Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity (Journal of Clinical Investigation (2009) 119, (2130-2133) DOI: 10.1172/JCI40001);Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity

Journal of Clinical Investigation

Volumn 119, Issue 8, 2009, Pages 2130-2133

  Palmiter, Richard D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; NEUROTRANSMITTER; PROLINE CARBOXYPEPTIDASE; PROOPIOMELANOCORTIN;

FOOD INTAKE; HORMONE ACTION; HUMAN; NEUROTRANSMITTER RELEASE; NOTE; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 68849097606     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI40001C1     Document Type: Erratum

References (18)

1. Smart, J.L., Tolle, V., and Low, M.J. 2006. Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. J. Clin. Invest. 116:495-505.
2. Krude, H., et al. 1998. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19:155-157.
3. Coll, A.P., et al. 2004. Proopiomelanocortin and energy balance: insights from human and murine genetics. J. Clin. Endocrinol. Metab. 89:2557-2562.
4. Faroogi, I.S. 2008. Monogenetic human obesity. Front. Horm. Res. 36:1-11.
5. Saper, C.B., Chou, T.C., and Elmquist, J.K. 2002. The need to feed: homeostatic and hedonic control of eating. Neuron. 36:199-211.
6. Cone, R.D. 2005. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 8:571-578.
7. Morton, G.J., Cummings, D.E., Baskin, D.G., Barsh, G.S., and Schwartz, M.W. 2006. Central nervous system control of food intake and body weight. Nature. 443:289-295.
8. Wallingford, N., et al. 2009. Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents. J. Clin. Invest. 119:2291-2303.
9. Prichard, L.E., Turnbull, A.V., and White, A. 2002. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signaling and obesity. J. Endocrinol. 172:411-421.
10. Jackson, R.S., et al. 1997. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat. Genet. 16:303-306.
11. Rouillé, Y., et al. 1995. Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front. Neuroendocrinol. 16:322-361.
12. Naggert, J.K., et al. 1995. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat. Genet. 10:135-142.
13. Skidgel, R.A., and Erdos, E.G. 1998. Cellular carboxypeptidases. Immunol. Rev. 161:129-141.
14. Schmaier, A.H. 2003. The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285:R1-R13.
15. Diament, A.L., and Warden, C.H. 2004. Multiple linked mouse chromosome 7 loci influence body fat mass. Int. J. Obes. Relat. Metab. Disord. 28:199-210.
16. McCarthy, J.J., et al. 2003. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. Hum. Genet. 114:87-98.
17. Wilkinson, C.W. 2006. Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins. Peptides. 27:453-471.
18. Guo, L., Munzberg, H., Stuart, R.C., Nillni, E.A., and Bjorbaek, C. 2004. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proc. Natl. Acad. Sci. U. S. A. 101:11797-11802.