2001) Distribution and co-localization of choline acetyltransferase and p75 neurotrophin receptors in the sheep basal forebrain: Implications for the use of a specific cholinergic immunotoxin. Neuroscience 104, 419-439. (Pubitemid 32493734)
2. Mufson EJ, Kordower JH (2001) Cholinergic basal forebrain systems in the primate central nervous system: Anatomy, connectivity, neurochemistry, aging, dementia, and experimental therapeutics. In Functional Neurobiology of Aging, Hof PR, Mobbs CV, eds. Academic Press, London, pp. 243-281.
3. Tremere LA, Pinaud R, Grosche J, Hartig W, Rasmusson DD (2000) Antibody for human p75 LNTR identifies choliner-gic basal forebrain of non-primate species. Neuroreport 11, 2177-2183. (Pubitemid 30485557)
4. Wu CK, Hersh LB, Geula C (2000) Cyto- and chemoarchi-tecture of basal forebrain cholinergic neurons in the common marmoset (Callithrix jacchus). Exp Neurol 165, 306-326.
5. Mufson EJ, Ma SY, Cochran EJ, Bennett DA, Beckett LA, Jaffar S, Saragovi HU, Kordower JH (2000) Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. J Comp Neurol 427, 19-30.
6. Mufson EJ, Ma SY, Dills J, Cochran EJ, Leurgans S, Wuu J, Bennett DA, Jaffar S, Gilmor ML, Levey AI, Kordower JH (2002) Loss of basal forebrain P75 (NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease. J Comp Neurol 443, 136-153. (Pubitemid 34052063)
7. Mufson EJ, Counts SE, Perez SE, GinsbergSD (2008)Cholin-ergic system during the progression of Alzheimer's disease: Therapeutic implications. Expert Rev Neurother 8, 1703-1718.
8. Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen DE (2009) Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75 (NTR) interaction. Ann Neurol 65, 294-303.
9. Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander GL, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM (2009) The p75 neurotrophin receptor promotes amyloid-beta (1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci 29, 10627-10637.
10. Chakravarthy B, Gaudet C, Menard M, Atkinson T, Brown L, Laferla FM, Armato U, Whitfield J (2010) Amyloid-beta peptides stimulate the expression of the p75 (NTR) neu-rotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. J Alzheimers Dis 19, 915-925.
11. Head E (2007) Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: Strategies for healthy aging. Ann N Y Acad Sci 1114, 398-406. (Pubitemid 350070373)
12. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cot-manCW (2008)Region specific neuron lossinthe aged canine hippocampus is reduced by enrichment. Neurobiol Aging 29, 39-50. (Pubitemid 350102716)
13. Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA (2008) Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antiox-idants and a program of behavioral enrichment: Relevance to Alzheimer's disease. Neurobiol Aging 29, 51-70. (Pubitemid 350102715)
14. Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW (2002) Oxidative damage increases with ageinacanine modelofhuman brain aging.J Neurochem 82, 375-381. (Pubitemid 34774628)
15. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW (1996) The canine as an animal model of human aging and dementia. Neurobiol Aging 17, 259-268. (Pubitemid 26167637)
16. Sarasa L, Gallego C, Monleon I, Olvera A, Canudas J, Montanes M, Pesini P, Sarasa M (2010) Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing. Neuroscience 171, 1091-1101.
17. Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW (2005) Chronic antioxidant and mitochondrial cofac-tor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry 29, 461-469. (Pubitemid 40417598)
18. Tapp PD, Siwak CT, Estrada J, Holowachuk D, Milgram NW (2003) Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm. Learn Mem 10, 148-160. (Pubitemid 36418725)
19. Adams B, Chan A, Callahan H, Siwak C, Tapp D, Ikeda-Douglas C, Atkinson P, Head E, Cotman CW, Milgram NW (2000) Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behav Brain Res 108, 47-56. (Pubitemid 30009726)
20. Head E, Mehta R, Hartley J, Kameka M, Cummings BJ, Cot-man CW, Ruehl WW, Milgram NW (1995) Spatial learning and memory as a function of age in the dog. Behav Neurosci 109, 851-858.
21. Siwak CT, Tapp PD, Milgram NW (2001) Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog. Learn Mem 8, 317-325. (Pubitemid 34037575)
22. Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW (1998) Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging 19, 415-425. (Pubitemid 29065491)
23. Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW (2000) Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging 21, 89-96. (Pubitemid 30224790)
24. Cummings BJ, Head E, Afagh AJ, Milgram NW, CotmanCW (1996) Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem 66, 11-23. (Pubitemid 26195731)
25. Bernedo V, Insua D, Suarez ML, Santamarina G, Sarasa M, Pesini P (2009) Beta-amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog. J Comp Neurol 513, 417-429.
26. Insua D, Suárez M-L, Santamarina G, Sarasa M, Pesini P (2010) Dogs with canine counterpart of Alzheimer's disease lose noradrenergic neurons. Neurobiol Aging 31, 625-635.
27. González-Martínez A, Rosado B, Pesini P, Suárez M-L, San-tamarina G, García-Belenguer S, Villegas A, Monleón I, Sarasa M (2011) Plasma beta-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease. Exp Gerontol 46, 590-596.
28. St Jacques R, Gorczyca W, Mohr G, Schipper HM (1996) Mapping of the basal forebrain cholinergic system of the dog:A choline acetyltransferase immunohistochemical study. J Comp Neurol 366, 717-725. (Pubitemid 26087303)
29. Geula C, Schatz CR, Mesulam MM (1993) Differential localization of NADPH-diaphorase and calbindin-D28k within the cholinergic neurons of the basal forebrain, striatum and brain-stem in the rat, monkey, baboon and human. Neuroscience 54, 461-476. (Pubitemid 23153755)
30. Ellison DW, Kowall NW, Martin JB (1987) Subset of neurons characterized by the presence of NADPH-diaphorase in human substantia innominata. J Comp Neurol 260, 233-245. (Pubitemid 17077698)
31. Downen M, Zhao ML, Lee P, Weidenheim KM, Dickson DW, Lee SC (1999) Neuronal nitric oxide synthase expression in developing and adult human CNS. J Neuropathol Exp Neurol 58, 12-21. (Pubitemid 29053021)
32. Menéndez L, Insua D, Rois JL, Santamarina G, Suárez ML, Pesini P (2006) The immunohistochemical localization of neuronal nitric oxide synthase in the basal forebrain of the dog. J Chem Neuroanat 31, 200-209.
33. Araujo JA, Studzinski CM, Milgram NW (2005) Further evidence for the cholinergic hypothesis of aging and dementia from the canine modelofaging. Prog Neuropsychopharmacol Biol Psychiatry 29, 411-422. (Pubitemid 40417593)
34. Studzinski CM, Araujo JA, Milgram NW (2005) The canine model of human cognitive aging and dementia: Pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Prog Neuropsychophar-macol Biol Psychiatry 29, 489-498. (Pubitemid 40417601)
35. Gundersen HJ (1986) Stereology of arbitrary particles. A review ofunbiased number and size estimators and the presentation ofsome new ones, in memory of William R. Thompson. J Microsc 143, 3-45.
36. West MJ (1993) New stereological methods for counting neurons. Neurobiol Aging 14, 275-285. (Pubitemid 23214693)
37. Mesulam MM, Mufson EJ, Wainer BH, Levey AI (1983) Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 10, 1185-1201. (Pubitemid 14178569)
38. Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR (1982) Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215, 1237-1239. (Pubitemid 12106486)
39. Russell MJ, Bobik M, White RG, Hou Y, Benjamin SA, Ged-des JW (1996) Age-specific onset of beta-amyloid in beagle brains. Neurobiol Aging 17, 269-273. (Pubitemid 26167638)
40. Wegiel J, Wisniewski HM, Dziewiatkowski J, Tarnawski M, Dziewiatkowska A, Morys J, Soltysiak Z, Kim KS (1996) Subpopulation of dogs with severe brain parenchymal beta amyloidosis distinguished with cluster analysis. Brain Res 728, 20-26. (Pubitemid 26254952)
41. Yoshino T, Uchida K, Tateyama S, Yamaguchi I, Nakayama H, Goto N (1996) A retrospective study of canine senile plaques and cerebral amyloid angiopathy. Vet Pathol 33, 230-234. (Pubitemid 126484266)
42. Nelson PT, Braak H, MarkesberyWR (2009) Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship. J Neuropathol Exp Neurol 68, 1-14.