Meta-analysis of the association of Pro12Ala polymorphism of peroxisome proliferator activated receptorγ gene with type 2 diabetes in Chinese Han population

Acta Academiae Medicinae Sinicae

Volumn 33, Issue 6, 2011, Pages 593-599

  Guo, Wu Lan ^a   Tang, Yong ^a   Han, Xue Yao ^a   Ji, Li Nong ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Diabetes mellitus, type 2; Meta analysis; Peroxisome proliferator activated receptor; Pro12Ala

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ARTICLE; CHINESE; DNA POLYMORPHISM; GENE FREQUENCY; HUMAN; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS;

ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, GENETIC; PPAR GAMMA;

EID: 84856563440     PISSN: 1000503X     EISSN: None     Source Type: Journal    
DOI: 10.3881/j.issn.1000-503X.2011.06.002     Document Type: Article

References (45)

1. Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism [J]. Endocr Rev, 1999, 20(5):649-688. (Pubitemid 30650602)
2. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor [J]. Cell, 1994, 79(7):1147-1156.
3. Okuno A, Tamemoto H, Tobe K, et al. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats [J]. J Clin Invest, 1998, 101(6):1354-1361. (Pubitemid 28145252)
4. Capeau J, Magré J, Lascols O, et al. Diseases of adipose tissue: genetic and acquired lipodystrophies [J]. Biochem Soc Trans, 2005, 33(Pt5):1073-1077. (Pubitemid 41659116)
5. Mukherjee R, Davies PJ, Crombie DL, et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists [J]. Nature, 1997, 386(6623):407-410. (Pubitemid 27154482)
6. Koch M, Rett K, Maerker E, et al. The PPARgamma2 amino acid polymorphism Pro12Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects [J]. Diabetologia, 1999, 42(6):758-762. (Pubitemid 29265595)
7. Hara K, Okada T, Tobe K, et al. The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes [J]. Biochem Biophys Res Commun, 2000, 271(1):212-216.
8. Lei HH, Chen MH, Yang WS, et al. Peroxisome proliferator-activated receptor gamma 2 Pro12Ala gene variant is strongly associated with larger body mass in the Taiwanese [J]. Metabolism, 2000, 49(10):1267-1270.
9. Deeb SS, Fajas L, Nemoto M, et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity [J]. Nat Genet, 1998, 20(3):284-287. (Pubitemid 28507675)
10. Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter-308 A/G polymorphism and SLE susceptibility [J]. Eur J Hum Genet, 2006, 14(3):364-371.
11. Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China [J]. N Engl J Med, 2010, 362(12):1090-1101.
12. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews [J]. Ann Intern Med, 1997, 127(9):820-826. (Pubitemid 27465551)
13. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses [J]. BMJ, 2003, 327(7414):557-560. (Pubitemid 37088507)
14. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis [J]. Stat Med, 2002, 21(11):1539-1558. (Pubitemid 34746062)
15. DerSimonian R, Laird N. Meta-analysis in clinical trials [J]. Control Clin Trials, 1986, 7(3):177-188. (Pubitemid 17189972)
16. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease [J]. J Natl Cancer Inst, 1959, 22(4):719-748.
17. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test [J]. BMJ, 1997, 315(7109):629-634. (Pubitemid 27387172)
18. Lin Y, Li P, Cai L, et al. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population [J]. BMC Med Genet, 2010, 11:97.
19. Tai ES, Corella D, Deurenberg-Yap M, et al. Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population [J]. J Lipid Res, 2004, 45(4):674-685. (Pubitemid 38405674)
20. Hu C, Zhang R, Wang C, et al. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population [J]. PLoS One, 2009, 4(10):e7643.
21. Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J]. Nat Genet, 2000, 26(1):76-80.
22. Gouda HN, Sagoo GS, Harding AH, et al. The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis [J]. Am J Epidemiol, 2010, 171(6):645-655.
23. Mori H, Ikegami H, Kawaguchi Y, et al. The Pro12 - > Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes [J]. Diabetes, 2001, 50(4):891-894. (Pubitemid 32242650)
24. Li LL, Ma XL, Ran JX, et al. Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects [J]. Clin Exp Pharmacol Physiol, 2008, 35(2):187-191.
25. Wang F, Han XY, Ren Q, et al. Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population [J]. Chin Med J (Engl), 2009, 122(20):2477-2482.