Tetraploid partial hydatidiform mole: A case report and review of the literature

International Journal of Gynecological Pathology

Volumn 31, Issue 1, 2012, Pages 73-79

  Murphy, Kathleen M ^a   Descipio, Cheryl ^b   Wagenfuehr, Jennifer ^a   Tandy, Sharon ^a   Mabray, Johanna ^a   Beierl, Katie ^b   Micetich, Kara ^c   Libby, Arlene L ^d   Ronnett, Brigitte M ^b  

^a ProPath Laboratory   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c Women's Clinic of Northern Colorado   (United States)

^d Summit Pathology   (United States)

Author keywords

Genotype; Hydatidiform mole; P57

Indexed keywords

PROTEIN P57;

ABORTION; ADULT; CASE REPORT; CURETTAGE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; PARTIAL HYDATIDIFORM MOLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SHORT TANDEM REPEAT; TETRAPLOIDY; THIRD TRIMESTER PREGNANCY; THORAX RADIOGRAPHY; ULTRASOUND;

ADULT; ANIMALS; ANTIBODIES, MONOCLONAL; CHROMOSOMES, HUMAN, X; CHROMOSOMES, HUMAN, Y; CYCLIN-DEPENDENT KINASE INHIBITOR P57; FEMALE; GENE DOSAGE; GENOTYPING TECHNIQUES; HUMANS; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICROSATELLITE REPEATS; PREGNANCY; PREGNANCY COMPLICATIONS, NEOPLASTIC; TETRAPLOIDY; UTERINE NEOPLASMS;

EID: 84856641532     PISSN: 02771691     EISSN: 15387151     Source Type: Journal    
DOI: 10.1097/PGP.0b013e31822555b3     Document Type: Review

References (15)

1. Fukunaga M, Katabuchi H, Nagasaka T, et al. Interobserver and intraobserver variability in the diagnosis of hydatidiform mole. Am J Surg Pathol 2005;29:942-47. (Pubitemid 40885018)
2. Howat AJ, Beck S, Fox H, et al. Can histopathologists reliably diagnose molar pregnancy. J Clin Pathol 1993;46: 599-602. (Pubitemid 23231810)
3. McConnell TG, Murphy KM, Hafez M, et al. Diagnosis and subclassification of hydatidiform moles using p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approach. Am J Surg Pathol 2009;33:805-17.
4. Chilosi M, Piazzola E, Lestani M, et al. Differential expression of p57kip2, a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease. Lab Invest 1998;78:269-76. (Pubitemid 28128890)
5. Castrillon DH, Sun D, Weremowicz S, et al. Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2. Am J Surg Pathol 2001;25:1225-30. (Pubitemid 32917114)
6. Popiolek DA, Yee H, Mittal K, et al. Multiplex short tandem repeat DNA analysis confirms the accuracy of p57(KIP2) immunostaining in the diagnosis of complete hydatidiform mole. Hum Pathol 2006;37:1426-34. (Pubitemid 44584331)
7. Bell KA, Van DV, Addya K, et al. Molecular genetic testing from paraffin-embedded tissue distinguishes nonmolar hydropic abortion from hydatidiform mole. Mol Diagn 1999;4:11-9.
8. Murphy KM, McConnell TG, Hafez MJ, et al. Molecular genotyping of hydatidiform moles: analytic validation of a multiplex short tandem repeat assay. J Mol Diagn 2009;11: 598-605.
9. Vejerslev LO, Dissing J, Hansen HE, et al. Hydatidiform mole: genetic origin in polyploid conceptuses. Hum Genet 1987;76: 11-9. (Pubitemid 17073732)
10. Surti U, Szulman AE, Wagner K, et al. Tetraploid partial hydatidiform moles: two cases with a triple paternal contribution and a 92,XXXY karyotype. Hum Genet 1986;72:15-21. (Pubitemid 16186469)
11. Sheppard DM, Fisher RA, Lawler SD, et al. Tetraploid conceptus with three paternal contributions. Hum Genet 1982;62:371-4. (Pubitemid 13117105)
12. Ronnett BM, DeScipio C, Murphy KM. Hydatidiform moles: ancillary techniques to refine diagnosis. Int J Gynecol Pathol 2011;30:101-16.
13. Sebire NJ, Fisher RA, Foskett M, et al. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG 2003;110:22-26. (Pubitemid 36034289)
14. McConnell TG, Norris-Kirby A, Hagenkord JM, et al. Complete hydatidiform mole with retained maternal chromosomes 6 and 11. Am J Surg Pathol 2009;33:1409-15.
15. Fisher RA, Nucci MR, Thaker HM, et al. Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case. Mod Pathol 2004; 17:1155-60. (Pubitemid 39128243)