Common variants in polygenic schizophrenia

Genome Biology

Volumn 10, Issue 9, 2009, Pages

  Glessner, Joseph T ^a   Hakonarson, Hakon ^b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN;

GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; META ANALYSIS; MULTIFACTORIAL INHERITANCE; REVIEW; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; META-ANALYSIS AS TOPIC; MULTIFACTORIAL INHERITANCE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; SCHIZOPHRENIA;

EID: 84856818976     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2009-10-9-236     Document Type: Short Survey

References (24)

1. Tandon R, Keshavan MS, Nasrallah HA. Schizophrenia, "just the facts" what we know in 2008. Schizophr Res 2008, 102:1-18. 10.1016/j.schres.2008.04.011, 18514488.
2. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, et al. International Human Genome Sequencing Consortium Initial sequencing and analysis of the human genome. Nature 2001, 409:860-921. 10.1038/35057062, 11237011, International Human Genome Sequencing Consortium.
3. Siva N. 1000 Genomes project. Nat Biotechnol 2008, 26:256.
4. Devlin B, Roeder K. Genomic control for association studies. Biometrics 1999, 55:997-1004. 10.1111/j.0006-341X.1999.00997.x, 11315092.
5. Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, Sklar P, Ruderfer DM, McQuillin A, Morris DW, O'Dushlaine CT, Corvin A, Holmans PA, Macgregor S, Gurling H, Blackwood DH, Craddock NJ, Gill M, Hultman CM, Kirov GK, Lichtenstein P, Muir WJ, Owen MJ, Pato CN, Scolnick EM, St Clair D, Williams NM, Georgieva L, Nikolov I, et al. The International Schizophrenia Consortium Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752. The International Schizophrenia Consortium.
6. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, Dudbridge F, Holmans PA, Whittemore AS, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Crowe RR, Oksenberg JR, Mirel DB, Kendler KS, Freedman R, Gejman PV. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009, 460:753-757.
7. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, et al. Common variants conferring risk of schizophrenia. Nature 2009, 460:744-747.
8. Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, Salyakina D, Imielinski M, Bradfield JP, Sleiman PM, Kim CE, Hou C, Frackelton E, Chiavacci R, Takahashi N, Sakurai T, Rappaport E, Lajonchere CM, Munson J, Estes A, Korvatska O, Piven J, Sonnenblick LI, Alvarez Retuerto AI, Herman EI, Dong H, Hutman T, Sigman M, Ozonoff S, Klin A, et al. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature 2009, 459:528-533. 10.1038/nature07999, 19404256.
9. Sharma RP, Rosen C, Kartan S, Guidotti A, Costa E, Grayson DR, Chase K. Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: Preliminary results from a clinical population. Schizophr Res 2006, 88:227-231. 10.1016/j.schres.2006.07.015, 16996718.
10. Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, Wang SC, Petronis A. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 2008, 82:696-711. 10.1016/j.ajhg.2008.01.008, 2427301, 18319075.
11. Wei J, Hemmings GP. The NOTCH4 locus is associated with susceptibility to schizophrenia. Nat Genet 2000, 25:376-377. 10.1038/78044, 10932176.
12. Luo X, Klempan TA, Lappalainen J, Rosenheck RA, Charney DS, Erdos J, van Kammen DP, Kranzler HR, Kennedy JL, Gelernter J. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Biol Psychiatry 2004, 55:112-117. 10.1016/S0006-3223(03)00588-2, 14732589.
13. Shiina T, Inoko H, Kulski JK. An update of the HLA genomic region, loci information and disease associations. Tissue Antigens 2004, 64:631-649. 10.1111/j.1399-0039.2004.00327.x, 15546336.
14. Raha-Chowdhury R, Andrews SR, Gruen JR. CAT 53: a protein phosphatase nuclear targeting subunit encoded in the MHC class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease. Mol Brain Res 2005, 138:70-83. 10.1016/j.molbrainres.2005.04.001, 15894402.
15. Cohly HH, Panja A. Immunological findings in autism. Int Rev Neurobiol 2005, 71:317-341. 10.1016/S0074-7742(05)71013-8, 16512356.
16. McElroy JP, Oksenberg JR. Multiple sclerosis genetics. Curr Top Microbiol Immunol 2008, 318:45-72. full_text, 18219814.
17. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 2008, 40:1053-1055. 10.1038/ng.201, 18677311.
18. Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov V, Lakshmi B, Findling RL, Sikich L, Stromberg T, Merriman B, Gogtay N, Butler P, Eckstrand K, Noory L, Gochman P, Long R, Chen Z, Davis S, Baker C, Eichler EE, Meltzer PS, et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 2008, 320:539-543. 10.1126/science.1155174, 18369103.
19. Stone JL, O'Donovan MC, Gurling H, Kirov GK, Blackwood DH, Corvin A, Craddock NJ, Gill M, Hultman CM, Lichtenstein P, McQuillin A, Pato CN, Ruderfer DM, Owen MJ, St Clair D, Sullivan PF, Sklar P, Purcell SM, Stone JL, Korn J, Macgregor S, Morris DW, O'Dushlaine CT, Daly MJ, Visscher PM, Holmans PA, Scolnick EM, Williams NM, Georgieva L, et al. The International Schizophrenia Consortium Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 2008, 455:237-241. 10.1038/nature07239, 18668038, The International Schizophrenia Consortium.
20. Stefansson H, Rujescu D, Cichon S, Pietiläinen OP, Ingason A, Steinberg S, Fossdal R, Sigurdsson E, Sigmundsson T, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Möller HJ, Hartmann A, et al. Large recurrent microdeletions associated with schizophrenia. Nature 2008, 455:232-236. 10.1038/nature07229, 2687075, 18668039.
21. Shi YY, He G, Zhang Z, Tang W, Zhang J, Zhao Q, Zhang J, Li XW, Xi ZR, Fang C, Zhao XZ, Feng GY, He L. A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population. Mol Psychiatry 2008, 13:911-913. 10.1038/mp.2008.69, 18800052.
22. Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, Shianna KV, Yoon W, Kasperaviciute D, Gennarelli M, Strittmatter WJ, Bonvicini C, Rossi G, Jayathilake K, Cola PA, McEvoy JP, Keefe RS, Fisher EM, St Jean PL, Giegling I, Hartmann AM, Möller HJ, Ruppert A, Fraser G, Crombie C, Middleton LT, St Clair D, Roses AD, Muglia P, Francks C, et al. A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet 2009, 5:e1000373. 10.1371/journal.pgen.1000373, 2631150, 19197363.
23. Glessner JT, Wang K, Cai G, Korvatska O, Kim CE, Wood S, Zhang H, Estes A, Brune CW, Bradfield JP, Imielinski M, Frackelton EC, Reichert J, Crawford EL, Munson J, Sleiman PM, Chiavacci R, Annaiah K, Thomas K, Hou C, Glaberson W, Flory J, Otieno F, Garris M, Soorya L, Klei L, Piven J, Meyer KJ, Anagnostou E, Sakurai T, et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 2009, 459:569-573. 10.1038/nature07953, 19404257.
24. Grant SFA, Hakonarson H. Microarray technology and applications in the arena of genome-wide association. Clin Chem 2008, 54:1116-1124. 10.1373/clinchem.2008.105395, 18499899.