Modification by the genes ALAD and VDR of lead-induced cognitive effects in children

NeuroToxicology

Volumn 33, Issue 1, 2012, Pages 37-43

  Pawlas, Natalia ^a   Broberg, Karin ^b   Olewińska, Elzbieta ^a   Prokopowicz, Adam ^a   Skerfving, Staffan ^b   Pawlas, Krystyna ^a,c  

^a INSTITUTE OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH   (Poland)

^b LUND UNIVERSITY   (Sweden)

^c WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Central nervous system; Gene environment interaction; IQ; Lead; Neurotoxicity; Polymorphism

Indexed keywords

LEAD; PORPHOBILINOGEN SYNTHASE; VITAMIN D RECEPTOR;

ARTICLE; BLOOD SAMPLING; CHILD; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DNA EXTRACTION; DNA MODIFICATION; DNA POLYMORPHISM; ETHNICITY; FEMALE; GENETIC SCREENING; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE DETECTION; HOMOZYGOSITY; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; NEUROTOXICITY; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOLOGIC TEST; SCHOOL CHILD;

ADOLESCENT; CHILD; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTELLIGENCE; INTELLIGENCE TESTS; LEAD; LEAD POISONING; MALE; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TESTS; POLAND; POLYMORPHISM, GENETIC; PORPHOBILINOGEN SYNTHASE; RECEPTORS, CALCITRIOL; RETROSPECTIVE STUDIES;

EID: 84856473787     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.10.012     Document Type: Article

References (27)

1. Bellinger D.C. Interpreting epidemiologic studies of developmental neurotoxicity: conceptual and analytic issues. Neurotoxicol Teratol 2009, 31:267-274.
2. Bellinger D.C. Lead neurotoxicity in children: knowledge gaps and research needs. Human developmental neurotoxicology 2006, 67-82. Taylor & Francis, New York. D.C. Bellinger (Ed.).
3. Bellinger D., Hu H., Titlebaum L., Needleman H.L. Attentional correlates of dentin and bone lead levels in adolescents. Arch Environ Health 1994, 49:98-105.
4. Chia S.E., Huijun Z., Theng T.M., Yap E. Possibilities of newer ALAD polymorphism influencing human susceptibility to effects of inorganic lead on the neurobehavioral functions. Neurotoxicology 2007, 28:312-317.
5. Epstein R.J., Lin K., Tan T.W. A functional significance for codon third bases. Gene 2000, 245:291-298.
6. Fredrick K., Ibba M. How the sequence of a gene can tune its translation. Cell 2010, 141:227-229.
7. Gao A., Lu X.T., Li Q.Y., Tian L. Effect of the delta-aminolevulinic acid dehydratase gene polymorphism on renal and neurobehavioral function in workers exposed to lead in China. Sci Total Environ 2010, 408:4052-4055.
8. Haynes E.N., Kalkwarf H.J., Hornung R., Wenstrup R., Dietrich K., Lanphear B.P. Vitamin D receptor Fok1 polymorphism and blood lead concentration in children. Environ Health Perspect 2003, 111:1665-1669.
9. Krieg E.F., Butler M.A., Chang M.H., Liu T., Yesupriya A., Lindegren M.L., et al. Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey. Neurotoxicol Teratol 2009, 31:364-371.
10. Krieg E.F., Butler M.A., Chang M.H., Liu T., Yesupriya A., Dowling N., et al. Lead and cognitive function in VDR genotypes in the third National Health and Nutrition Examination Survey. Neurotoxicol Teratol 2010, 32:262-272.
11. Kmiecik-Małecka E., Małecki A., Pawlas N., Woźniakowa Y., Pawlas K. The effect of blood lead concentration on EEG, brain electric activity mapping and psychological tests results in children. Pol J Environ Stud 2009, 18:1021-1027.
12. Lanphear B.P., Hornung R., Khoury J., Yolton K., Baghurst P., Bellinger D.C., et al. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect 2005, 113:894-899.
13. Matczak A., Piotrowska A., Ciarkowska W. Skala Inteligencji Wechslera dla Dzieci - Wersja Zmodyfikowana WISC-R 1997, Polskie Towarzystwo Psychologiczne, Warszawa. 2nd ed.
14. Mazumdar M., Bellinger D.C., Gregas M., Abanilla K., Bacic J., Needleman H.L. Low-level environmental lead exposure in childhood and adult intellectual function: a follow-up study. Environ Health 2011, 10(24). [online 30 March 2011]. 10.1186/1476-069X-10-24.
15. Nordberg G.F., Gerhardsson L., Broberg K., Mumtaz M., Ruiz P., Fowler B.A. Interactions in metal toxicology. Handbook on the toxicology of metals 2007, 117-145. Academic Press/Elsevier, [chapter 7]. G.F. Nordberg, B.A. Fowler, M. Nordberg, L.T. Friberg (Eds.).
16. Rajan P., Kelsey K.T., Schwartz J.D., Bellinger D.C., Weuve J., Sparrow D., et al. Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study. Am J Epidemiol 2007, 166(12):1400-1408.
17. Rajan P., Kelsey K.T., Schwartz J.D., Bellinger D.C., Weuve J., Spiro A., et al. Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study. J Occup Environ Med 2008, 50:1053-1061.
18. Rezende V.B., Barbosa F., Montenegro M.F., Sandrim V.C., Gerlach R.F., Tanus-Santos J.E. Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects. Arch Toxicol 2008, 82:29-36.
19. Schwartz B.S., Lee B.K., Lee G.S., Stewart W.F., Simon D., Kelsey K., et al. Associations of blood lead, dimercaptosuccinic acid chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes. Environ Health Perspect 2000, 108:949-954.
20. Scinicariello F., Murray H.E., Moffett D.B., Abadin H.G., Sexton M.J. Lead and -aminolevulic acid dehydratase polymorphism: where does it lead? A meta-analysis. Environ Health Perspect 2007, 115:35-41.
21. Stoeppler M., Brandt K., Rains T.C. Contribution to automated trace analysis. Part II. Rapid method for the automated determination of lead in whole blood by electrothermal atomic-absorption spectrophotometry. Analyst 1978, 103:714-722.
22. Strömberg U., Lundh T., Skerfving S. Yearly measurements of blood lead in Swedish children since 1978: the declining trend continues in the petrol-lead-free period 1995-2007. Environ Res 2008, 107:332-335.
23. Uitterlinden A.G., Fang Y., van Meurs J.B.J., Pols H.A.P., van Leeuwen J.P.T.M. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004, 338:143-156.
24. Wechsler D. Manual for Wechler intelligence scale for children - revised 1974, The Psychological Corporation, San Antionio, TX.
25. Weuve J., Kelsey K.T., Schwartz J., Bellinger D., Wright R.O., Rajan P., et al. Delta-aminolevulinic acid dehydratase polymorphism and the relation between low level lead exposure and the Mini-Mental Status Examination in older men: the Normative Aging Study. Occup Environ Med 2006, 63(11):746-753.
26. Zhao Y., Wang L., Shen H.B., Wang Z.X., Wei Q.Y., Chen F. Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis. J Toxicol Environ Health A 2007, 70:1986-1994.
27. Zheng G., Tian L., Liang Y., Broberg K., Lei L., Guo W., et al. δ-Aminolevulinic acid dehydratase genotype predicts toxic effects of lead on worker's peripheral nervous system. Neurotoxicology 2011, 32(4):374-382.