Xanthoceraside attenuates amyloid β peptide25-35-induced learning and memory impairments in mice

Psychopharmacology

Volumn 219, Issue 1, 2012, Pages 181-190

  Lu, Ping ^a   Mamiya, Takayoshi ^a   Lu, Lingling ^a   Mouri, Akihiro ^a   Ikejima, Takashi ^b   Kim, Hyoung Chum ^c   Zou, Li Bo ^b   Nabeshima, Toshitaka ^a,d  

^a MEIJO UNIVERSITY   (Japan)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c Kangwon National University   (South Korea)

^d Japanese Drug Organization of Appropriate Use and Research   (Japan)

Author keywords

Amyloid ; IL 4; iNOS; Learning and memory; Nitrotyrosine; Xanthoceraside

Indexed keywords

3 NITROTYROSINE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 4; MESSENGER RNA; UNCLASSIFIED DRUG; XANTHOCERASIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MECHANISM; HIPPOCAMPUS; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED ICR; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; SAPONINS; TRITERPENES;

EID: 84856643383     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2386-1     Document Type: Article

References (47)

1. KT Akama LJ Van Eldik 2000 β-Amyloid stimulation of inducible nitric oxide synthase in astrocytes is IL-1β- and TNF-α-dependent, and involves a TNF-α receptor-associated factor- and NF kappa B-inducing kinase-dependent signaling mechanism J Biol Chem 275 7918 7924 10713108 10.1074/jbc.275.11.7918 1:CAS:528:DC%2BD3cXitVyltrk%3D (Pubitemid 30159700)
2. T Alkam A Nitta H Mizoguchi K Saito M Seshima A Itoh K Yamada T Nabeshima 2008 Restraining tumor necrosis factor-alpha by thalidomide prevents the amyloid β-induced impairment of recognition memory in mice Behav Brain Res 189 100 106 18325608 10.1016/j.bbr.2007.12.014 1:CAS:528:DC%2BD1cXjtleisLk%3D
3. RB Banati J Gehrmann P Schubert GW Kreutzberg 1993 Cytotoxicity of microglia Glia 7 111 118 8423058 10.1002/glia.440070117 1:STN:280: DyaK3s7jvVOgug%3D%3D
4. K Blennow MJ de Leon H Zetterberg 2006 Alzheimer's disease Lancet 368 387 403 16876668 10.1016/S0140-6736(06)69113-7 1:CAS:528:DC%2BD28XnsFymsbY%3D (Pubitemid 44108123)
5. JP Bolanos A Almeida V Stewart S Peuchen JM Land JB Clark SJ Heales 1997 Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases J Neurochem 68 2227 2240 9166714 10.1046/j.1471-4159.1997.68062227.x 1:CAS:528:DyaK2sXjsVOgu7g%3D (Pubitemid 27218141)
6. O Butovsky M Koronyo-Hamaoui G Kunis E Ophir G Landa H Cohen M Schwartz 2006 Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1 Proc Natl Acad Sci USA 103 11784 11789 16864778 10.1073/pnas.0604681103 1:CAS:528: DC%2BD28XotFagurk%3D (Pubitemid 44182528)
7. DA Butterfield A Castegna CM Lauderback J Drake 2002 Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death Neurobiol Aging 23 655 664 12392766 10.1016/S0197-4580(01)00340-2 (Pubitemid 35217687)
8. DA Butterfield T Reed SF Newman R Sultana 2007 Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment Free Radic Biol Med 43 658 677 17664130 10.1016/j.freeradbiomed.2007.05.037 1:CAS:528:DC%2BD2sXotlSms7s%3D (Pubitemid 47102132)
9. CC Chao S Hu TW Molitor EG Shaskan PK Peterson 1992 Activated microglia mediate neuronal cell injury via a nitric oxide mechanism J Immunol 149 2736 2741 1383325 1:CAS:528:DyaK3sXht1aku7c%3D
10. TY Chi LH Wang C Qu BZ Yang XF Ji Y Wang T Okuyama O Yoshihito LB Zou 2009 Protective effects of xanthoceraside on learning and memory impairment induced by Abeta (25-35) in mice J Asian Nat Prod Res 11 1019 1027 20183271 10.1080/10286020903337832 1:CAS:528:DC%2BD1MXhsVyitbbO
11. TY Chi LH Wang XF Ji W Li Y Wang LB Zou 2010 Protective effects of xanthoceraside on learning and memory impairment induced by intracerebroventricular injections of Aβ1-42 in mice J Shenyang Pharm Univ 27 314 319 1:CAS:528:DC%2BC3cXmvVyjtr0%3D
12. RM Clarke F O'Connell A Lyons MA Lynch 2007 The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-beta1-42 in the rat hippocampus in vivo Neuropharmacology 52 136 145 16920163 10.1016/j.neuropharm.2006.07.031 1:CAS:528:DC%2BD2sXisVOntQ%3D%3D (Pubitemid 46026837)
13. EM Coccia E Stellacci G Marziali G Weiss A Battistini 2000 IFN-gamma and IL-4 differently regulate inducible NO synthase gene expression through IRF-1 modulation Int Immunol 12 977 985 10882409 10.1093/intimm/12.7.977 1:CAS:528:DC%2BD3cXls12jt7g%3D (Pubitemid 30599352)
14. CK Combs JC Karlo SC Kao GE Landreth 2001 β-Amyloid stimulation of microglia and monocytes results in TNF-α dependent expression of inducible nitric oxide synthase and neuronal apoptosis J Neurosci 21 1179 1188 11160388 1:CAS:528:DC%2BD3MXhtFers7c%3D (Pubitemid 32128763)
15. MA Gruden TB Davidova M Malisauskas RD Sewell NI Voskresenskaya K Wilhelm EI Elistratova VV Sherstnev LA Morozova-Roche 2007 Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta(25-35) oligomers, S100b and neurotransmitters J Neuroimmunol 186 181 192 17477976 10.1016/j.jneuroim.2007.03.023 1:CAS:528:DC%2BD2sXlvVOmtLY%3D (Pubitemid 46773048)
16. MT Heneka PA Loschmann M Gleichmann M Weller JB Schulz U Wullner T Klockgether 1998 Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide J Neurochem 71 88 94 9648854 10.1046/j.1471-4159.1998.71010088.x 1:CAS:528:DyaK1cXktFams7s%3D (Pubitemid 28292538)
17. SJ Hewett CA Csernansky DW Choi 1994 Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS Neuron 13 487 494 7520256 10.1016/0896-6273(94)90362-X 1:CAS:528:DyaK2cXlslKktrY%3D (Pubitemid 24275103)
18. Institute for Laboratory Animal Research (1996) Guide for the Care and Use of Laboratory Animals, 7th ed. Commission on Life Sciences, National Research Council, Washington, DC. http://www.nap.edu/catalog/5140.html
19. K Ishii F Muelhauser U Liebl M Picard S Kühl B Penke T Bayer M Wiessler M Hennerici K Beyreuther T Hartmann K Fassbender 2000 Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase FASEB J 14 1485 1489 10928982 10.1096/fj.14.11.1485 1:CAS:528:DC%2BD3cXlslaqtrg%3D (Pubitemid 30636553)
20. T Kiyota S Okuyama RJ Swan MT Jacobsen HE Gendelman T Ikezu 2010 CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice FASEB J 24 3093 3102 20371618 10.1096/fj.10-155317 1:CAS:528:DC%2BC3cXhtVeitrzN
21. B Klementiev T Novikova V Novitskaya PS Walmod O Dmytriyeva B Pakkenberg V Berezin E Bock 2007 A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35 Neuroscience 145 209 224 17223274 10.1016/j.neuroscience.2006.11.060 1:CAS:528:DC%2BD2sXhvVGms7w%3D (Pubitemid 46227730)
22. T Kubo S Nishimura Y Kumagae I Kaneko 2002 In vivo conversion of racemized beta-amyloid ([D-Ser 26] Abeta 1-40) to truncated and toxic fragments ([D-Ser 26]Abeta 25-35/40) and fragment presence in the brains of Alzheimer's patients J Neurosci Res 70 474 483 12391608 10.1002/jnr.10391 1:CAS:528:DC%2BD38XosVejsrw%3D (Pubitemid 35222384)
23. R Lalonde 2002 The neurobiological basis of spontaneous alternation Neurosci Biobehav Rev 26 91 104 11835987 10.1016/S0149-7634(01)00041-0 1:CAS:528:DC%2BD38XhtVKntbk%3D (Pubitemid 34130537)
24. A Ledeboer JJ Brevé S Poole FJ Tilders AM Van Dam 2000 Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells Glia 30 134 142 10719355 10.1002/(SICI)1098-1136(200004)30: 2<134::AID-GLIA3>3.0.CO;2-3 1:STN:280:DC%2BD3c7osFGmsQ%3D%3D (Pubitemid 30199427)
25. SC Lee ML Zhao A Hirano DW Dickson 1999 Inducible nitric oxide synthase immunoreactivity in the Alzheimer disease hippocampus: association with Hirano bodies, neurofibrillary tangles, and senile plaques J Neuropathol Exp Neurol 58 1163 1169 10560659 10.1097/00005072-199911000-00006 1:CAS:528:DyaK1MXnvVartrc%3D (Pubitemid 29519840)
26. XX Liu XF Ji LL Lu BZ Yang LH Wang LB Zou 2007 Improvement of ethanol extract from husk of Xanthoceras sorbifolia on rats with learning and memory dysfunction Chin Tradit Herb Drugs 12 106 110
27. P Lu T Mamiya A Mouri LL Lu T Nagai M Hiramatsu LB Zou T Ikejima T Nabeshima 2009 Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice Br J Pharmacol 157 1270 1277 19552690 10.1111/j.1476-5381.2009.00295.x 1:CAS:528:DC%2BD1MXhtVelt7bF
28. P Lu T Mamiya LL Lu A Mouri M Niwa M Hiramatsu LB Zou T Nagai T Ikejima T Nabeshima 2009 Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice J Pharmacol Exp Ther 331 319 326 19638571 10.1124/jpet.109.155069 1:CAS:528:DC%2BD1MXht1GjtLzN
29. A Lyons RJ Griffin CE Costelloe RM Clarke MA Lynch 2007 IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro J Neurochem 101 771 781 17250684 10.1111/j.1471-4159.2006.04370.x 1:CAS:528: DC%2BD2sXlsV2ksLY%3D (Pubitemid 46633315)
30. T Maurice BP Lockhart A Privat 1996 Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction Brain Res 706 181 193 8822355 10.1016/0006-8993(95)01032-7 1:CAS:528:DyaK28Xns1yitQ%3D%3D (Pubitemid 26048681)
31. L Meda MA Cassatella GI Szendrei L Otvos Jr P Baron M Villalba D Ferrari F Rossi 1995 Activation of microglial cells by beta-amyloid protein and interferon-gamma Nature 374 647 650 7715705 10.1038/374647a0 1:CAS:528:DyaK2MXltVOhsLs%3D
32. R Medeiros RD Prediger GF Passos P Pandolfo FS Duarte JL Franco AL Dafre G Di Giunta CP Figueiredo RN Takahashi MM Campos JB Calixto 2007 Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein J Neurosci 27 5394 5404 17507561 10.1523/JNEUROSCI.5047-06.2007 1:CAS:528:DC%2BD2sXlvFGhsrg%3D (Pubitemid 46790177)
33. J Meunier J Ieni T Maurice 2006 The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor Br J Pharmacol 149 998 1012 17057756 10.1038/sj.bjp.0706927 1:CAS:528:DC%2BD28Xht12gsLvN (Pubitemid 44950803)
34. E Molina-Holgado A Arévalo-Martín A Castrillo L Boscá JM Vela C Guaza 2002 Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes J Neurochem 81 1242 1252 12068072 10.1046/j.1471-4159.2002.00925.x 1:CAS:528:DC%2BD38XltVWks78%3D (Pubitemid 34809258)
35. Y Morishima Y Gotoh J Zieg T Barrett H Takano R Flavell RJ Davis Y Shirasaki ME Greenberg 2001 Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand J Neurosci 21 7551 7560 11567045 1:STN:280:DC%2BD3MritFGlsg%3D%3D (Pubitemid 32904954)
36. CJ Pike AJ Walencewicz-Wasserman J Kosmoski DH Cribbs CG Glabe CW Cotman 1995 Structure-activity analyses of β-amyloid peptides: contributions of the β25-35 region to aggregation and neurotoxicity J Neurochem 64 253 265 7798921 10.1046/j.1471-4159.1995.64010253.x 1:CAS:528:DyaK2MXislSjsbg%3D
37. CD Reiter RJ Teng JS Beckman 2000 Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite J Biol Chem 275 32460 32466 10906340 10.1074/jbc.M910433199 1:CAS:528:DC%2BD3cXnslOitr4%3D
38. WA Sands V Bulut A Severn D Xu FY Liew 1994 Inhibition of nitric oxide synthesis by interleukin-4 may involve inhibiting the activation of protein kinase C epsilon Eur J Immunol 24 2345 2350 7523136 10.1002/eji.1830241013 1:CAS:528:DyaK2cXmt1yntb8%3D (Pubitemid 24303076)
39. MA Smith PL Richey Harris LM Sayre JS Beckman G Perry 1997 Widespread peroxynitrite-mediated damage in Alzheimer's disease J Neurosci 17 2653 2657 9092586 1:CAS:528:DyaK2sXisValtL4%3D (Pubitemid 27154998)
40. MY Stepanichev IM Zdobnova II Zarubenko YV Moiseeva NA Lazareva MV Onufriev NV Gulyaeva 2004 Amyloid-beta(25-35)-induced memory impairments correlate with cell loss in rat hippocampus Physiol Behav 80 647 655 14984798 10.1016/j.physbeh.2003.11.003 1:CAS:528:DC%2BD2cXhsFWrsrg%3D (Pubitemid 38230963)
41. MY Stepanichev IM Zdobnova II Zarubenko NA Lazareva NV Gulyaeva 2006 Studies of the effects of central administration of β-amyloid peptide (25-35): pathomorphological changes in the hippocampus and impairment of spatial memory Neurosci Behav Physiol 36 101 106 16328175 10.1007/s11055-005-0167-1 1:CAS:528:DC%2BD28XhsFeit7c%3D (Pubitemid 43149518)
42. M Tanaka A Sotomatsu T Yoshida S Hirai A Nishida 1994 Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death J Neurochem 63 266 270 8207432 10.1046/j.1471-4159.1994.63010266.x 1:CAS:528:DyaK2cXksFWlsbg%3D (Pubitemid 24184927)
43. MH Tran K Yamada A Olariu M Mizuno XH Ren T Nabeshima 2001 Amyloid beta-peptide induces nitric oxide production in rat hippocampus: association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors FASEB J 15 1407 1409 11387239 1:CAS:528:DC%2BD3MXlvVers74%3D
44. MH Tran K Yamada A Nakajima M Mizuno J He H Kamei T Nabeshima 2003 Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction Mol Psychiatry 8 407 412 12740598 10.1038/sj.mp.4001240 1:CAS:528:DC%2BD3sXjsFOjtbc%3D (Pubitemid 36609665)
45. DM Walsh DJ Selkoe 2004 Deciphering the molecular basis of memory failure in Alzheimer's disease Neuron 44 181 193 15450169 10.1016/j.neuron.2004.09.010 1:CAS:528:DC%2BD2cXovVOks78%3D (Pubitemid 39348839)
46. MN Wallace JG Geddes DA Farquar MR Masson 1997 Nitric oxide synthase in reactive astrocytes adjacent to β-amyloid Exp Neurol 144 266 272 9168828 10.1006/exnr.1996.6373 1:CAS:528:DyaK2sXjtlOjtbY%3D (Pubitemid 27224555)
47. QW Xie HJ Cho J Calaycay RA Mumford KM Swiderek TD Lee A Ding T Troso C Nathan 1999 Cloning and characterization of inducible nitric oxide synthase from mouse macrophages Science 256 225 228 10.1126/science.1373522