-
3
-
-
28844449401
-
Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials
-
Bell D.W. Lynch T.J. Haserlat S.M. Harris P.L. Okimoto R.A. Brannigan B.W. (2005) Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol 23: 8081–8092.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8081-8092
-
-
Bell, D.W.1
Lynch, T.J.2
Haserlat, S.M.3
Harris, P.L.4
Okimoto, R.A.5
Brannigan, B.W.6
-
4
-
-
33748445361
-
Symptom improvement in lung cancer patients treated with erlotinib: quality of life analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21
-
Bezjak A. Tu D. Seymour L. Clark G. Trajkovic A. Zukin M. (2006) Symptom improvement in lung cancer patients treated with erlotinib: quality of life analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol 24: 3831–3837.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3831-3837
-
-
Bezjak, A.1
Tu, D.2
Seymour, L.3
Clark, G.4
Trajkovic, A.5
Zukin, M.6
-
6
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
-
Cappuzzo F. Ciuleanu T. Stelmakh L. Cicenas S. Szczesna A. Juhasz E. (2010) Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 11: 521–529.
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
Cicenas, S.4
Szczesna, A.5
Juhasz, E.6
-
7
-
-
34248385777
-
Gefitinib (IRESSA) in patients of Asian origin with refractory advanced non-small cell lung cancer: subset analysis from the ISEL study
-
Chang A. Parikh P. Thongprasert S. Tan E.H. Perng R.P. Ganzon D. (2006) Gefitinib (IRESSA) in patients of Asian origin with refractory advanced non-small cell lung cancer: subset analysis from the ISEL study. J Thorac Oncol 1: 847–855.
-
(2006)
J Thorac Oncol
, vol.1
, pp. 847-855
-
-
Chang, A.1
Parikh, P.2
Thongprasert, S.3
Tan, E.H.4
Perng, R.P.5
Ganzon, D.6
-
8
-
-
4444286324
-
Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells
-
Chang G.C. Hsu S.L. Tsai J.R. Liang F.P. Lin S.Y. Sheu G.T. (2004) Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells. Biochem Pharmacol 68: 1453–1464.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1453-1464
-
-
Chang, G.C.1
Hsu, S.L.2
Tsai, J.R.3
Liang, F.P.4
Lin, S.Y.5
Sheu, G.T.6
-
9
-
-
78649973178
-
Inhibition of ALK, PI3K/MEK and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene
-
Chen Z. Sasaki T. Tan X. Carretero J. Shimamura T. Li D. (2010) Inhibition of ALK, PI3K/MEK and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene. Cancer Res 70: 9827–9836.
-
(2010)
Cancer Res
, vol.70
, pp. 9827-9836
-
-
Chen, Z.1
Sasaki, T.2
Tan, X.3
Carretero, J.4
Shimamura, T.5
Li, D.6
-
10
-
-
70350225538
-
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
-
Ciuleanu T. Brodowicz T. Zielinski C. Kim J.H. Krzakowski M. Laack E. (2009) Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 374: 1432–1440.
-
(2009)
Lancet
, vol.374
, pp. 1432-1440
-
-
Ciuleanu, T.1
Brodowicz, T.2
Zielinski, C.3
Kim, J.H.4
Krzakowski, M.5
Laack, E.6
-
11
-
-
77955268612
-
Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL, MO19390): a phase 4 study
-
Crino L. Dansin E. Garrido P. Griesinger F. Laskin J. Pavlakis N. (2010) Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL, MO19390): a phase 4 study. Lancet Oncol 11: 733–740.
-
(2010)
Lancet Oncol
, vol.11
, pp. 733-740
-
-
Crino, L.1
Dansin, E.2
Garrido, P.3
Griesinger, F.4
Laskin, J.5
Pavlakis, N.6
-
12
-
-
55349109940
-
Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells
-
Damiani L.A. Yingling C.M. Leng S. Romo P.E. Nakamura J. Belinsky S.A. (2008) Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Res 68: 9005–9014.
-
(2008)
Cancer Res
, vol.68
, pp. 9005-9014
-
-
Damiani, L.A.1
Yingling, C.M.2
Leng, S.3
Romo, P.E.4
Nakamura, J.5
Belinsky, S.A.6
-
13
-
-
70349474058
-
Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL)
-
(, 15 Suppl., ):
-
De Boer R. Arrieta Ó. Gottfried M. Blackhall F.H. Raats J. Yang C.H. (2009) Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL). J Clin Oncol 27(15 Suppl.): 8010.
-
(2009)
J Clin Oncol
, vol.27
, pp. 8010
-
-
De Boer, R.1
Arrieta, Ó.2
Gottfried, M.3
Blackhall, F.H.4
Raats, J.5
Yang, C.H.6
-
14
-
-
77649222572
-
Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial
-
Douillard J.Y. Shepherd F.A. Hirsh V. Mok T. Socinski M.A. Gervais R. (2010) Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial. J Clin Oncol 28: 744–752.
-
(2010)
J Clin Oncol
, vol.28
, pp. 744-752
-
-
Douillard, J.Y.1
Shepherd, F.A.2
Hirsh, V.3
Mok, T.4
Socinski, M.A.5
Gervais, R.6
-
15
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman J.A. Zejnullahu K. Mitsudomi T. Song Y. Hyland C. Park J.O. (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316: 1039–1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
-
16
-
-
0035893318
-
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
-
Fisher G.H. Wellen S.L. Klimstra D. Lenczowski J.M. Tichelaar J.W. Lizak M.J. (2001) Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 15: 3249–3262.
-
(2001)
Genes Dev
, vol.15
, pp. 3249-3262
-
-
Fisher, G.H.1
Wellen, S.L.2
Klimstra, D.3
Lenczowski, J.M.4
Tichelaar, J.W.5
Lizak, M.J.6
-
17
-
-
0015008620
-
Isolation of a tumor factor responsible for angiogenesis
-
Folkman J. Merler E. Abernathy C. Williams G. (1971) Isolation of a tumor factor responsible for angiogenesis. J Exp Med 133: 275–288.
-
(1971)
J Exp Med
, vol.133
, pp. 275-288
-
-
Folkman, J.1
Merler, E.2
Abernathy, C.3
Williams, G.4
-
19
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
-
Fukuoka M. Yano S. Giaccone G. Tamura T. Nakagawa K. Douillard J.Y. (2003) Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J Clin Oncol 21: 2237–2246.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
-
20
-
-
70349725169
-
S0536: Carboplatin, paclitaxel, cetuximab, and bevacizumab followed by cetuximab and bevacizumab maintenance in advanced non-small cell lung cancer (NSCLC): A SWOG phase II study
-
(, 15 Suppl., ):
-
Gandara D. Kim E.S. Herbst R.S. Moon J. Redman M.W. Dakhil S.R. (2010) S0536: Carboplatin, paclitaxel, cetuximab, and bevacizumab followed by cetuximab and bevacizumab maintenance in advanced non-small cell lung cancer (NSCLC): A SWOG phase II study. J Clin Oncol 27(15 Suppl.): 8015.
-
(2010)
J Clin Oncol
, vol.27
, pp. 8015
-
-
Gandara, D.1
Kim, E.S.2
Herbst, R.S.3
Moon, J.4
Redman, M.W.5
Dakhil, S.R.6
-
21
-
-
34248140107
-
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial
-
Gatzemeier U. Pluzanska A. Szczesna A. Kaukel E. Roubec J. De Rosa F. (2007) Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol 25: 1545–1552.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1545-1552
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
Kaukel, E.4
Roubec, J.5
De Rosa, F.6
-
22
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial—INTACT 1
-
Giaccone G. Herbst R.S. Manegold C. Scagliotti G. Rosell R. Miller V. (2004) Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial—INTACT 1. J Clin Oncol 22: 777–784.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
-
23
-
-
78651083043
-
A phase III randomized, double-blind, placebo controlled trial of the epidermal growth factor receptor inhibitor gefitinib in completely resected stage IB–IIIA NSCLC. In: Proceedings of the ASCO 2010, Chicago
-
(, Suppl., ):
-
Goss G.D. Lorimer I. Tsao M.S. O–Callaghan C.J. Ding K. Masters G.A. (2010) A phase III randomized, double-blind, placebo controlled trial of the epidermal growth factor receptor inhibitor gefitinib in completely resected stage IB–IIIA NSCLC. In: Proceedings of the ASCO 2010, Chicago. J Clin Oncol 28(Suppl.): 18s.
-
(2010)
J Clin Oncol
, vol.28
, pp. 18s
-
-
Goss, G.D.1
Lorimer, I.2
Tsao, M.S.3
O–Callaghan, C.J.4
Ding, K.5
Masters, G.A.6
-
24
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial—INTACT 2
-
Herbst R.S. Giaccone G. Schiller J.H. Natale R.B. Miller V. Manegold C. (2004) Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial—INTACT 2. J Clin Oncol 22: 785–794.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
-
25
-
-
36048982143
-
Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
-
Herbst R.S. O–Neill V.J. Fehrenbacher L. Belani C.P. Bonomi P.D. Hart L. (2007) Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 25: 4743–4750.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4743-4750
-
-
Herbst, R.S.1
O–Neill, V.J.2
Fehrenbacher, L.3
Belani, C.P.4
Bonomi, P.D.5
Hart, L.6
-
26
-
-
24944440830
-
TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
-
Herbst R.S. Prager D. Hermann R. Fehrenbacher L. Johnson B.E. Sandler A. (2005) TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 23: 5892–5899.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
Fehrenbacher, L.4
Johnson, B.E.5
Sandler, A.6
-
27
-
-
77954035012
-
Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial
-
Herbst R.S. Sun Y. Eberhardt W.E. Germonpre P. Saijo N. Zhou C. (2010) Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 11: 619–626.
-
(2010)
Lancet Oncol
, vol.11
, pp. 619-626
-
-
Herbst, R.S.1
Sun, Y.2
Eberhardt, W.E.3
Germonpre, P.4
Saijo, N.5
Zhou, C.6
-
28
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman J.G. Baylin S.B. (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042–2054.
-
(2003)
N Engl J Med
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
29
-
-
33750962024
-
Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
-
Hirsch F.R. Varella-Garcia M. Bunn P.A. Jr Franklin W.A. Dziadziuszko R. Thatcher N. (2006) Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol 24: 5034–5042.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5034-5042
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Bunn, P.A.3
Franklin, W.A.4
Dziadziuszko, R.5
Thatcher, N.6
-
30
-
-
34548535031
-
Multicenter, randomized, phase II trial of CI-1033, an irreversible pan-ERBB inhibitor, for previously treated advanced non small-cell lung cancer
-
Janne P.A. von Pawel J. Cohen R.B. Crino L. Butts C.A. Olson S.S. (2007) Multicenter, randomized, phase II trial of CI-1033, an irreversible pan-ERBB inhibitor, for previously treated advanced non small-cell lung cancer. J Clin Oncol 25: 3936–3944.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3936-3944
-
-
Janne, P.A.1
von Pawel, J.2
Cohen, R.B.3
Crino, L.4
Butts, C.A.5
Olson, S.S.6
-
31
-
-
78650927471
-
Randomized phase II trial of erlotinib (E) alone or in combination with carboplatin/paclitaxel (CP) in never or light former smokers with advanced lung adenocarcinoma: CALGB 30406
-
(, 15 Suppl., ):
-
Janne P.A. Wang X.F. Socinski M.A. Crawford J. Capelletti M. Edelman M.J. (2010) Randomized phase II trial of erlotinib (E) alone or in combination with carboplatin/paclitaxel (CP) in never or light former smokers with advanced lung adenocarcinoma: CALGB 30406. J Clin Oncol 28(15 Suppl.): 7503.
-
(2010)
J Clin Oncol
, vol.28
, pp. 7503
-
-
Janne, P.A.1
Wang, X.F.2
Socinski, M.A.3
Crawford, J.4
Capelletti, M.5
Edelman, M.J.6
-
32
-
-
77956227862
-
Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
-
(, 15 Suppl., ):
-
Jassem J. Langer C.J. Karp D.D. Mok T. Benner R.J. Green S.J. (2010) Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol 28(15 Suppl.): 7500.
-
(2010)
J Clin Oncol
, vol.28
, pp. 7500
-
-
Jassem, J.1
Langer, C.J.2
Karp, D.D.3
Mok, T.4
Benner, R.J.5
Green, S.J.6
-
34
-
-
33744788136
-
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
-
Ji H. Li D. Chen L. Shimamura T. Kobayashi S. McNamara K. (2006) The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell 9: 485–495.
-
(2006)
Cancer Cell
, vol.9
, pp. 485-495
-
-
Ji, H.1
Li, D.2
Chen, L.3
Shimamura, T.4
Kobayashi, S.5
McNamara, K.6
-
35
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
Johnson D.H. Fehrenbacher L. Novotny W.F. Herbst R.S. Nemunaitis J.J. Jablons D.M. (2004) Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 22: 2184–2191.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2184-2191
-
-
Johnson, D.H.1
Fehrenbacher, L.2
Novotny, W.F.3
Herbst, R.S.4
Nemunaitis, J.J.5
Jablons, D.M.6
-
36
-
-
66349091290
-
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
-
Karp D.D. Paz-Ares L.G. Novello S. Haluska P. Garland L. Cardenal F. (2009) Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 27: 2516–2522.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2516-2522
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
Haluska, P.4
Garland, L.5
Cardenal, F.6
-
37
-
-
0024801035
-
Vascular permeability factor, an endothelial cell mitogen related to PDGF
-
Keck P.J. Hauser S.D. Krivi G. Sanzo K. Warren T. Feder J. (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309–1312.
-
(1989)
Science
, vol.246
, pp. 1309-1312
-
-
Keck, P.J.1
Hauser, S.D.2
Krivi, G.3
Sanzo, K.4
Warren, T.5
Feder, J.6
-
38
-
-
45149102984
-
Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023
-
Kelly K. Chansky K. Gaspar L.E. Albain K.S. Jett J. Ung Y.C. (2008) Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023. J Clin Oncol 26: 2450–2456.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2450-2456
-
-
Kelly, K.1
Chansky, K.2
Gaspar, L.E.3
Albain, K.S.4
Jett, J.5
Ung, Y.C.6
-
39
-
-
77949886293
-
Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer
-
Khambata-Ford S. Harbison C.T. Hart L.L. Awad M. Xu L.A. Horak C.E. (2010) Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer. J Clin Oncol 28: 918–927.
-
(2010)
J Clin Oncol
, vol.28
, pp. 918-927
-
-
Khambata-Ford, S.1
Harbison, C.T.2
Hart, L.L.3
Awad, M.4
Xu, L.A.5
Horak, C.E.6
-
40
-
-
56249109644
-
Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial
-
Kim E.S. Hirsh V. Mok T. Socinski M.A. Gervais R. Wu Y.L. (2008) Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet 372: 1809–1818.
-
(2008)
Lancet
, vol.372
, pp. 1809-1818
-
-
Kim, E.S.1
Hirsh, V.2
Mok, T.3
Socinski, M.A.4
Gervais, R.5
Wu, Y.L.6
-
42
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
-
Kris M.G. Natale R.B. Herbst R.S. Lynch T.J. Jr Prager D. Belani C.P. (2003) Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290: 2149–2158.
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch, T.J.4
Prager, D.5
Belani, C.P.6
-
44
-
-
78049395323
-
Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind phase III trial (ZEPHYR)
-
(, 25 Suppl., ):
-
Lee L. Hirsh V. Park K. Qinn S. Plajman C.R. Perng R. (2010) Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind phase III trial (ZEPHYR). J Clin Oncol 28(25 Suppl.): 7525.
-
(2010)
J Clin Oncol
, vol.28
, pp. 7525
-
-
Lee, L.1
Hirsh, V.2
Park, K.3
Qinn, S.4
Plajman, C.R.5
Perng, R.6
-
45
-
-
73949154122
-
Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer
-
Leidner R.S. Fu P. Clifford B. Hamdan A. Jin C. Eisenberg R. (2009) Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer. J Clin Oncol 27: 5620–5626.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5620-5626
-
-
Leidner, R.S.1
Fu, P.2
Clifford, B.3
Hamdan, A.4
Jin, C.5
Eisenberg, R.6
-
47
-
-
47949123984
-
Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung
-
Licchesi J.D. Westra W.H. Hooker C.M. Herman J.G. (2008a) Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung. Clin Cancer Res 14: 2570–2578.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2570-2578
-
-
Licchesi, J.D.1
Westra, W.H.2
Hooker, C.M.3
Herman, J.G.4
-
49
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch T.J. Bell D.W. Sordella R. Gurubhagavatula S. Okimoto R.A. Brannigan B.W. (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129–2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
50
-
-
77949891126
-
Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099
-
Lynch T.J. Patel T. Dreisbach L. McCleod M. Heim W.J. Hermann R.C. (2010) Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099. J Clin Oncol 28: 911–917.
-
(2010)
J Clin Oncol
, vol.28
, pp. 911-917
-
-
Lynch, T.J.1
Patel, T.2
Dreisbach, L.3
McCleod, M.4
Heim, W.J.5
Hermann, R.C.6
-
52
-
-
67449113768
-
Cancer DNA methylation: molecular mechanisms and clinical implications
-
McCabe M.T. Brandes J.C. Vertino P.M. (2009) Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res 15: 3927–3937.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3927-3937
-
-
McCabe, M.T.1
Brandes, J.C.2
Vertino, P.M.3
-
53
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
-
Mitsudomi T. Morita S. Yatabe Y. Negoro S. Okamoto I. Tsurutani J. (2010) Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 11: 121–128.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
Negoro, S.4
Okamoto, I.5
Tsurutani, J.6
-
55
-
-
34249049000
-
Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
-
Morgillo F. Kim W.Y. Kim E.S. Ciardiello F. Hong W.K. Lee H.Y. (2007) Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res 13: 2795–2803.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2795-2803
-
-
Morgillo, F.1
Kim, W.Y.2
Kim, E.S.3
Ciardiello, F.4
Hong, W.K.5
Lee, H.Y.6
-
56
-
-
33750571170
-
Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
-
Morgillo F. Woo J.K. Kim E.S. Hong W.K. Lee H.Y. (2006) Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res 66: 10100–10111.
-
(2006)
Cancer Res
, vol.66
, pp. 10100-10111
-
-
Morgillo, F.1
Woo, J.K.2
Kim, E.S.3
Hong, W.K.4
Lee, H.Y.5
-
57
-
-
70349476412
-
Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST)
-
(, 15 Suppl., ):
-
Natale R.B. Thongprasert S. Greco F.A. Thomas M. Tsai C.M. Sunpaweravong P. (2009) Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST). J Clin Oncol 27(15 Suppl.): 8009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 8009
-
-
Natale, R.B.1
Thongprasert, S.2
Greco, F.A.3
Thomas, M.4
Tsai, C.M.5
Sunpaweravong, P.6
-
58
-
-
84856607331
-
Survival impact of newly approved therapeutic agents in patients with advanced non-small cell lung cancer (NSCLC): A SEER-Medicare database analysis
-
(, 15 Suppl., ):
-
Owonikoko T.K. Ramalingam S.S. Behera M. Brande S.J.C. Saba N. Bhimani C. (2010) Survival impact of newly approved therapeutic agents in patients with advanced non-small cell lung cancer (NSCLC): A SEER-Medicare database analysis. J Clin Oncol 28(15 Suppl.): 7633.
-
(2010)
J Clin Oncol
, vol.28
, pp. 7633
-
-
Owonikoko, T.K.1
Ramalingam, S.S.2
Behera, M.3
Brande, S.J.C.4
Saba, N.5
Bhimani, C.6
-
59
-
-
2342624080
-
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
-
Paez J.G. Janne P.A. Lee J.C. Tracy S. Greulich H. Gabriel S. (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304: 1497–1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
-
60
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W. Miller V.A. Politi K.A. Riely G.J. Somwar R. Zakowski M.F. (2005a) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2: e73.
-
(2005)
PLoS Med
, vol.2
, pp. e73
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
Riely, G.J.4
Somwar, R.5
Zakowski, M.F.6
-
61
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao W. Wang T.Y. Riely G.J. Miller V.A. Pan Q. Ladanyi M. (2005b) KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS medicine 2: e17.
-
(2005)
PLoS medicine
, vol.2
, pp. e17
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
Miller, V.A.4
Pan, Q.5
Ladanyi, M.6
-
62
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial
-
Pirker R. Pereira J.R. Szczesna A. von Pawel J. Krzakowski M. Ramlau R. (2009) Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 373: 1525–1531.
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
von Pawel, J.4
Krzakowski, M.5
Ramlau, R.6
-
63
-
-
77956848562
-
Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer
-
Ramalingam S.S. Harvey R.D. Saba N. Owonikoko T.K. Kauh J. Shin D.M. (2010a) Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer. Cancer 116: 3903–3909.
-
(2010)
Cancer
, vol.116
, pp. 3903-3909
-
-
Ramalingam, S.S.1
Harvey, R.D.2
Saba, N.3
Owonikoko, T.K.4
Kauh, J.5
Shin, D.M.6
-
64
-
-
73949140461
-
Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer
-
Ramalingam S.S. Maitland M.L. Frankel P. Argiris A.E. Koczywas M. Gitlitz B. (2010b) Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. J Clin Oncol 28: 56–62.
-
(2010)
J Clin Oncol
, vol.28
, pp. 56-62
-
-
Ramalingam, S.S.1
Maitland, M.L.2
Frankel, P.3
Argiris, A.E.4
Koczywas, M.5
Gitlitz, B.6
-
65
-
-
77951473661
-
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
-
Reck M. von Pawel J. Zatloukal P. Ramlau R. Gorbounova V. Hirsh V. (2010) Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 21: 1804–1809.
-
(2010)
Ann Oncol
, vol.21
, pp. 1804-1809
-
-
Reck, M.1
von Pawel, J.2
Zatloukal, P.3
Ramlau, R.4
Gorbounova, V.5
Hirsh, V.6
-
66
-
-
62449124416
-
Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
-
Reck M. von Pawel J. Zatloukal P. Ramlau R. Gorbounova V. Hirsh V. (2009) Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 27: 1227–1234.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1227-1234
-
-
Reck, M.1
von Pawel, J.2
Zatloukal, P.3
Ramlau, R.4
Gorbounova, V.5
Hirsh, V.6
-
67
-
-
53249145767
-
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
-
Riely G.J. Kris M.G. Rosenbaum D. Marks J. Li A. Chitale D.A. (2008) Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 14: 5731–5734.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5731-5734
-
-
Riely, G.J.1
Kris, M.G.2
Rosenbaum, D.3
Marks, J.4
Li, A.5
Chitale, D.A.6
-
68
-
-
58249092152
-
Randomized phase II study of pulse erlotinib before or after carboplatin and paclitaxel in current or former smokers with advanced non-small-cell lung cancer
-
Riely G.J. Rizvi N.A. Kris M.G. Milton D.T. Solit D.B. Rosen N. (2009) Randomized phase II study of pulse erlotinib before or after carboplatin and paclitaxel in current or former smokers with advanced non-small-cell lung cancer. J Clin Oncol 27: 264–270.
-
(2009)
J Clin Oncol
, vol.27
, pp. 264-270
-
-
Riely, G.J.1
Rizvi, N.A.2
Kris, M.G.3
Milton, D.T.4
Solit, D.B.5
Rosen, N.6
-
70
-
-
77951639655
-
Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
-
Scagliotti G. Novello S. von Pawel J. Reck M. Pereira J.R. Thomas M. (2010) Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 28: 1835–1842.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1835-1842
-
-
Scagliotti, G.1
Novello, S.2
von Pawel, J.3
Reck, M.4
Pereira, J.R.5
Thomas, M.6
-
71
-
-
77954584507
-
Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer
-
Sequist L.V. Besse B. Lynch T.J. Miller V.A. Wong K.K. Gitlitz B. (2010) Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer. J Clin Oncol 28: 3076–3083.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3076-3083
-
-
Sequist, L.V.1
Besse, B.2
Lynch, T.J.3
Miller, V.A.4
Wong, K.K.5
Gitlitz, B.6
-
75
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M. Choi Y.L. Enomoto M. Takada S. Yamashita Y. Ishikawa S. (2007) Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448: 561–566.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
-
76
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N. Chang A. Parikh P. Rodrigues Pereira J. Ciuleanu T. von Pawel J. (2005) Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366: 1527–1537.
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Rodrigues Pereira, J.4
Ciuleanu, T.5
von Pawel, J.6
-
77
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J. Koopman M. Cats A. Rodenburg C.J. Creemers G.J. Schrama J.G. (2009) Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 360: 563–572.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.5
Schrama, J.G.6
-
78
-
-
0242298326
-
Lethal combinations
-
Tucker C.L. Fields S. (2003) Lethal combinations. Nat Genet 35: 204–205.
-
(2003)
Nat Genet
, vol.35
, pp. 204-205
-
-
Tucker, C.L.1
Fields, S.2
-
81
-
-
0031417677
-
Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy
-
Weinstein I.B. Begemann M. Zhou P. Han E.K. Sgambato A. Doki Y. (1997) Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. Clin Cancer Res 3: 2696–2702.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 2696-2702
-
-
Weinstein, I.B.1
Begemann, M.2
Zhou, P.3
Han, E.K.4
Sgambato, A.5
Doki, Y.6
-
82
-
-
44249121733
-
Erlotinib for advanced non-small-cell lung cancer in the elderly: an analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21
-
Wheatley-Price P. Ding K. Seymour L. Clark G.M. Shepherd F.A. (2008) Erlotinib for advanced non-small-cell lung cancer in the elderly: an analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol 26: 2350–2357.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2350-2357
-
-
Wheatley-Price, P.1
Ding, K.2
Seymour, L.3
Clark, G.M.4
Shepherd, F.A.5
-
85
-
-
79954606282
-
Efficacy results from the randomised phase III optimal (CTONG 0802) study comparing first-line erlotinib versus carboplatin (CBDCA) plus gemcitabine (GEM), in Chinese advanced nonsmall-cell lung cancer (NSCLC) patients (pts) with EGFR activating mutations
-
(, Suppl. 8, ):
-
Zhou C. Wu Y.-L. Chen G. Feng J. Liu X. Wang C. (2010) Efficacy results from the randomised phase III optimal (CTONG 0802) study comparing first-line erlotinib versus carboplatin (CBDCA) plus gemcitabine (GEM), in Chinese advanced nonsmall-cell lung cancer (NSCLC) patients (pts) with EGFR activating mutations. Ann Oncol 21(Suppl. 8): LBA 13.
-
(2010)
Ann Oncol
, vol.21
, pp. LBA 13
-
-
Zhou, C.1
Wu, Y.-L.2
Chen, G.3
Feng, J.4
Liu, X.5
Wang, C.6
-
86
-
-
72949092456
-
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
-
Zhou W. Ercan D. Chen L. Yun C.H. Li D. Capelletti M. (2009) Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462: 1070–1074.
-
(2009)
Nature
, vol.462
, pp. 1070-1074
-
-
Zhou, W.1
Ercan, D.2
Chen, L.3
Yun, C.H.4
Li, D.5
Capelletti, M.6
|