N-acetylcysteine as an additive to crystalloid cardioplegia increased oxidative stress capacity in CABG patients

Scandinavian Cardiovascular Journal

Volumn 37, Issue 6, 2003, Pages 349-355

  Vento, Antti ^a   Nemlander, Arto ^a   Aittomäki, Juha ^a   Salo, Jarmo ^a   Karhunen, Janne ^a   Rämö, O Juhani ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DRUG ADDITIVE; GLUTATHIONE; LORAZEPAM; MYELOPEROXIDASE; NITRIC ACID DERIVATIVE; PLEGISOL;

ADULT; AORTA CLAMPING; ARTICLE; BLOOD SAMPLING; CARDIOPLEGIA; CLINICAL ARTICLE; CLINICAL OBSERVATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; CORONARY REPERFUSION; CORONARY SINUS; CRYSTALLOID; DRUG EFFICACY; DRUG SOLUTION; HEART ARRHYTHMIA; HEART EJECTION FRACTION; HEART FUNCTION; HEART HEMODYNAMICS; HEART MUSCLE BIOPSY; HEART MUSCLE ISCHEMIA; HUMAN; INCIDENCE; INFLAMMATION; INFORMED CONSENT; LEUKOCYTE; LIVER DYSFUNCTION; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE;

ACETYLCYSTEINE; BLOOD CHEMICAL ANALYSIS; CARDIOPLEGIC SOLUTIONS; CORONARY ARTERIOSCLEROSIS; CORONARY ARTERY BYPASS; ENERGY METABOLISM; FREE RADICAL SCAVENGERS; HEMODYNAMIC PROCESSES; HUMANS; LIPID PEROXIDATION; MALE; MIDDLE AGED; OXIDATIVE STRESS; PEROXIDASE; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VENTRICULAR FUNCTION;

EID: 0742324527     PISSN: 14017431     EISSN: None     Source Type: Journal    
DOI: 10.1080/14017430310015406     Document Type: Article

References (23)

1. Hansen PR. Role of neutrophils in myocardial ischemia and reperfusion. Circulation 1995; 91: 1872-1885.
2. Reilly PM, Schiller HJ, Bulkley GB. Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites. Am J Surg 1991; 161: 488-503.
3. Sisto T, Paajanen H, Metsä-Ketelä T, Harmoinen A, Nordback I, Tarkka M. Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting. Ann Thorac Surg 1995; 59: 1519-1523.
4. Ferrari R, Ceconi C, Curello S, et al. Oxygen free radicals and myocardial damage: Protective role of thiol-containing agents. Am J Med 1991; 91 Suppl 3C: 95-105.
5. Menasche P, Grousset C, Gaudel Y, Mouas C, Piwnica A. Maintenance of the myocardial thiol pool by N-acetylcysteine. J Thorac Cardiovasc Surg 1992; 103: 936-944.
6. Suzuki K, Ota H, Sasagawa S, Sakatoni T, Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Ann Biochem 1983; 132: 345-352.
7. Laihia JK, Jansen CT, Ahotupa M. Lucigenin and linoleate enhanced chemiluminescent assay for superoxide dismutase activity. Free Rad Biol Med 1993; 14: 457-461.
8. Saville B. A scheme for the colorimetric determination of microgram amounts of thiols. Analyst 1985; 83: 670-672.
9. Takada M, Ikenoya S, Yuzuhira T, Katayama K. Simultaneous determination of reduced and oxidized ubiquinones. Methods Enzymol 1985; 105: 147-155.
10. Vasankari T, Kujala U, Heinonen O, Kapanen J, Ahotupa M. Measurement of plasma lipid peroxidation during exercise using three different methods: Diene conjugation, thiobarbituric acid reactive material and fluorescent chromolipids. Clin Chim Acta 1995; 234: 63-69.
11. Uotila JT, Kirkkola A-L, Rorarius M, Tuimala RJ, Metsä-Ketelä T. The total peroxyl radical-trapping ability of plasma and the cerebrospinal fluid in normal and preclampic parturients. Free Rad Biol Med 1994; 16: 581-590.
12. Menasche P, Pascuier C, Bellucci S, Lorente P, Jaillon P, Piwnica A. Deferoxamine reduces neutrophil-mediated free radical production during cardiopulmonary bypass in man. J Thorac Cardiovasc Surg 1988; 96: 582-589.
13. Vinten-Johansen J, Chiantella V, Faust KB, et al. Myocardial protection with blood cardioplegia in ischemically injured hearts: Reduction of reoxygenation injury with allopurinol. Ann Thorac Surg 1988; 45: 319-326.
14. Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical superoxide and hypochlorous acid. Free Rad Biol Med 1989; 6: 593-597.
15. Brunet J, Boily M-J, Cordeau S, Des Rosiers C. Effects of N-acetylcysteine in the rat heart reperfused after low-flow ischemia: Evidence for direct scavenging of hydroxyl radicals and a nitric oxide-dependent increase in coronary flow. Free Rad Biol Med 1995; 19: 627-638.
16. Sochman J, Kole J, Vrána M, Fabián J. Cardioprotective effects of N-acetylcysteine: The reduction in the extent of infarction and occurrence of reperfusion arrhythmias in the dog. Int J Cardiol 1990; 28: 191-196.
17. Arstall M, Yang J, Stafford I, Betts WH, Horowitz JD. N-Acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction: Safety and biochemical effects. Circulation 1995; 92: 2855-2862.
18. Ichihara T, Yasuura K, Maseki T, et al. The effects of using a leukocyte removal filter during cold blood cardioplegia. Surgery Today 1994; 24: 966-972.
19. Weisman HF, Bartow T, Leppo MK, et al. Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 1990; 249: 146-151.
20. Amsterdam AA, Pan H-L, Rendig SV, Symons JD, Fletcher MP, Longhurst SC. Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocking agent by inhibition of neutrophil activity without reduction of neutrophil migration. J Am Coll Cardiol 1993; 22: 1738-1744.
21. Nicolini FA, Mehta JL, Nichols WW, Donnelly WH, Luostarinen R, Saldeen TGP. Leukocyte elastase inhibition and t-PA-induced coronary artery thrombosis in dogs: Beneficial effects on myocardial histology. Am Heart J 1991; 122: 1245-1251.
22. Thies JC, Teklote J, Clauer U, et al. The efficacy of N-acetylcysteine as a hepatoprotective agent in liver transplantation. Transpl Int 1998; 11: 390-392.
23. Devlin J, Ellis AE, McPeake J, Heaton N, Wendon JA, Williams R. N-Acetylcysteine improves indocyanine green extraction and oxygen transport during hepatic dysfunction. Crit Care Med 1997; 25: 236-242.