Potential new method of mixture effects testing using metabolomics and Caenorhabditis elegans

Journal of Proteome Research

Volumn 11, Issue 2, 2012, Pages 1446-1453

  Jones, Oliver A H ^a   Swain, Suresh C ^b   Svendsen, Claus ^c   Griffin, Julian L ^a   Sturzenbaum, Stephen R ^b   Spurgeon, David J ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CENTRE FOR ECOLOGY AND HYDROLOGY   (United Kingdom)

Author keywords

metabonomics; mixture effects; NMR; pollution; systems toxicology

Indexed keywords

ALANINE; AMINO ACID; ARGININE; BETAINE; CHLORPYRIFOS; CHOLINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; ISOLEUCINE; LACTIC ACID; LYSINE; MALONIC ACID; NICKEL; ORNITHINE; PROLINE; SUCCINIC ACID; TAURINE; TRICARBOXYLIC ACID; VALINE;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; FLUORESCENCE CORRELATION SPECTROSCOPY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; POLLUTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; WILD TYPE;

ANIMALS; CAENORHABDITIS ELEGANS; CHLORPYRIFOS; DRUG SYNERGISM; ECOTOXICOLOGY; METABOLOME; METABOLOMICS; NICKEL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PRINCIPAL COMPONENT ANALYSIS; TOXICITY TESTS;

CAENORHABDITIS ELEGANS; MAMMALIA; VERTEBRATA;

EID: 84856655837     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr201142c     Document Type: Article

References (33)

1. Jones, O. A. H.; Maguire, M. L.; Griffin, J. L. Environmental pollution and diabetes: A neglected association? Lancet 2008, 371 (9609) 287-288
2. Robinson, P.; MacDonell, M. Priorities for mixtures health effects research Environ. Toxicol. Pharmacol. 2004, 18 (3) 201-213
3. REACH further. Nature 2011, 475 (7355), 139-140.
4. Ankley, G. T.; Bennett, R. S.; Erickson, R. J.; Hoff, D. J.; Hornung, M. W.; Johnson, R. D.; Mount, D. R.; Nichols, J. W.; Russom, C. L.; Schmieder, P. K.; Serrrano, J. A.; Tietge, J. E.; Villeneuve, D. L. Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment Environ. Toxicol. Chem. 2010, 29 (3) 730-741
5. Atherton, H. J.; Jones, O. A. H.; Malik, S.; Miska, E. A.; Griffin, J. L. A comparative metabolomic study of NHR-49 in Caenorhabditis elegans and PPAR-alpha in the mouse FEBS Lett. 2008, 582 (12) 1661-1666
6. The C. elegans Sequencing Consortium, Genome sequence of the nematode C. elegans: A platform for investigating biology. Science 1998, 282, (5396), 2012-2018.
7. Dengg, M.; van Meel, J. C. A. Caenorhabditis elegans as model system for rapid toxicity assessment of pharmaceutical compounds J. Pharmacol. Toxicol. Methods 2004, 50 (3) 209-214
8. Li, Y.; Wang, Y.; Yin, L.; Pu, Y.; Wang, D. Using the nematode Caenorhabditis elegans as a model animal for assessing the toxicity induced by microcystin-LR J. Environ. Sci. 2009, 21 (3) 395-401
9. Jones, O. A. H.; Griffin, J. L.; Dondero, F.; Viarengo, A. Metabolic profiling of Mytilus galloprovincialis and its potential applications for pollution assessment Mar. Ecol.: Prog. Ser. 2008, 369, 169-179
10. Vandenbrouck, T.; Jones, O. A. H.; Dom, N.; Griffin, J. L.; De Coen, W. Mixtures of similarly acting compounds in Daphnia magna: From gene to metabolite and beyond Environ. Int. 2010, 36 (3) 254-268
11. Oliver, S. G. Functional genomics: Lessons from yeast Philos. Trans. R. Soc., B 2002, 357 (1417) 17-23
12. Jones, O. A. H.; Walker, L. A.; Nicholson, J. K.; Shore, R. F.; Griffin, J. L. Cellular acidosis in rodents exposed to cadmium is caused by adaptation of the tissue rather than an early effect of toxicity Comp. Biochem. Physiol. D: Genomics Proteomics 2007, 2 (4) 316-321
13. Strange, K.; Christensen, M.; Morrison, R. Primary culture of Caenorhabditis elegans developing embryo cells for electrophysiological, cell biological and molecular studies Nat. Protocols 2007, 2 (4) 1003-1012
14. Geier, F. M.; Want, E. J.; Leroi, A. M.; Bundy, J. G. Cross-platform comparison of Caenorhabditis elegans tissue extraction strategies for comprehensive metabolome coverage Anal. Chem. 2011, 83 (10) 3730-3736
15. 1H-NMR spectroscopy NMR Biomed. 2002, 15, 37-44
16. Fan, T. W.-M. Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures Prog. Nucl. Magn. Reson. Spectrosc. 1996, 28 (2) 161-219
17. Gullberg, J.; Jonsson, P.; Nordstrom, A.; Sjostrom, M.; Moritz, T. Design of experiments: An efficient strategy to identify factors influencing extraction and derivatization of Arabidopsis thaliana samples in metabolomic studies with gas chromatography/mass spectrometry Anal. Biochem. 2004, 331 (2) 283-295
18. Morrison, W. R.; Smith, L. M. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol J. Lipid Res. 1964, 5, 600-608
19. Blaise, B. J.; Giacomotto, J.; Triba, M. N.; Toulhoat, P.; Piotto, M.; Emsley, L.; Ségalat, L.; Dumas, M.-E.; Bénédicte, E. Metabolic profiling strategy of Caenorhabditis elegans by whole-organism nuclear magnetic resonance J. Proteome Res. 2009, 8 (5) 2542-2550
20. Holmes, E.; Antti, H. Chemometric contributions to the evolution of metabonomics: Mathematical solutions to characterising and interpreting complex biological NMR spectra Analyst 2002, 127, 1549-1557
21. Blaise, B. J.; Giacomotto, J.; Elena, B.; Dumas, M.-E.; Toulhoat, P.; Ségalat, L.; Emsley, L. Metabotyping of Caenorhabditis elegans reveals latent phenotypes Proc. Natl. Acad. Sci. U. S. A. 2007, 104 (50) 19808-19812
22. Brock, T. J.; Browse, J.; Watts, J. L. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans Genetics 2007, 176 (2) 865-875
23. Horikawa, M.; Nomura, T.; Hashimoto, T.; Sakamoto, K. Elongation and desaturation of fatty acids are critical in growth, lipid metabolism and ontogeny of Caenorhabditis elegans J. Biochem. 2008, 144 (2) 149-158
24. Martin, F.-P. J.; Spanier, B.; Collino, S.; Montoliu, I.; Kolmeder, C.; Giesbertz, P.; Affolter, M.; Kussmann, M.; Daniel, H.; Kochhar, S.; Rezzi, S. Metabotyping of Caenorhabditis elegans and their culture media revealed unique metabolic phenotypes associated to amino acid deficiency and insulin-like signaling J. Proteome Res. 2011, 10 (3) 990-1003
25. Satouchi, K.; Hirano, K.; Sakaguchi, M.; Takehara, H.; Matsuura, F. Phospholipids from the free-living nematode Caenorhabditis elegans Lipids 1993, 28 (9) 837-840
26. Kniazeva, M.; Crawford, Q. T.; Seiber, M.; Wang, C. Y.; Han, M. Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development PLoS Biol. 2004, 2 (9) E257
27. Zeitoun-Ghandour, S.; Leszczyszyn, O. I.; Blindauer, C. A.; Geier, F. M.; Bundy, J. G.; Stürzenbaum, S. R. C.elegans metallothioneins: Response to and defence against ROS toxicity Mol. BioSyst. 2011, 7 (8) 2397-2406
28. Hughes, S.; Bundy, J.; Want, E.; Kille, P.; Stürzenbaum, S. R. The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins J. Proteome Res. 2009, 8 (7) 3512-3519
29. Svendsen, C.; Siang, P.; Lister, L. J.; Rice, A.; Spurgeon, D. J. Similarity, independence, or interaction for binary mixture effects of nerve toxicants for the nematode Caenorhabditis elegans Environ. Toxicol. Chem. 2010, 29 (5) 1182-1191
30. Combes, D.; Fedon, Y.; Toutant, J. P.; Arpagaus, M. Acetylcholinesterase genes in the nematode Caenorhabditis elegans Int. Rev. Cytol. 2001, 209, 207-239
31. Jones, D.; Candido, E. P. M. Feeding is inhibited by sublethal concentrations of toxicants and by heat stress in the nematode Caenorhabditis elegans: Relationship to the cellular stress response J. Exp. Zool. 1999, 284 (2) 147-157
32. 1H NMR based urine metabolic profiles of male Wistar Han rats: Implications for biomarker discovery Biomarkers 2004, 9 (2) 156-179
33. Spurgeon, D. J.; Jones, O. A. H.; Dorne, J. L. C. M.; Svendsen, C.; Swain, S.; Sturzenbaum, S. R. Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures Sci. Total Environ. 2010, 408 (18) 3725-3734