Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells

Biology of Reproduction

Volumn 86, Issue 1, 2012, Pages

  Ortega, Israel ^a,b   Cress, Amanda B ^a   Wong, Donna H ^a   Villanueva, Jesus A ^a   Sokalska, Anna ^a,c   Moeller, Ben C ^d   Stanley, Scott D ^d   Duleba, Antoni J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b IVI Madrid   (Spain)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Androgens androgen receptor; Cell culture; CYP17A1; Ovarian theca interstitial cells; Ovary; Simvastatin; Steroid hormones steroid hormone receptors; Steroidogenesis; Theca cells

Indexed keywords

22 HYDROXYCHOLESTEROL; ANDROGEN; CHOLESTEROL; CYTOCHROME P450; CYTOCHROME P450 CYP17A1; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; MESSENGER RNA; SIMVASTATIN; UNCLASSIFIED DRUG; 22-HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; FARNESYL TRANS TRANSFERASE; GERANYLGERANYLTRANSFERASE TYPE I; GERANYLGERANYLTRANSFERASE TYPE-I; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID PHOSPHATE; SESQUITERPENE; STEROID 17ALPHA MONOOXYGENASE; TRANSFERASE;

ANDROGEN SYNTHESIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG INHIBITION; ENZYME REGULATION; FEMALE; GENE EXPRESSION; LEYDIG CELL; MASS SPECTROMETRY; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PRENYLATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; STEROIDOGENESIS; THECA CELL; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OVARY; SPRAGUE DAWLEY RAT;

RATTUS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; CELLS, CULTURED; FARNESYLTRANSTRANSFERASE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROXYCHOLESTEROLS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; OVARY; POLYISOPRENYL PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SESQUITERPENES; SIMVASTATIN; STEROID 17-ALPHA-HYDROXYLASE; SUBSTRATE SPECIFICITY;

EID: 84856863673     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.111.094714     Document Type: Article

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