Major ozonated autohaemotherapy in the treatment of limb ulcers not responding to conventional therapy

International Journal of Ozone Therapy

Volumn 10, Issue 2, 2011, Pages 85-98

  De Monte, A ^a   Gori, C ^b  

^a UNIVERSITY HOSPITAL OF UDINE   (Italy)

^b PASS Outpatients Clinic   (Italy)

Author keywords

Chronic ulceration; Leg ulcer; Oxidative stress; Ozone therapy; Regenerative medicine

Indexed keywords

BUPIVACAINE; FREE RADICAL; MORPHINE; OXYGEN RADICAL; OZONE;

ADULT; AGED; BLOOD AUTOTRANSFUSION; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONSERVATIVE TREATMENT; FEMALE; HEALTH CARE SYSTEM; HUMAN; LEG ULCER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATION; OXIDATIVE STRESS; OZONE THERAPY; PATHOPHYSIOLOGY; REGENERATIVE MEDICINE; REVIEW; SURGICAL TECHNIQUE; ULCER; VENOUS STASIS;

EID: 84856880168     PISSN: 19723539     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. Bergqvist D, Lindholm C, Nelzén O. Chronic leg ulcers: the impact of venous disease. J Vasc Surg. 1999; 29: 752-755. (Pubitemid 29181257)
2. Callam M, Harper RD, Dale JJ, et al. Chronic ulcer of the leg: clinical history. Br Med J. 1987; 294: 1389-1391. (Pubitemid 17078946)
3. Gohel M, Poskitt K. Chronic ulceration of the leg. Surgery. 2010; 28: 273-276.
4. Phillips T, Stanton B, Provan A, et al. A study of the impact of leg ulcers on quality of life: financial, social and psychologic implications. J Am Acad Dermatol. 1994; 31: 49-53. (Pubitemid 24198162)
5. Arzini A. Ulcere arti inferiori: epidemiologia e inquadramento diagnostico. Presented at the meeting on "Ulcere venose arti inferiori", Garbagnate M.se (MI); 2011.
6. Progetto di legge N. 4409. http://www.camera.it/-dati/leg14/lavori/ stampati/sk4500/relazion/4409.htm.
7. Chiefari M, Genovese E. Fisiopatologia del dolore vascolare. http://www.vulnologia.it/BIBLIOTECA/PDF/DOLORE/fisiopatologiadeldolorevascolare. pdf.
8. Canedo-Dorantes L, Garcìa-Cantù R, Berrera R, et al. Healing of chronic arterial and venous leg ulcers with systemic electromagnetic fields. Archives Med Research. 2002; 33: 281-289. (Pubitemid 34553356)
9. Coleridge-Smith P. Leg ulcer treatment. J Vasc Surg. 2009; 49: 804-808.
10. Poblete H, Elias S. Venus ulcers: new options in treatment: minimally invasive vein surgery. J Am Coll Certif Wound Spec. 2009; 1: 12-19.
11. Tan J, Abisi S, Smith A. et al. A painless method of ultrasonic assisted debridement of chronic leg ulcers: a pilot study. Eur J Vasc Endovasc Surg. 2007; 33: 234-238. (Pubitemid 46076267)
12. Bocci V. What happens in the intracellular environment after blood ozonization? In: Bocci Ved. Oxygen-ozone therapy: a critical evaluation. Dordrecht: Kluwer; 2002. p.121-172.
13. 3-AHT. In: Oxygenozone therapy: a critical evaluation. Bocci Ved. Oxygenozone therapy: a critical evaluation. Dordrecht: Kluwer; 2002. p. 375-80.
14. Bocci V. Scientific and medical aspects of ozone therapy. State of the art. Amsterdam: Elsevier Inc.; 2006. p. 425-435.
15. Bocci V. Is it true that ozone is always toxic? The end of a dogma. Toxicol Appl Pharmacol. 2006; 216: 493-504. (Pubitemid 44584318)
16. Diegelmann R, Evans M. Wound healing an overview of acute and delayed healing. Front Biosci. 2004; 9: 283-289. (Pubitemid 38925460)
17. Hidalgo AD, Disa JJ. Plastic surgical reconstruction. In: Wilmore D. Care of the surgical patient. New York: scientific American Inc.; 1998. X (3) 1-18.
18. Lawrence TW, Bevin GA, Sheldon FG. Acute wound care. Wilmore D. Care of the surgical patient. New York: scientific American Inc.; 1998. I (8), 1-18.
19. Reilly MP, Kelly AS, Schiller JH, et al. Reactive oxygen metabolites. In: Wilmore D. Care of the surgical patient. New York: scientific American Inc.; 1996. II (13), 1-32.
20. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003; 83: 835-860.
21. Chin GA, Schulz GS, Diegelmann RF, et al. Biochemistry of wound healing in wound care practice. In: Sheffield PJ, Smith APS, Fife CE eds. Wound care practice. Flagstaff AZ: Best Publishing Co.; 2004. 2, 45-65.
22. Bannister HL. Integumental system: skin and breasts. Dermal repair. In: Williams P, Bannister L, Beny Meds. Gray's Anatomy. New York: Churchill Livingstone; 1995. 5, 412-17.
23. Wound healing. http://wikidoc.org//index.php/Wound-healing.
24. Turrens FJ. Mitochondrial formation of reactive oxygen species. J. Physiol. 2003; 552: 335-344.
25. Halliwel B, Gutteridget J. Oxygen toxicity, oxygen radicals, transition metal and disease. Biochem J. 1984; 219: 1-14.
26. Fridovich I. Superoxide anion radical (O2), superoxide dismutases, and related matters. J Biol Chemist. 1997; 272: 18515-18517. (Pubitemid 27318184)
27. Fridovich I. Oxygen toxicity: a radical explanation. J Exp Biol. 1998; 201: 1203-1209. (Pubitemid 28278324)
28. Halliwell B. Oxygen radicals, nitric oxide and human inflammatory joint disease. Ann Rheum Dis. 1995; 54: 505-510.
29. Guzy DR, Schumacker TP. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp Physiol. 2006; 91: 807-819.
30. Gutierrez J, Ballinger WS, Darley-Usmar MV et al. Free radicals, mitochondria and oxidized lipids. The emerging role in signal transduction in vascular cells. Circ Res. 2006; 99: 924-932. (Pubitemid 44657795)
31. Re L, Mawsouf M, Menéndez S, et al. Ozone therapy: clinical and basic evidence of its therapeutic potential. Arch Med Res. 2007; 28: 2-4.
32. Ajamieh HH, Menéndez S, Martinez-Sànchez G, et al. Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat of hepatic ischeamia-reperfusion. Liver International. 2004; 24: 55-62. (Pubitemid 38351214)
33. Ajamieh HH, Berkìlanga J, Merino N, et al. Role of protein synthesis in the protection conferred by ozone-oxidative-preconditioning in hepatic ischaemia/reperfusion. Transplant International. 2005; 18: 604-612. (Pubitemid 41726865)
34. Nitric oxide: biology and chemistry. http://www.elsevier.com/wps/find/ journaldescription.cws-home/622926/description
35. De Monte A, Zee van der H, Bocci V. Major ozonated autohemotherapy in chronic limb ischemia with ulcerations. J Altern Complement Med. 2005; 11: 363-366.
36. De Monte A, Girardis M. Ozonated autohaemotherapy induces healing of human chronic ulcers not responding to conventional pharmacological and surgical treatment: clinical study. Int J Art Org. 2008; 31: P 99.
37. Martínez-Sánchez G, Al-Dalain SM, Menéndez S, et al. Therapeutic efficacy of ozone in patients with diabetic foot. Eur J Pharmacol. 2005; 523: 151-161. (Pubitemid 41562387)
38. Dell'Aglio R, Zambello A. La grande autoemoterapia. Int J Ozone Ther. 2007; 2: 111.
39. De Monte A, Gori C. Efficacia della grande autoemoterapia con Ozono nel trattamento delle ulcere distrofiche. Int J Ozone Ther. 2007; 6: 111-113.
40. Izzo A. Oxygen-ozone treatment of leg ulcers. personal experience. Int J Ozone Ther. 2008; 2: 126-133.
41. Faus Vitoria J. A case of gangrenous pyoderma treated with ozone therapy. Int J Ozone Ther. 2008; 2: 161-165.
42. De Monte A. Autoemoterapia-GAET (grande autoemoterapia). Int J Ozone Ther. 2009; 2: 160-161.
43. De Monte A, Gori C. major ozonated autohaemotherapy in the treatment of limb ulcers not responding to conventional therapy. Int J Ozone Ther. 2011; 10: 46-47.
44. Capuano C, Tabaracci G. Oxygen ozone treatment for lower limb peripheral arterial disease. Int J Ozone Ther. 2011; 10: 48.
45. Borrelli E, Dall'Aglio R. Attualità in tema di G.A.E.T. Int J Ozone Ther. 2009; 8: 34.
46. Coppola L, Giunta R, Verrazzo G, et al. Influence of ozone in hemoglobin oxygen affinity in type-2 diabetic patients with peripheral vascular disease: in vitro studies. Diabete Metab. 1995; 21: 252-255.