Gastrointestinal and hepatic manifestations of Sjogren syndrome

Journal of Clinical Gastroenterology

Volumn 46, Issue 1, 2012, Pages 25-30

  Ebert, Ellen Catherine ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Celiac sprue; Esophagus; Hepatitis C; Liver disease; Pancreas; Primary biliary cirrhosis; Stomach

Indexed keywords

LA ANTIBODY; RO ANTIBODY;

ABDOMINAL DISCOMFORT; AUTOIMMUNE HEPATITIS; CELIAC DISEASE; CLONAL VARIATION; CONSTIPATION; DENTAL CARIES; DIARRHEA; DYSGEUSIA; DYSPEPSIA; DYSPHAGIA; GASTRITIS; GASTROINTESTINAL SYMPTOM; HEPATITIS C; HEPATOMEGALY; HUMAN; IRON DEFICIENCY ANEMIA; LIVER DISEASE; NAUSEA; NONALCOHOLIC FATTY LIVER; NONHUMAN; PANCREAS INSUFFICIENCY; PANCREATITIS; PERNICIOUS ANEMIA; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; REVIEW; SALIVATION; SIALOADENITIS; SJOEGREN SYNDROME; VASCULITIS; XEROSTOMIA;

ANIMALS; AUTOANTIBODIES; DEGLUTITION DISORDERS; GASTROINTESTINAL DISEASES; HUMANS; LIVER DISEASES; MOUTH DISEASES; SJOGREN'S SYNDROME;

EID: 84856478732     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3182329d9c     Document Type: Review

References (110)

1. Vitali C. Classification criteria for Sjogren's syndrome. Ann Rheum Dis. 2003;62:94-95.
2. Huo AP, Lin KC, Chou CT. Predictive and prognostic value of antinuclear antibodies and rheumatoid factor in primary Sjogren's syndrome. Internat J Rheum Dis. 2010;13:39-47.
3. Ter Borg EJ, Risselada AP, Kelder JC. Relation of systemic autoantibodies to the number of extraglandular manifestations in primary Sjogren's syndrome: a retrospective analysis of 65 patients in the Netherlands. Semin Arthritis Rheum. 2011;40:547-551.
4. Bloch KJ, Buchanan WW, Wohl MJ, et al. Sjogren's syndrome: a clinical, pathological, and serological study of sixty-two cases. Medicine. 1965;44:187-2231.
5. Soto-Rojas AE, Villa AR, Sifuentes-Osornio J, et al. Oral candidiasis and Sjogren's syndrome. J Rheumatol. 1998;25:911-915.
6. Doig JA, Whaley K, Dick WC, et al. Otolaryngological aspects of Sjogren's syndrome. Br Med J. 1971;4:460-463.
7. Soto-Rojas AE, Villa AR, Sifuentes-Osornio J, et al. Oral manifestations in patients with Sjogren's syndrome. J Rheumatol. 1998;25:906-910.
8. Waterman SA, Gordon TP, Rischmueller M. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjogren's syndrome. Arthritis Rheum. 2000;43:1647-1654.
9. Dawson LJ, Allison HE, Stanbury J, et al. Putative antimuscarinic antibodies cannot be detected in patients with primary Sjogren's syndrome using conventional immunological approaches. Rheumatology. 2004;43:1488-1495.
10. Porter SR, Scully C, Hegarty AM. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:28-46.
11. Papas AS, Sherrer YS, Charney M, et al. Successful treatment of dry mouth and dry eye symptoms in Sjogren's syndrome patients with oral pilocarpine. A randomized, placebo-controlled, dose-adjustment study. J Clin Rheumatol. 2004;10:169-177.
12. Kjellen G, Fransson SG, Lindstrom F, et al. Esophageal function, radiography, and dysphagia in Sjogren's syndrome. Dig Dis Sci. 1986;31:225-229.
13. Mandl T, Ekberg O, Wollmer P, et al. Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjogren's syndrome. Scand J Rheumatol. 2007;36:394-401.
14. Anselmino M, Zaninotto G, Costantini M, et al. Esophageal motor function in primary Sjogren's syndrome: correlation with dysphagia and xerostomia. Dig Dis Sci. 1997;42:113-118.
15. Volter F, Fain O, Mathieu E, et al. Esophageal function and Sjogren's syndrome. Dig Dis Sci. 2004;49:248-253.
16. Palma R, Freire A, Freitas J, et al. Esophageal motility disorders in patients with Sjogren's syndrome. Dig Dis Sci. 1994;39:758-761.
17. Grande L, Lacima G, Ros E, et al. Esophageal motor function in primary Sjogren's syndrome. Am J Gastroenterol. 1993;88:378-381.
18. Turk T, Pirildar T, Tunc E, et al. Manometric assessment of esophageal motility in patients with primary Sjogren's syndrome. Rheumatol Int. 2005;25:246-249.
19. Rhodus NL, Colby S, Moller K, et al. Quantitative assessment of dysphagia in patients with primary and secondary Sjogren's syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:305-310.
20. Rogus-Pulia NM, Logemann JA. Effects of reduced saliva production on swallowing in patients with Sjogren's syndrome. Dysphagia. 2011;26:295-303.
21. Tsianos EB, Chiras CD, Drosos AA, et al. Oesophageal dysfunction in patients with primary Sjogren's syndrome. Ann Rheum Dis. 1985;44:610-613.
22. Rosztoczy A, Kovacs L, Wittmann T, et al. Manometric assessment of impaired esophageal motor function in primary Sjogren's syndrome. Clin Exp Rheumatol. 2001;19:147-152.
23. Simila S, Kokkonen J, Kaski M. Achalasia sicca: juvenile Sjogren's syndrome with achalasia and gastric hyposecretion. Eur J Pediatr. 1978;129:175-181.
24. El Miedany YM, Baddour M, Ahmed I, et al. Sjogren's syndrome: concomitant H. pylori infection and possible correlation with clinical parameters. Joint Bone Spine. 2005;72:135-141.
25. Collin P, Karvonen AL, Korpela M, et al. Gastritis classified in accordance with the Sydney system in patients with primary Sjogren's syndrome. Scand J Gastroenterol. 1997;32:108-111.
26. Biagini MR, Milani S, Fedi P, et al. Duodenal ulcer and Sjogren's syndrome in patients with primary biliary cirrhosis: a causal association? Am J Gastroenterol. 1991;86:1190-1193.
27. Maury CPJ, Tornroth T, Teppo AM. Atrophic gastritis in Sjogren's syndrome: morphologic, biochemical, and immunologic findings. Arthritis Rheum. 1985;28:388-394.
28. Ostuni PA, Germana B, Di Mario F, et al. Gastric involvement in primary Sjogren's syndrome. Clin Exp Rheumatol. 1993;11:21-25.
29. Pokorny G, Karacsony G, Lonovics J, et al. Types of atrophic gastritis in patients with primary Sjogren's syndrome. Ann Rheum Dis. 1991;50:97-100.
30. Buchanan WW, Cox AG, RMcG Harden, et al. Gastric studies in Sjogren's syndrome. Gut. 1966;7:351-354.
31. Kilpi A, Bergroth V, Konttinen YT, et al. Lymphocyte infiltrations of the gastric mucosa in Sjogren's syndrome: an immunoperoxidase study using monoclonal antibodies in the avidin-biotin-peroxidase method. Arthritis Rheum. 1983;26:1196-1200.
32. Nardi N, Brito-Zeron P, Ramos-Casals M, et al. Circulating auto-antibodies against nuclear and non-nuclear antigens in primary Sjogren's syndrome: prevalence and clinical significance in 335 patients. Clin Rheumatol. 2006;25:341-346.
33. Pedro-Botet J, Coll J, Tomas S, et al. Primary Sjogren's syndrome associated with chronic atrophic gastritis and pernicious anemia. J Clin Gastroenterol. 1993;16:146-148.
34. Theander E, Nilsson I, Manthorpe R, et al. Seroprevalence of Helicobacter pylori in primary Sjogren's syndrome. Clin Exp Rheumatol. 2001;19:633-638.
35. Aragona P, Magazzu G, Macchia G, et al. Presence of antibodies against H. pylori and its heat shock protein 60 in the serum of patients with Sjogren's syndrome. J Rheumatol. 1999;26:1306-1311.
36. Ferraccioli GF, Sorrentino D, De Vita S, et al. B cell clonality in gastric lymphoid tissues of patients with Sjogren's syndrome. Ann Rheum Dis. 1996;55:311-316.
37. Sorrentino D, Faller G, Devita S, et al. Helicobacter pylori associated antigastric autoantibodies: role in Sjogren's syndrome gastritis. Helicobacter. 2004;9:46-53.
38. De Vita S, Boiocchi M, Sorrentino D, et al. Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjogren's syndrome. Arthritis Rheum. 1997;40:318-331.
39. Krogh K, Asmussen K, Stengaard-Pedersen K, et al. Bowel symptoms in patients with primary Sjogren's syndrome. Scand J Rheumatol. 2007;36:407-409.
40. Szodoray P, Barta Z, Lakos G, et al. Coeliac disease in Sjogren's syndrome-a study of 111 Hungarian patients. Rheumatol Int. 2004;24:278-282.
41. Iltanen S, Collin P, Korpela M, et al. Coeliac disease and markers of celiac disease latency in patients with primary Sjogren's syndrome. Am J Gastroenterol. 1999;94:1042-1046.
42. Liden M, Kristjansson G, Valtysdottir S, et al. Gluten sensitivity in patients with primary Sjogren's syndrome. Scand J Gastroenterol. 2007;42:962-967.
43. Alvarez-Celorio MD, Angeles-Angeles A, Kraus A. Primary Sjogren's syndrome and celiac disease: causal association or serendipity? J Clin Rheumatol. 2000;6:194-197.
44. Maclaurin BP, Matthews N, Kilpatrick JA. Coeliac disease associated with auto-immune thyroiditis, Sjogren's syndrome, and a lymphocytotoxic serum factor. Aust New Zealand J Med. 1972;2:405-411.
45. Patinen P, Aine L, Collin P, et al. Oral findings in celiac disease and Sjogren's syndrome. Oral Dis. 2004;10:330-334.
46. Liden M, Kristjansson G, Valtysdottir S, et al. Cow's milk protein sensitivity assessed by the mucosal patch technique is related to irritable bowel syndrome in patients with primary Sjogren's syndrome. Clin Exp Allergy. 2008;38:929-935.
47. Gainey R, Rooney PJ, Alspaugh M. Sjogren's syndrome and Crohn's disease. Clin Exp Rheumatol. 1985;3:67-69.
48. Katsanos KH, Saougos V, Kosmidou M, et al. Sjogren's syndrome in a patient with ulcerative colitis and primary sclerosing cholangitis: case report and review of the literature. J Crohn Colitis. 2009;3:200-203.
49. Johnson CD. Obstructive jaundice in a patient with ulcerative colitis, Sjogren's syndrome, and sarcoidosis. J Royal Soc Med. 1989;82:362.
50. Cox NJ, McCrea JD. A case of Sjogren's syndrome, sarcoidosis, previous ulcerative colitis, and gastric autoantibodies. Br J Dermatol. 1996;134:1138-1140.
51. Palm A, Moum B, Gran JT. Estimation of Sjogren's syndrome among IBD patients: a six year post-diagnostic prevalence study. Scand J Rheumatol. 2002;31:140-145.
52. Ikeda H, Toyonaga A, Suga H, et al. A case of pneumatosis cystoides coli associated with Sjogren's syndrome. Dig Endosc. 1996;8:302-305.
53. Nagayama Y, Fujisawa A, Furutani A, et al. Carcinoma of the sigmoid colon associated with Sjogren's syndrome. J Clin Gastroenterol. 1993;17:268-269.
54. Adachi Y, Yabana T, Kohri T, et al. A case of chronic idiopathic intestinal pseudo-obstruction with Sjogren's syndrome. Jpn J Gastroenterol. 1990;87:1223-1227.
55. Doyle MK. Vasculitis associated with connective tissue disorders. Curr Rheum Reports. 2006;8:312-316.
56. Kelly CA, Foster H, Pal B, et al. Primary Sjogren's syndrome in north east England-a longitudinal study. Br J Rheumatol. 1991;30:437-442.
57. Hayakawa T, Naruse S, Kitagawa M, et al. Clinical aspects of autoimmune pancreatitis in Sjogren's syndrome. J Pancreas (online). 2001;1:88-92.
58. Coll J, Navarro S, Tomas R, et al. Exocrine pancreatic function in Sjogren's syndrome. Arch Intern Med. 1989;149:848-852.
59. Grindulis KA, Roy S. Renal and pancreatic calcification in rheumatoid arthritis with Sjogren's syndrome. Br J Rheumatol. 1987;26:212-215.
60. Koopmans PP, Bodeutsch C, de Wilde PCM, et al. Primary Sjogren's syndrome presenting as a case of sarcoidosis and a suspected pancreatic tumour. Ann Rheum Dis. 1990;49:407-409.
61. Safadi R, Ligumsky M, Goldin E, et al. Increased serum CA 19-9 antibodies in Sjogren's syndrome. Postgrad Med J. 1998;74:543-544.
62. Fenster LF, Buchanan WW, Laster L, et al. Studies of pancreatic function in Sjogren's syndrome. Ann Intern Med. 1964;61:498-508.
63. Dreiling DA, Soto JM. The pancreatic involvement in disseminated "collagen" disorders: studies of pancreatic secretion in patients with scleroderma and Sjogren's "disease". Am J Gastroenterol. 1976;66:546-553.
64. Lankisch PG, Otto J, Arglebe C, et al. Pancreatic function in Sjogren's syndrome. Dig Dis Sci. 1988;33:1499.
65. Nishimori I, Morita M, Kino J, et al. Pancreatic involvement in patients with Sjogren's syndrome and primary biliary cirrhosis. Intern J Gastroint Cancer. 1995;17:47-54.
66. Gobelet C, Gerster JC, Rappoport G, et al. A controlled study of the exocrine pancreatic function in Sjogren's syndrome and rheumatoid arthritis. Clin Rheumatol. 1983;2:139-143.
67. Afzelius P, Fallentin EM, Larsen S, et al. Pancreatic function and morphology in Sjogren's syndrome. Scand J Gastroenterol. 2010;45:752-758.
68. Waldram R, Kopelman H, Tsantoulas D, et al. Chronic pancreatitis, sclerosing cholangitis, and sicca complex in two siblings. Lancet. 1975;1:550-552.
69. Montefusco PP, Geiss AC, Bronzo RL, et al. Sclerosing cholangitis, chronic pancreatitis, and Sjogren's syndrome: a syndrome complex. Am J Surg. 1984;147:822-826.
70. Pickartz T, Pickartz H, Lochs H, et al. Overlap syndrome of autoimmune pancreatitis and cholangitis associated with secondary Sjogren's syndrome. Eur J Gastroenterol Hepatol. 2004;16:1295-1299.
71. Takeda Y, Ohya T. Sicca symptom in a patient with hemochromatosis: minor salivary gland biopsy for differential diagnosis. Internat J Oral Max Surg. 1987;16:745-748.
72. Miller EB, Shichmanter R, Friedman JA, et al. Granulomatous hepatitis and Sjogren's syndrome: an association. Semin Arthritis Rheum. 2006;36:153-158.
73. Csepregi A, Szodoray P, Zeher M. Do autoantibodies predict autoimmune liver disease in primary Sjogren's syndrome? Data of 180 patients upon a 5 year follow-up. Scand J Immunol. 2002;56:623-629.
74. Montano-Loza AJ, Crispin-Acuna JC, Remes-Troche JM, et al. Abnormal hepatic biochemistries and clinical liver disease in patients with primary Sjogren's syndrome. Ann Hepatol. 2007;6:150-155.
75. Kaplan MI, Ike RW. The liver is a common non-exocrine target in primary Sjogren's syndrome: a retrospective review. BMC Gastroenterol. 2002;2:21-30.
76. Tokuno T, Takahashi H, Suzuki C, et al. Analysis of B-cell clonality in the hepatic tissue of patients with Sjogren's syndrome. Scand J Rheumatol. 2003;32:268-272.
77. Okubo H, Maekawa H, Ogawa K, et al. Pseudolymphoma of the liver associated with Sjogren's syndrome. Scand J Rheumatol. 2001;30:117-119.
78. McFarlane IG, Wojcicka BM, Tsantoulas DC, et al. Cellular immune responses to salivary antigens in autoimmune liver disease with sicca syndrome. Clin Exp Immunol. 1976;25:389-395.
79. Dorner T, Held C, Trebeljahr G, et al. Serologic characteristics in primary biliary cirrhosis associated with sicca syndrome. Scand J Gastroenterol. 1994;29:655-660.
80. Uddenfeldt P, Danielsson A, Forssell A, et al. Features of Sjogren's syndrome in patients with primary biliary cirrhosis. J Intern Med. 1991;230:443-448.
81. Tsianos EV, Hoofnagle JH, Fox PC, et al. Sjogren's syndrome in patients with primary biliary cirrhosis. Hepatology. 1990;11:730-734.
82. Alarcon-Segovia D, Diaz-Jouanen E, Fishbein E. Features of Sjogren's syndrome in primary biliary cirrhosis. Ann Intern Med. 1973;36:31-36.
83. Hansen BU, Lindgren S, Eriksson S, et al. Clinical and immunological features of Sjogren's syndrome in patients with primary biliary cirrhosis with emphasis on focal sialadenitis. Acta Med Scand. 1988;224:611-619.
84. Dorner T, Feist E, Held C, et al. Differential recognition of the 52-kd Ro (SS-A) antigen by sera from patients with primary biliary cirrhosis and primary Sjogren's syndrome. Hepatology. 1996;24:1404-1407.
85. Skopouli FN, Barbatis C, Moutsopoulos HM. Liver involvement in primary Sjogren's syndrome. J Rheumatol. 1994;33:745-748.
86. Zurgil N, Bakimer R, Moutsopoulos M, et al. Antimitochondrial (pyruvate dehydrogenase) autoantibodies in autoimmune rheumatic diseases. J Clin Immunol. 1992;12:201-209.
87. Tsuneyama K, Van de Water J, Nakanuma Y, et al. Human combinatorial autoantibodies and mouse monoclonal antibodies to PDC-E2 produce abnormal apical staining of salivary glands in patients with coexistent primary biliary cirrhosis and Sjogren's syndrome. Hepatology. 1994;20:893-898.
88. Fujikura S, Davis PA, Prindiville T, et al. Sjogren's syndrome and primary biliary cirrhosis: presence of autoantibodies to purified mitochondrial 2-oxoacid dehydrogenases. J Rheumatol. 1990;17:1453-1457.
89. Karp JK, Akpek EK, Anders RA. Autoimmune hepatitis in patients with primary Sjogren's syndrome: a series of two-hundred and two patients. Int J Clin Exp Pathol. 2010;3:582-586.
90. Matsumoto T, Morizane T, Aoki Y, et al. Autoimmune hepatitis in primary Sjogren's syndrome: pathological study of the livers and labial salivary glands in 17 patients with primary Sjogren's syndrome. Pathol Int. 2005;55:70-76.
91. Archimandritis A, Tjivras M, Tsirantonaki M, et al. Sjogren's syndrome with antimitochondrial antibody-negative primary biliary cirrhosis: a case of autoimmune cholangitis. J Clin Gastroenterol. 1995;20:268-270.
92. Ferreiro MC, Prieto MH, Rodriguez SB, et al. Whole stimulated salivary flow in patients with chronic hepatitis C virus infection. J Oral Pathol Med. 2002;31:117-120.
93. Haddad J, Deny P, Munz-Gotheil C, et al. Lymphocytic sialadenitis of Sjogren's syndrome associated with chronic hepatitis C virus liver disease. Lancet. 1992;339:321-323.
94. Poet JL, Tonolli-Serabian I, Garnier PP. Chronic hepatitis C and Sjogren's syndrome. J Rheumatol. 1994;21:1376-1377.
95. Almasio A, Provenzano G, Scimeni M, et al. Hepatitis C virus and Sjogren's syndrome. Lancet. 1992;339:989-990.
96. Verbaan H, Carlson J, Eriksson S, et al. Extrahepatic manifestations of chronic hepatitis C infection and the interrelationship between primary Sjogren's syndrome and hepatitis C in Swedish patients. J Intern Med. 1999;245:127-132.
97. Ramos-Casals M, Garcia-Carrasco M, Cervera R, et al. Sjogren's syndrome and hepatitis C virus. Clin Rheumatol. 1999;18:93-100.
98. Jorgensen C, Legouffe MC, Perney P, et al. Sicca syndrome associated with hepatitis C virus infection. Arthritis Rheum. 1996;39:1166-1171.
99. De Vita S, Damato R, De Marchi G, et al. True primary Sjogren's syndrome in a subset of patients with hepatitis C infection: a model linking chronic infection to chronic sialadenitis. Isr Med Assoc J. 2002;4:1101-1105.
100. Ramos-Casals M, Garcia-Carrasco M, Cervera R, et al. Hepatitis C virus infection mimicking primary Sjogren syndrome. Medicine. 2001;80:1-8.
101. Loustaud-Ratti V, Riche A, Liozon E, et al. Prevalence and characteristics of Sjogren's syndrome or sicca syndrome in chronic hepatitis C virus infection: a prospective study. J Rheumatol. 2001;28:2245-2251.
102. Takamatsu K, Koyanagi Y, Okita K, et al. Hepatitis C virus RNA in saliva. Lancet. 1990;336:1515.
103. Arrieta JJ, Rodriguez-Inigo E, Ortiz-Movilla N, et al. In situ detection of hepatitis C virus RNA in salivary glands. Am J Pathol. 2001;158:259-264.
104. Hsu HH, Wright TL, Luba D, et al. Failure to detect hepatitis C virus genome in human secretions with the polymerase chain reaction. Hepatology. 1991;14:763-767.
105. Prunoiu C, Georgescu EF, Georgescu M, et al. Sjogren's syndrome associated with chronic hepatitis C-the benefit of the antiviral treatment. Rom J Morph Embry. 2008;49:557-562.
106. Unoki H, Moriyama A, Tabaru A, et al. Development of Sjogren's syndrome during treatment with recombinant human interferon-alpha-2b for chronic hepatitis C. J Gastroenterol. 1996;31:723-727.
107. Coll J, Gambus G, Corominas J, et al. Immunohistochemistry of minor salivary gland biopsy specimens from patients with Sjogren's syndrome with and without hepatitis C virus infection. Ann Rheum Dis. 1997;56:390-392.
108. Ramos-Casals M, Loustaud-Ratti V, De Vita S, et al. Sjogren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases. Medicine. 2005;84:81-89.
109. De Re V, De Vita S, Gasparotto D, et al. Salivary gland B cell lymphoproliferative disorders in Sjogren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas. Eur J Immunol. 2002;32:903-910.
110. Koike K, Moriya K, Ishibashi K, et al. Sialadenitis histologically resembling Sjogren syndrome in mice transgenic for hepatitis C virus envelope genes. Proc Natl Acad Sci USA. 1997;94:233-236.