Retinal venular calibre dilatation after intravitreal ranibizumab treatment for neovascular age-related macular degeneration

Clinical and Experimental Ophthalmology

Volumn 40, Issue 1, 2012, Pages 59-66

  Wickremasinghe, Sanjeewa S ^a   Guymer, Robyn H ^a   Wong, Tien Y ^a,b   Kawasaki, Ryo ^a   Wong, Wanling ^b   Qureshi, Salmaan ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Age related macular degeneration (AMD); Choroidal neovascularization; Vasculature; Venule

Indexed keywords

RANIBIZUMAB;

AGED; ARTERIOLE; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EYE PHOTOGRAPHY; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; IMAGE QUALITY; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; RETINA ARTERY; RETINA BLOOD VESSEL; RETINA MACULA AGE RELATED DEGENERATION; RETINA VEIN; RETINAL VASCULAR CALIBER; TREATMENT RESPONSE; VASODILATATION; VENULE; VISUAL ACUITY;

AGED; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; DILATATION, PATHOLOGIC; FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; INTRAVITREAL INJECTIONS; MALE; PROSPECTIVE STUDIES; RETINAL VEIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VISUAL ACUITY; WET MACULAR DEGENERATION;

EID: 84856628304     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/j.1442-9071.2011.02613.x     Document Type: Article

References (36)

1. Wong TY, Chakravarthy U, Klein R etal. The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis. Ophthalmology 2008; 115: 116-26.
2. Brown DM, Kaiser PK, Michels M etal. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1432-44.
3. Rosenfeld PJ, Brown DM, Heier JS etal. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1419-31.
4. Grunwald JE, Metelitsina TI, Dupont JC, Ying GS, Maguire MG. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci 2005; 46: 1033-8.
5. Grunwald JE, Hariprasad SM, DuPont J etal. Foveolar choroidal blood flow in age-related macular degeneration. Invest Ophthalmol Vis Sci 1998; 39: 385-90.
6. Kwak N, Okamoto N, Wood JM, Campochiaro PA. VEGF is major stimulator in model of choroidal neovascularization. Invest Ophthalmol Vis Sci 2000; 41: 3158-64.
7. Kim I, Ryan AM, Rohan R etal. Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes. Invest Ophthalmol Vis Sci 1999; 40: 2115-21.
8. Marneros AG, Fan J, Yokoyama Y etal. Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol 2005; 167: 1451-9.
9. Nishijima K, Ng YS, Zhong L etal. Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am J Pathol 2007; 171: 53-67.
10. Saint-Geniez M, Maharaj AS, Walshe TE etal. Endogenous VEGF is required for visual function: evidence for a survival role on muller cells and photoreceptors. PLoS ONE 2008; 3: e3554.
11. Saint-Geniez M, Maldonado AE, D'Amore PA. VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci 2006; 47: 3135-42.
12. Wirostko B, Wong TY, Simo R. Vascular endothelial growth factor and diabetic complications. Prog Retin Eye Res 2008; 27: 608-21.
13. Edirisinghe I, Yang SR, Yao H etal. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J 2008; 22: 2297-310.
14. Ameri H, Chader GJ, Kim JG, Sadda SR, Rao NA, Humayun MS. The effects of intravitreous bevacizumab on retinal neovascular membrane and normal capillaries in rabbits. Invest Ophthalmol Vis Sci 2007; 48: 5708-15.
15. Kamba T, Tam BY, Hashizume H etal. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 2006; 290: H560-76.
16. Sun C, Wang JJ, Mackey DA, Wong TY. Retinal vascular caliber: systemic, environmental, and genetic associations. Surv Ophthalmol 2009; 54: 74-95.
17. Papadopoulou DN, Mendrinos E, Mangioris G, Donati G, Pournaras CJ. Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration. Ophthalmology 2009; 116: 1755-61.
18. Mendrinos E, Mangioris G, Papadopoulou D, Donati G, Pournaras C. One year results of the effect of intravitreal ranibizumab on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 2009; [Epub ahead of print] Accessed 4th July 2011
19. Wong TY, Klein R, Islam FM etal. Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol 2006; 141: 446-55.
20. Grading diabetic retinopathy from stereoscopic color fundus photographs-an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 1991; 98 (5 Suppl.): 786-806.
21. Hubbard LD, Brothers RJ, King WN etal. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 1999; 106: 2269-80.
22. Wong TY, Knudtson MD, Klein R, Klein BE, Meuer SM, Hubbard LD. Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology 2004; 111: 1183-90.
23. Knudtson MD, Lee KE, Hubbard LD, Wong TY, Klein R, Klein BE. Revised formulas for summarizing retinal vessel diameters. Curr Eye Res 2003; 27: 143-9.
24. Sun C, Liew G, Wang JJ etal. Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore Malay Eye Study. Invest Ophthalmol Vis Sci 2008; 49: 1784-90.
25. Aiello LP, Brucker AJ, Chang S etal. Evolving guidelines for intravitreous injections. Retina 2004; 24 (5 Suppl.): S3-19.
26. Anderson DH, Radeke MJ, Gallo NB etal. The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res 2010; 29 (Pt2): 95-112.
27. Bressler SB. Introduction: understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration. Ophthalmology 2009; 116 (10 Suppl.): S1-7.
28. Wong TY, Islam FM, Klein R etal. Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci 2006; 47: 2341-50.
29. Yoo SA, Kwok SK, Kim WU. Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention. Mediators Inflamm 2008; 2008: 129873.
30. Detmar M, Brown LF, Schon MP etal. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 1998; 111: 1-6.
31. Canavese M, Altruda F, Ruzicka T, Schauber J. Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis - a possible target for novel therapies? J Dermatol Sci 2010; 58 (Pt 3): 171-6.
32. Wickremasinghe SS, Michalova K, Gilhotra J etal. Acute intraocular inflammation after intravitreous injections of bevacizumab for treatment of neovascular age-related macular degeneration. Ophthalmology 2008; 115: 1911-15.
33. Wu L, Martinez-Castellanos MA, Quiroz-Mercado H etal. Twelve-month safety of intravitreal injections of bevacizumab (Avastin): results of the Pan-American Collaborative Retina Study Group (PACORES). Graefes Arch Clin Exp Ophthalmol 2008; 246: 81-7.
34. Forooghian F, Cukras C, Meyerle CB, Chew EY, Wong WT. Tachyphylaxis after intravitreal bevacizumab for exudative age-related macular degeneration. Retina 2009; 29: 723-31.
35. Jeganathan VS, Kawasaki R, Wang JJ etal. Retinal vascular caliber and age-related macular degeneration: the Singapore Malay Eye Study. Am J Ophthalmol 2008; 146: 954-9. e1.
36. Bakri SJ, Snyder MR, Reid JM, Pulido JS, Ezzat MK, Singh RJ. Pharmacokinetics of intravitreal ranibizumab (Lucentis). Ophthalmology 2007; 114: 2179-82.