Endosomal actin remodeling by Coronin-1A controls lipoprotein uptake and degradation in macrophages

Circulation Research

Volumn 110, Issue 3, 2012, Pages 450-455

  Hölttä Vuori, Maarit ^a   Vainio, Saara ^a   Kauppi, Maria ^a   Van Eck, Miranda ^b   Jokitalo, Eija ^c   Ikonen, Elina ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

actin cytoskeleton; lipoprotein endocytosis; macrophage

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; ACTIN; CHOLESTEROL ESTER; COFILIN; CORONIN 1A; F ACTIN; KHELLIN; NIEMANN PICK TYPE C1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOSOME; GENE INACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE MICROSCOPY; LIPID HYDROLYSIS; LIPID OXIDATION; LYSOSOME; MOLECULAR MODEL; MORPHOLOGY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; UPREGULATION; WILD TYPE;

ACTINS; ANIMALS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CHOLESTEROL; ENDOSOMES; LIPOPROTEINS; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MODELS, ANIMAL; ORGANELLES; PROTEOLYSIS;

EID: 84856762147     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.256842     Document Type: Article

References (20)

1. Tabas I, Zha X, Beatini N, Myers JN, Maxfield FR. The actin cytoskeleton is important for the stimulation of cholesterol esterification by atherogenic lipoproteins in macrophages. J Biol Chem. 1994;269: 22547-22556. (Pubitemid 24273359)
2. Grosheva I, Haka AS, Qin C, Pierini LM, Maxfield FR. Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization. Arterioscler Thromb Vasc Biol. 2009;29:1615-1621.
3. de Hostos EL, Rehfuess C, Bradtke B, Waddell DR, Albrecht R, Murphy J, Gerisch G. Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and cell motility. J Cell Biol. 1993; 120:163-173.
4. Maniak M, Rauchenberger R, Albrecht R, Murphy J, Gerisch G. Coronin involved in phagocytosis: dynamics of particle-induced relocalization visualized by a green fluorescent protein Tag. Cell. 1995;83:915-924. (Pubitemid 26006533)
5. Chan KT, Creed SJ, Bear JE. Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends Cell Biol. 2011;21:481-488.
6. Jayachandran R, Sundaramurthy V, Combaluzier B, Mueller P, Korf H, Huygen K, Miyazaki T, Albrecht I, Massner J, Pieters J. Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell. 2007;130:37-50. (Pubitemid 47031320)
7. Foger N, Rangell L, Danilenko DM, Chan AC. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science. 2006; 313:839-842. (Pubitemid 44223353)
8. Loftus SK, Morris JA, Carstea ED, Gu JZ, Cummings C, Brown A, Ellison J, Ohno K, Rosenfeld MA, Tagle DA, Pentchev PG, Pavan WJ. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science. 1997;277:232-235. (Pubitemid 27446077)
9. Ikonen E, Hölttä-Vuori M. Cellular pathology of Niemann-Pick type C disease. Semin Cell Dev Biol. 2004;15:445-454. (Pubitemid 38781906)
10. Anand PK, Kaul D. Vitamin D3-dependent pathway regulates TACO gene transcription. Biochem Biophys Res Commun. 2003;310:876-877. (Pubitemid 37188703)
11. Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA. 2003;100:12027-12032. (Pubitemid 37271509)
12. Jones NL, Reagan JW, Willingham MC. The pathogenesis of foam cell formation: modified LDL stimulates uptake of co-incubated LDL via macropinocytosis. Arterioscler Thromb Vasc Biol. 2000;20:773-781. (Pubitemid 30151693)
13. Collins RF, Touret N, Kuwata H, Tandon NN, Grinstein S, Trimble WS. Uptake of oxidized low density lipoprotein by CD36 occurs by an actindependent pathway distinct from macropinocytosis. J Biol Chem. 2009; 284:30288-30297.
14. Racoosin EL, Swanson JA. Macropinosome maturation and fusion with tubular lysosomes in macrophages. J Cell Biol. 1993;121:1011-1020. (Pubitemid 23154262)
15. Gandhi M, Jangi M, Goode BL. Functional surfaces on the actin-binding protein coronin revealed by systematic mutagenesis. J Biol Chem. 2010; 285:34899-34908.
16. Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011;470:414-418.
17. Bernstein BW, Bamburg JR. ADF/cofilin: a functional node in cell biology. Trends Cell Biol. 2010;20:187-195.
18. Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell. 2007;128:915-929. (Pubitemid 46341411)
19. Gandhi M, Achard V, Blanchoin L, Goode BL. Coronin switches roles in actin disassembly depending on the nucleotide state of actin. Mol Cell. 2009;34:364-374.
20. Liebl D, Griffiths G. Transient assembly of F-actin by phagosomes delays phagosome fusion with lysosomes in cargo-overloaded macrophages. J Cell Sci. 2009;122:2935-2945.