Programmed cell death of keratinocytes culminates in apoptotic secretion of a humectant upon secretagogue action of acetylcholine

Journal of Cell Science

Volumn 114, Issue 6, 2001, Pages 1189-1204

  Nguyen, Vu Thuong ^a   Ndoye, Assane ^a   Hall, Leon L ^a   Zia, Shaheen ^a   Arredondo, Juan ^a   Chernyavsky, Alexander I ^a   Kist, David A ^b   Zelickson, Brian D ^b   Lawry, Monica A ^a,c   Grando, Sergei A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c KAISER PERMANENTE MEDICAL CENTER   (United States)

Author keywords

Acetylcholine; Cornification; Filaggrin; Keratinocyte; Muscarinic receptor; Nicotinic receptor

Indexed keywords

ACETYLCHOLINE; ALPHA9 NICOTINIC RECEPTOR; BUNGAROTOXIN RECEPTOR; CALCIUM; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT; FILAGGRIN; HUMECTANT; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE PHASE; CELL GROWTH; CELL SECRETION; CELL TRANSFORMATION; CELL VOLUME; CHOLINERGIC ACTIVITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; CYTOSOL; EPIDERMIS; GLYCOCALYX; GRANULAR CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERCELLULAR SPACE; KERATINOCYTE; OSMOTIC PRESSURE; PRECURSOR; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS REGULATION; SQUAMOUS EPITHELIUM; WEIGHT;

ACETYLCHOLINE; APOPTOSIS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOPLASM; EPIDERMIS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; KERATINOCYTES; RECEPTORS, MUSCARINIC;

EID: 0035071051     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Bignold, L. P. and Ferrante, A. (1988). Effects of cytochalasin B, N-formyl peptide and plasma on polarisation, zeiosis (blebbing) and degranulation of polymorphonuclear leukocytes in suspension. Cell Biol Int. Rep. 12, 195-203.
2. Boddeke, H. W., Buttini, M., Lichtsteiner, M. and Enz, A. (1992). M1 muscarinic receptors mediate intracellular calcium release in NB-OK1 human neuroblastoma cells. Arch. Pharmacol. 346, 255-261.
3. Boess, F. G., Balasubramanian, M. K., Brammer, M. J. and Campbell, I. C. (1990). Stimulation of muscarinic acetylcholine receptors increases synaptosomal free calcium concentration by protein kinase-dependent opening of L-type calcium channels. J. Neurochem. 55, 230-236.
4. Brailoiu, E. and Van Der Kloot, W. (1996). Bromoacetylcholine and acetylcholinesterase introduced via liposomes into motor nerve endings block increases in quantal size. Pfluegers Arch. Enr. J. Physiol. 432, 413-418.
5. Brody, I. (1960). The ultrastructure of the tonofibrils in the keratinization process of normal human epidermis. J. Ultrastruct. Res. 4, 264-297.
6. Brown, M. R. and Chew, C. S. (1989). Carbachol-induced protein phosphorylation in parietal cells: Regulation by intracellular calcium concentration. Am J. Physiol. 257, G99-G110.
7. Burgoyne, R. D., Handel, S. E., Morgan, A., Rennison, M. E., Turner, M. D. and Wilde, C. J. (1991). Calcium the cytoskeleton and calpactin annexin II in exocytotic secretion from adrenal chromaffin and mammary epithelial cells. Biochem. Soc. Trans 19, 1085-1090.
8. Caulfield, M. P. (1993). Muscarinic receptors characterization coupling and function. Pharmacol. Ther. 58, 319-379.