Adding ROS quenchers to cold K + cardioplegia reduces superoxide emission during 2-hour global cold cardiac ischemia

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 17, Issue 1, 2012, Pages 93-101

  Aldakkak, Mohammed ^a   Stowe, David F ^a,b,c   Heisner, James S ^a   Riess, Matthias L ^a,b   Camara, Amadou K S ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Marquette University   (United States)

Author keywords

hypothermia; ischemia; mitochondrial redox state; ROS quenchers

Indexed keywords

BENZOIC ACID DERIVATIVE; CARDIOVASCULAR AGENT; CATALASE; FLAVINE ADENINE NUCLEOTIDE; GLUTATHIONE; MANGANESE DERIVATIVE; MN(III) TETRAKIS (4 BENZOIC ACID) PORPHYRIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; POTASSIUM ION; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CARDIOPLEGIA; CELL FUNCTION; COLD ISCHEMIA; CONTROLLED STUDY; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE WALL; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART MUSCLE REPERFUSION; HYPOTHESIS; ISOLATED HEART; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; REDOX STRESS; SPECTROFLUOROMETRY;

ANIMALS; CARDIOPLEGIC SOLUTIONS; COLD ISCHEMIA; GUINEA PIGS; HEART ARREST, INDUCED; HEART RATE; HYPERTONIC SOLUTIONS; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; POTASSIUM COMPOUNDS; RANDOM ALLOCATION; REACTIVE OXYGEN SPECIES; SUPEROXIDES; TIME FACTORS;

EID: 84856953884     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248410389815     Document Type: Article

References (49)

1. Riess ML, Camara AK, Kevin LG, An J, Stowe DF.. Reduced reactive O2 species formation and preserved mitochondrial NADH and [Ca2+] levels during short-term 17°C ischemia in intact hearts. Cardiovasc Res. 2004 ; 61 (3). 580-590 (Pubitemid 38210163)
2. Camara AK, Aldakkak M, Heisner JS, et al. ROS scavenging before 27°C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state. Am J Physiol Cell Physiol. 2007 ; 292 (6). C2021-2031
3. Camara AK, Riess ML, Kevin LG, Novalija E, Stowe DF.. Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart. Am J Physiol Heart Circ Physiol. 2004 ; 286 (4). H1289-1299
4. Menasche P, Grousset C, Gauduel Y, Mouas C, Piwnica A.. [Protective effects of inhibitors of oxygen free radicals on the ischemic and reperfused heart. Applications to cardioplegia]. Archives des maladies du coeur et des vaisseaux. 1986 ; 79 (13). 1918-1923 (Pubitemid 17004589)
5. Tossios P, Bloch W, Huebner A, et al. N-acetylcysteine prevents reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery: results of a randomized, double-blind, placebo-controlled clinical trial. J Thorac Cardiovasc Surg. 2003 ; 126 (5). 1513-1520 (Pubitemid 37449181)
6. Vento AE, Nemlander A, Aittomaki J, Salo J, Karhunen J, Ramo OJ.. N-acetylcysteine as an additive to crystalloid cardioplegia increased oxidative stress capacity in CABG patients. Scand Cardiovasc J. 2003 ; 37 (6). 349-355 (Pubitemid 38159352)
7. Ytrehus K, Gunnes S, Myklebust R, Mjos OD.. Protection by superoxide dismutase and catalase in the isolated rat heart reperfused after prolonged cardioplegia: a combined study of metabolic, functional, and morphometric ultrastructural variables. Cardiovasc Res. 1987 ; 21 (7). 492-499 (Pubitemid 17106450)
8. Aldakkak M, Stowe DF, Chen Q, Lesnefsky EJ, Camara AK.. Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release. Cardiovasc Res. 2008 ; 77 (2). 406-415 (Pubitemid 351197651)
9. Vanden Hoek TL, Li C, Shao Z, Schumacker PT, Becker LB.. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol. 1997 ; 29 (9). 2571-2583 (Pubitemid 27404448)
10. An J, Varadarajan SG, Camara A, et al. Blocking Na+/H+ exchange reduces [Na+]i and [Ca2+]i load after ischemia and improves function in intact hearts. Am J Physiol Heart Circ Physiol. 2001 ; 281 (6). H2398-2409
11. Kevin LG, Camara AK, Riess ML, Novalija E, Stowe DF.. Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2003 ; 284 (2). H566-574
12. Kevin LG, Novalija E, Riess ML, Camara AK, Rhodes SS, Stowe DF.. Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts. Anesth Analg. 2003 ; 96 (4). 949-955 (Pubitemid 36359021)
13. Riess ML, Camara AK, Chen Q, Novalija E, Rhodes SS, Stowe DF.. Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea pig intact hearts. Am J Physiol Heart Circ Physiol. 2002 ; 283 (1). H53-60
14. Riess ML, Camara AK, Novalija E, Chen Q, Rhodes SS, Stowe DF.. Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid. Anesth Analg. 2002 ; 95 (6). 1540-1546 (Pubitemid 35423937)
15. Scaduto RC, Grotyohann LW.. Hydrolysis of Ca2+-sensitive fluorescent probes by perfused rat heart. Am J Physiol Heart Circ Physiol. 2003 ; 285 (5). H2118-2124
16. Brandes R, Bers DM.. Increased work in cardiac trabeculae causes decreased mitochondrial NADH fluorescence followed by slow recovery. Biophys J. 1996 ; 71 (2). 1024-1035 (Pubitemid 26289184)
17. Chance B, Williamson JR, Jamieson D, Schoenner B.. Properties and kinetics of reduced pyridine nucleotide fluorescence of the isolated and in vivo rat heart. Biochem Z. 1965 ; 341: 357-377
18. Nuutinen EM.. Subcellular origin of the surface fluorescence of reduced nicotinamide nucleotides in the isolated perfused rat heart. Basic Res Cardiol. 1984 ; 79 (1). 49-58 (Pubitemid 14179782)
19. Oldendorf WH, Cornford ME, Brown WJ.. The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann Neurol. 1977 ; 1 (5). 409-417
20. Barth E, Stammler G, Speiser B, Schaper J.. Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man. J Mol Cell Cardiol. 1992 ; 24 (7). 669-681
21. Vinnakota KC, Bassingthwaighte JB.. Myocardial density and composition: a basis for calculating intracellular metabolite concentrations. Am J Physiol Heart Circ Physiol. 2004 ; 286 (5). H1742 - H1749
22. Camara AK, Chen Q, An J, et al. Comparison of hyperkalemic cardioplegia with altered CaCl2 and MgCl2 on Ca2+i transients and function after warm global ischemia in isolated hearts. J Cardiovasc Surg (Torino). 2004 ; 45 (1). 1-13 (Pubitemid 38514969)
23. Zhao H, Joseph J, Fales HM, et al. Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc Natl Acad Sci U S A. 2005 ; 102 (16). 5727-5732 (Pubitemid 40559627)
24. Zhao H, Kalivendi S, Zhang H, et al. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic Biol Med. 2003 ; 34 (11). 1359-1368 (Pubitemid 36570409)
25. Brandes R, Figueredo VM, Camacho SA, Baker AJ, Weiner MW.. Investigation of factors affecting fluorometric quantitation of cytosolic Ca2+ in perfused hearts. Biophys J. 1993 ; 65 (5). 1983-1993 (Pubitemid 23334866)
26. Stowe DF, Fujita S, An J, Paulsen RA, Varadarajan SG, Smart SC.. Modulation of myocardial function and Ca2+ sensitivity by moderate hypothermia in guinea pig isolated hearts. Am J Physiol. 1999 ; 277 (6 Pt 2). H2321 - H2332
27. Aldakkak M, Stowe DF, Heisner JS, Spence M, Camara AK.. Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function. J Cardiovasc Pharmacol. 2008 ; 52 (3). 236-244
28. Riess ML, Rhodes SS, Stowe DF, Aldakkak M, Camara AK.. Comparison of cumulative planimetry versus manual dissection to assess experimental infarct size in isolated hearts. J Pharmacol Toxicol Methods. 2009 ; 60 (3). 275-280
29. An J, Camara AK, Riess ML, Rhodes SS, Varadarajan SG, Stowe DF.. Improved mitochondrial bioenergetics by anesthetic preconditioning during and after 2 hours of 27°C ischemia in isolated hearts. J Cardiovasc Pharmacol. 2005 ; 46 (3). 280-287 (Pubitemid 41262829)
30. Belzer FO, Southard JH.. Principles of solid-organ preservation by cold storage. Transplantation. 1988 ; 45 (4). 673-676
31. Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR.. Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26°C: comparison to ViaSpan solution. Am J Physiol Heart Circ Physiol. 2007 ; 293 (1). H895 - H901
32. Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR.. Low-flow perfusion of guinea pig isolated hearts with 26°C air-saturated Lifor solution for 20 hours preserves function and metabolism. J Heart Lung Transplant. 2008 ; 27 (9). 1008-1015
33. Camara AK, An J, Chen Q, et al. Na+/H+ exchange inhibition with cardioplegia reduces cytosolic Ca2+ and myocardial damage after cold ischemia. J Cardiovasc Pharmacol. 2003 ; 41 (5). 686-698 (Pubitemid 36523170)
34. Ross JD, Ripper R, Law WR, et al. Adding bupivacaine to high-potassium cardioplegia improves function and reduces cellular damage of rat isolated hearts after prolonged, cold storage. Anesthesiology. 2006 ; 105 (4). 746-752 (Pubitemid 44477321)
35. Stowe DF, Heisner JS, An J, et al. Inhibition of Na+/H+ isoform-1 exchange protects hearts perfused after 6-hour cardioplegic cold storage. J Heart Lung Transplant. 2002 ; 21 (3). 374-382 (Pubitemid 34224101)
36. Andreyev AY, Kushnareva YE, Starkov AA.. Mitochondrial metabolism of reactive oxygen species. Biochemistry. 2005 ; 70 (2). 200-214 (Pubitemid 40512329)
37. Aon MA, Cortassa S, Maack C, O'Rourke B.. Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem. 2007 ; 282 (30). 21889-21900 (Pubitemid 47195754)
38. Camara AK, Lesnefsky EJ, Stowe DF.. Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal. 2010 ; 13 (3). 279-347
39. Hanukoglu I, Rapoport R.. Routes and regulation of NADPH production in steroidogenic mitochondria. Endocrine research. 1995 ; 21 (1-2). 231-241
40. Outten CE, Culotta VC.. A novel NADH kinase is the mitochondrial source of NADPH in Saccharomyces cerevisiae. The EMBO journal. 2003 ; 22 (9). 2015-2024 (Pubitemid 36565527)
41. Allen DG, Xiao XH.. Role of the cardiac Na+/H+ exchanger during ischemia and reperfusion. Cardiovasc Res. 2003 ; 57 (4). 934-941 (Pubitemid 36324598)
42. Bernard M, Menasche P, Pietri S, Grousset C, Piwnica A, Cozzone PJ.. Cardioplegic arrest superimposed on evolving myocardial ischemia. Improved recovery after inhibition of hydroxyl radical generation by peroxidase or deferoxamine. A 31P nuclear resonance study. Circulation. 1988 ; 78 (5 Pt 2). III164-172
43. Menasche P, Grousset C, Gauduel Y, Mouas C, Piwnica A.. Enhancement of cardioplegic protection with the free-radical scavenger peroxidase. Circulation. 1986 ; 74 (5 Pt 2). III138-144
44. Menasche P, Grousset C, Gauduel Y, Mouas C, Piwnica A.. Prevention of hydroxyl radical formation: a critical concept for improving cardioplegia. Protective effects of deferoxamine. Circulation. 1987 ; 76 (5 Pt 2). V180-185 (Pubitemid 17162537)
45. Menasche P, Grousset C, Gauduel Y, Mouas C, Piwnica A.. [A new concept of cardioplegic protection in cardiac surgery: iron chelation]. Archives des maladies du coeur et des vaisseaux. 1988 ; 81 (6). 811-816
46. Menasche P, Grousset C, Gauduel Y, Piwnica A.. A comparative study of free radical scavengers in cardioplegic solutions. Improved protection with peroxidase. J Thorac Cardiovasc Surg. 1986 ; 92 (2). 264-271 (Pubitemid 16040213)
47. Myers CL, Weiss SJ, Kirsh MM, Shepard BM, Shlafer M.. Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts. J Thorac Cardiovasc Surg. 1986 ; 91 (2). 281-289 (Pubitemid 16164441)
48. Shlafer M, Kane PF, Kirsh MM.. Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart. J Thorac Cardiovasc Surg. 1982 ; 83 (6). 830-839 (Pubitemid 13097348)
49. Gallagher KP, Buda AJ, Pace D, Gerren RA, Shlafer M.. Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion. Circulation. 1986 ; 73 (5). 1065-1076 (Pubitemid 16102199)