"Delayed death" phenomenon: A synergistic action of cyclophosphamide and exogenous DNA

Gene

Volumn 495, Issue 2, 2012, Pages 134-145

  Dolgova, Evgenia V ^a   Proskurina, Anastasia S ^a   Nikolin, Valeriy P ^a   Popova, Nelly A ^a,b   Alyamkina, Ekaterina A ^a   Orishchenko, Konstantin E ^a   Rogachev, Vladimir A ^a   Efremov, Yaroslav R ^a   Dubatolova, Tatiana D ^a   Prokopenko, Anastasia V ^a   Chernykh, Elena R ^c   Ostanin, Alexandr A ^c   Taranov, Oleg S ^d   Omigov, Vladimir V ^d   Zagrebelniy, Stanislav N ^b   Bogachev, Sergey S ^a   Shurdov, Mikhail A ^e  

^a INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^c INSTITUTE OF CLINICAL IMMUNOLOGY   (Russian Federation)

^d STATE RESEARCH CENTER OF VIROLOGY AND BIOTECHNOLOGY VECTOR   (Russian Federation)

^e LLC Panagen ^*  (Russian Federation)

Author keywords

Apoptosis; Bone marrow cells; Involution of lymphoid organs; Mouse short interspersed elements; Systemic inflammation

Indexed keywords

CD34 ANTIGEN; CYCLOPHOSPHAMIDE; DNA; REPETITIVE DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; HEMATOPOIETIC STEM CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTERNALIZATION; LYMPHOID PROGENITOR CELL; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD43; APOPTOSIS; BONE MARROW CELLS; CYCLOPHOSPHAMIDE; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; HEMATOPOIETIC STEM CELLS; HUMANS; INTERSPERSED REPETITIVE SEQUENCES; LYMPHOID TISSUE; MICE; MICE, INBRED CBA; MORBIDITY; MORTALITY;

ANIMALIA; MUS;

EID: 84856700793     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2011.12.032     Document Type: Article

References (41)

1. Akkari Y.M., Bateman R.L., Reifsteck C.A., Olson S.B., Grompe M. DNA replication is required to elicit cellular responses to psoralen-induced DNA interstrand cross-links. Mol. Cell. Biol. 2000, 20:8283-8289.
2. Aliamkina E.A., et al. Protamine association with exogenous DNA's versus its ability to inhibit experimental tumors. Vopr. Onkol. 2009, 55:765-768. (In Russian).
3. Alyamkina E.A., et al. Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their allostimulatory activity. Cell. Immunol. 2010, 262:120-126.
4. Coban C., Koyama S., Takeshita F., Akira S., Ishii K.J. Molecular and cellular mechanisms of DNA vaccines. Hum. Vaccin. 2008, 4:453-456.
5. Decker P., Wolburg H., Rammensee H.G. Nucleosomes induce lymphocyte necrosis. Eur. J. Immunol. 2003, 33:1978-1987.
6. Decker P., Singh-Jasuja H., Haager S., Kötter I., Rammensee H.G. Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: consequences on inflammation. J. Immunol. 2005, 174:3326-3334.
7. Derbyshire M.K., Epstein L.H., Young C.S., Munz P.L., Fishel R. Nonhomologous recombination in human cells. Mol. Cell. Biol. 1994, 14:156-169.
8. Dolgova E.V., et al. A leukocyte-stimulating effect of exogenous DNA fragments protected with protamine in the cyclophosphamide-induced myelosuppression in mice. Vopr. Onkol. 2009, 55:761-764. (In Russian).
9. Dolgova E.V., Likhacheva A.S., Orishchenko K.E., Alyamkina E.A., Bogachev S.S., Shurdov M.A. Repair of interstand crosslinks in a DNA molecule. VOGiS Herald 2010, 14:332-356. (In Russian).
10. Domeyer B.E., Sladek N.E. Inhibition by cyanamide of 4-hydroxycyclophosphamide/aldophosphamide oxidation to carboxyphosphamide. Biochem. Pharmacol. 1981, 30:2065-2073.
11. Drosophila: a practical approach Edited by Roberts, D.B. 1986, IRL Press, Oxford-Washington, DC.
12. Fleming R.A. An overview of cyclophosphamide and ifosfamide pharmacology. Pharmacotherapy 1997, 17:146-154.
13. Kotnis A., Du L., Liu C., Popov S.W., Pan-Hammarström Q. Non-homologous end joining in class switch recombination: the beginning of the end. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2009, 364:653-665.
14. Kramerov D.A., Vassetzky N.S. Structure and origin of a novel dimeric retroposon B1-diD. J. Mol. Evol. 2001, 52:137-143.
15. Kruglyakov P.V., Sokolova I.B., Polyntsev D.G. Stem cells from adult differentiated tissues. Cytology 2008, 50:557-567.
16. Lee S.H., et al. The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:18075-18080.
17. Lees-Miller S.P., Meek K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie 2003, 85:1161-1173.
18. Likhacheva A.S., et al. Integration of human DNA fragments into the cell genomes of certain tissues from adult mice treated with cytostatic cyclophosphamide in combination with human DNA. Gene Ther. Mol. Biol. 2007, 11:185-202.
19. Likhacheva A.S., et al. Exogenous DNA can be captured by stem cells and be involved in their rescue from death after lethal-dose Γ-radiation. Gene Ther. Mol. Biol. 2007, 11:305-314.
20. Likhacheva A.S., et al. Involvement of exogenous DNA in the molecular processes in somatic cell. VOGiS Herald 2008, 12:426-473. (In Russian).
21. Magaña-Schwencke N., Henriques J.A., Chanet R., Moustacchi E. The fate of 8-methoxypsoralen photoinduced crosslinks in nuclear and mitochondrial yeast DNA: comparison of wild-type and repair-deficient strains. Proc. Natl. Acad. Sci. U. S. A. 1982, 79:1722-1726.
22. Martin D.A., Elkon K.B. Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a toll-like receptor 9-independent pathway. Arthritis Rheum. 2006, 54:951-962.
23. Mazur L., Czyzewska A. Immunocytochemical analysis of apoptotic bone marrow cells after treatment of mice with WR-2721 and chemotherapeutic drugs. Folia Histochem. Cytobiol. 2001, 39:63-66.
24. McMahon J.M., Wells K.E., Bamfo J.E., Cartwright M.A., Wells D.J. Inflammatory responses following direct injection of plasmid DNA into skeletal muscle. Gene Ther. 1998, 5:1283-1290.
25. Mondal T.K., Bhatta D., Ray P.K., Pal P. Synergistic immunopotentiating effects induced by T-cell and B-cell superantigen in mice. Immunol. Invest. 2001, 30:169-180.
26. Murata S., Takasaki N., Saiton M., Okada N. Determination of the phylogenetic relationships among Pacific salmonids by using short interspersed elements (SINEs) as temporal landmarks of evolution. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:6995-6999.
27. Niedernhofer L.J., et al. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol. Cell. Biol. 2004, 24:5776-5787.
28. Nikolin V.P., et al. Effect of exogenous DNA injection on leukopoietic repair and antitumor action of cyclophosphamide. Vopr. Onkol. 2006, 52:336-340. (In Russian).
29. Orkin S.H., Zon L.I. Hematopoiesis: an evolving paradigm for stem cell biology. Cell 2008, 132:631-644.
30. Paques F., Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 1999, 63:349-404.
31. Pinkel D., Straume T., Gray J.W. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc. Natl. Acad. Sci. U. S. A. 1986, 83:2934-2938.
32. Rossi D.J., Jamieson C.H., Weissman I.L. Stems cells and the pathways to aging and cancer. Cell 2008, 132:681-696.
33. Rothfuss A., Grompe M. Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol. Cell. Biol. 2004, 24:123-134.
34. Salem M.L., El-Naggar S.A., Cole D.J. Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo. Cell. Immunol. 2010, 261:134-143.
35. Serdobova I.M., Kramerov D.A. Short retroposons of the B2 superfamily: evolution and application for the study of rodent phylogeny. J. Mol. Evol. 1998, 46:202-214.
36. Shirota H., Ishii K.J., Takakuwa H., Klinman D.M. Contribution of interferon-beta to the immune activation induced by double-stranded DNA. Immunology 2006, 118:302-310.
37. Silva J., Smith A. Capturing pluripotency. Cell 2008, 132:532-536.
38. Stanyon R., Galleni R. A rapid fibroblast culture technique for high resolution karyotypes. Ital. J. Zool. 1991, 58:81-83.
39. Vassetzky N.S., Ten O.A., Kramerov D.A. B1 and related SINEs in mammalian genomes. Gene 2003, 319:149-160.
40. Wang H., et al. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res. 2005, 65:4020-4030.
41. Yu L.J., Drewes P., Gustafsson K., Brain E.G., Hecht J.E., Waxman D.J. In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. J. Pharmacol. Exp. Ther. 1999, 288:928-937.