Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1550-1556

  Shen, Hong C ^a   Ding, Fa Xiang ^a   Jiang, Jinlong ^a   Verras, Andreas ^a   Chabin, Renee M ^a   Xu, Suoyu ^a   Tong, Xinchun ^a   Chen, Qing ^a   Xie, Dan ^a   Lassman, Mike E ^a   Bhatt, Urmi R ^a   Garcia Calvo, Margarita M ^a   Geissler, Wayne ^a   Shen, Zhu ^a   Murphy, Beth Ann ^a   Gorski, Judith N ^a   Wiltsie, Judyann ^a   Roy, Ranabir Sinha ^a   Hale, Jeffrey J ^a   Pinto, Shirly ^a   Shen, Dong Ming ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Brain penetrant; Inhibitors; PrCP; Prolylcarboxypeptidase

Indexed keywords

BENZODIHYDROISOFURAN; PROLINE CARBOXYPEPTIDASE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN; DIET; DRUG BIOAVAILABILITY; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; METABOLISM; NONHUMAN; OBESITY; PLASMA; PLASMA PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; WEIGHT REDUCTION;

MUS;

EID: 84856670929     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.002     Document Type: Article

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