Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1299-1305

  Shen, Hong C ^a   Ding, Fa Xiang ^a   Zhou, Changyou ^a   Xiong, Yusheng ^a   Verras, Andreas ^a   Chabin, Renee M ^a   Xu, Suoyu ^a   Tong, Xinchun ^a   Xie, Dan ^a   Lassman, Michael E ^a   Bhatt, Urmi R ^a   Garcia Calvo, Margarita M ^a   Geissler, Wayne ^a   Shen, Zhu ^a   Chen, Dunlu ^a   Sinharoy, Ranabir ^a   Hale, Jeffery J ^a   Tata, James R ^a   Pinto, Shirly ^a   Shen, Dong Ming ^a   Colletti, Steven L ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Benzimidazole pyrrolidinyl amides; Inhibitors; Obesity; PrCP; Prolylcarboxypeptidase

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; PEPTIDE HYDROLASE INHIBITOR; PROLINE CARBOXYPEPTIDASE; PYRROLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG SYNTHESIS; EX VIVO STUDY; FOOD INTAKE; IC 50; MOUSE; NONHUMAN; WEIGHT REDUCTION;

AMIDES; ANIMALS; BENZIMIDAZOLES; CARBOXYPEPTIDASES; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951723090     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.090     Document Type: Article

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