α-Tocopherol succinate-modified chitosan as a micellar delivery system for paclitaxel: Preparation, characterization and in vitro/in vivo evaluations

International Journal of Pharmaceutics

Volumn 423, Issue 2, 2012, Pages 480-488

  Liang, Na ^a   Sun, Shaoping ^b   Li, Xuefeng ^a   Piao, Hongze ^a   Piao, Hongyu ^a   Cui, Fude ^a   Fang, Liang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY   (China)

Author keywords

Tocopherol succinate; Chitosan; Hydrophobically modified; Paclitaxel; Polymeric micelle

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; CHITOSAN; PACLITAXEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CLINICAL EFFECTIVENESS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; ENCAPSULATION; EXPERIMENTAL RABBIT; FEMALE; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICELLE; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; TUMOR VOLUME; UTERINE CERVIX CANCER; X RAY DIFFRACTION; ZETA POTENTIAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; HEMOLYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; PACLITAXEL; PARTICLE SIZE; RABBITS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; TOCOPHEROLS; UTERINE CERVICAL NEOPLASMS;

EID: 84856511087     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.12.004     Document Type: Article

References (31)

1. A.W.G. Alani, Y. Bae, D.A. Rao, and G.S. Kwon Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel Biomaterials 31 2010 1765 1772
2. A. Bernkop-Schnürch, and M.E. Krajicek Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates J. Control. Release 50 1998 215 223 (Pubitemid 28044116)
3. H.M. Burt, X. Zhang, P. Toleikis, L. Embree, and W.L. Hunter Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel Colloids Surf. B: Biointerfaces 16 1999 161 171 (Pubitemid 29486803)
4. X.-G. Chen, C.M. Lee, and H.-J. Park O/W emulsification for the self-aggregation and nanoparticle formation of linoleic acid-modified chitosan in the aqueous system J. Agric. Food Chem. 51 2003 3135 3139
5. X.-G. Chen, C.-S. Liu, C.-G. Liu, X.-H. Meng, C.M. Lee, and H.-J. Park Preparation and biocompatibility of chitosan microcarriers as biomaterial Biochem. Eng. J. 27 2006 269 274 (Pubitemid 41531671)
6. F. Danhier, N. Magotteaux, B. Ucakar, N. Lecouturier, M. Brewster, and V. Préat Novel self-assembling PEG-p-(CL-co-TMC) polymeric micelles as safe and effective delivery system for paclitaxel Eur. J. Pharm. Biopharm. 73 2009 230 238
7. A. Fischer, M.C. Houzelle, P. Hubert, M.A.V. Axelos, C. Geoffroy-Chapotot, M.C. Carré, M.L. Viriot, and E. Dellacherie Detection of intramolecular associations in hydrophobically modified pectin derivatives using fluorescent probes Langmuir 14 1998 4482 4488 (Pubitemid 128595241)
8. J.K. Francis Suh, and H.W.T. Matthew Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review Biomaterials 21 2000 2589 2598
9. H. Gelderblom, J. Verweij, K. Nooter, and A. Sparreboom Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation Eur. J. Cancer 37 2001 1590 1598 (Pubitemid 32778603)
10. F.-Q. Hu, G.-F. Ren, H. Yuan, Y.-Z. Du, and S. Zeng Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel Colloids Surf. B: Biointerfaces 50 2006 97 103 (Pubitemid 43946659)
11. F.-Q. Hu, X.-l. Wu, Y.-Z. Du, J. You, and H. Yuan Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin Eur. J. Pharm. Biopharm. 69 2008 117 125 (Pubitemid 351467161)
12. M. Huo, Y. Zhang, J. Zhou, A. Zou, D. Yu, Y. Wu, J. Li, and H. Li Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug Int. J. Pharm. 394 2010 162 173
13. K. Kalyanasundaram, and J.K. Thomas Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems J. Am. Chem. Soc. 99 1977 2039 2044
14. K. Kataoka, T. Matsumoto, M. Yokoyama, T. Okano, Y. Sakurai, S. Fukushima, K. Okamoto, and G.S. Kwon Doxorubicin-loaded poly(ethylene glycol)-poly(β-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance J. Control. Release 64 2000 143 153 (Pubitemid 30035315)
15. C. Kim, S.C. Lee, S.W. Kang, I.C. Kwon, Y.-H. Kim, and S.Y. Jeong Synthesis and the micellar characteristics of poly(ethylene oxide)-deoxycholic acid conjugates Langmuir 16 2000 4792 4797
16. G.S. Kwon, and T. Okano Polymeric micelles as new drug carriers Adv. Drug Deliv. Rev. 21 1996 107 116 (Pubitemid 26401713)
17. K.Y. Lee, I.C. Kwon, Y.H. Kim, W.H. Jo, and S.Y. Jeong Preparation of chitosan self-aggregates as a gene delivery system J. Control. Release 51 1998 213 220 (Pubitemid 28252873)
18. R.T. Liggins, W.L. Hunter, and H.M. Burt Solid-state characterization of paclitaxel J. Pharm. Sci. 86 1997 1458 1463 (Pubitemid 28018330)
19. C.-G. Liu, K.G.H. Desai, X.-G. Chen, and H.-J. Park Linolenic acid-modified chitosan for formation of self-assembled nanoparticles J. Agric. Food Chem. 53 2004 437 441
20. H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J. Control. Release 65 2000 271 284 (Pubitemid 30122932)
21. H. Montazeri Aliabadi, D.R. Brocks, and A. Lavasanifar Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution Biomaterials 26 2005 7251 7259 (Pubitemid 41133577)
22. T. Ngawhirunpat, N. Wonglertnirant, P. Opanasopit, U. Ruktanonchai, R. Yoksan, K. Wasanasuk, and S. Chirachanchai Incorporation methods for cholic acid chitosan-g-mPEG self-assembly micellar system containing camptothecin Colloids Surf. B: Biointerfaces 74 2009 253 259
23. P.B. Nielsen, A. Müllertz, T. Norling, and H.G. Kristensen The effect of α-tocopherol on the in vitro solubilisation of lipophilic drugs Int. J. Pharm. 222 2001 217 224 (Pubitemid 32568365)
24. G. Qu, Z. Yao, C. Zhang, X. Wu, and Q. Ping PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel: in vitro characterization and in vivo evaluation Eur. J. Pharm. Sci. 37 2009 98 105
25. R.R. Sawant, R.M. Sawant, and V.P. Torchilin Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity Eur. J. Pharm. Biopharm. 70 2008 51 57
26. A.K. Singla, A. Garg, and D. Aggarwal Paclitaxel and its formulations Int. J. Pharm. 235 2002 179 192 (Pubitemid 34185449)
27. V. Torchilin Micellar nanocarriers: pharmaceutical perspectives Pharm. Res. 24 2007 1 16 (Pubitemid 44902565)
28. X. Xu, L. Li, J. Zhou, S. Lu, Y. Jie, X. Yin, and J. Ren Preparation and characterization of N-succinyl-N′-octyl chitosan micelles as doxorubicin carriers for effective anti-tumor activity Colloids Surf. B: Biointerfaces 55 2007 222 228 (Pubitemid 46274249)
29. C. Zhang, Q. Ping, and H. Zhang Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system Colloids Surf. B: Biointerfaces 39 2004 69 75 (Pubitemid 39473356)
30. W. Zhang, Y. Shi, Y. Chen, S. Yu, J. Hao, J. Luo, X. Sha, and X. Fang Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance Eur. J. Pharm. Biopharm. 75 2010 341 353
31. C.L. Zhao, M.A. Winnik, G. Riess, and M.D. Croucher Fluorescence probe techniques used to study micelle formation in water-soluble block copolymers Langmuir 6 1990 514 516 (Pubitemid 20663816)