What is the best pulmonary diagnostic approach for wheezing patients with normal spirometry?

Respiratory Care

Volumn 57, Issue 1, 2012, Pages 39-49

  Busse, William W ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Airway hyperresponsiveness; Airway inflammation; Asthma; Bronchial provocation testing

Indexed keywords

BIOLOGICAL MARKER; HYPERTONIC SOLUTION; MANNITOL; METHACHOLINE; NITRIC OXIDE;

ASTHMA; COUGHING; DYSPNEA; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; INHALATION TEST; INTERMETHOD COMPARISON; PATIENT ASSESSMENT; PHYSICAL EXAMINATION; PREDICTIVE VALUE; REVIEW; SENSITIVITY AND SPECIFICITY; SPIROMETRY; WHEEZING;

ADULT; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; DIURETICS, OSMOTIC; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MANNITOL; RESPIRATORY FUNCTION TESTS; RESPIRATORY SOUNDS; SPIROMETRY;

EID: 84856797920     PISSN: 00201324     EISSN: 19433654     Source Type: Journal    
DOI: 10.4187/respcare.01449     Document Type: Review

References (24)

1. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001;344(5):350-362.
2. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010;181(4):315-23.
3. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 2001;357(9258):752-756.
4. Busse WW. The relationship of airway hyperresponsiveness and airway inflammation: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 2010;138(2 Suppl):4S-10S.
5. Cockcroft DW, Davis BE. Mechanisms of airway hyperresponsiveness. J Allergy Clin Immunol 2006;118(3):551-559.
6. National Heart Lung and Blood Institute. Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma-full report 2007. www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm. Accessed October 31, 2011.
7. Boushey HA. Clinical diagnosis in adults. In: Barnes PJ, Grunstein MJ, Leff AR, Woolcock AJ, editors. Asthma. Baltimore: Lippincott-Raven; 1997;1391-1403.
8. Bateman ED, Boushey HA, Bousquet J, Busse WW, Clark TJ, Pauwels RA, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma Control study. Am J Respir Crit Care Med 2004;170(8):836-844.
9. Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med 2000;343(15):1054-1063.
10. Wenzel SE, Busse WW. Severe asthma: lessons from the Severe Asthma Research Program. J Allergy Clin Immunol 2007;119(1):14-21.
11. Cockcroft DW. Bronchial challenge testing. In: Adkinson NF Jr, Bochner BS, Busse WW, Holgate ST, Lemanske RF Jr, Simons FER, editors. Middleton's Allergy Principles & Practice. London: Elsevier; 2009:1295-1308.
12. American Association for Respiratory Care. Clinical Practice Guideline. Methacholine challenge testing: 2001 revision & update. Respir Care 2001;46(5):523-530.
13. Sont JK, Willems LN, Bel EH, Van Krieken JH, Vandenbroucke JP, Sterk PJ. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 1999;159(4 Pt 1):1043-1051.
14. Anderson SD, Brannan JD. Bronchial provocation testing: the future. Curr Opin Allergy Clin Immunol 2011;11(1):46-52.
15. Anderson SD, Charlton B, Weiler JM, Nichols S, Spector SL, Pearlman DS; A305 Study Group. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res 2009;10:4.
16. Cockcroft DW. Direct challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 2010;138(2 Suppl):18S-24S.
17. Barnes PJ, Dweik RA, Gelb AF, Gibson PG, George SC, Grasemann H, et al. Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest 2010;138(3):682-692.
18. Malmberg LP, Pelkonen AS, Haahtela T, Turpeinen M. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax 2003;58(6):494-499.
19. Deykin A, Massaro AF, Drazen JM, Israel E. Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. Am J Respir Crit Care Med 2002;165(12):1597-1601.
20. Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax 1998;53(2):91-95.
21. Smith AD, Cowan JO, Filsell S, McLachlan C, Monti-Sheehan G, Jackson P, et al. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med 2004;169(4):473-478.
22. Nair P, Pizzichini MM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009;360(10):985-993.
23. Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360(10):973-984.
24. O'Byrne PM, Gauvreau GM, Brannan JD. Provoked models of asthma: what have we learnt? Clin Exp Allergy 2009;39(2):181-192.