Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: Secondary analyses of a randomized controlled trial

Fertility and Sterility

Volumn 97, Issue 2, 2012, Pages 501-508

  Stener Victorin, Elisabet ^a,b   Baghaei, Fariba ^a   Holm, Göran ^a   Janson, Per Olof ^a   Olivecrona, Gunilla ^c   Lönn, Malin ^a   Manners Holm, Louise ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

Acupuncture; adipocyte size; exercise; hemostatic factor; insulin resistance; plasminogen activator inhibitor 1

Indexed keywords

FIBRINOGEN; LIPOPROTEIN LIPASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; VON WILLEBRAND FACTOR;

ADIPOSE TISSUE; ADULT; ANTHROPOMETRY; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ELECTROACUPUNCTURE; ENZYME ACTIVITY; FEMALE; FIBRINOLYSIS; HEMODYNAMICS; HUMAN; INSULIN SENSITIVITY; KINESIOTHERAPY; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE;

ADIPOCYTES; ADULT; BIOLOGICAL MARKERS; BLOOD COAGULATION; BLOOD PRESSURE; ELECTROACUPUNCTURE; EXERCISE THERAPY; FEMALE; FIBRINOGEN; FIBRINOLYSIS; HEART RATE; HUMANS; INSULIN RESISTANCE; LIPOPROTEIN LIPASE; OXYGEN CONSUMPTION; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYCYSTIC OVARY SYNDROME; PROSPECTIVE STUDIES; SUBCUTANEOUS FAT, ABDOMINAL; SWEDEN; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84856405124     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.11.010     Document Type: Article

References (50)

1. W.A. March, V.M. Moore, K.J. Willson, D.I. Phillips, R.J. Norman, and M.J. Davies The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria Hum Reprod 25 2010 544 551
2. The Rotterdam EA-sPcwg Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) Hum Reprod 19 2004 41 47
3. L. Manneras-Holm, H. Leonhardt, J. Kullberg, E. Jennische, A. Oden, and G. Holm Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance J Clin Endocrinol Metab 96 2011 E304 E311
4. H.J. Teede, S. Hutchison, S. Zoungas, and C. Meyer Insulin resistance, the metabolic syndrome, diabetes, and cardiovascular disease risk in women with PCOS Endocrine 30 2006 45 53 (Pubitemid 46020329)
5. A. Dunaif, K.R. Segal, W. Futterweit, and A. Dobrjansky Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome Diabetes 38 1989 1165 1174 (Pubitemid 19250404)
6. L. Manneras-Holm, F. Baghaei, G. Holm, P.O. Janson, C. Ohlsson, and M. Lonn Coagulation and fibrinolytic disturbances in women with polycystic ovary syndrome J Clin Endocrinol Metab 96 2011 1068 1076
7. F. Carmassi, F. De Negri, R. Fioriti, A. De Giorgi, C. Giannarelli, and F. Fruzzetti Insulin resistance causes impaired vasodilation and hypofibrinolysis in young women with polycystic ovary syndrome Thromb Res 116 2005 207 214 (Pubitemid 40776019)
8. Y.B. Sverrisdottir, T. Mogren, J. Kataoka, P.O. Janson, and E. Stener-Victorin Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth? Am J Physiol Endocrinol Metab 294 2008 E576 E581
9. ACOG Practice Bulletin No. 108: Polycystic ovary syndrome Obstet Gynecol 114 2009 936 949
10. L.J. Moran, S.K. Hutchison, R.J. Norman, and H.J. Teede Lifestyle changes in women with polycystic ovary syndrome Cochrane Database Syst Rev 2 2011 CD007506
11. G. Ladson, W.C. Dodson, S.D. Sweet, A.E. Archibong, A.R. Kunselman, and L.M. Demers The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study Fertil Steril 95 2011 1059 1066
12. K. Hoeger, K. Davidson, L. Kochman, T. Cherry, L. Kopin, and D.S. Guzick The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials J Clin Endocrinol Metab 93 2008 4299 4306 (Pubitemid 352789525)
13. E.T. Poehlman, R.V. Dvorak, W.F. DeNino, M. Brochu, and P.A. Ades Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial J Clin Endocrinol Metab 85 2000 2463 2468 (Pubitemid 32269201)
14. S.K. Hutchison, N.K. Stepto, C.L. Harrison, L.J. Moran, B.J. Strauss, and H.J. Teede Effects of exercise on insulin resistance and body composition in overweight and obese women with and without polycystic ovary syndrome J Clin Endocrinol Metab 96 2011 E48 E56
15. J.A. Colwell Effects of exercise on platelet function, coagulation, and fibrinolysis Diabetes Metab Rev 1 1986 501 512
16. C. Coulson, and J. Jenkins Complementary and alternative medicine utilisation in NHS and private clinic settings: a United Kingdom survey of 400 infertility patients J Exp Clin Assist Reprod 2 2005 5
17. J.F. Smith, M.L. Eisenberg, S.G. Millstein, R.D. Nachtigall, A.W. Shindel, and H. Wing The use of complementary and alternative fertility treatment in couples seeking fertility care: data from a prospective cohort in the United States Fertil Steril 93 2010 2169 2174
18. M. Stankiewicz, C. Smith, H. Alvino, and R. Norman The use of complementary medicine and therapies by patients attending a reproductive medicine unit in South Australia: a prospective survey Aust N Z J Obstet Gynaecol 47 2007 145 149 (Pubitemid 46390193)
19. E. Jedel, F. Labrie, A. Oden, G. Holm, L. Nilsson, and P.O. Janson Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial Am J Physiol Endocrinol Metab 300 2011 E37 E45
20. M.H. Lai, H.X. Ma, H. Yao, H. Liu, X.H. Song, and W.Y. Huang [Effect of abdominal acupuncture therapy on the endocrine and metabolism in obesity-type polycystic ovarian syndrome patients] Zhen Ci Yan Jiu 35 2010 298 302
21. L.M. Pastore, C.D. Williams, J. Jenkins, and J.T. Patrie True and sham acupuncture produced similar frequency of ovulation and improved LH to FSH ratios in women with polycystic ovary syndrome J Clin Endocrinol Metab 96 2011 3143 3150
22. B.Y. Chen, and J. Yu Relationship between blood radioimmunoreactive beta-endorphin and hand skin temperature during the electro-acupuncture induction of ovulation Acupunct Electrother Res 16 1991 1 5
23. E. Stener-Victorin, U. Waldenstrom, U. Tagnfors, T. Lundeberg, G. Lindstedt, and P.O. Janson Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome Acta Obstet Gynecol Scand 79 2000 180 188 (Pubitemid 30119790)
24. E. Stener-Victorin, E. Jedel, P.O. Janson, and Y.B. Sverrisdottir Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome Am J Physiol Regul Integr Comp Physiol 297 2009 R387 R395
25. G. Grassi, G. Seravalle, F. Quarti-Trevano, F. Scopelliti, R. Dell'Oro, and G. Bolla Excessive sympathetic activation in heart failure with obesity and metabolic syndrome: characteristics and mechanisms Hypertension 49 2007 535 541
26. F. Liang, and D. Koya Acupuncture: is it effective for treatment of insulin resistance? Diabetes Obes Metab 12 2010 555 569
27. S.H. Cho, J.S. Lee, L. Thabane, and J. Lee Acupuncture for obesity: a systematic review and meta-analysis Int J Obes (Lond) 33 2009 183 196
28. J. Johansson, F. Yi, R. Shao, M. Lonn, H. Billig, and E. Stener-Victorin Intense acupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome Am J Physiol Endocrinol Metab 299 2010 E551 E559
29. L. Manneras, I.H. Jonsdottir, A. Holmang, M. Lonn, and E. Stener-Victorin Low-frequency electro-acupuncture and physical exercise improve metabolic disturbances and modulate gene expression in adipose tissue in rats with dihydrotestosterone-induced polycystic ovary syndrome Endocrinology 149 2008 3559 3568 (Pubitemid 351919588)
30. F. Liang, R. Chen, A. Nakagawa, M. Nishizawa, S. Tsuda, and H. Wang Low-frequency electroacupuncture improves insulin sensitivity in obese diabetic mice through activation of SIRT1/PGC-1alpha in skeletal muscle Evid Based Complement Alternat Med 2011 2011 735297
31. S. Ishikawa, M. Murai, T. Sato, M. Sunagawa, E. Tokita, and S.K. Aung Promotion of blood fluidity by inhibition of platelet adhesion using electroacupuncture stimulation J Acupunct Meridian Stud 4 2011 44 53
32. J. Chen, C. Li, P. Ding, and Y. Ma Effect of acupuncture on plasmic levels of insulin, glucagon and hypercoagulability in NIDDM complicated by acute cerebral infarction J Tradit Chin Med 21 2001 267 269
33. L. Feng, J. Zhang, C. Wei, and Y. Sun Clinical observation on 30 cases of transient cerebral ischemia attack treated with acupuncture and medication J Tradit Chin Med 27 2007 100 102 (Pubitemid 350103909)
34. H.S. Randeva, K.C. Lewandowski, J. Drzewoski, K. Brooke-Wavell, C. O'Callaghan, and L. Czupryniak Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome J Clin Endocrinol Metab 87 2002 4496 4501 (Pubitemid 35247032)
35. R.B. Goldrick Morphological changes in the adipocyte during fat deposition and mobilization Am J Physiol 212 1967 777 782
36. D.R. Rosing, P. Brakman, D.R. Redwood, R.E. Goldstein, G.D. Beiser, and T. Astrup Blood fibrinolytic activity in man. Diurnal variation and the response to varying intensities of exercise Circ Res 27 1970 171 184
37. V. Fonseca, S.C. Guba, and L.M. Fink Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis Endocrinol Rev 20 1999 738 759 (Pubitemid 30650604)
38. M.E. Stegenga, S.N. van der Crabben, M. Levi, A.F. de Vos, M.W. Tanck, and H.P. Sauerwein Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans Diabetes 55 2006 1807 1812 (Pubitemid 44324136)
39. S. Tessier, E. Riesco, M. Lacaille, F. Perusse, J. Weisnagel, and J. Dore Impact of walking on adipose tissue lipoprotein lipase activity and expression in pre- and postmenopausal women Obes Facts 3 2010 191 199
40. R.B. Simsolo, J.M. Ong, and P.A. Kern The regulation of adipose tissue and muscle lipoprotein lipase in runners by detraining J Clin Invest 92 1993 2124 2130 (Pubitemid 23333515)
41. R.A. Wild, E. Carmina, E. Diamanti-Kandarakis, A. Dokras, H.F. Escobar-Morreale, and W. Futterweit Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society J Clin Endocrinol Metab 95 2010 2038 2049
42. S. Balducci, S. Zanuso, A. Nicolucci, P. De Feo, S. Cavallo, and P. Cardelli Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES) Arch Intern Med 170 2010 1794 1803
43. C. Vigorito, F. Giallauria, S. Palomba, T. Cascella, F. Manguso, and R. Lucci Beneficial effects of a three-month structured exercise training program on cardiopulmonary functional capacity in young women with polycystic ovary syndrome J Clin Endocrinol Metab 92 2007 1379 1384 (Pubitemid 46556413)
44. E.A. Macklin, P.M. Wayne, L.A. Kalish, P. Valaskatgis, J. Thompson, and M.C. Pian-Smith Stop Hypertension with the Acupuncture Research Program (SHARP): results of a randomized, controlled clinical trial Hypertension 48 2006 838 845 (Pubitemid 44610995)
45. J.M. Park, A.S. Shin, S.U. Park, I.S. Sohn, W.S. Jung, and S.K. Moon The acute effect of acupuncture on endothelial dysfunction in patients with hypertension: a pilot, randomized, double-blind, placebo-controlled crossover trial J Altern Complement Med 16 2010 883 888
46. M.J. Chen, W.S. Yang, J.H. Yang, C.L. Chen, H.N. Ho, and Y.S. Yang Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome Hypertension 49 2007 1442 1447
47. H.M. Langevin, P.M. Wayne, H. Macpherson, R. Schnyer, R.M. Milley, and V. Napadow Paradoxes in acupuncture research: strategies for moving forward Evid Based Complement Alternat Med 2011 2011 180 185
48. K. Linde, A. Streng, S. Jurgens, A. Hoppe, B. Brinkhaus, and C. Witt Acupuncture for patients with migraine: a randomized controlled trial JAMA 293 2005 2118 2125 (Pubitemid 40617064)
49. D. Melchart, A. Streng, A. Hoppe, B. Brinkhaus, C. Witt, and S. Wagenpfeil Acupuncture in patients with tension-type headache: randomised controlled trial BMJ 331 2005 376 382
50. A. Enblom, M. Lekander, M. Hammar, A. Johnsson, E. Onelov, and M. Ingvar Getting the grip on nonspecific treatment effects: emesis in patients randomized to acupuncture or sham compared to patients receiving standard care PLoS One 6 2011 e14766