Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients

Digestive and Liver Disease

Volumn 44, Issue 3, 2012, Pages 245-250

  Arciello, Mario ^a,b   Petta, Salvatore ^c   Leoni, Valerio ^d   Iannucci, Gino ^e   Labbadia, Giancarlo ^e   Cammà, Carlo ^c   Craxì, Antonio ^c   Balsano, Clara ^a,b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b Laboratory of Molecular Virology and Oncology   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

^d DEPARTMENT OF NEUROSURGERY   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Chronic hepatitis C infection; Lipid metabolism; Non alcoholic fatty liver disease; Oxidative stress

Indexed keywords

7 OXOCHOLESTEROL; 7BETA HYDROXYCHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXYSTEROL;

ADULT; ALCOHOLIC FATTY LIVER; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHRONIC HEPATITIS; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; ISOTOPE DILUTION GAS CHROMATOGRAPHY; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL;

ADULT; CHOLESTEROL, LDL; FATTY LIVER; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; HYDROXYCHOLESTEROLS; KETOCHOLESTEROLS; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OXIDATIVE STRESS;

EID: 84856586374     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2011.10.022     Document Type: Article

References (28)

1. Sasaki Y. Does oxidative stress participate in the development of hepatocellular carcinoma?. J Gastroenterol 2006, 41:1135-1148.
2. Koike K. Pathogenesis of HCV-associated HCC: dual-pass carcinogenesis through activation of oxidative stress and intracellular signaling. Hepatol Res 2007, 37(Suppl. 2):S115-S120.
3. Mahmood S., Yamada G., Niiyama G., et al. Effect of vitamin E on serum aminotransferase and thioredoxin levels in patients with viral hepatitis C. Free Radic Res 2003, 37:781-785.
4. Marotta F., Yoshida C., Barreto R., et al. Oxidative-inflammatory damage in cirrhosis: effect of vitamin E and a fermented papaya preparation. J Gastroenterol Hepatol 2007, 22:697-703.
5. Abo K., Mio T., Sumino K. Comparative analysis of plasma and erythrocyte 7-ketocholesterol as a marker for oxidative stress in patients with diabetes mellitus. Clin Biochem 2000, 33:541-547.
6. Willy P.J., Umesono K., Ong E.S., et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 1995, 9:1033-1045.
7. Groot P.H., Pearce N.J., Yates J.W., et al. Synthetic LXR agonists increase LDL in CETP species. J Lipid Res 2005, 46:2182-2191.
8. Quinet E.M., Basso M.D., Halpern A.R., et al. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J Lipid Res 2009, 50:2358-2370.
9. Repa J.J., Mangelsdorf D.J. The liver X receptor gene team: potential new players in atherosclerosis. Nat Med 2002, 8:1243-1248.
10. Corradini S.G., Micheletta F., Natoli S., et al. High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. Liver Transpl 2005, 11:1494-1504.
11. Syed G.H., Amako Y., Siddiqui A. Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol Metab 2010, 21:33-40.
12. Tsutsumi T., Suzuki T., Shimoike T., et al. Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity. Hepatology 2002, 35:937-946.
13. Moriishi K., Mochizuki R., Moriya K., et al. Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis. Proc Natl Acad Sci USA 2007, 104:1661-1666.
14. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
15. Bellentani S., Saccoccio G., Masutti F., et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000, 132:112-117.
16. Colloredo G., Guido M., Sonzogni A., et al. Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease. J Hepatol 2003, 39:239-244.
17. Kleiner D.E., Brunt E.M., Van Natta M., et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 411:313-321.
18. Scheuer P.J. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991, 13:372-374.
19. SAS Technical Report SAS/STAT software: changes and enhancement, release 6.07 1992, SAS Institute, Inc., Cary, NC.
20. Schroepfer G.J. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 2000, 80:361-554.
21. Anticoli S., Arciello M., Mancinetti A., et al. 7-Ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells. J Cell Physiol 2010, 222:586-595.
22. Pal S., Polyak S.J., Bano N., et al. Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1. J Gastroenterol Hepatol 2010, 25:627-634.
23. Endo K., Oyama T., Saiki A., et al. Determination of serum 7-ketocholesterol concentrations and their relationships with coronary multiple risks in diabetes mellitus. Diabetes Res Clin Pract 2008, 80:63-68.
24. Petit J.M., Benichou M., Duvillard L., et al. Hepatitis C virus-associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis. Am J Gastroenterol 2003, 98:1150-1154.
25. Corey K.E., Kane E., Munroe C., et al. Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-up. Hepatology 2009, 50:1030-1037.
26. Negro F., Sanyal A.J. Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. Liver Int 2009, 29(Suppl. 2):26-37.
27. Fimia G.M., Tripodi M., Alonzi T. Transgenic models for hepatitis C virus pathogenesis. Cell Death Differ 2003, 10(Suppl. 1):S16-S18.
28. Amako Y., Sarkeshik A., Hotta H., et al. Role of oxysterol binding protein in hepatitis C virus infection. J Virol 2009, 83:9237-9246.