Chitosan enhances mineralization during osteoblast differentiation of human bone marrow-derived mesenchymal stem cells, by upregulating the associated genes

Cell Proliferation

Volumn 44, Issue 6, 2011, Pages 537-549

  Mathews, S ^a   Gupta, P K ^a   Bhonde, R ^a   Totey, S ^b  

^a Manipal Academy of Higher Education   (India)

^b Kasiak Research Pvt Ltd   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; CALCIUM; CHITOSAN; COLLAGEN TYPE 1; OSTEOCALCIN; OSTEONECTIN; OSTEOPONTIN; COLLAGEN TYPE I, ALPHA 1 CHAIN;

ARTICLE; CALCIUM BINDING; CELL ADHESION; CELL AGGREGATION; CELL DIFFERENTIATION; CELL VIABILITY; GENE CONTROL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MATERIAL COATING; MESENCHYMAL STEM CELL; MINERALIZATION; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TISSUE CULTURE; BONE MARROW CELL; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM;

BONE MARROW CELLS; CALCIUM; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHITOSAN; COLLAGEN TYPE I; HUMANS; INTEGRIN-BINDING SIALOPROTEIN; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOCALCIN; OSTEONECTIN; OSTEOPONTIN; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84856425217     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2011.00788.x     Document Type: Article

References (48)

1. Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos. Int. 17, 1726-1733.
2. Salgado AJ, Coutinho OP, Reis RL (2004) Bone tissue engineering: state of the art and future trends. Macromol. Biosci. 4, 743-765.
3. Kneser U, Schaefer DJ, Polykandriotis E, Horch RE (2006) Tissue engineering of bone: the reconstructive surgeon's point of view. J. Cell Mol. Med. 10, 7-19.
4. Bajada S, Mazakova I, Richardson JB, Ashammakhi N (2008) Updates on stem cells and their applications in regenerative medicine. J. Tissue Eng. Regen. Med. 2, 169-183.
5. Meijer GJ, de Bruijn JD, Koole R, van Blitterswijk CA (2007) Cell-based bone tissue engineering. PLoS Med. 4, e9.
6. Corona BT, Ward CL, Harrison BS, Christ GJ (2010) Regenerative medicine: basic concepts, current status, and future applications. J. Investig. Med. 58, 849-858.
7. Bianco P, Robey PG (2001) Stem cells in tissue engineering. Nature 414, 118-121.
8. Chatterjea A, Meijer G, van Blitterswijk C, de Boer J (2010) Clinical application of human mesenchymal stromal cells for bone tissue engineering. Stem Cells Int. 2010, 215625.
9. Mauney J, Volloch V, Kaplan DL (2005) Role of adult mesenchymal stem cells in bone tissue engineering applications. Current status and future prospects. Tissue Eng. 11, 787-802.
10. Hernandez EC, Mikos AG (2008) New biomaterials as scaffolds for tissue engineering. Pharm. Res. 25, 2345-2347.
11. Meinel L, Karageorgiou V, Fajardo R, Snyder B, Shinde-Patil V, Zichner L et al. (2004) Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Ann. Biomed. Eng. 32, 112-122.
12. Nair LS, Laurencin CT (2006) Polymers as biomaterials for tissue engineering and controlled drug delivery. Adv. Biochem. Eng. Bio-technol. 102, 47-90.
13. Peniche C, Fernández M, Rodríguez G, Parra J, Jimenez J, Bravo AL et al. (2007) Cell supports of chitosan/hyaluronic acid and chondroitin sulphate systems. Morphology and biological behaviour. J. Mater. Sci. Mater. Med. 18, 1719-1726.
14. Yang X, Chen X, Wang H (2009) Acceleration of osteogenic differentiation of preosteoblastic cells by chitosan containing nanofibrous scaffolds. Biomacromolecules 10, 2772-2778.
15. Venkatesan J, Kim SK (2010) Chitosan composites for bone tissue engineering - an overview. Mar. Drugs 8, 2252-2266.
16. Pal R, Hanwate M, Totey SM (2008) Effect of holding time, temperature and different parenteral solutions on viability and functionality of adult bone marrow-derived mesenchymal stem cells before transplantation. J. Tissue Eng. Regen. Med. 2, 436-444.
17. + cord blood cells on glycosaminoglycan surfaces. Stem Cells 17, 295-305.
18. Sabokbar A, Millett PJ, Myer B, Rushton N (1994) A rapid, quantitative assay for measuring alkaline phosphatase activity in osteoblastic cells in vitro. Bone Miner. 27, 57-67.
19. Mori K, Shioi A, Jono S, Nishizawa Y, Morii H (1998) Expression of matrix Gla protein (MGP) in an in vitro model of vascular calcification. FEBS Lett. 433, 19-22.
20. -ΔΔCT method. Methods 25, 402-408.
21. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147.
22. Caplan AI (1991) Mesenchymal stem cells. J. Orthop. Res. 9, 641-650.
23. Lin SJ, Jee SH, Hsaio WC, Lee SJ, Young TH (2005) Formation of melanocyte spheroids on the chitosan-coated surface. Biomaterials 26, 1413-1422.
24. Clegg RE, Leavesley DI, Pearcy MJ (2005) Mediation of biomaterial-cell interactions by adsorbed proteins: a review. Tissue Eng. 11, 1-18.
25. Hallab NJ, Bundy KJ, O'Connor K, Clark R, Moses RL (1995) Cell adhesion to biomaterials: correlations between surface charge, surface roughness, adsorbed protein, and cell morphology. J. Long Term Eff. Med. Implants 5, 209-231.
26. Chandra V, G S, Phadnis S, Nair PD, Bhonde RR (2009) Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells. Stem Cells 27, 1941-1953.
27. Sila-Asna M, Bunyaratvej A, Maeda S, Kitaguchi H, Bunyaratavej N (2007) Osteoblast differentiation and bone formation gene expression in strontium-inducing bone marrow mesenchymal stem cell. Kobe J. Med. Sci. 53, 25-35.
28. Allen MJ (2003) Biochemical markers of bone metabolism in animals: uses and limitations. Vet. Clin. Pathol. 32, 101-113.
29. Siffert RS (1951) The role of alkaline phosphatase in osteogenesis. J. Exp. Med. 93, 415-426.
30. Golub EE, Boesze-Battaglia K (2007) The role of alkaline phosphatase in mineralization. Curr. Opin. Orthop. 18, 444-448.
31. Balcerzak M, Hamade E, Zhang L, Pikula S, Azzar G, Radisson J et al. (2003) The roles of annexins and alkaline phosphatase in mineralization process. Acta Biochim. Pol. 50, 1019-1038.
32. Gong Z, Wezeman FH (2004) Inhibitory effect of alcohol on osteogenic differentiation in human bone marrow-derived mesenchymal stem cells. Alcohol. Clin. Exp. Res. 28, 468-479.
33. Clarke B (2008) Normal bone anatomy and physiology. Clin. J. Am. Soc. Nephrol. 3, S131-S139.
34. Park CJ, Gabrielson NP, Pack DW, Jamison RD, Wagoner Johnson AJ (2009) The effect of chitosan on the migration of neutrophil-like HL60 cells, mediated by IL-8. Biomaterials 30, 436-444.
35. Scanga VI, Goraltchouk A, Nussaiba N, Shoichet MS, Morshead CM (2010) Biomaterials for neural-tissue engineering-chitosan supports the survival, migration, and differentiation of adult-derived neural stem and progenitor cells. Can. J. Chem. 88, 277-287.
36. Fakhry A, Schneider GB, Zaharias R, Senel S (2004) Chitosan supports the initial attachment and spreading of osteoblasts preferentially over fibroblasts. Biomaterials 25, 2075-2079.
37. Komori T (2002) Runx2, a multifunctional transcription factor in skeletal development. J. Cell. Biochem. 87, 1-8.
38. Lian JB, Javed A, Zaidi SK, Lengner CJ, Montecino M, Van Wijnen AJ et al. (2004) Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit. Rev. Eukaryot. Gene Expr. 14, 1-2.
39. Zhu W, Robey PG, Boskey AL (2009) The regulatory role of matrix proteins in mineralization of bone. In: Marcus R, Feldman D, Nelson D, Rosen CJ, ed. Fundamentals of Osteoporosis, pp. 153-202. San Diego, CA: Elsevier Academic Press.
40. Ganss B, Kim RH, Sodek J (1999) Bone sialoprotein. Crit. Rev. Oral Biol. Med. 10, 79-98.
41. Roach HI (1994) Why does bone matrix contain non-collagenous proteins? The possible roles of osteocalcin, osteonectin, osteopontin and bone sialoprotein in bone mineralisation and resorption Cell Biol. Int. 18, 617-628.
42. Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, Martin GR (1981) Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26(1 Pt 1): 99-105.
43. Kim GS (1993) Mineralization of bone and osteocalcin gene expression. J. Oral Biol. 17, 101-106.
44. Malaval L, Liu F, Roche P, Aubin JE (1999) Kinetics of osteoprogenitor proliferation and osteoblast differentiation in vitro. J. Cell. Biochem. 74, 616-627.
45. Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H (2006) Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene 372, 62-70.
46. Zhang C (2010) Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx. J. Orthop. Surg. Res. 5, 37.
47. Kulterer B, Friedl G, Jandrositz A, Sanchez-Cabo F, Prokesch A, Paar C et al. (2007) Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation. BMC Genomics 8, 70.
48. Karner E, Unger C, Sloan AJ, Richter LA, Sugars RV, Wendel M (2007) Bone matrix formation in osteogenesis cultures derived from human embryonic stem cells in vitro. Stem Cells Dev. 16, 1-13.