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Volumn 23, Issue 2, 2012, Pages 121-131

The platelet hyporesponsiveness to clopidogrel in acute coronary syndrome patients treated with 75mg/day clopidogrel may be overcome within 1 month of treatment

Author keywords

Acute coronary syndrome; clopidogrel; inflammation; leukocytes; platelets; thrombosis

Indexed keywords

ADENOSINE DIPHOSPHATE; CD40 LIGAND; CLOPIDOGREL; THROMBIN RECEPTOR ACTIVATING PEPTIDE; VASODILATOR STIMULATED PHOSPHOPROTEIN;

EID: 84856947396     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2011.597527     Document Type: Article
Times cited : (24)

References (40)
  • 1
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007;357:2482-2494.
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Davi, G.1    Patrono, C.2
  • 2
    • 58249133166 scopus 로고    scopus 로고
    • Role of antiplatelet therapy across the spectrum of patients with coronary artery disease
    • Bhatt DL. Role of antiplatelet therapy across the spectrum of patients with coronary artery disease. Am J Cardiol 2009;103:11A-19A.
    • (2009) Am J Cardiol , vol.103
    • Bhatt, D.L.1
  • 3
    • 42249102617 scopus 로고    scopus 로고
    • P2 receptors, platelet function and pharmacological implications
    • DOI 10.1160/TH07-11-0673
    • Gachet C. P2 receptors, platelet function and pharmacological implications. Thromb Haemost 2008;99:466-472. (Pubitemid 351549282)
    • (2008) Thrombosis and Haemostasis , vol.99 , Issue.3 , pp. 466-472
    • Gachet, C.1
  • 4
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996;348:1329-1339.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 5
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • DOI 10.1056/NEJMoa010746
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001;345:494-502. (Pubitemid 32758501)
    • (2001) New England Journal of Medicine , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 7
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • DOI 10.1001/jama.288.19.2411
    • Steinhubl SR, Berger PB, Mann JT III, Fry ET, DeLago A, Wilmer C, Topol EJ. CREDO investigators. Clopidogrel for the reduction of events during observation: Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial. JAMA 2002;288:2411-2420. (Pubitemid 35340537)
    • (2002) Journal of the American Medical Association , vol.288 , Issue.19 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Tift Mann III, J.3    Fry, E.T.A.4    DeLago, A.5    Wilmer, C.6    Topol, E.J.7
  • 8
    • 70350459370 scopus 로고    scopus 로고
    • Mechanisms of platelet activation: Need for new strategies to protect against platelet-mediated atherothrombo-sis
    • Jennings LK. Mechanisms of platelet activation: Need for new strategies to protect against platelet-mediated atherothrombo-sis. Thromb Haemost 2009;102:248-257.
    • (2009) Thromb Haemost , vol.102 , pp. 248-257
    • Jennings, L.K.1
  • 10
    • 65649099288 scopus 로고    scopus 로고
    • Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting
    • Antonino MJ, Mahla E, Bliden KP, Tantry US, Gurbel PA. Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting. Am J Cardiol 2009;103:1546-1550.
    • (2009) Am J Cardiol , vol.103 , pp. 1546-1550
    • Antonino, M.J.1    Mahla, E.2    Bliden, K.P.3    Tantry, U.S.4    Gurbel, P.A.5
  • 11
    • 56349140778 scopus 로고    scopus 로고
    • The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) study
    • Saw J, Madsen EH, Chan S, Maurer-Spurej E. The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) study. J Am Coll Cardiol 2008;52:1826-1833.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1826-1833
    • Saw, J.1    Madsen, E.H.2    Chan, S.3    Maurer-Spurej, E.4
  • 12
    • 0036714323 scopus 로고    scopus 로고
    • 12 receptor antagonist AR-C69931MX but not aspirin
    • Storey RF, Judge HM, Wilcox RG, Heptinstall S. Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Thromb Haemost 2002;88:488-494. (Pubitemid 35021609)
    • (2002) Thrombosis and Haemostasis , vol.88 , Issue.3 , pp. 488-494
    • Storey, R.F.1    Judge, H.M.2    Wilcox, R.G.3    Heptinstall, S.4
  • 13
    • 2542488125 scopus 로고    scopus 로고
    • Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome
    • DOI 10.1016/j.jacc.2003.10.071, PII S0735109704004978
    • Xiao Z, Theroux P. Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. J Am Coll Cardiol 2004;43:1982-1988. (Pubitemid 38686790)
    • (2004) Journal of the American College of Cardiology , vol.43 , Issue.11 , pp. 1982-1988
    • Xiao, Z.1    Theroux, P.2
  • 14
    • 1642410985 scopus 로고    scopus 로고
    • Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes
    • DOI 10.1161/01.CIR.0000124581.18191.15
    • Mitsios JV, Papathanasiou AI, Rodis FI, Elisaf M, Goudevenos JA, Tselepis AD. Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes. Circulation 2004;109:1335-1338. (Pubitemid 38387816)
    • (2004) Circulation , vol.109 , Issue.11 , pp. 1335-1338
    • Mitsios, J.V.1    Papathanasiou, A.I.2    Rodis, F.I.3    Elisaf, M.4    Goudevenos, J.A.5    Tselepis, A.D.6
  • 15
    • 41249093357 scopus 로고    scopus 로고
    • Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: A multicenter randomized prospective study
    • DOI 10.1016/j.jacc.2007.12.044, PII S0735109708005664
    • Bonello L, Camoin-Jau L, Arques S, Boyer C, Panagides D, Wittenberg O, Simeoni MC, Barragan P, Dignat-George F, Paganelli F. Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: A multicenter randomized prospective study. J Am Coll Cardiol 2008; 51:1404-1411. (Pubitemid 351447314)
    • (2008) Journal of the American College of Cardiology , vol.51 , Issue.14 , pp. 1404-1411
    • Bonello, L.1    Camoin-Jau, L.2    Arques, S.3    Boyer, C.4    Panagides, D.5    Wittenberg, O.6    Simeoni, M.-C.7    Barragan, P.8    Dignat-George, F.9    Paganelli, F.10
  • 16
    • 0032873146 scopus 로고    scopus 로고
    • Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets. Definition and detection of ticlopidine/clopidogrel effects
    • Schwarz UR, Geiger J, Walter U, Eigenthaler M. Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets-definition and detection of ticlopidine/clopidogrel effects. Thromb Haemost 1999; 82:1145-1152. (Pubitemid 29419734)
    • (1999) Thrombosis and Haemostasis , vol.82 , Issue.3 , pp. 1145-1152
    • Schwarz, U.R.1    Geiger, J.2    Walter, U.3    Eigenthaler, M.4
  • 17
    • 33746850259 scopus 로고    scopus 로고
    • Human platelets secrete the plasma type of platelet-activating factor acetylhydrolase primarily associated with microparticles
    • DOI 10.1161/01.ATV.0000228821.79588.ef, PII 0004360520060800000034
    • Mitsios JV, Vini MP, Stengel D, Ninio E, Tselepis AD. Human platelets secrete the plasma type of platelet-activating factor acetylhydrolase primarily associated with microparti-cles. Arterioscler Thromb Vasc Biol 2006;26:1907-1913. (Pubitemid 44305349)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.8 , pp. 1907-1913
    • Mitsios, J.V.1    Vini, M.P.2    Stengel, D.3    Ninio, E.4    Tselepis, A.D.5
  • 19
    • 3142723389 scopus 로고    scopus 로고
    • The concordance of self-report with other measures of medication adherence: A summary of the literature
    • Garber MC, Nau DP, Erickson SR, Aikens JE, Lawrence JB. The concordance of self-report with other measures of medication adherence: A summary of the literature. Med Care 2004;42(7):649-652.
    • (2004) Med Care , vol.42 , Issue.7 , pp. 649-652
    • Garber, M.C.1    Nau, D.P.2    Erickson, S.R.3    Aikens, J.E.4    Lawrence, J.B.5
  • 21
    • 33748948717 scopus 로고    scopus 로고
    • Benefit of a 600-mg Loading Dose of Clopidogrel on Platelet Reactivity and Clinical Outcomes in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome Undergoing Coronary Stenting
    • DOI 10.1016/j.jacc.2006.06.049, PII S0735109706018225
    • Cuisset T, Frere C, Quilici J, Morange PE, Nait-Saidi L, Carvajal J, Lehmann A, Lambert M, Bonnet JL, Alessi MC. Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol 2006;48:1339-1345. (Pubitemid 44436814)
    • (2006) Journal of the American College of Cardiology , vol.48 , Issue.7 , pp. 1339-1345
    • Cuisset, T.1    Frere, C.2    Quilici, J.3    Morange, P.-E.4    Nait-Saidi, L.5    Carvajal, J.6    Lehmann, A.7    Lambert, M.8    Bonnet, J.-L.9    Alessi, M.-C.10
  • 22
    • 42249097011 scopus 로고    scopus 로고
    • Testing antiplatelet therapy
    • Gachet C, Aleil B. Testing antiplatelet therapy. Eur Heart J Suppl 2008;10(suppl A):A28-A34.
    • (2008) Eur Heart J Suppl , vol.10 , Issue.SUPPL. A
    • Gachet, C.1    Aleil, B.2
  • 24
    • 77953911457 scopus 로고    scopus 로고
    • Working group on high on-treatment platelet reactivity. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    • Bonello L, Tantry US, Marcucci R, Blindt R, Angiolillo DJ, Becker R, Bhatt DL, Cattaneo M, Collet JP, Cuisset T, et al. Working group on high on-treatment platelet reactivity. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. JACC 2010;56:919-933.
    • (2010) JACC , vol.56 , pp. 919-933
    • Bonello, L.1    Tantry, U.S.2    Marcucci, R.3    Blindt, R.4    Angiolillo, D.J.5    Becker, R.6    Bhatt, D.L.7    Cattaneo, M.8    Collet, J.P.9    Cuisset, T.10
  • 25
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • DOI 10.1161/01.CIR.0000072771.11429.83
    • Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 2003;107:2908-2913. (Pubitemid 36736631)
    • (2003) Circulation , vol.107 , Issue.23 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 26
    • 77949568294 scopus 로고    scopus 로고
    • A randomised study comparing the antiplatelet and antinflammatory effect of clopidogrel 150mg/day versus 75mg/day in patients with ST-segment elevation acute myocardial infarction and poor responsiveness to clopidogrel: Results from the DOUBLE study
    • Palmerini T, Barozzi C, Tomasi L, Sangiorgi D, Marzocchi A, De Servi S, Ortolani P, Bacchi Reggiani L, Alessi L, Lauria G, et al. A randomised study comparing the antiplatelet and antinflammatory effect of clopidogrel 150mg/day versus 75mg/day in patients with ST-segment elevation acute myocardial infarction and poor responsiveness to clopidogrel: Results from the DOUBLE study. Thromb Res 2010;125:309-314.
    • (2010) Thromb Res , vol.125 , pp. 309-314
    • Palmerini, T.1    Barozzi, C.2    Tomasi, L.3    Sangiorgi, D.4    Marzocchi, A.5    De Servi, S.6    Ortolani, P.7    Bacchi Reggiani, L.8    Alessi, L.9    Lauria, G.10
  • 27
    • 57549090390 scopus 로고    scopus 로고
    • Clopidogrel 150 mg/day to overcome low responsiveness in patients undergoing elective percutaneous coronary intervention: Results from the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) randomized study
    • Aleil B, Jacquemin L, De Poli F, Zaehringer M, Collet JP, Montalescot G, Cazenave JP, Dickele MC, Monassier JP, Gachet C. Clopidogrel 150 mg/day to overcome low responsiveness in patients undergoing elective percutaneous coronary intervention: Results from the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) randomized study. JACC Cardiovasc Interv 2008;1:631-638.
    • (2008) JACC Cardiovasc Interv , vol.1 , pp. 631-638
    • Aleil, B.1    Jacquemin, L.2    De Poli, F.3    Zaehringer, M.4    Collet, J.P.5    Montalescot, G.6    Cazenave, J.P.7    Dickele, M.C.8    Monassier, J.P.9    Gachet, C.10
  • 28
    • 34248397644 scopus 로고    scopus 로고
    • A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days
    • DOI 10.1093/eurheartj/ehl489
    • von Beckerath N, Kastrati A, Wieczorek A, Pogatsa-Murray G, Sibbing D, Graf I, Schomig A. A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days. Eur Heart J 2007;28:1814-1819. (Pubitemid 47236637)
    • (2007) European Heart Journal , vol.28 , Issue.15 , pp. 1814-1819
    • Von Beckerath, N.1    Kastrati, A.2    Wieczorek, A.3    Pogatsa-Murray, G.4    Sibbing, D.5    Graf, I.6    Schomig, A.7
  • 29
    • 38649143111 scopus 로고    scopus 로고
    • Platelet microparticles and vascular cells interactions: A checkpoint between the haemostatic and thrombotic responses
    • DOI 10.1080/09537100701817232, PII 790037253
    • Morel O, Morel N, Freyssinet JM, Toti F. Platelet micropar-ticles and vascular cells interactions: A checkpoint between the haemostatic and thrombotic responses. Platelets 2008;19:9-23. (Pubitemid 351171554)
    • (2008) Platelets , vol.19 , Issue.1 , pp. 9-23
    • Morel, O.1    Morel, N.2    Freyssinet, J.-M.3    Toti, F.4
  • 31
    • 33846118743 scopus 로고    scopus 로고
    • Platelets as immune cells: Bridging inflammation and cardiovascular disease
    • DOI 10.1161/01.RES.0000252802.25497.b7, PII 0000301220070105000007
    • von Hundelshausen P, Weber C. Platelets as immune cells: Bridging inflammation and cardiovascular disease. Circ Res 2007;100:27-40. (Pubitemid 46066771)
    • (2007) Circulation Research , vol.100 , Issue.1 , pp. 27-40
    • Von Hundelshausen, P.1    Weber, C.2
  • 33
    • 0029815017 scopus 로고    scopus 로고
    • Increased neutrophil-platelet adhesion in patients with unstable angina
    • Ott I, Neumann FJ, Gawaz M, Schmitt M, Schomig A. Increased neutrophil-platelet adhesion in patients with unstable angina. Circulation 1996;94:1239-1246. (Pubitemid 26307248)
    • (1996) Circulation , vol.94 , Issue.6 , pp. 1239-1246
    • Ott, I.1    Neumann, F.-J.2    Gawaz, M.3    Schmitt, M.4    Schomig, A.5
  • 34
    • 0037035461 scopus 로고    scopus 로고
    • Increased platelet binding to circulating monocytes in acute coronary syndromes
    • DOI 10.1161/01.CIR.0000015700.27754.6F
    • Sarma J, Laan CA, Alam S, Jha A, Fox KA, Dransfield I. Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation 2002;105:2166-2171. (Pubitemid 34517160)
    • (2002) Circulation , vol.105 , Issue.18 , pp. 2166-2171
    • Sarma, J.1    Laan, C.A.2    Alam, S.3    Jha, A.4    Fox, K.A.A.5    Dransfield, I.6
  • 35
    • 74249083865 scopus 로고    scopus 로고
    • Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients
    • Muhlestein JB. Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients. Thromb Haemost 2010;103:71-82.
    • (2010) Thromb Haemost , vol.103 , pp. 71-82
    • Muhlestein, J.B.1
  • 36
    • 13044263119 scopus 로고    scopus 로고
    • A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
    • Trumel C, Payrastre B, Plantavid M, Hechler B, Viala C, Presek P, Martinson EA, Cazenave JP, Chap H, Gachet C. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Blood 1999;94:4156-4165.
    • (1999) Blood , vol.94 , pp. 4156-4165
    • Trumel, C.1    Payrastre, B.2    Plantavid, M.3    Hechler, B.4    Viala, C.5    Presek, P.6    Martinson, E.A.7    Cazenave, J.P.8    Chap, H.9    Gachet, C.10
  • 37
    • 10644287731 scopus 로고    scopus 로고
    • Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention
    • DOI 10.1080/0953710412331272532
    • Smith SM, Judge HM, Peters G, Storey RF. Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention. Platelets 2004;15:465-474. (Pubitemid 39656854)
    • (2004) Platelets , vol.15 , Issue.8 , pp. 465-474
    • Smith, S.M.G.1    Judge, H.M.2    Peters, G.3    Storey, R.F.4
  • 38
    • 77958005516 scopus 로고    scopus 로고
    • On behalf of the CURRENT-OASIS 7 trial investigators, Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): A randomised factorial trial
    • Mehta SR, Tanguay J-F, Eikelboom JW, Jolly SS, Joyner CD, Granger CB, Granger CB, Faxon DP, Rupprecht HJ, Budaj A, et al. on behalf of the CURRENT-OASIS 7 trial investigators. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): A randomised factorial trial. Lancet 2010;376:1233-1243.
    • (2010) Lancet , vol.376 , pp. 1233-1243
    • Mehta, S.R.1    Tanguay, J.-F.2    Eikelboom, J.W.3    Jolly, S.S.4    Joyner, C.D.5    Granger, C.B.6    Granger, C.B.7    Faxon, D.P.8    Rupprecht, H.J.9    Budaj, A.10
  • 39
    • 0141986521 scopus 로고    scopus 로고
    • Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function - A flow cytometry study
    • DOI 10.1016/S0195-668X(03)00442-1
    • Neubauer H, Gunesdogan B, Hanefeld C, Spiecker M, Mugge A. Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function-a flow cytometry study. Eur Heart J 2003;24:1744-1749. (Pubitemid 37236863)
    • (2003) European Heart Journal , vol.24 , Issue.19 , pp. 1744-1749
    • Neubauer, H.1    Gunesdogan, B.2    Hanefeld, C.3    Spiecker, M.4    Mugge, A.5


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