Altered distribution of platelet-activating factor-acetylhydrolase activity between LDL and HDL as a function of the severity of hypercholesterolemia

Journal of Lipid Research

Volumn 43, Issue 2, 2002, Pages 256-263

  Tsimihodimos, Vasilis ^a   Karabina, Sonia Athena P ^b   Tambaki, Afroditi P ^b   Bairaktari, Eleni ^a   Miltiadous, George ^a   Goudevenos, John A ^a   Cariolou, Marios A ^c   Chapman, M John ^d   Tselepis, Alexandros D ^b   Elisaf, Moses ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY OF IOANNINA   (Greece)

^c CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS   (Cyprus)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Familial hypercholesterolemia; High density lipoprotein; Lipoprotein subspecies; Low density lipoprotein; PAF acetylhydrolase; Polygenic hypercholesterolemia

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME LOCALIZATION; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; ULTRACENTRIFUGATION;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ADULT; APOLIPOPROTEINS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; ENZYME ACTIVATION; FEMALE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; LIPOPROTEINS; MALE; MIDDLE AGED; PHOSPHOLIPASES A; SEVERITY OF ILLNESS INDEX;

EID: 0036186708     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Platelet-activating factor and its analogs: Metabolic pathways and related intracellular processes
2. Platelet-activating factor (PAF): Implications for coronary heart and vascular diseases
3. Platelet activating factor acetylhydrolases
4. Human plasma platelet-activating factor acetylhydrolase. Oxidatively fragmented phospholipids as substrates
5. Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells
6. Structural identification by mass spectroscopy of oxidized phospholipids in minimally oxidized low density lipoprotein that induced monocyte/endothelial interactions and evidence for their presence in vivo
7. 2, platelet activating factor acetylhydrolase, generates two bioactive products during the oxidation of low density lipoprotein: Use of a novel inhibitor
8. 2 in atherogenesis
9. Human plasma platelet-activating factor acetylhydrolase: Association with lipoprotein particles and role in the degradation of platelet -activating factor
10. PAF-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma. Catalytic characteristics and relation to the monocyte-derived enzyme
11. Increased activity of platelet-activating factor acetylhydrolase in low-density lipoprotein subfractions induces enhanced lysophosphatidylcholine production during oxidation in patients with heterozygous familial hypercholesterolaemia
12. Oxidative structural modifications of low density lipoprotein in homozygous familial hypercholesterolaemia
13. Familial hypercholesterolaemia and platelet activating factor acetylhydrolase: Difference between the homozygous and heterozygous form
14. PAF-acetylhydrolase activity in familial hypercholesterolaemia
15. Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics
16. Characterization and geographic distribution of the low density lipoprotein receptor (LDLR) gene mutations in northwestern Greece
17. A density gradient ultracentrifugal procedure for isolation of the major lipoprotein classes from human serum
18. Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small dense LDL
19. 2+-induced oxidative modification in vitro
20. Determinants of plasma platelet-activating factor acetylhydrolase: Heritability and relationship to plasma lipoproteins
21. Receptor-mediated control of cholesterol metabolism
22. Dissociable and nondissociable forms of platelet-activating factor acetylhydrolase in human plasma LDL: Implications for LDL oxidative susceptibility
23. Apolipoprotein B400 conformation and partile surface charge in human LDL subspecies: Implication for LDL receptor interaction
24. Human macrophages secrete platelet-activating factor acetylhydrolase
25. Liver cells secrete the plasma form of platelet-activating factor acetylhydrolase
26. The fate of platelet-activating factor: PAF acetylhydrolase from plasma and tissues
27. PAF-acetylhydrolase predominantly present in LDL in healthy subjects, is associated with HDL in a patient with LDL deficiency
28. Lipoproteins alter the catalytic behavior of the platelet-activating factor acetylhydrolase in human plasma
29. Platelet-activating factor formation during oxidative modification of low-density lipoprotein when PAF-acetylhydrolase has been inactivated
30. Platelet-activating factor (PAF) stimulates the production o PAF-acetylhydrolase by the human hepatoma cell line, HepG2
31. Risks of ischemic heart-disease in familial hyperlipoproteinaemia states
32. Platelet-activating factor acetylhydrolase in plasma lipoproteins from patients with ischemic stroke
33. Plasma platelet-activating factor degradation in patients with severe coronary artery disease
34. Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infraction
35. Plasma platelet activating factor acetylhydrolase activity is not associated with premature coronary atherosclerosis
36. Platelet aggregatory response to platelet activating factor (PAF), ex vivo, and PAF-acetylhydrolase activity in patients with unstable angina: Effect of c7E3 Fab (abciximab) therapy
37. 2 as an independent predictor of coronary heart disease
38. HDL and the inflammatory response induced by LDL-derived oxidized phospholipids
39. Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase
40. Hydrolysis of platelet-activating factor by serum paraoxonase
41. HDL-associated PAF-AH reduces endothelial adhesiveness in apoE-/- mice
42. Identification of the G994 - T missense mutation in exon 9 of the plasma platelet activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men
43. Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population