Prevention of bone loss in ovariectomized rats by pulsatile transdermal iontophoretic administration of human PTH(1-34)

Journal of Pharmaceutical Sciences

Volumn 91, Issue 2, 2002, Pages 350-361

  Suzuki, Yasuyuki ^a   Nagase, Yoshinori ^a   Iga, Katsumi ^a   Kawase, Masahiro ^a   Oka, Masahiro ^a   Yanai, Shigeo ^a   Matsumoto, Yukihiro ^a   Nakagawa, Shizue ^a   Fukuda, Tsunehiko ^a   Adachi, Hirotoshi ^b   Higo, Naruhito ^b   Ogawa, Yasuaki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b HISAMITSU PHARMACEUTICAL CO INC   (Japan)

Author keywords

Anabolic effect; AUC; BA; Bone mineral density; Femur; HPTH(1 34); Intermittent administration; Iontophoresis; Osteoporosis; Ovariectomy; Patch; Pharmacodynamic; Pharmacokinetic; Pulsatile administration; Pulse; Repeating on and off current; Subcutaneous administration; Transdermal absorption; Transdermal delivery

Indexed keywords

PARATHYROID HORMONE;

ANIMAL MODEL; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; IONTOPHORESIS; NONHUMAN; OVARIECTOMY; RAT;

EID: 0036171267     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10019     Document Type: Article

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