Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-γ production

Journal of Immunology

Volumn 184, Issue 2, 2010, Pages 545-549

  Basu, Aninda ^a   Hoerning, Andre ^a   Datta, Dipak ^a   Edelbauer, Monika ^a   Stack, Maria P ^a   Calzadilla, Katiana ^a   Pal, Soumitro ^a   Briscoe, David M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SEMAXANIB; SMALL INTERFERING RNA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; CD45 ANTIGEN; FLT1 PROTEIN, HUMAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

ARTICLE; CD4+ T LYMPHOCYTE; CD45RO+ T LYMPHOCYTE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FAR WESTERN BLOTTING; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; BIOSYNTHESIS; CELL CULTURE; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHEMOTAXIS; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; JURKAT CELLS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 76249097322     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900397     Document Type: Article

References (20)

1. Folkman, J. 1995. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1: 27-31.
2. Walsh, D. A., and C. I. Pearson. 2001. Angiogenesis in the pathogenesis of inflammatory joint and lung diseases. Arthritis Res. 3: 147-153.
3. Reinders, M. E., M. Sho, A. Izawa, P. Wang, D. Mukhopadhyay, K. E. Koss, C. S. Geehan, A. D. Luster, M. H. Sayegh, and D. M. Briscoe. 2003. Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J. Clin. Invest. 112: 1655-1665.
4. Watanabe, H., A. J.Mamelak, B.Wang, B. G.Howell, I. Freed,C. Esche, M.Nakayama, G. Nagasaki, D. J. Hicklin, R. S. Kerbel, and D. N. Sauder. 2004. Anti-vascular endothelial growth factor receptor-2 (Flk-1/KDR) antibody suppresses contact hypersensitivity. Exp. Dermatol. 13: 671-681.
5. Sho, M., S. Akashi, H. Kanehiro, K. Hamada, H. Kashizuka, N. Ikeda, T. Nomi, Y. Kuzumoto, Y. Tsurui, H. Yoshiji, et al. 2005. Function of the vascular endothelial growth factor receptors Flt-1 and Flk-1/KDR in the alloimmune response in vivo. Transplantation 80: 717-722.
6. Barleon, B., S. Sozzani, D. Zhou, H. A. Weich, A. Mantovani, and D. Marmé. 1996. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87: 3336-3343. (Pubitemid 26115364)
7. Mor, F., F. J. Quintana, and I. R. Cohen. 2004. Angiogenesis-inflammation crosstalk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. J. Immunol. 172: 4618-4623. (Pubitemid 38375280)
8. Lee, C. G., H. Link, P. Baluk, R. J. Homer, S. Chapoval, V. Bhandari, M. J. Kang, L. Cohn, Y. K. Kim, D. M. McDonald, and J. A. Elias. 2004. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat. Med. 10: 1095-1103.
9. Kim, Y. S., S. W. Hong, J. P. Choi, T. S. Shin, H. G. Moon, E. J. Choi, S. G. Jeon, S. Y. Oh, Y. S. Gho, Z. Zhu, and Y. K. Kim. 2009. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J. Immunol. 183: 5113-5120.
10. Soker, S., S. Takashima, H. Q. Miao, G. Neufeld, and M. Klagsbrun. 1998. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92: 735-745.
11. Klagsbrun, M., and P. A. D'Amore. 1996. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev. 7: 259-270.
12. Sarris, M., K. G. Andersen, F. Randow, L. Mayr, and A. G. Betz. 2008. Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity 28: 402-413.
13. Shin, J. Y., I. H. Yoon, J. S. Kim, B. Kim, and C. G. Park. 2009. Vascular endothelial growth factor-induced chemotaxis and IL-10 from T cells. Cell. Immunol. 256: 72-78.
14. Blazquez, C., N. Cook, K. Micklem, A. L. Harris, K. C. Gatter, and F. Pezzella. 2006. Phosphorylated KDR can be located in the nucleus of neoplastic cells. Cell Res. 16: 93-98.
15. + T lymphocytes into vascular endothelial growth factor-carrying cells by intercellular neuropilin-1 transfer. J. Immunol. 177: 1460-1469.
16. Dias, S., K. Hattori, Z. Zhu, B. Heissig, M. Choy, W. Lane, Y. Wu, A. Chadburn, E. Hyjek, M. Gill, et al. 2000. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J. Clin. Invest. 106: 511-521.
17. Tordjman, R., Y. Lepelletier, V. Lemarchandel, M. Cambot, P. Gaulard, O. Hermine, and P. H. Roméo. 2002. A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nat. Immunol. 3: 477-482.
18. Roth, S. J., T. G. Diacovo, M. B. Brenner, J. P. Rosat, J. Buccola, C. T. Morita, and T. A. Springer. 1998. Transendothelial chemotaxis of human α/β and γ/δ T lymphocytes to chemokines. Eur. J. Immunol. 28: 104-113.
19. Zeng, H., H. F. Dvorak, and D. Mukhopadhyay. 2001. Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/ VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways. J. Biol. Chem. 276: 26969-26979.
20. Moelling, K., K. Schad, M. Bosse, S. Zimmermann, and M. Schweneker. 2002. Regulation of Raf-Akt cross-talk. J. Biol. Chem. 277: 31099-31106.