Formation and characterization of pDNA-loaded alginate microspheres for oral administration in mice

Journal of Bioscience and Bioengineering

Volumn 113, Issue 2, 2012, Pages 133-140

  Nograles, Nadine ^a   Abdullah, Syahril ^a   Shamsudin, Mariana Nor ^a   Billa, Nashiru ^b   Rosli, Rozita ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITY OF NOTTINGHAM MALAYSIA CAMPUS   (Malaysia)

Author keywords

Alginate microspheres; DNA vaccine; Encapsulation; Oral delivery; W O emulsion

Indexed keywords

ACIDIC ENVIRONMENT; AVERAGE DIAMETER; BALB/C MICE; BIODISTRIBUTIONS; DNA VACCINE; EXPRESSION VECTORS; FLOW-CYTOMETRIC ANALYSIS; GENE DELIVERY; GREEN FLUORESCENT PROTEIN; INTESTINAL CELLS; INTESTINAL MUCOSA; MAXIMUM LOAD; NATURAL POLYSACCHARIDE; ORAL ADMINISTRATION; ORAL DELIVERY; PLASMID DNA (PDNA); REPORTER GENE; SIZE REDUCTIONS; W/O EMULSION; WATER-IN-OIL;

ALGINATE; EMULSIFICATION; ENCAPSULATION; GENE THERAPY; GENE TRANSFER; MAMMALS; TISSUE; VACCINES;

MICROSPHERES;

ALGINIC ACID; DNA VACCINE; GREEN FLUORESCENT PROTEIN; MICROSPHERE; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; EMULSION; ENCAPSULATION; FEMALE; FLOW CYTOMETRY; GENE DELIVERY SYSTEM; INTESTINE CELL; MOUSE; NONHUMAN; PH;

ADMINISTRATION, ORAL; ALGINATES; ANIMALS; DNA; GENE TRANSFER TECHNIQUES; GLUCURONIC ACID; GREEN FLUORESCENT PROTEINS; HEXURONIC ACIDS; MICE; MICROSPHERES; PARTICLE SIZE; PLASMIDS; TISSUE DISTRIBUTION;

MAMMALIA; MURINAE; MUS;

EID: 84856791930     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2011.10.003     Document Type: Article

References (34)

1. Bowersock T., HogenEsch H., Suckow M., Guimond P., Martin S., Borie D., Torregrosa S., Park H., Park K. Oral vaccination of animals with antigens encapsulated in alginate microspheres. Vaccine 1999, 17:1804-1811.
2. Rodrigues A., Hirsch D., Figueiredo H., Logato P., Moraes Ā.M. Production and characterisation of alginate microparticles incorporating Aeromonas hydrophila designed for fish oral vaccination. Process Biochem. 2006, 41:638-643.
3. Ajdary S., Dobakhti F., Taghikhani M., Riazi-Rad F., Rafiei S., Rafiee-Tehrani M. Oral administration of BCG encapsulated in alginate microspheres induces strong Th1 response in BALB/c mice. Vaccine 2007, 25:4595-4601.
4. Bhakta G., Mitra S., Maitra A. DNA encapsulated magnesium and manganous phosphate nanoparticles: potential non-viral vectors for gene delivery. Biomaterials 2005, 26:2157-2163.
5. Dobakhti F., Rahimi F., Dehpour A., Taghikhani M., Ajdary S., Rafiei S., Rafiee-Tehrani M. Stabilizing effects of calcium alginate microspheres on mycobacterium bovis BCG intended for oral vaccination. J. Microencapsul. 2006, 23:844-854.
6. Sarmento B., Ribeiro A., Veiga F., Sampaio P., Neufeld R., Ferreira D. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm. Res. 2007, 24:2198-2206.
7. Tønnesen H.H., Karlsen J. Alginate in drug delivery systems. Drug Dev. Ind. Pharm. 2002, 28:621-630.
8. Silva C.M., Ribeiro A.J., Figueiredo M., Ferreira D., Veiga F. Microencapsulation of hemoglobin in chitosan-coated alginate microspheres prepared by emulsification/internal gelation. AAPS J. 2005, 7:903-913.
9. Simpson N.E., Grant S.C., Blackband S.J., Constantinidis I. NMR properties of alginate microbeads. Biomaterials 2003, 24:4941-4948.
10. Sone T., Nagamori E., Ikeuchi T., Mizukami A., Takakura Y., Kajiyama S., Fukusaki E., Harashima S., Kobayashi A., Fukui K. A novel gene delivery system in plants with calcium alginate micro-beads. J. Biosci. Bioeng. 2002, 94:87-91.
11. Suckow M.A., Jarvinen L.Z., HogenEsch H., Park K., Bowersock T.L. Immunization of rabbits against a bacterial pathogen with an alginate microparticle vaccine. J. Control. Release 2002, 85:227-235.
12. Tian J.Y., Sun X.Q., Chen X.G. Formation and oral administration of alginate microspheres loaded with pDNA coding for lymphocystis disease virus (LCDV) to Japanese flounder. Fish Shellfish Immunol. 2008, 24:592-599.
13. Aggarwal N., HogenEsch H., Guo P., North A., Suckow M., Mittal S.K. Biodegradable alginate microspheres as a delivery system for naked DNA. Can. J. Vet. Res. 1999, 63:148.
14. Mittal S.K., Aggarwal N., Sailaja G., Van Olphen A., HogenEsch H., North A., Hays J., Moffatt S. Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response. Vaccine 2000, 19:253-263.
15. Syahril N.A., Mariana N.S., Sidhu H.S., Rosil R. In vitro expression of the ctxB toxin gene towards the development of a DNA vaccine against cholera. Mol. Biol. Today 2002, 3:71-77.
16. Martoni C., Bhathena J., Jones M.L., Urbanska A.M., Chen H., Prakash S. Investigation of microencapsulated BSH active Lactobacillus in the simulated human GI tract. J. Biomed. Biotechnol. 2007, 2007:13864.
17. Scheppler L., Vogel M., Zuercher A.W., Zuercher M., Germond J.E., Miescher S.M., Stadler B.M. Recombinant Lactobacillus johnsonii as a mucosal vaccine delivery vehicle. Vaccine 2002, 20:2913-2920.
18. Kumar R.S., Ishaq Ahmed V.P., Parameswaran V., Sudhakaran R., Sarath Babu V., Sahul Hameed A.S. Potential use of chitosan nanoparticles for oral delivery of DNA vaccine in Asian sea bass (Lates calcarifer) to protect from Vibrio (Listonella) anguillarum. Fish Shellfish Immunol. 2008, 25:47-56.
19. Perret V., Lev R., Pigman W. Simple method for the preparation of single cell suspensions from normal and tumorous rat colonic mucosa. Br. Med. J. 1977, 18:382-385.
20. Smidsrød O., Skjaok-Brk G. Alginate as immobilization matrix for cells. Trends Biotechnol. 1990, 8:71-78.
21. Tavakol M., Vasheghani-Farahani E., Dolatabadi-Farahani T., Hashemi-Najafabadi S. Sulfasalazine release from alginate-N, O-carboxymethyl chitosan gel beads coated by chitosan. Carbohydr. Polym. 2009, 77:326-330.
22. Vandenberg G., Drolet C., Scott S., De la Noüe J. Factors affecting protein release from alginate-chitosan coacervate microcapsules during production and gastric/intestinal simulation. J. Control. Release 2001, 77:297-307.
23. Quong D., Neufeld R. DNA protection from extracapsular nucleases, within chitosan-or poly-L-lysine-coated alginate beads. Biotechnol. Bioeng. 1998, 60:124-134.
24. Mofidi N., Aghai-Moghadam M., Sarbolouki M. Mass preparation and characterization of alginate microspheres. Process Biochem. 2000, 35:885-888.
25. Kwok K.K., Groves M.J., Burgess D.J. Production of 5-15 μm diameter alginate-polylysine microcapsules by an air-atomization technique. Pharm. Res. 1991, 8:341-344.
26. Lin S.Y., Ayres J.W. Calcium alginate beads as core carriers of 5-aminosalicylic acid. Pharm. Res. 1992, 9:1128-1131.
27. Silva C.M., Ribeiro A.J., Ferreira D., Veiga F. Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation. Eur. J. Pharm. Sci. 2006, 29:148-159.
28. Takka S., Ocak Ö.H., Acartürk F. Formulation and investigation of nicardipine HCl-alginate gel beads with factorial design-based studies. Eur. J. Pharm. Sci. 1998, 6:241-246.
29. Singh M., O'Hagan D. The preparation and characterization of polymeric antigen delivery systems for oral administration. Adv. Drug Deliv. Rev. 1998, 34:285-304.
30. Thu B., Bruheim P., Espevik T., Smidsrød O., Soon-Shiong P., Skjåk-Bræk G. Alginate polycation microcapsules: I. Interaction between alginate and polycation. Biomaterials 1996, 17:1031-1040.
31. Coppi G., Sala N., Bondi M., Sergi S., Iannuccelli V. Ex-vivo evaluation of alginate microparticles for Polymyxin B oral administration. J. Drug Target. 2006, 14:599-606.
32. Coppi G., Montanari M., Rossi T., Bondi M., Iannuccelli V. Cellular uptake and toxicity of microparticles in a perspective of polymyxin B oral administration. Int. J. Pharm. 2010, 385:42-46.
33. Borges O., Cordeiro-da-Silva A., Romeijn S.G., Amidi M., de Sousa A., Borchard G., Junginger H.E. Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination. J. Control. Release 2006, 114:348-358.
34. Nicoletti C. Unsolved mysteries of intestinal M cells. Gut 2000, 47:735-739.