Synthesis and in vitro antiproliferative activity of 2-methyl-3-(2- piperazin-1-yl-ethyl)-pyrido[1,2-a]pyrimidin-4-one derivatives against human cancer cell lines

Archives of Pharmacal Research

Volumn 35, Issue 1, 2012, Pages 51-57

  Mallesha, Lingappa ^a   Mohana, Kikkeri N ^a   Veeresh, Bantal ^b   Alvala, Ravi ^b   Mallika, Alvala ^c  

^a UNIVERSITY OF MYSORE   (India)

^b G Pullareddy College of Pharmacy   (India)

^c INSTITUTE OF LIFE SCIENCES   (India)

Author keywords

Antiproliferative activity; Human cancer cell lines; MTT assay; Piperazine; Sulfonyl chlorides

Indexed keywords

2 METHYL 3 (2 PIPERAZIN 1 YL ETHYL) PYRIDO[1,2 A]PYRIMIDIN 4 ONE DERIVATIVE; 2 METHYL 3 (2 PIPERAZIN 1 YL ETHYL)PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 METHYL 3 [2 [4 (2 NITRO BENZENESULFONYL)PIPERAZIN 1 YL]ETHYL]PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 METHYL 3 [2 [4 (2,4,6 TRIMETHYL BENZENESULFONYL)PIPERAZIN 1 YL]ETHYL] PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 METHYL 3 [2 [4 (4 NITRO BENZENESULFONYL)PIPERAZIN 1 YL] ETHYL]PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 METHYL 3 [2 [4 (4 TRIFLUOROMETHYL BENZENESULFONYL)PIPERAZIN 1 YL]ETHYL]PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 METHYL 3 [2 [4 (TOLUENE 4 SULFONYL)PIPERAZIN 1 YL]ETHYL]PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 (2 CHLOROETHYL) 2 METHYL 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 [1 (PYRIDIN 2 YLAMINO)ETHYLIDENE]DIHYDROFURAN 2 (3H) ONE; 3 [2 (4 BENZENESULFONYL PIPERAZIN 1 YL) ETHYL] 2 METHYL PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 [2 (4 METHANESULFONYL PIPERAZIN 1 YL)ETHYL] 2 METHYL PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 [2 [4 (3 METHOXY BENZENESULFONYL)PIPERAZIN 1 YL]ETHYL] 2 METHYL PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 [2 [4 (4 CHLORO BENZENESULFONYL)PIPERAZIN 1 YL]ETHYL] 2 METHYL PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 [2 [4 (4 METHOXY BENZENESULFONYL)PIPERAZIN 1 YL]ETHYL] 2 METHYL PYRIDO[1,2 A]PYRIMIDIN 4 ONE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; PIPERAZINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; K562 CELLS; PIPERAZINES; PYRIMIDINES;

EID: 84856912921     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0105-z     Document Type: Article

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