메뉴 건너뛰기




Volumn 19, Issue 1, 2012, Pages 21-27

Granzymes, cytotoxic granules and cell death: The early work of Dr. Jurg Tschopp

Author keywords

CTL; cytotoxic granule; granzyme; lymphocyte; NK cell; perforin

Indexed keywords

GRANZYME; PERFORIN; SERINE PROTEINASE;

EID: 84856712612     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.156     Document Type: Review
Times cited : (20)

References (66)
  • 1
    • 0022749230 scopus 로고
    • Granules of cytolytic T-lymphocytes contain two serine esterases
    • Masson D, Nabholz M, Estrade C, Tschopp J. Granules of cytolytic T-lymphocytes contain two serine esterases. EMBO J 1986; 5: 1595-1600.
    • (1986) EMBO J , vol.5 , pp. 1595-1600
    • Masson, D.1    Nabholz, M.2    Estrade, C.3    Tschopp, J.4
  • 2
    • 0023645045 scopus 로고
    • A family of serine esterases in lytic granules of cytolytic T lymphocytes
    • Masson D, Tschopp J. A family of serine esterases in lytic granules of cytolytic T lymphocytes. Cell 1987; 49: 679-685.
    • (1987) Cell , vol.49 , pp. 679-685
    • Masson, D.1    Tschopp, J.2
  • 3
    • 0023820255 scopus 로고
    • Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation
    • Jenne DE, Tschopp J. Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation. Immunol Rev 1988; 103: 53-71.
    • (1988) Immunol Rev , vol.103 , pp. 53-71
    • Jenne, D.E.1    Tschopp, J.2
  • 4
    • 0026474805 scopus 로고
    • Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
    • Shi L, Kam CM, Powers JC, Aebersold R, Greenberg AH. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med 1992; 176: 1521-1529.
    • (1992) J Exp Med , vol.176 , pp. 1521-1529
    • Shi, L.1    Kam, C.M.2    Powers, J.C.3    Aebersold, R.4    Greenberg, A.H.5
  • 5
    • 0026532606 scopus 로고
    • A natural killer cell granule protein that induces DNA fragmentation and apoptosis
    • Shi L, Kraut RP, Aebersold R, Greenberg AH. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J Exp Med 1992; 175: 553-566.
    • (1992) J Exp Med , vol.175 , pp. 553-566
    • Shi, L.1    Kraut, R.P.2    Aebersold, R.3    Greenberg, A.H.4
  • 6
    • 0025973806 scopus 로고
    • A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene
    • Shiver JW, Henkart PA. A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene. Cell 1991; 64: 1175-1181. (Pubitemid 121001204)
    • (1991) Cell , vol.64 , Issue.6 , pp. 1175-1181
    • Shiver, J.W.1    Henkart, P.A.2
  • 7
    • 0026753388 scopus 로고
    • Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A
    • Shiver JW, Su L, Henkart PA. Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A. Cell 1992; 71: 315-322.
    • (1992) Cell , vol.71 , pp. 315-322
    • Shiver, J.W.1    Su, L.2    Henkart, P.A.3
  • 8
    • 0028265815 scopus 로고
    • Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown
    • Nakajima H, Henkart PA. Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown. J Immunol 1994; 152: 1057-1063. (Pubitemid 24134330)
    • (1994) Journal of Immunology , vol.152 , Issue.3 , pp. 1057-1063
    • Nakajima, H.1    Henkart, P.A.2
  • 9
    • 65549121526 scopus 로고    scopus 로고
    • The molecular basis for perforin oligomerization and transmembrane pore assembly
    • Baran K, Dunstone M, Chia J, Ciccone A, Browne KA, Clarke CJ et al. The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity 2009; 30: 684-695.
    • (2009) Immunity , vol.30 , pp. 684-695
    • Baran, K.1    Dunstone, M.2    Chia, J.3    Ciccone, A.4    Browne, K.A.5    Clarke, C.J.6
  • 11
    • 0016597777 scopus 로고
    • Isolation and characterization of indidivual functionally reactive cytotoxic T lymphocytes: Conjugation, killing and recylcing at the single cell level
    • Zagury D, Bernard J, Thierness N, Feldman M, Berke G. Isolation and characterization of indidivual functionally reactive cytotoxic T lymphocytes: Conjugation, killing and recylcing at the single cell level. Eur J Immunol 1975; 5: 818-822.
    • (1975) Eur J Immunol , vol.5 , pp. 818-822
    • Zagury, D.1    Bernard, J.2    Thierness, N.3    Feldman, M.4    Berke, G.5
  • 12
    • 0018182447 scopus 로고
    • Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells. II. Morphogenesis of secretory granules and intracellular vacuoles
    • Bykovskaja SN, Rytenko AN, Rauschenbach MO, Bykovsky AF. Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells. II. Morphogenesis of secretory granules and intracellular vacuoles. Cell Immunol 1978; 40: 175-185. (Pubitemid 9040245)
    • (1978) Cellular Immunology , vol.40 , Issue.1 , pp. 175-185
    • Bykovskaja, S.N.1    Rytenko, A.N.2    Rauschenbach, M.O.3    Bykovsky, A.F.4
  • 13
    • 0019186938 scopus 로고
    • Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity
    • Doumarshkin RR, Deteix P, Simone CB, Henkart P. Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity. Clin Exp Immunol 1980; 42: 554-560. (Pubitemid 11247478)
    • (1980) Clinical and Experimental Immunology , vol.42 , Issue.3 , pp. 554-560
    • Dourmashkin, R.R.1    Deteix, P.2    Simone, C.B.3    Henkart, P.4
  • 14
    • 0020679842 scopus 로고
    • Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells
    • DOI 10.1038/302442a0
    • Podack ER, Dennert G. Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells. Nature 1983; 302: 442-445. (Pubitemid 13164334)
    • (1983) Nature , vol.302 , Issue.5907 , pp. 442-445
    • Podack, E.R.1    Dennert, G.2
  • 16
    • 0022253052 scopus 로고
    • Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes
    • Masson D, Tschopp J. Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes. J Biol Chem 1985; 260: 9069-9072. (Pubitemid 15249876)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.16 , pp. 9069-9072
    • Masson, D.1    Tschopp, J.2
  • 17
    • 0022430248 scopus 로고
    • Specific release of proteoglycans from human natural killer cells during target lysis
    • Schmidt RE, MacDermott RP, Bartley G, Bertovich M, Amato DA, Austen KF et al. Specific release of proteoglycans from human natural killer cells during target lysis. Nature 1985; 318: 289-291. (Pubitemid 16206731)
    • (1985) Nature , vol.31 B , Issue.6043 , pp. 289-291
    • Schmidt, R.E.1    MacDermott, R.P.2    Bartley, G.3
  • 18
    • 0022297121 scopus 로고
    • Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis
    • MacDermott RP, Schmidt RE, Caulfield JP, Hein A, Bartley GT, Ritz J et al. Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis. J Exp Med 1985; 162: 1771-1787. (Pubitemid 16149675)
    • (1985) Journal of Experimental Medicine , vol.162 , Issue.6 , pp. 1771-1787
    • MacDermott, R.P.1    Schmidt, R.E.2    Caulfield, J.P.3
  • 19
    • 0022496723 scopus 로고
    • Serine esterase in cytolytic T lymphocytes
    • Pasternack MS, Verret CR, Liu MA, Eisen HN. Serine esterase in cytolytic T lymphocytes. Nature 1986; 322: 740-743. (Pubitemid 16074124)
    • (1986) Nature , vol.322 , Issue.6081 , pp. 740-743
    • Pasternack, M.S.1    Verret, C.R.2    Liu, M.A.3    Eisen, H.N.4
  • 21
    • 0018981527 scopus 로고
    • The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases
    • Redelman D, Hudig D. The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases. J Immunol 1980; 124: 870-878.
    • (1980) J Immunol , vol.124 , pp. 870-878
    • Redelman, D.1    Hudig, D.2
  • 22
    • 0018825585 scopus 로고
    • Effects of N(α)-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes
    • Chang TW, Eisen HN. Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes. J Immunol 1980; 124: 1028-1033. (Pubitemid 10105294)
    • (1980) Journal of Immunology , vol.124 , Issue.3 , pp. 1028-1033
    • Chang, T.W.1    Eisen, H.N.2
  • 23
    • 0021745386 scopus 로고
    • The requirement for proteinase activity for human lymphocyte-mediated natural cytotoxicity (NK): Evidence that the proteinase is serine dependent and has aromatic amino acid specificity of cleavage
    • Hudig D, Redelman D, Minning LL. The requirement for proteinase activity for human lymphocyte-mediated natural cytotoxicity (NK): evidence that the proteinase is serine dependent and has aromatic amino acid specificity of cleavage. J Immunol 1984; 133: 2647-2654. (Pubitemid 15206920)
    • (1984) Journal of Immunology , vol.133 , Issue.5 , pp. 2647-2654
    • Hudig, D.1    Redelman, D.2    Minning, L.L.3
  • 24
    • 0019425866 scopus 로고
    • Inhibition of human natural cytotoxicity by macromolecular antiproteases
    • Hudig D, Haverty T, Fulcher C, Redelman D, Mendelsohn J. Inhibition of human natural cytotoxicity by macromolecular antiproteases. J Immunol 1981; 126: 1569-1574. (Pubitemid 11149266)
    • (1981) Journal of Immunology , vol.126 , Issue.4 , pp. 1569-1574
    • Hudig, D.1    Haverty, T.2    Fulcher, C.3
  • 25
    • 0021859627 scopus 로고
    • A novel serine esterase expressed by cytotoxic T lymphocytes
    • DOI 10.1038/314743a0
    • Pasternack MS, Eisen HN. A novel serine esterase expressed by cytotoxic T lymphocytes. Nature 1985; 314: 743-745. (Pubitemid 15050074)
    • (1985) Nature , vol.314 , Issue.6013 , pp. 743-745
    • Pasternack, M.S.1    Eisen, H.N.2
  • 26
    • 0020032614 scopus 로고
    • Polymerization of the ninth component of complement (C9): Formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement
    • DOI 10.1073/pnas.79.2.574
    • Podack ER, Tschopp J. Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement. Proc Natl Acad Sci USA 1982; 79: 574-578. (Pubitemid 12137752)
    • (1982) Proceedings of the National Academy of Sciences of the United States of America , vol.79 , Issue.2 , pp. 574-578
    • Podack, E.R.1    Tschopp, J.2
  • 27
    • 0019948302 scopus 로고
    • Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9
    • DOI 10.1038/298534a0
    • Tschopp J, Muller-Eberhard HJ, Podack ER. Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9. Nature 1982; 298: 534-538. (Pubitemid 12038654)
    • (1982) Nature , vol.298 , Issue.5874 , pp. 534-538
    • Tschopp, J.1    Muller-Eberhard, H.J.2    Podack, E.R.3
  • 28
    • 0024215011 scopus 로고
    • Inhibition of lymphocyte protease granzyme A by antithrombin III
    • DOI 10.1016/0161-5890(88)90043-0
    • Masson D, Tschopp J. Inhibition of lymphocyte protease granzyme A by antithrombin III. Mol Immunol 1988; 25: 1283-1289. (Pubitemid 19023143)
    • (1988) Molecular Immunology , vol.25 , Issue.12 , pp. 1283-1289
    • Masson, D.1    Tschopp, J.2
  • 29
    • 0023807487 scopus 로고
    • Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes
    • Jenne D, Rey C, Haefliger JA, Qiao BY, Groscurth P, Tschopp J. Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. Proc Natl Acad Sci USA 1988; 85: 4814-4818.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4814-4818
    • Jenne, D.1    Rey, C.2    Haefliger, J.A.3    Qiao, B.Y.4    Groscurth, P.5    Tschopp, J.6
  • 32
    • 0022517633 scopus 로고
    • Inhibition of the lytic activity of perforin by lipoproteins
    • Tschopp J, Masson D, Schafer S. Inhibition of the lytic activity of perforin by lipoproteins. J Immunol 1986; 137: 1950-1953. (Pubitemid 16021110)
    • (1986) Journal of Immunology , vol.137 , Issue.6 , pp. 1950-1953
    • Tschopp, J.1    Masson, D.2    Schafer, S.3
  • 33
    • 0023204627 scopus 로고
    • Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans
    • DOI 10.1016/0161-5890(87)90002-2
    • Tschopp J, Masson D. Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans. Mol Immunol 1987; 24: 907-913. (Pubitemid 17149495)
    • (1987) Molecular Immunology , vol.24 , Issue.9 , pp. 907-913
    • Tschopp, J.1    Masson, D.2
  • 34
    • 0022466507 scopus 로고
    • Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis
    • Tschopp J, Masson D, Stanley KK. Structural/functional similarity between proteins involved in complement-and cytotoxic T-lymphocyte-mediated cytolysis. Nature 1986; 322: 831-834. (Pubitemid 16055254)
    • (1986) Nature , vol.322 , Issue.6082 , pp. 831-834
    • Tschopp, J.1    Masson, D.2    Stanley, K.K.3
  • 35
    • 0024476926 scopus 로고
    • 2+-dependent receptor molecule or lymphocyte perforin
    • DOI 10.1038/337272a0
    • Tschopp J, Schafer S, Masson D, Peitsch MC, Heusser C. Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin. Nature 1989; 337: 272-274. (Pubitemid 19030565)
    • (1989) Nature , vol.337 , Issue.6204 , pp. 272-274
    • Tschopp, J.1    Schafer, S.2    Masson, D.3    Peitsch, M.C.4    Heusser, C.5
  • 36
    • 0024565022 scopus 로고
    • Absence of homologous restriction factors does not affect CTL-mediated cytolysis
    • DOI 10.1002/eji.1830190137
    • Krahenbuhl OP, Peter HH, Tschopp J. Absence of homologous restriction factor does not affect CTL-mediated cytolysis. Eur J Immunol 1989; 19: 217-219. (Pubitemid 19069314)
    • (1989) European Journal of Immunology , vol.19 , Issue.1 , pp. 217-219
    • Krahenbuhl, O.P.1    Peter, H.H.2    Tschopp, J.3
  • 37
    • 34548670476 scopus 로고    scopus 로고
    • Structure of C8α-MACPF reveals mechanism of membrane attack in complement immune defense
    • DOI 10.1126/science.1147103
    • Hadders MA, Beringer DX, Gros P. Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. Science 2007; 317: 1552-1554. (Pubitemid 47417434)
    • (2007) Science , vol.317 , Issue.5844 , pp. 1552-1554
    • Hadders, M.A.1    Beringer, D.X.2    Gros, P.3
  • 39
    • 0027968994 scopus 로고
    • Resistance of CTL to perforin-mediated lysis. Evidence for a lymphocyte membrane protein interacting with perforin
    • Muller C, Tschopp J. Resistance of CTL to perforin-mediated lysis. Evidence for a lymphocyte membrane protein interacting with perforin. J Immunol 1994; 153: 2470-2478.
    • (1994) J Immunol , vol.153 , pp. 2470-2478
    • Muller, C.1    Tschopp, J.2
  • 40
    • 0023927292 scopus 로고
    • Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli
    • Garcia-Sanz JA, Velotti F, MacDonald HR, Masson D, Tschopp J, Nabholz M. Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli. Immunology 1988; 64: 129-134.
    • (1988) Immunology , vol.64 , pp. 129-134
    • Garcia-Sanz, J.A.1    Velotti, F.2    MacDonald, H.R.3    Masson, D.4    Tschopp, J.5    Nabholz, M.6
  • 42
    • 0025855444 scopus 로고
    • Immunohistochemical localization of granzyme B antigen in cytotoxic cells in human tissues
    • Hameed A, Truong LD, Price V, Kruhenbuhl O, Tschopp J. Immunohistochemical localization of granzyme B antigen in cytotoxic cells in human tissues. Am J Pathol 1991; 138: 1069-1075.
    • (1991) Am J Pathol , vol.138 , pp. 1069-1075
    • Hameed, A.1    Truong, L.D.2    Price, V.3    Kruhenbuhl, O.4    Tschopp, J.5
  • 45
    • 0025950813 scopus 로고
    • Debate: The mechanism of lymphocyte-mediated killing. Lymphocyte-triggered internal target disintegration
    • Berke G. Debate: the mechanism of lymphocyte-mediated killing. Lymphocyte-triggered internal target disintegration. Immunol Today 1991; 12: 396-399.
    • (1991) Immunol Today , vol.12 , pp. 396-399
    • Berke, G.1
  • 46
    • 0026005218 scopus 로고
    • Debate: The mechanism of lymphocyte-mediated killing. Perforin-induced pore formation
    • Krahenbuhl O, Tschopp J. Debate: the mechanism of lymphocyte-mediated killing. Perforin-induced pore formation. Immunol Today 1991; 12: 399-402.
    • (1991) Immunol Today , vol.12 , pp. 399-402
    • Krahenbuhl, O.1    Tschopp, J.2
  • 47
    • 0024614958 scopus 로고
    • CTL-mediated cytolysis: Perforin and alternative pathways?
    • Nabholz M, Tschopp J. CTL-mediated cytolysis: perforin and alternative pathways? Immunol Lett 1989; 20: 179-180.
    • (1989) Immunol Lett , vol.20 , pp. 179-180
    • Nabholz, M.1    Tschopp, J.2
  • 48
    • 0023299447 scopus 로고
    • The role of cytoplasmic granule components in cytolytic lymphocyte-mediated cytolysis
    • Tschopp J, Nabholz M. The role of cytoplasmic granule components in cytolytic lymphocyte-mediated cytolysis. Ann Inst Pasteur Immunol 1987; 138: 290-295.
    • (1987) Ann Inst Pasteur Immunol , vol.138 , pp. 290-295
    • Tschopp, J.1    Nabholz, M.2
  • 49
    • 0023841072 scopus 로고
    • Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes
    • Allbritton NL, Verret CR, Wolley RC, Eisen HN. Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes. J Exp Med 1988; 167: 514-527. (Pubitemid 18073651)
    • (1988) Journal of Experimental Medicine , vol.167 , Issue.2 , pp. 514-527
    • Allbritton, N.L.1    Verret, C.R.2    Wolley, R.C.3    Eisen, H.N.4
  • 50
    • 0024582820 scopus 로고
    • The cytolytic T lymphocyte and its mode of action
    • DOI 10.1016/0165-2478(89)90075-8
    • Berke G. The cytolytic T lymphocyte and its mode of action. Immunol Lett 1989; 20: 169-178. (Pubitemid 19080568)
    • (1989) Immunology Letters , vol.20 , Issue.3 , pp. 169-178
    • Berke, G.1
  • 51
    • 0023803245 scopus 로고
    • Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro
    • Berke G, Rosen D. Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro. J Immunol 1988; 141: 1429-1436.
    • (1988) J Immunol , vol.141 , pp. 1429-1436
    • Berke, G.1    Rosen, D.2
  • 52
    • 0024317943 scopus 로고
    • Evidence for multiple lytic pathways used by cytotoxic T lymphocytes
    • Ostergaard HL, Clark WR. Evidence for multiple lytic pathways used by cytotoxic T lymphocytes. J Immunol 1989; 143: 2120-2126. (Pubitemid 19245175)
    • (1989) Journal of Immunology , vol.143 , Issue.7 , pp. 2120-2126
    • Ostergaard, H.L.1    Clark, W.R.2
  • 53
    • 0023626618 scopus 로고
    • Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes
    • DOI 10.1038/330072a0
    • Trenn G, Takayama H, Sitkovsky MV. Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes. Nature 1987; 330: 72-74. (Pubitemid 17152417)
    • (1987) Nature , vol.330 , Issue.6143 , pp. 72-74
    • Trenn, G.1    Takayama, H.2    Sitkovsky, M.V.3
  • 54
    • 0020972291 scopus 로고
    • Internal disintegration model of cytotoxic lymphocyte-induced target damage
    • Russell JH. Internal disintegration model of cytotoxic lymphocyte-induced target damage. Immunol Rev 1983; 72: 97-118. (Pubitemid 13008741)
    • (1983) Immunological Reviews , vol.72 , pp. 97-118
    • Russell, J.H.1
  • 56
    • 0023705408 scopus 로고
    • Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes
    • Gromkowski SH, Brown TC, Masson D, Tschopp J. Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes. J Immunol 1988; 141: 774-778.
    • (1988) J Immunol , vol.141 , pp. 774-778
    • Gromkowski, S.H.1    Brown, T.C.2    Masson, D.3    Tschopp, J.4
  • 57
    • 33645742877 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
    • Waterhouse NJ, Sutton VR, Sedelies KA, Ciccone A, Jenkins M, Turner SJ et al. Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. J Cell Biol 2006; 173: 133-144.
    • (2006) J Cell Biol , vol.173 , pp. 133-144
    • Waterhouse, N.J.1    Sutton, V.R.2    Sedelies, K.A.3    Ciccone, A.4    Jenkins, M.5    Turner, S.J.6
  • 60
    • 0025962661 scopus 로고
    • Human cytotoxic lymphocyte granzyme B: Its purification from granules and the characterization of substrate and inhibitor specificity
    • Poe M, Blake JT, Boulton DA, Gammon M, Sigal NH, Wu JK et al. Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. J Biol Chem 1991; 266: 98-103. (Pubitemid 21906095)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.1 , pp. 98-103
    • Poe, M.1    Blake, J.T.2    Boulton, D.A.3    Gammon, M.4    Sigal, N.H.5    Wu, J.K.6    Zweerink, H.J.7
  • 61
    • 0025000275 scopus 로고
    • Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides
    • Acha-Orbea H, Scarpellino L, Hertig S, Dupuis M, Tschopp J. Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides. EMBO J 1990; 9: 3815-3819.
    • (1990) EMBO J , vol.9 , pp. 3815-3819
    • Acha-Orbea, H.1    Scarpellino, L.2    Hertig, S.3    Dupuis, M.4    Tschopp, J.5
  • 62
    • 0028486130 scopus 로고
    • Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes
    • Kojima H, Shinohara N, Hanaoka S, Someya-Shirota Y, Takagaki Y, Ohno H et al. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity 1994; 1: 357-364.
    • (1994) Immunity , vol.1 , pp. 357-364
    • Kojima, H.1    Shinohara, N.2    Hanaoka, S.3    Someya-Shirota, Y.4    Takagaki, Y.5    Ohno, H.6
  • 65
    • 0028927607 scopus 로고
    • The Fas death factor
    • Nagata S, Golstein P. The Fas death factor. Science 1995; 267: 1449-1456.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 66


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.