Synthesis and antitumor activity of novel aroylthiourea derivatives of podophyllotoxin

Investigational New Drugs

Volumn 30, Issue 1, 2012, Pages 17-24

  Zhao, Yu ^a   Wang, Chengniu ^a   Wu, Zhonghua ^a   Fang, Jinghuai ^a   Zhu, Li ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Antitumor; Aroylthiourea; Podophyllotoxin; Synthesis

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4BETA (2'' BROMOBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (2'' CHLOROBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (2'' IODOBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (2'' METHYLBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (3'' CHLOROBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (3'' METHYLBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (4'' CHLOROBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (4'' FLUOROBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (4'' METHYLBENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (ALPHA NAPHTHOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (BENZOYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; 4BETA (THIENYLTHIOUREIDO) 4 DEOXYPODOPHYLLOTOXIN; ACRIDINE ORANGE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETHIDIUM BROMIDE; HOE 33342; PODOPHYLLOTOXIN DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL STRAIN HCT116; CELL STRAIN HEPG2; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DNA DETERMINATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; M PHASE CELL CYCLE CHECKPOINT; PRIORITY JOURNAL;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; DNA, CATENATED; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINTS; HCT116 CELLS; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; M PHASE CELL CYCLE CHECKPOINTS; MOLECULAR STRUCTURE; PODOPHYLLOTOXIN; STAINING AND LABELING; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TIME FACTORS;

EID: 84856555530     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9508-1     Document Type: Article

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