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Volumn 78, Issue 2, 2007, Pages 282-289

Immunohistochemical evaluation of Ki-67 expression and apoptosis in cyclosporin A-induced gingival overgrowth

Author keywords

Apoptosis; Cell division; Gingival overgrowth pathogenesis; Immunohistochemistry; In situ hybridization; Ki 67 antigen

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; KI 67 ANTIGEN; NIFEDIPINE; PHENYTOIN;

EID: 33847783333     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2007.060051     Document Type: Article
Times cited : (18)

References (45)
  • 3
    • 0026625484 scopus 로고
    • Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors
    • Pernu HE, Pernu LM, Huttunen KR, Nieminen PA, Knuuttila ML. Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. J Periodontol 1992;63:548-553.
    • (1992) J Periodontol , vol.63 , pp. 548-553
    • Pernu, H.E.1    Pernu, L.M.2    Huttunen, K.R.3    Nieminen, P.A.4    Knuuttila, M.L.5
  • 4
    • 0020457354 scopus 로고
    • The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro
    • Modeer T, Dahllof G, Otteskog P. The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro. Acta Odontol Scand 1982;40: 353-357.
    • (1982) Acta Odontol Scand , vol.40 , pp. 353-357
    • Modeer, T.1    Dahllof, G.2    Otteskog, P.3
  • 6
    • 3042702736 scopus 로고    scopus 로고
    • Connective tissue metabolism and gingival overgrowth
    • Trackman PC, Kantarci A. Connective tissue metabolism and gingival overgrowth. Crit Rev Oral Biol Med 2004;15:165-175.
    • (2004) Crit Rev Oral Biol Med , vol.15 , pp. 165-175
    • Trackman, P.C.1    Kantarci, A.2
  • 7
  • 8
    • 20344385742 scopus 로고    scopus 로고
    • Gingival tissue proteoglycan and chondroitin-4-sulphate levels in cyclosporin A-induced gingival overgrowth and the effects of initial periodontal treatment
    • Vardar S, Baylas H, Zihnioǧlu F, Buduneli N, Emingil G, Atilla G. Gingival tissue proteoglycan and chondroitin-4-sulphate levels in cyclosporin A-induced gingival overgrowth and the effects of initial periodontal treatment. J Clin Periodontol 2005;32:634-639.
    • (2005) J Clin Periodontol , vol.32 , pp. 634-639
    • Vardar, S.1    Baylas, H.2    Zihnioǧlu, F.3    Buduneli, N.4    Emingil, G.5    Atilla, G.6
  • 9
    • 0029355305 scopus 로고
    • Stereologic study of cyclosporin A-induced gingival overgrowth in renal transplant patients
    • Wondimu B, Reinholt FP, Modeer T. Stereologic study of cyclosporin A-induced gingival overgrowth in renal transplant patients. Eur J Oral Sci 1995;103:199-206.
    • (1995) Eur J Oral Sci , vol.103 , pp. 199-206
    • Wondimu, B.1    Reinholt, F.P.2    Modeer, T.3
  • 11
    • 0023281214 scopus 로고
    • Cyclosporin-induced gingival overgrowth: Correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva
    • McGaw T, Lam S, Coates J. Cyclosporin-induced gingival overgrowth: Correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. Oral Surg Oral Med Oral Pathol 1987;64:293-297.
    • (1987) Oral Surg Oral Med Oral Pathol , vol.64 , pp. 293-297
    • McGaw, T.1    Lam, S.2    Coates, J.3
  • 12
    • 0029160385 scopus 로고
    • Iatrogenic gingival overgrowth in cardiac transplantation
    • Thomason JM, Seymour RA, Ellis JS, et al. Iatrogenic gingival overgrowth in cardiac transplantation. J Periodontol 1995;66:742-746.
    • (1995) J Periodontol , vol.66 , pp. 742-746
    • Thomason, J.M.1    Seymour, R.A.2    Ellis, J.S.3
  • 13
    • 0031904418 scopus 로고    scopus 로고
    • Crevicular fluid interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 levels in renal transplant patients receiving cyclosporine A
    • Atilla G, Kütükçüler N. Crevicular fluid interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 levels in renal transplant patients receiving cyclosporine A. J Periodontol 1998;69:784-790.
    • (1998) J Periodontol , vol.69 , pp. 784-790
    • Atilla, G.1    Kütükçüler, N.2
  • 14
    • 0035147714 scopus 로고    scopus 로고
    • Are inflammatory cytokines potential mediators of phenytoin-induced gingival overgrowth?
    • Buduneli N, Atilla G, Kütükçüler N. Are inflammatory cytokines potential mediators of phenytoin-induced gingival overgrowth? Turkish J Med Sci 2001;31:41-46.
    • (2001) Turkish J Med Sci , vol.31 , pp. 41-46
    • Buduneli, N.1    Atilla, G.2    Kütükçüler, N.3
  • 15
    • 0028116286 scopus 로고
    • Cyclosporine A upregulates interleukin-6 gene expression in human gingiva: Possible mechanism for gingival overgrowth
    • Williamson MS, Miller EK, Plemons J, Rees T, Iacopino AM. Cyclosporine A upregulates interleukin-6 gene expression in human gingiva: Possible mechanism for gingival overgrowth. J Periodontol 1994;65:895-903.
    • (1994) J Periodontol , vol.65 , pp. 895-903
    • Williamson, M.S.1    Miller, E.K.2    Plemons, J.3    Rees, T.4    Iacopino, A.M.5
  • 16
    • 0342902149 scopus 로고    scopus 로고
    • Evaluation of transforming growth factor-β1 level in crevicular fluid of cyclosporin A-treated patients
    • Buduneli N, Kütükçüler N, Aksu G, Atilla G. Evaluation of transforming growth factor-β1 level in crevicular fluid of cyclosporin A-treated patients. J Periodontol 2001;72:526-531.
    • (2001) J Periodontol , vol.72 , pp. 526-531
    • Buduneli, N.1    Kütükçüler, N.2    Aksu, G.3    Atilla, G.4
  • 17
    • 18044373481 scopus 로고    scopus 로고
    • Immunohistochemical analysis of epidermal growth factor receptor in cyclosporine A-induced gingival overgrowth
    • Buduneli N, Saǧol Ö, Atilla G, Duman S, Holmstrup P. Immunohistochemical analysis of epidermal growth factor receptor in cyclosporine A-induced gingival overgrowth. Acta Odontol Scand 2001;59:367-371.
    • (2001) Acta Odontol Scand , vol.59 , pp. 367-371
    • Buduneli, N.1    Saǧol, Ö.2    Atilla, G.3    Duman, S.4    Holmstrup, P.5
  • 18
    • 0030614422 scopus 로고    scopus 로고
    • Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: Possible mechanism of drug-induced gingival hyperplasia
    • Iacopino AM, Doxey D, Cutler CW, et al. Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: Possible mechanism of drug-induced gingival hyperplasia. J Periodontol 1997;68:73-83.
    • (1997) J Periodontol , vol.68 , pp. 73-83
    • Iacopino, A.M.1    Doxey, D.2    Cutler, C.W.3
  • 19
    • 0029870512 scopus 로고    scopus 로고
    • PDGF-B producing cells and PDGF-B gene expression in normal gingival and cyclosporine A-induced gingival overgrowth
    • Plemons JM, Dill RE, Rees TD, Dyer BJ, Ng MC, Iacopino AM. PDGF-B producing cells and PDGF-B gene expression in normal gingival and cyclosporine A-induced gingival overgrowth. J Periodontol 1996; 67:264-270.
    • (1996) J Periodontol , vol.67 , pp. 264-270
    • Plemons, J.M.1    Dill, R.E.2    Rees, T.D.3    Dyer, B.J.4    Ng, M.C.5    Iacopino, A.M.6
  • 20
    • 3142583579 scopus 로고    scopus 로고
    • Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A-treated patients
    • Buduneli N, Buduneli E, Çinar S, Atilla G, Lappin D, Kinane D. Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A-treated patients. J Clin Periodontol 2004;31: 556-561.
    • (2004) J Clin Periodontol , vol.31 , pp. 556-561
    • Buduneli, N.1    Buduneli, E.2    Çinar, S.3    Atilla, G.4    Lappin, D.5    Kinane, D.6
  • 21
    • 0026680874 scopus 로고
    • Apoptosis and programmed cell death in immunity
    • Cohen J, Duke R. Apoptosis and programmed cell death in immunity. Annu Rev Immunol 1992;10:267-293.
    • (1992) Annu Rev Immunol , vol.10 , pp. 267-293
    • Cohen, J.1    Duke, R.2
  • 22
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-1462.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 23
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J, Lemke M, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984;133: 1710-1715.
    • (1984) J Immunol , vol.133 , pp. 1710-1715
    • Gerdes, J.1    Lemke, M.2    Baisch, H.3    Wacker, H.H.4    Schwab, U.5    Stein, H.6
  • 24
    • 0027622805 scopus 로고
    • Detection of cell proliferation in tissue sections
    • Bacchi CE, Gown AM. Detection of cell proliferation in tissue sections. Braz J Med Biol Res 1993;26:677-687.
    • (1993) Braz J Med Biol Res , vol.26 , pp. 677-687
    • Bacchi, C.E.1    Gown, A.M.2
  • 26
    • 0033094124 scopus 로고    scopus 로고
    • Relative proportions of mononuclear cell types in periodontal lesions analyzed by immunohistochemistry
    • Lappin DF, Koulouri O, Radvar M, Hodge P, Kinane DF. Relative proportions of mononuclear cell types in periodontal lesions analyzed by immunohistochemistry. J Clin Periodontol 1999;26:183-189.
    • (1999) J Clin Periodontol , vol.26 , pp. 183-189
    • Lappin, D.F.1    Koulouri, O.2    Radvar, M.3    Hodge, P.4    Kinane, D.F.5
  • 27
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992;119: 493-501.
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 29
    • 0032441638 scopus 로고    scopus 로고
    • In situ detection of apoptosis at sites of chronic bacterially induced inflammation in human gingiva
    • Tonetti MS, Cortellini D, Lang NP. In situ detection of apoptosis at sites of chronic bacterially induced inflammation in human gingiva. Infect Immun 1998;66: 5190-5195.
    • (1998) Infect Immun , vol.66 , pp. 5190-5195
    • Tonetti, M.S.1    Cortellini, D.2    Lang, N.P.3
  • 30
    • 0032177050 scopus 로고    scopus 로고
    • Drugs and oral disorders
    • Rees TD. Drugs and oral disorders. Periodontol 2000 1998;18:21-36.
    • (1998) Periodontol 2000 , vol.18 , pp. 21-36
    • Rees, T.D.1
  • 31
    • 0031957453 scopus 로고    scopus 로고
    • Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis
    • Thomas SE, Andoh TF, Pichler RH, et al. Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis. Kidney Int 1998;53:897-908.
    • (1998) Kidney Int , vol.53 , pp. 897-908
    • Thomas, S.E.1    Andoh, T.F.2    Pichler, R.H.3
  • 32
    • 0038219553 scopus 로고    scopus 로고
    • Evaluation of p53, bcl-2, and interleukin-15 levels in gingival crevicular fluid of cyclosporin A-treated patients
    • Buduneli E, Genel F, Atilla G, Kütükçüler N. Evaluation of p53, bcl-2, and interleukin-15 levels in gingival crevicular fluid of cyclosporin A-treated patients. J Periodontol 2003; 74:506-511.
    • (2003) J Periodontol , vol.74 , pp. 506-511
    • Buduneli, E.1    Genel, F.2    Atilla, G.3    Kütükçüler, N.4
  • 33
    • 20244385940 scopus 로고    scopus 로고
    • Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures
    • Esposito C, Fornoni A, Cornacchia F, et al. Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures. Kidney Int 2000;58:123-130.
    • (2000) Kidney Int , vol.58 , pp. 123-130
    • Esposito, C.1    Fornoni, A.2    Cornacchia, F.3
  • 34
    • 0037446611 scopus 로고    scopus 로고
    • Activation of transcription factors AP-1 and NF-kappaB in chronic cyclosporine A nephrotoxicity: Role in beneficial effects of magnesium supplementation
    • Asai T, Nakatani T, Tamada S, et al. Activation of transcription factors AP-1 and NF-kappaB in chronic cyclosporine A nephrotoxicity: Role in beneficial effects of magnesium supplementation. Transplantation 2003;75:1040-1044.
    • (2003) Transplantation , vol.75 , pp. 1040-1044
    • Asai, T.1    Nakatani, T.2    Tamada, S.3
  • 35
    • 22844450004 scopus 로고    scopus 로고
    • Cyclosporin A affects signaling events differentially in human gingival fibroblasts
    • Bostrom A, Bharath H, Saulewicz A, Narayanan AS. Cyclosporin A affects signaling events differentially in human gingival fibroblasts. J Dent Res 2005;84:532-536.
    • (2005) J Dent Res , vol.84 , pp. 532-536
    • Bostrom, A.1    Bharath, H.2    Saulewicz, A.3    Narayanan, A.S.4
  • 37
    • 0029859442 scopus 로고    scopus 로고
    • CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts
    • Watanabe A, Takeshita A, Kitano Z, Hanazawa S. CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts. Infect Immun 1996;64:4488-4494.
    • (1996) Infect Immun , vol.64 , pp. 4488-4494
    • Watanabe, A.1    Takeshita, A.2    Kitano, Z.3    Hanazawa, S.4
  • 38
    • 0025185411 scopus 로고
    • Immunohistochemical analysis of effect of cyclosporine A on gingival epithelium
    • Niimi A, Tohnai I, Kaneda T, Takeuchi M, Nagura M. Immunohistochemical analysis of effect of cyclosporine A on gingival epithelium. J Oral Pathol Med 1990; 19:397-403.
    • (1990) J Oral Pathol Med , vol.19 , pp. 397-403
    • Niimi, A.1    Tohnai, I.2    Kaneda, T.3    Takeuchi, M.4    Nagura, M.5
  • 39
    • 0036668582 scopus 로고    scopus 로고
    • Nifedipine induces gingival epithelial hyperplasia in rats through inhibition of apoptosis
    • Shimizu Y, Kataoka M, Seto H, Kido J, Nagata T. Nifedipine induces gingival epithelial hyperplasia in rats through inhibition of apoptosis. J Periodontol 2002; 73:861-867.
    • (2002) J Periodontol , vol.73 , pp. 861-867
    • Shimizu, Y.1    Kataoka, M.2    Seto, H.3    Kido, J.4    Nagata, T.5
  • 40
    • 13844315484 scopus 로고    scopus 로고
    • Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients
    • Bulut ÖE, Sökmensüer LK, Bulut Ş, Tasman F, Müftüoǧlu S. Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. J Periodontol 2004;75:1655-1662.
    • (2004) J Periodontol , vol.75 , pp. 1655-1662
    • Bulut, Ö.E.1    Sökmensüer, L.K.2    Bulut, Ş.3    Tasman, F.4    Müftüoǧlu, S.5
  • 41
    • 20744433970 scopus 로고    scopus 로고
    • Effect of cyclosporin A on apoptosis and expression of p53 and bcl-2 proteins in the gingiva of renal transplant patients
    • Bulut Ş, Özdemir BH, Alaaddinoǧlu EE, Oduncuoǧlu FB, Bulut ÖE, Demirhan B. Effect of cyclosporin A on apoptosis and expression of p53 and bcl-2 proteins in the gingiva of renal transplant patients. J Periodontol 2005;76:691-695.
    • (2005) J Periodontol , vol.76 , pp. 691-695
    • Bulut, Ş.1    Özdemir, B.H.2    Alaaddinoǧlu, E.E.3    Oduncuoǧlu, F.B.4    Bulut, Ö.E.5    Demirhan, B.6
  • 42
    • 0028232611 scopus 로고
    • Evaluation of AgNOR and Ki-67 antigen as cell kinetic parameters in oral dysplasia and carcinomas
    • Zoeller J, Flentje M, Sinn P, Born IA. Evaluation of AgNOR and Ki-67 antigen as cell kinetic parameters in oral dysplasia and carcinomas. Anal Cell Pathol 1994;7:77-88.
    • (1994) Anal Cell Pathol , vol.7 , pp. 77-88
    • Zoeller, J.1    Flentje, M.2    Sinn, P.3    Born, I.A.4
  • 43
    • 0033021646 scopus 로고    scopus 로고
    • Expression of p53 protein and Ki-67 antigen in gingival hyperplasia induced by nifedipine and phenytoin
    • Saito K, Mori S, Tanda N, Sakamoto S. Expression of p53 protein and Ki-67 antigen in gingival hyperplasia induced by nifedipine and phenytoin. J Periodontol 1999;70:581-586.
    • (1999) J Periodontol , vol.70 , pp. 581-586
    • Saito, K.1    Mori, S.2    Tanda, N.3    Sakamoto, S.4
  • 44
    • 1542652945 scopus 로고    scopus 로고
    • Vigabatrin-induced modification of Ki-67 expression in gingival epithelium: Immunohistochemical study of a short series
    • Mesa F, Aguilar M, Gonzales-Moles MA, et al. Vigabatrin-induced modification of Ki-67 expression in gingival epithelium: Immunohistochemical study of a short series. J Periodontal Res 2004;39:66-71.
    • (2004) J Periodontal Res , vol.39 , pp. 66-71
    • Mesa, F.1    Aguilar, M.2    Gonzales-Moles, M.A.3
  • 45
    • 0034977435 scopus 로고    scopus 로고
    • Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth
    • Nurmenniemi PK, Pernu HE, Knuuttila MLE. Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. J Periodontol 2001;72:167-173.
    • (2001) J Periodontol , vol.72 , pp. 167-173
    • Nurmenniemi, P.K.1    Pernu, H.E.2    Knuuttila, M.L.E.3


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