Muscarinic receptor agonists and antagonists: Effects on keratinocyte functions

Handbook of Experimental Pharmacology

Volumn 208, Issue , 2012, Pages 429-450

  Grando, Sergei A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adhesion; Apoptosis; Differentiation; Migration; Oral and epidermal keratinocytes; Proliferation

Indexed keywords

ACETYLCHOLINE; ARECOLINE; ATROPINE; BETHANECHOL; CARBACHOL; CHOLINERGIC RECEPTOR; CYTOKINE; GROWTH FACTOR; HUMECTANT; METHACHOLINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NICOTINIC RECEPTOR; PILOCARPINE; PIRENZEPINE; PLACEBO; PROPYLBENZILOYLCHOLINE MUSTARD; SCOPOLAMINE;

APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL ADHESION; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CHOLINERGIC STIMULATION; CORNEA INJURY; DRUG MECHANISM; HAIR FOLLICLE; HUMAN; INFLAMMATORY DISEASE; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SIGNAL TRANSDUCTION; SKIN INJURY; SKIN ULCER; STRUCTURE ACTIVITY RELATION; ULCER; WOUND HEALING; ANIMAL; CELL CYCLE; CELL MOTION; DRUG EFFECT; METABOLISM; REVIEW; SKIN DISEASE;

ACETYLCHOLINE; ANIMALS; CELL ADHESION; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; KERATINOCYTES; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; SKIN DISEASES;

EID: 84856647862     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-23274-9_18     Document Type: Article

References (85)

1. Arredondo J, Hall LL, Ndoye A, Chernyavsky AI, Jolkovsky DL, Grando SA (2003) Muscarinic acetylcholine receptors regulating cell cycle progression are expressed in human gingival keratinocytes. J Periodontal Res 38:79-89 (Pubitemid 37463601)
2. Arredondo J, Chernyavsky AI, Marubio LM, Beaudet AL, Jolkovsky DL, Pinkerton KE, Grando SA (2005) Receptor-mediated tobacco toxicity: regulation of gene expression through a3b2 nicotinic receptor in oral epithelial cells. Am J Pathol 166:597-613 (Pubitemid 40189055)
3. Beutner EH, Chorzelski TP, Jablonska S (1985) Immunofluorescence tests. Clinical significance of sera and skin in bullous diseases. Int J Dermatol 24:405-421 (Pubitemid 15246713)
4. Carsi-Gabrenas JM, Van Der Zee EA, Luiten PGM, Potter LT (1997) Non-selectivity of the monoclonal antibody M35 for subtypes of muscarinic acetylcholine receptors. Brain Res Bull 44:25-31 (Pubitemid 27375174)
5. Chaffins ML, Collison D, Fivenson DP (1993) Treatment of pemphigus and linear IgA dermatosis with nicotinamide and tetracycline: a review of 13 cases. J Am Acad Dermatol 28:998-1000 (Pubitemid 23160654)
6. Chang MC, Ho YS, Lee PH, Chan CP, Lee JJ, Hahn LJ, Wang YJ, Jeng JH (2001) Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 22:1527-1535 (Pubitemid 32898711)
7. Cheng YA, Shiue LF, Yu HS, Hsieh TY, Tsai CC (2000) Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments. Kaohsiung J Med Sci 16:126-133
8. Chernyavsky AI, Arredondo J, Marubio LM, Grando SA (2004a) Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes. J Cell Sci 117:5665-5679 (Pubitemid 40012212)
9. Chernyavsky AI, Arredondo J, Wess J, Karlsson E, Grando SA (2004b) Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization by M3 and M4 muscarinic receptors. J Cell Biol 166:261-272 (Pubitemid 38988778)
10. Chernyavsky AI, Arredondo J, Karlsson E, Wessler I, Grando SA (2005) The Ras/Raf-1/MEK1/ ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration. J Biol Chem 280:39220-39228 (Pubitemid 41713874)
11. Chernyavsky AI, Arredondo J, Vetter DE, Grando SA (2007) Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization. Exp Cell Res 313:3542-3555 (Pubitemid 47404552)
12. Chernyavsky AI, Arredondo J, Piser T, Karlsson E, Grando SA (2008) Differential coupling of M1 muscarinic and a7 nicotinic receptors to inhibition of pemphigus acantholysis. J Biol Chem 283:3401-3408
13. Colley AM, Cavanagh HD, Law ML (1987) Effects of topical carbamylcholine on corneal epithelial resurfacing. Metab Pediatr Syst Ophthalmol 10:71-72 (Pubitemid 18071533)
14. Curtis CA, Wheatley M, Bansal S, Birdsall NJ, Eveleigh P, Pedder EK, Poyner D, Hulme EC (1989) Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor. J Biol Chem 264:489-495 (Pubitemid 19027630)
15. Dillon RS (1991) Role of cholinergic nervous system in healing neuropathic lesions: preliminary studies and prospective, double-blinded, placebo-controlled studies. Angiology 42:767-778
16. DiPalma JR (1994) Basic pharmacology in medicine, 4th edn. McGraw-Hill, New York
17. Donaldson DJ, Mahan JT (1988) Keratinocyte migration and the extracellular matrix. J Invest Dermatol 90:623-628
18. Elgoyhen AB, Johnson DS, Boulter J, Vetter DE, Heinemann S (1994) a9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79:705-715 (Pubitemid 24363813)
19. 2 muscarinic acetylcholine receptor (mAchR) subtype is present in human epidermal keratinocytes in situ and in vivo. J Invest Dermatol 123:1206-1207 (Pubitemid 39586850)
20. Er H (1997) The effect of topical parasympathomimetics on corneal epithelial healing in rabbits. Doc Ophthalmol 93:327-335 (Pubitemid 28261027)
21. Gajewski W (1970) Disappearance of psoriatic skin rashes in the course of atropine therapy. Pol Tyg Lek 25:1815-1816
22. Gao YJ, Ling TY, Yin XM, Li X, Huang Y (2007) Effects of arecoline and nicotine on the expression of hTERT in oral keratinocytes. Zhonghua Kou Qiang Yi Xue Za Zhi 42:26-30
23. Ghelardini C, Galeotti N, Lelli C, Bartolini A (2001) M1 receptor activation is a requirement for arecoline analgesia. Farmaco 56:383-385 (Pubitemid 32622103)
24. Grabovoi AN, Prosha MV, Shcherbak LF (1994) Effects of carbacholine and noradrenaline on tissue reactions in healing of skin wounds (in Russian). Klin Khir 6:54-56
25. Grando SA (1997) Biological functions of keratinocyte cholinergic receptors. J Investig Dermatol Symp Proc 2:41-48 (Pubitemid 27323376)
26. Grando SA (2000) Autoimmunity to keratinocyte acetylcholine receptors in pemphigus. Dermatology (Basel) 201:290-295 (Pubitemid 32037553)
27. Grando SA (2004) New approaches to the treatment of pemphigus. J Investig Dermatol Symp Proc 9:84-91 (Pubitemid 38096204)
28. Grando SA (2006) Cholinergic control of epidermal cohesion in norm and pathology. Exp Dermatol 15:265-282 (Pubitemid 43349068)
29. Grando SA, Dahl MV (1993) Activation of keratinocyte muscarinic acetylcholine receptors reverses pemphigus acantholysis. J Eur Acad Dermatol Venereol 2:72-86 (Pubitemid 23178422)
30. Grando SA, Horton RM (1997) The keratinocyte cholinergic system with acetylcholine as an epidermal cytotransmitter. Curr Opin Dermatol 4:262-268
31. Grando SA, Kurzen H (2009) Cholinergic control of keratinocyte cohesion. In: Cirillo N, Lanza A, Gombo F (eds) Pathophysiology of the desmosome. Research Signpost, Kerela, India, pp 87-104
32. Grando SA, Lynch PJ (1993) Muscarinic antagonist scopolamine protects keratinocyte monolayers from morphological transformations induced by enalapril and thiol drugs. J Invest Dermatol 100:541
33. Grando SA, Crosby AM, Zelickson BD, Dahl MV (1993a) Agarose gel keratinocyte outgrowth system as a model of skin re-epithelization: requirement of endogenous acetylcholine for outgrowth initiation. J Invest Dermatol 101:804-810 (Pubitemid 23357489)
34. Grando SA, Kist DA, Qi M, Dahl MV (1993b) Human keratinocytes synthesize, secrete and degrade acetylcholine. J Invest Dermatol 101:32-36 (Pubitemid 23213008)
35. Grando SA, Horton RM, Pereira EFR, Diethelm-Okita BM, George PM, Albuquerque EX, Conti- Fine BM (1995a) A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes. J Invest Dermatol 105:774-781 (Pubitemid 26006352)
36. Grando SA, Zelickson BD, Kist DA, Weinshenker D, Bigliardi PL, Wendelschafer-Crabb G, Kennedy WR, Dahl MV (1995b) Keratinocyte muscarinic acetylcholine receptors: immunolocalization and partial characterization. J Invest Dermatol 104:95-100
37. Grando SA, Pittelkow MR, Schallreuter KU (2006) Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance. J Invest Dermatol 126:1948-1965
38. 2) in the rat skin. Cell Tissue Res 300:389-396 (Pubitemid 30459841)
39. Harris AK (1990) Protrusive activity of the cell surface and the movements of tissue cells. In: Akkas N (ed) Biomechanics of active movement and deformation of cells, vol 42, NATO ASI Series H. Springer, Heidelberg, pp 249-294
40. Hasse S, Chernyavsky AI, Grando SA, Paus R (2007) The M4 muscarinic acetylcholine receptor plays a key role in the control of murine hair follicle cycling and pigmentation. Life Sci 80:2248-2252 (Pubitemid 46818260)
41. Iraji F, Yoosefi A (2006) Healing effect of Pilocarpine gel 4% on skin lesions of pemphigus vulgaris. Int J Dermatol 45:743-746 (Pubitemid 44056680)
42. Jeng JH, Hahn LJ, Lin BR, Hsieh CC, Chan CP, Chang MC (1999) Effects of areca nut, inflorescence piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes. J Oral Pathol Med 28:64-71
43. Jeng JH, Wang YJ, Chiang BL, Lee PH, Chan CP, Ho YS, Wang TM, Lee JJ, Hahn LJ, Chang MC (2003) Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 24:1301-1315
44. Kalantari M, Molina DM, Farhadieh M, Morrow WJ, Liang X, Felgner PL, Grando SA (2011) New targets of pemphigus vulgaris antibodies identified by protein array technology. Exp Dermatol 20(2):154-156
45. Kebabian JW, Neumeyer JL (1994) The RBI handbook of receptor classification. Research Biochemicals International, Natick, p 122
46. Klapproth H, Reinheimer T, Metzen J, Munch M, Bittinger F, Kirkpatrick CJ, Hohle KD, Schemann M, Racke K, Wessler I (1997) Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man. Naunyn Schmiedebergs Arch Pharmacol 355:515-523 (Pubitemid 27140478)
47. Koeppen A, Klein J, Erb C, Loeffelholz K (1997) Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. J Pharmacol Exp Ther 282:1139-1145 (Pubitemid 27408288)
48. Kurzen H, Brenner S (2006) Significance of autoimmunity to non-desmoglein targets in pemphigus. Autoimmunity 39:549-556 (Pubitemid 44768923)
49. Kurzen H, Schallreuter KU (2004) Novel aspects in cutaneous biology of acetylcholine synthesis and acetylcholine receptors. Exp Dermatol 13(Suppl 4):27-30 (Pubitemid 39654438)
50. Kurzen H, Berger H, Jager C, Hartschuh W, Naher H, Gratchev A, Goerdt S, DeichmannM(2004) Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin. J Invest Dermatol 123:937-949 (Pubitemid 39391941)
51. Kurzen H, Henrich C, Booken D, Poenitz N, Gratchev A, Klemke CD, Engstner M, Goerdt S, Maas-Szabowski N (2006) Functional characterization of the epidermal cholinergic system in vitro. J Invest Dermatol 126:2458-2472 (Pubitemid 44582268)
52. Kurzen H, Wessler I, Kirkpatrick CJ, Kawashima K, Grando SA (2007) The non-neuronal cholinergic system of human skin. Horm Metab Res 39:125-135 (Pubitemid 46535570)
53. Lanza A, Stellavato A, Heulfe I, Landi C, Gombos F, Cirillo N (2009) Serum of patients with oral pemphigus vulgaris impairs keratinocyte wound repair in vitro: a time-lapse study on the efficacy of methylprednisolone and pyridostigmine bromide. Oral Dis 15:478-483
54. Larjava H, Salo T, Haapasalmi K, Kramer RH, Heino J (1993) Expression of integrins and basement membrane components by wound keratinocytes. J Clin Invest 92:1425-1435 (Pubitemid 23273921)
55. Leiber D, Harbon S, Guillet JG, Andre C, Strosberg AD (1984) Monoclonal antibodies to purified muscarinic receptor display agonist-like activity. Proc Natl Acad Sci U S A 81:4331-4334 (Pubitemid 14052438)
56. MacCallum DE, Hall PA (1999) Biochemical characterization of pKi67 with the identification of a mitotic-specific form associated with hyperphosphorylation and altered DNA binding. Exp Cell Res 252:186-198 (Pubitemid 29485138)
57. Marchisio PC, Bondanza S, Cremona O, Cancedda R, De Luca M (1991) Polarized expression of integrin receptors (a6b4, a2b1, a3b1, and aVb5) and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes. J Cell Biol 112:761-773
58. 2 and M4 muscarinic receptor subtypes mediating cyclic AMP inhibition. Mol Pharmacol 40:1014-1022
59. Menon GK, Brown BE, Elias PM (1986) Avian epidermal differentiation: role of lipids in permeability barrier formation. Tissue & Cell 18:71-82 (Pubitemid 16127462)
60. Metzger M, Just L, Boss A, Drews U (2005) Identification and functional characterization of the muscarinic receptor M3 in the human keratinocyte cell line HaCaT. Cells Tissues Organs 180:96-105 (Pubitemid 41197106)
61. Namazi MR (2004) Practice pearl: gargling with cholinergic ophthalmic drops for treating the oral lesions of pemphigus vulgaris. J Drugs Dermatol 3:484-485
62. Ndoye A, Buchli R, Greenberg B, Nguyen VT, Zia S, Rodriguez JG, Webber RJ, Lawry MA, Grando SA (1998) Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis. J Invest Dermatol 111:410-416
63. Nguyen VT, Lee TX, Ndoye A, Shultz LD, Pittelkow MR, Dahl MV, Lynch PJ, Grando SA (1998) The pathophysiological significance of non-desmoglein targets of pemphigus autoimmunity. Pemphigus vulgaris and foliaceus patients develop antibodies against keratinocyte cholinergic receptors. Arch Dermatol 134:971-980
64. Nguyen VT, Ndoye A, Grando SA (2000a) Novel human a9 acetylcholine receptor regulating keratinocyte adhesion is targeted by pemphigus vulgaris autoimmunity. Am J Pathol 157:1377-1391
65. Nguyen VT, Ndoye A, Grando SA (2000b) Pemphigus vulgaris antibody identifies pemphaxin - a novel keratinocyte annexin-like molecule binding acetylcholine. J Biol Chem 275: 29466-29476 (Pubitemid 32043822)
66. Nguyen VT, Ndoye A, Hall LL, Zia S, Arredondo J, Chernyavsky AI, Kist DA, Zelickson BD, Lawry MA, Grando SA (2001) Programmed cell death of keratinocytes culminates in apoptotic secretion of a humectant upon secretagogue action of acetylcholine. J Cell Sci 114:1189-1204 (Pubitemid 32288532)
67. Nguyen VT, Arredondo J, Chernyavsky AI, Kitajima Y, Grando SA (2003) Keratinocyte acetylcholine receptors regulate cell adhesion. Life Sci 72:2081-2085 (Pubitemid 36298951)
68. Nguyen VT, Arredondo J, Chernyavsky AI, Pittelkow MR, Kitajima Y, Grando SA (2004a) Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists. Arch Dermatol 140:327-334 (Pubitemid 38332484)
69. Nguyen VT, Chernyavsky AI, Arredondo J, Bercovich D, Orr-Urtreger A, Vetter DE, Wess J, Beaudet AL, Kitajima Y, Grando SA (2004b) Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes. Exp Cell Res 294:534-549 (Pubitemid 38326750)
70. Nishimura KY, Isseroff RR, Nuccitelli R (1996) Human keratinocytes migrate to the negative pole in direct current electric fields comparable to those measured in mammalian wounds. J Cell Sci 109:199-207 (Pubitemid 26037940)
71. O'Keefe EJ, Woodley D, Castillo G, Russell N, Payne RE Jr (1984) Production of soluble and cellassociated fibronectin by cultured keratinocytes. J Invest Dermatol 82:150-155 (Pubitemid 14184254)
72. Ozturk F, Kurt E, Inan UU, Emiroglu L, Ilker SS (1999) The effects of acetylcholine and propolis extract on corneal epithelial wound healing in rats. Cornea 18:466-471 (Pubitemid 29294072)
73. Paus R, Muller-Rover S, Van Der Veen C, Maurer M, Eichmuller S, Ling G, Hofmann U, Foitzik K, Mecklenburg L, Handjiski B (1999) A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. J Invest Dermatol 113:523-532 (Pubitemid 29489612)
74. Romanenko AV (1987) The action of nicotinamide on neuromuscular transmission. Fiziol Zh 33:51-56
75. Schafer IA, Kovach M, Price RL, Fratianne RB (1991) Human keratinocytes cultured on collagen gels form an epidermis which synthesizes bullous pemphigoid antigens and alpha 2 beta 1 integrins and secretes laminin, type IV collagen, and heparan sulfate proteoglycan at the basal cell surface. Exp Cell Res 195:443-457 (Pubitemid 121006345)
76. Schoenwaelder SM, Burridge K (1999) Bidirectional signaling between the cytoskeleton and integrins. Curr Opin Cell Biol 11:274-286 (Pubitemid 29164045)
77. Stoytcheva M, Zlatev R (1996) Bioelectrocatalytical studies of the effect of some pharmaceuticals on the acetylcholinesterase activity. Electroanalysis 8:676-679 (Pubitemid 126419573)
78. Thangjam GS, Kondaiah P (2009) Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res 44:673-682
79. Theriot JA, Mitchison TJ (1991) Actin microfilament dynamics in locomoting cells. Nature 352:126-131 (Pubitemid 21896707)
80. Tsurimoto T (1999) PCNA binding proteins. Front Biosci 4:849-858
81. Wessler I. New use of active ingredients which affect non-neuronal acetylcholine functions PCT Gazette WO 98/00119 Boehringer Ingelheim KG Germany
82. Wessler I (1998) New use of active ingredients which affect non-neuronal acetylcholine functions PCT Gazette WO 98/00119. Boehringer Ingelheim KG, Germany Wessler I, Kirkpatrick CJ, Racke K (1999) The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin Exp Pharmacol Physiol 26:198-205 (Pubitemid 29128015)
83. Xia L, Tian-You L, Yi-Jun G, Dong-Sheng T, Wen-Hui L (2009) Arecoline and oral keratinocytes may affect the collagen metabolism of fibroblasts. J Oral Pathol Med 38:422-426
84. Xie DP, Chen LB, Liu CY, Zhang CL, Liu KJ, Wang PS (2004) Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. Chin J Physiol 47:89-94 (Pubitemid 38868124)
85. 2-muscarinic receptor. Chin J Physiol 43:23-28