Immunohistochemical analysis of CD45ROM + T cells and vascular endothelial growth factor expression in cyclosporin A-induced rat gingival tissue

Journal of Periodontology

Volumn 83, Issue 2, 2012, Pages 248-255

  Alptekin, Nilgün Özlem ^a   Üstün, Kemal ^b   Yaprak, Emre ^c   Avunduk, Mustafa Cihat ^a   Ataoǧlu, Tamer ^a  

^a SELCUK UNIVERSITY   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

^c GATA HAYDARPASA TRAINING HOSPITAL   (Turkey)

Author keywords

Animal; CD4 antigen; CD45RO antigen; Models; Vascular endothelial growth factor A

Indexed keywords

CD45 ANTIGEN; CYCLOSPORIN; VASCULOTROPIN A;

ANIMAL; ARTICLE; BIOSYNTHESIS; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEMICALLY INDUCED DISORDER; GINGIVA OVERGROWTH; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MALE; METABOLISM; RAT; SPRAGUE DAWLEY RAT; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD45; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYCLOSPORINE; GINGIVAL OVERGROWTH; IMMUNOLOGIC MEMORY; MALE; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTE SUBSETS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84856636985     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2011.110034     Document Type: Article

References (50)

1. Rateitschak-Plüss EM, Hefti A, Lörtscher R, Thiel G. Initial observation that cyclosporin-A induces gingival enlargement in man. J Clin Periodontol 1983;10:237-246. (Pubitemid 13071204)
2. Goldman MH, Barnhart G, Mohanakumar T, et al. Cyclosporine in cardiac transplantation. Surg Clin North Am 1985;65:637-659. (Pubitemid 16245114)
3. Guijarro C, Massy ZA, Kasiske BL. Clinical correlation between renal allograft failure and hyperlipidemia. Kidney Int Suppl 1995;52:S56-S59.
4. Massy ZA, Kasiske BL. Post-transplant hyperlipidemia: Mechanisms and management. J Am Soc Nephrol 1996;7:971-977. (Pubitemid 27465958)
5. Kasiske BL, Guijarro C, Massy ZA, Wiederkehr MR, Ma JZ. Cardiovascular disease after renal transplantation. J Am Soc Nephrol 1996;7:158-165. (Pubitemid 26067103)
6. Shu Z, Pu X, Xiong X, Li Q, Wang Y, Zhai S. Differential expression of plasma proteins in cyclosporine A-induced rat acute nephrotoxicity. Biosci Biotechnol Biochem 2009;73:592-598.
7. Tyldesley WR, Rotter E. Gingival hyperplasia induced by cyclosporin-A. Br Dent J 1984;157:305-309.
8. Uzel MI, Kantarci A, Hong HH, et al. Connective tissue growth factor in drug-induced gingival overgrowth. J Periodontol 2001;72:921-931. (Pubitemid 33665220)
9. Buduneli N, Buduneli E, Cinar S, Lappin D, Kinane DF. Immunohistochemical evaluation of Ki-67 expression and apoptosis in cyclosporin A-induced gingival overgrowth. J Periodontol 2007;78:282-289.
10. Guo J, Wang W, Yao L, Yan F. Local inflammation exacerbates cyclosporine A-induced gingival overgrowth in rats. Inflammation 2008;31:399-407.
11. Vardar S, Baylas H, Zihnioǧlu F, Buduneli N, Emingil G, Atilla G. Gingival tissue proteoglycan and chondroitin- 4-sulphate levels in cyclosporin A-induced gingival overgrowth and the effects of initial periodontal treatment. J Clin Periodontol 2005;32: 634-639. (Pubitemid 40780232)
12. Buduneli N, Buduneli E, Ciotanar S, Atilla G, Lappin D, Kinane D. Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A-treated patients. J Clin Periodontol 2004;31: 556-561. (Pubitemid 38901226)
13. Mathur A, Michalowicz BS. Cell-mediated immune system regulation in periodontal diseases. Crit Rev Oral Biol Med 1997;8:76-89. (Pubitemid 27132233)
14. Hassell TM, Romberg E, Sobhani S, Lesko L, Douglas R. Lymphocyte-mediated effects of cyclosporine on human fibroblasts. Transplant Proc 1988;20(Suppl. 3): 993-1002.
15. O'Valle F, Mesa FL, Gómez-Morales M, et al. Immunohistochemical study of 30 cases of cyclosporin Ainduced gingival overgrowth. J Periodontol 1994;65: 724-730. (Pubitemid 24236704)
16. Pernu HE, Knuuttila ML. Macrophages and lymphocyte subpopulations in nifedipine- and cyclosporin Aassociated human gingival overgrowth. J Periodontol 2001;72:160-166. (Pubitemid 32539488)
17. Bulut S, Alaaddinoglu EE, Bilezikcxi B, Demirhan B, Moray G. Immunohistochemical analysis of lymphocyte subpopulations in cyclosporin A-induced gingival overgrowth. J Periodontol 2002;73:892-899. (Pubitemid 34965822)
18. McNeill L, Cassady RL, Sarkardei S, Cooper JC, Morgan G, Alexander DR. CD45 isoforms in T cell signalling and development. Immunol Lett 2004;92: 125-134. (Pubitemid 38470059)
19. Gemmell E, Feldner B, Seymour GJ. CD45RA and CD45RO positive CD4 cells in human peripheral blood and periodontal disease tissue before and after stimulation with periodontopathic bacteria. Oral Microbiol Immunol 1992;7:84-88.
20. Yamazaki K, Nakajima T, Aoyagi T, Hara K. Immunohistological analysis of memory T lymphocytes and activated B lymphocytes in tissues with periodontal disease. J Periodontal Res 1993;28:324-334.
21. Yamamura Y, Gupta R, Morita Y, et al. Effector function of resting T cells: Activation of synovial fibroblasts. J Immunol 2001;166:2270-2275. (Pubitemid 32173457)
22. Summers KL, O'Donnell JL, Hart DN. Co-expression of the CD45RA and CD45RO antigens on T lymphocytes in chronic arthritis. Clin Exp Immunol 1994;97: 39-44. (Pubitemid 24244052)
23. Lee IG, Ye J, Kim JC. The involvement of multipotential progenitor cells in Mooren's ulcer. Yonsei Med J 2005;46:353-358. (Pubitemid 40959875)
24. Dawes R, Petrova S, Liu Z, Wraith D, Beverley PC, Tchilian EZ. Combinations of CD45 isoforms are crucial for immune function and disease. J Immunol 2006;176:3417-3425. (Pubitemid 43363989)
25. Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 1992;13: 18-32.
26. Aoki M, Pawankar R, Niimi Y, Kawana S. Mast cells in basal cell carcinoma express VEGF, IL-8 and RANTES. Int Arch Allergy Immunol 2003;130:216-223. (Pubitemid 36359525)
27. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989;161:851-858. (Pubitemid 19162712)
28. Ohm JE, Gabrilovich DI, Sempowski GD, et al. VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression. Blood 2003;101: 4878-4886. (Pubitemid 36857749)
29. Freeman MR, Schneck FX, Gagnon ML, et al. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis. Cancer Res 1995;55:4140-4145.
30. Fu E, Nieh S, Wikesjö UM. The effect of plaque retention on cyclosporine-induced gingival overgrowth in rats. J Periodontol 1997;68:92-98. (Pubitemid 27099502)
31. Wassef R, Cohen Z, Langer B. Pharmacokinetic profiles of cyclosporine in rats. Influence of route of administration and dosage. Transplantation 1985;40: 489-493. (Pubitemid 16196198)
32. Avunduk MC, Avunduk AM, Oztekin E, Baltaci AK, Ozyazgan Y, Mogolkoc R. Etanercept treatment in the endotoxin-induced uveitis of rats. Exp Eye Res 2004; 79:357-365. (Pubitemid 39164473)
33. Granelli-Piperno A, Keane M, Steinman RM. Evidence that cyclosporine inhibits cell-mediated immunity primarily at the level of the T lymphocyte rather than the accessory cell. Transplantation 1988;46(Suppl. 2): 53S-60S.
34. Cebeci I, Kantarci A, Gürel N, et al. Analysis of peripheral blood leukocytes in patients with cyclosporine A-induced gingival hyperplasia. J Periodontol 1998;69: 1435-1439. (Pubitemid 29061201)
35. Umaña A, Gómez A, Durán MM, Porras L. Lymphocyte subtypes and adhesion molecules in actinic prurigo: Observations with cyclosporin A. Int J Dermatol 2002; 41:139-145. (Pubitemid 34601107)
36. Abdulamir AS, Hafidh RR, Abubakar F, Abbas KA. Changing survival, memory cell compartment, and T-helper balance of lymphocytes between severe and mild asthma. BMC Immunol 2008;16:73.
37. Stemme S, Holm J, Hansson GK. T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1. Arterioscler Thromb 1992;12:206-211.
38. Yao Z, Painter SL, Fanslow WC, et al. Human IL-17: A novel cytokine derived from T cells. J Immunol 1995; 155:5483-5486.
39. Beklen A, Ainola M, Hukkanen M, Gürgan C, Sorsa T, Konttinen YT. MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis. J Dent Res 2007;86:347-351.
40. Chi W, Yang P, Zhu X, et al. Production of interleukin- 17 in Behcet's disease is inhibited by cyclosporin A. Mol Vis 2010;16:880-886.
41. Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res 2000;55:15-35, discussion 35-36.
42. Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 1993;4:1317-1326. (Pubitemid 24045761)
43. Chen YT, Tu HP, Chin YT, et al. Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats. J Periodontol 2005;76:2267-2275.
44. Cetinkaya BO, Acikgoz G, Ayas B, Aliyev E, Sakallioglu EE. Increased expression of vascular endothelial growth factor in cyclosporin A-induced gingival overgrowth in rats. J Periodontol 2006;77:54-60. (Pubitemid 43949657)
45. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.
46. Shin JY, Yoon IH, Kim JS, Kim B, Park CG. Vascular endothelial growth factor-induced chemotaxis and IL- 10 from T cells. Cell Immunol 2009;256:72-78.
47. Mulligan JK, Day TA, Gillespie MB, Rosenzweig SA, Young MR. Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions. Hum Immunol 2009;70:375-382.
48. Basu A, Hoerning A, Datta D, et al. Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production. J Immunol 2010;184:545-549.
49. Du R, Lu KV, Petritsch C, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008;13:206-220. (Pubitemid 351318372)
50. Seymour RA, Thomason JM, Ellis JS. The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol 1996;23:165-175. (Pubitemid 126731916)