메뉴 건너뛰기




Volumn 33, Issue 1, 2012, Pages 29-33

Iron chelaton therapy with Deferasirox: Optimizing dosage and therapy initiation;Eisenchelat-Therapie mit Deferasirox: Therapiebeginn und Dosisoptimierung

Author keywords

adherence; deferasirox; diarrhea; dosing; iron overload; tolerability

Indexed keywords

DEFERASIROX; IRON;

EID: 84856722811     PISSN: 0722219X     EISSN: 14391279     Source Type: Journal    
DOI: 10.1055/s-0031-1281866     Document Type: Article
Times cited : (1)

References (35)
  • 1
    • 73949156661 scopus 로고    scopus 로고
    • Deferasirox: An update
    • 01
    • Porter JB. Deferasirox: an update. Hemoglobin: 2009; 33 01 70 S75
    • (2009) Hemoglobin , vol.33
    • Porter, J.B.1
  • 2
    • 57049084100 scopus 로고    scopus 로고
    • Long-term efficacy and safety of deferasirox
    • 02
    • Cappellini MD. Long-term efficacy and safety of deferasirox. Blood Rev: 2008; 22 02 S35 S41
    • (2008) Blood Rev , vol.22
    • Cappellini, M.D.1
  • 4
    • 77950425913 scopus 로고    scopus 로고
    • Deferasirox pharmacokinetics in patients with adequate versus inadequate response
    • Chirnomas D, Smith AL, Braunstein J et al. Deferasirox pharmacokinetics in patients with adequate versus inadequate response. Blood: 2009; 114 4009 4013
    • (2009) Blood , vol.114 , pp. 4009-4013
    • Chirnomas, D.1    Smith, A.L.2    Braunstein, J.3
  • 5
    • 47549099814 scopus 로고    scopus 로고
    • Absolute oral bioavailability and disposition of deferasirox in healthy human subjects
    • DOI 10.1177/0091270008320316
    • Sechaud R, Robeva A, Belleli R et al. Absolute oral bioavailability and disposition of deferasirox in healthy human subjects. J Clin Pharmacol: 2008; 48 919 925 (Pubitemid 352009486)
    • (2008) Journal of Clinical Pharmacology , vol.48 , Issue.8 , pp. 919-925
    • Sechaud, R.1    Robeva, A.2    Belleli, R.3    Balez, S.4
  • 7
    • 35848958149 scopus 로고    scopus 로고
    • Current treatment strategies in low-risk myelodysplastic syndromes
    • DOI 10.1016/j.ctrv.2007.07.005, PII S0305737207000874
    • Giagounidis A, Germing U, Aul C. Current treatment strategies in low-risk myelodysplastic syndromes. Cancer Treat Rev: 2007; 33 01 S19 S24 (Pubitemid 350056318)
    • (2007) Cancer Treatment Reviews , vol.33 , Issue.SUPPL. 1
    • Giagounidis, A.A.N.1    Germing, U.2    Aul, C.3
  • 8
    • 77955268192 scopus 로고    scopus 로고
    • Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study
    • Gattermann N, Finelli C, Porta MD et al. Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: results from the large 1-year EPIC study. Leuk Res: 2010; 34 1143 1150
    • (2010) Leuk Res , vol.34 , pp. 1143-1150
    • Gattermann, N.1    Finelli, C.2    Porta, M.D.3
  • 9
    • 78650996705 scopus 로고    scopus 로고
    • Continued improvement in myocardial T2* over two years of deferasirox therapy in beta-thalassemia major patients with cardiac iron overload
    • Pennell DJ, Porter JB, Cappellini MD et al. Continued improvement in myocardial T2* over two years of deferasirox therapy in beta-thalassemia major patients with cardiac iron overload. Haematologica: 2011; 96 48 54
    • (2011) Haematologica , vol.96 , pp. 48-54
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3
  • 11
    • 77952956043 scopus 로고    scopus 로고
    • Matched-pair analysis of 186 MDS patients receiving iron chelation therapy or transfusion therapy only
    • Fox F, Kundgen A, Nachtkamp K et al. Matched-pair analysis of 186 MDS patients receiving iron chelation therapy or transfusion therapy only. Blood (ASH Annual Meeting Abstracts): 2009; 114 1747
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 1747
    • Fox, F.1    Kundgen, A.2    Nachtkamp, K.3
  • 12
    • 77952959079 scopus 로고    scopus 로고
    • Does iron chelation therapy improve survival in regularly transfused lower risk MDS patients? A multicenter study by the GFM
    • Rose C, Brechignac S, Vassilief D et al. Does iron chelation therapy improve survival in regularly transfused lower risk MDS patients? A multicenter study by the GFM. Leuk Res: 2010; 34 864 870
    • (2010) Leuk Res , vol.34 , pp. 864-870
    • Rose, C.1    Brechignac, S.2    Vassilief, D.3
  • 13
    • 33646414765 scopus 로고    scopus 로고
    • A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia
    • Cappellini MD, Cohen A, Piga A et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood: 2006; 107 3455 3462
    • (2006) Blood , vol.107 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3
  • 14
    • 70450133176 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox (Exjade) with up to 4. 5 years of treatment in patients with thalassemia major: A pooled analysis
    • Cappellini MD, Galanello R, Piga A et al. Efficacy and safety of deferasirox (Exjade) with up to 4. 5 years of treatment in patients with thalassemia major: a pooled analysis. ASH Annual Meeting Abstracts: 2008; 112 5411
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 5411
    • Cappellini, M.D.1    Galanello, R.2    Piga, A.3
  • 15
    • 78249238634 scopus 로고    scopus 로고
    • Efficacy and tolerability of deferasirox doses >30 mg/kg/day in patients with transfusion-dependent anemia and iron overload
    • 01 (abstract 845)
    • Cappellini MD, Taher A, Vichinsky E et al. Efficacy and tolerability of deferasirox doses >30 mg/kg/day in patients with transfusion-dependent anemia and iron overload. Haematologica: 2008; 93 01 336 (abstract 845)
    • (2008) Haematologica , vol.93 , pp. 336
    • Cappellini, M.D.1    Taher, A.2    Vichinsky, E.3
  • 16
    • 77950682176 scopus 로고    scopus 로고
    • Tailoring iron chelation by iron intake and serum ferritin: The prospective EPIC study of deferasirox in 1744 patients with transfusion- dependent anemias
    • Cappellini MD, Porter J, El-Beshlawy A et al. Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias. Haematologica: 2010; 95 557 566
    • (2010) Haematologica , vol.95 , pp. 557-566
    • Cappellini, M.D.1    Porter, J.2    El-Beshlawy, A.3
  • 17
    • 65349152022 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: The ESCALATOR study
    • Taher A, El-Beshlawy A, Elalfy MS et al. Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: the ESCALATOR study. Eur J Haematol: 2009; 82 458 465
    • (2009) Eur J Haematol , vol.82 , pp. 458-465
    • Taher, A.1    El-Beshlawy, A.2    Elalfy, M.S.3
  • 19
    • 42949148046 scopus 로고    scopus 로고
    • Clinical application of deferasirox: Practical patient management
    • DOI 10.1002/ajh.21119
    • Vichinsky E. Clinical application of deferasirox: practical patient management. Am J Hematol: 2008; 83 398 402 (Pubitemid 351614754)
    • (2008) American Journal of Hematology , vol.83 , Issue.5 , pp. 398-402
    • Vichinsky, E.1
  • 20
    • 70449403619 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload
    • Taher A, Cappellini MD, Vichinsky E et al. Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload. Br J Haematol: 2009; 147 752 759
    • (2009) Br J Haematol , vol.147 , pp. 752-759
    • Taher, A.1    Cappellini, M.D.2    Vichinsky, E.3
  • 21
    • 70349297213 scopus 로고    scopus 로고
    • Therapie der sekundären Hämochromatose
    • Gattermann N. Therapie der sekundären Hämochromatose. Dt Ärztebl Int: 2009; 106 499 504
    • (2009) Dt Ärztebl Int , vol.106 , pp. 499-504
    • Gattermann, N.1
  • 22
    • 77951240325 scopus 로고    scopus 로고
    • Improved treatment satisfaction and convenience with deferasirox in iron-overloaded patients with beta-Thalassemia: Results from the ESCALATOR Trial
    • Taher A, Al Jefri A, Elalfy MS et al. Improved treatment satisfaction and convenience with deferasirox in iron-overloaded patients with beta-Thalassemia: Results from the ESCALATOR Trial. Acta Haematol: 2010; 123 220 225
    • (2010) Acta Haematol , vol.123 , pp. 220-225
    • Taher, A.1    Al Jefri, A.2    Elalfy, M.S.3
  • 23
    • 0018164919 scopus 로고
    • Non-specific serum iron in thalassaemia: An abnormal serum iron fraction of potential toxicity
    • Hershko C, Graham G, Bates GW et al. Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity. Br J Haematol: 1978; 40 255 263 (Pubitemid 9040657)
    • (1978) British Journal of Haematology , vol.40 , Issue.2 , pp. 255-263
    • Hershko, C.1    Graham, G.2    Bates, G.W.3    Rachmilewitz, E.A.4
  • 25
    • 4444274916 scopus 로고    scopus 로고
    • Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded β-thalassemia/HbE patients treated with an oral chelator
    • DOI 10.1182/blood-2004-02-0630
    • Pootrakul P, Breuer W, Sametband M et al. Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator. Blood: 2004; 104 1504 1510 (Pubitemid 39166531)
    • (2004) Blood , vol.104 , Issue.5 , pp. 1504-1510
    • Pootrakul, P.1    Breuer, W.2    Sametband, M.3    Sirankapracha, P.4    Hershko, C.5    Cabantchik, Z.I.6
  • 26
    • 66349087582 scopus 로고    scopus 로고
    • Iron Chelation with Deferasirox (Exjade) Improves Iron Burden in Patients with Myelodysplastic Syndromes (MDS)
    • List AF, Baer MR, Steensma D et al. Iron Chelation with Deferasirox (Exjade) Improves Iron Burden in Patients with Myelodysplastic Syndromes (MDS). ASH Annual Meeting Abstracts: 2008; 112 634
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 634
    • List, A.F.1    Baer, M.R.2    Steensma, D.3
  • 27
    • 70449349104 scopus 로고    scopus 로고
    • Effect of deferasirox (Exjade) on labile plasma iron levels in heavily iron-overloaded patients with transfusion-dependent anemias enrolled in the large-scale, prospective 1-year EPIC trial
    • Porter JB, Cappellini MD, El-Beshlawy A et al. Effect of deferasirox (Exjade) on labile plasma iron levels in heavily iron-overloaded patients with transfusion-dependent anemias enrolled in the large-scale, prospective 1-year EPIC trial. Blood (ASH Annual Meeting Abstracts): 2008; 112 3881
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 3881
    • Porter, J.B.1    Cappellini, M.D.2    El-Beshlawy, A.3
  • 28
    • 65349110837 scopus 로고    scopus 로고
    • Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia
    • Daar S, Pathare A, Nick H et al. Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia. Eur J Haematol: 2009; 82 454 457
    • (2009) Eur J Haematol , vol.82 , pp. 454-457
    • Daar, S.1    Pathare, A.2    Nick, H.3
  • 29
    • 55049112520 scopus 로고    scopus 로고
    • Deferasirox (ICL670; Exjade) reduces serum ferritin (SF) and labile plasma iron (LPI) in patients with myelodysplastic syndromes (MDS)
    • List AF, Baer MR, Steensma D et al. Deferasirox (ICL670; Exjade) reduces serum ferritin (SF) and labile plasma iron (LPI) in patients with myelodysplastic syndromes (MDS). ASH Annual Meeting Abstracts: 2007; 110 1470
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 1470
    • List, A.F.1    Baer, M.R.2    Steensma, D.3
  • 30
    • 77957738725 scopus 로고    scopus 로고
    • Prospective assessment of effects on iron-overload parameters of deferasirox therapy in patients with myelodysplastic syndromes
    • Greenberg PL, Koller CA, Cabantchik ZI et al. Prospective assessment of effects on iron-overload parameters of deferasirox therapy in patients with myelodysplastic syndromes. Leuk Res: 2010; 34 1560 1565
    • (2010) Leuk Res , vol.34 , pp. 1560-1565
    • Greenberg, P.L.1    Koller, C.A.2    Cabantchik, Z.I.3
  • 31
    • 70449363999 scopus 로고    scopus 로고
    • Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients
    • Zanninelli G, Breuer W, Cabantchik ZI. Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients. Br J Haematol: 2009; 147 744 751
    • (2009) Br J Haematol , vol.147 , pp. 744-751
    • Zanninelli, G.1    Breuer, W.2    Cabantchik, Z.I.3
  • 32
    • 78651061167 scopus 로고    scopus 로고
    • Improved efficacy and tolerability of oral deferasirox by twice-daily dosing for patients with transfusion-dependent beta-thalassemia
    • Chang HH, Lu MY, Liao YM et al. Improved efficacy and tolerability of oral deferasirox by twice-daily dosing for patients with transfusion-dependent beta-thalassemia. Pediatr Blood Cancer: 2010; 56 420 424
    • (2010) Pediatr Blood Cancer , vol.56 , pp. 420-424
    • Chang, H.H.1    Lu, M.Y.2    Liao, Y.M.3
  • 33
    • 84856748156 scopus 로고    scopus 로고
    • Pharmacogenetic Study of Deferasirox, An Iron Chelating Agent
    • Kang HJ, Lee JW, Choi J-Y et al. Pharmacogenetic Study of Deferasirox, An Iron Chelating Agent. ASH Annual Meeting Abstracts: 2010; 116 2060
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 2060
    • Kang, H.J.1    Lee, J.W.2    Choi, J.-Y.3
  • 34
    • 55549139528 scopus 로고    scopus 로고
    • Consensus statement on iron overload in myelodysplastic syndromes
    • Bennett JM. Consensus statement on iron overload in myelodysplastic syndromes. Am J Hematol: 2008; 83 858 861
    • (2008) Am J Hematol , vol.83 , pp. 858-861
    • Bennett, J.M.1
  • 35
    • 78651287827 scopus 로고    scopus 로고
    • Iron overload in MDS-pathophysiology, diagnosis, and complications
    • Gattermann N, Rachmilewitz EA. Iron overload in MDS-pathophysiology, diagnosis, and complications. Ann Hematol: 2011; 90 1 10
    • (2011) Ann Hematol , vol.90 , pp. 1-10
    • Gattermann, N.1    Rachmilewitz, E.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.