Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: A randomized controlled trial

American Journal of Physiology - Endocrinology and Metabolism

Volumn 300, Issue 1, 2011, Pages

  Jedel, Elizabeth ^a   Labrie, Fernand ^b   Odén, Anders ^c   Holm, Göran ^d   Nilsson, Lars ^d   Janson, Per Olof ^d   Lind, Anna Karin ^d   Ohlsson, Claes ^d   Stener Victorin, Elisabet ^d,e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LAVAL UNIVERSITY   (Canada)

^c CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Acupuncture; Androgens; Estrogens; Exercise; Glucuronidated androgen metabolites; Oligomenorrhea; Sex steroid precursors

Indexed keywords

FOLLITROPIN; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN;

ADULT; AMENORRHEA; ARTICLE; BODY MASS; DIZZINESS; ELECTROACUPUNCTURE; ERYTHEMA; EXERCISE; FEMALE; FITNESS; GAS CHROMATOGRAPHY; HEMATOMA; HORMONE DETERMINATION; HUMAN; HYPERANDROGENISM; IMMUNOASSAY; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MENSTRUAL CYCLE; NAUSEA; OLIGOMENORRHEA; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 78650764162     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00495.2010     Document Type: Article

References (33)

1. ACOG Practice Bulletin No. 108. Polycystic ovary syndrome. Obstet Gynecol 114: 936-949, 2009.
2. Ahmed MI, Duleba AJ, El Shahat O, Ibrahim ME, Salem A. Naltrexone treatment in clomiphene resistant women with polycystic ovary syndrome. Hum Reprod 23: 2564-2569, 2008.
3. Åstrand PO. Quantification of exercise capability and evaluation of physical capacity in man. Prog Cardiovasc Dis 19: 51-67, 1976.
4. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar- Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 91: 456-488, 2009.
5. Benner S, Benner K. Improved performance in endurance sports through acupuncture. Sportverletz Sportschaden 24: 140-143, 2010.
6. Blank SK, McCartney CR, Helm KD, Marshall JC. Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty. Semin Reprod Med 25: 352-359, 2007.
7. Bonica J. The Management of Pain. London: Lea & Febiger, 1990, p. 2107.
8. Chen BY, Yu J. Relationship between blood radioimmunoreactive beta-endorphin and hand skin temperature during the electro-acupuncture induction of ovulation. Acupunct Electrother Res 16: 1-5, 1991.
9. Feng Y, Johansson J, Shao R, Månneras L, Fernandez-Rodriguez J, Billig H, Stener-Victorin E. Hypothalamic neuroendocrine functions in rats with dihydrotestosterone-induced polycystic ovary syndrome: effects of low-frequency electro-acupuncture. PLoS One 4: e6638, 2009.
10. Finniss DG, Kaptchuk TJ, Miller F, Benedetti F. Biological, clinical, and ethical advances of placebo effects. Lancet 375: 686-695, 2010.
11. Hatch R, Rosenfield RL, Kim MH, Tredway D. Hirsutism: implications, etiology, management. Am J Obstet Gynecol 140: 815-830, 1981.
12. Hoeger K, Davidson K, Kochman L, Cherry T, Kopin L, Guzick DS. The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials. J Clin Endocrinol Metab 93: 4299-4306, 2008.
13. Hoeger KM, Kochman L, Wixom N, Craig K, Miller RK, Guzick DS. A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: a pilot study. Fertil Steril 82: 421-429, 2004.
14. Kaptchuk TJ, Kelley JM, Conboy LA, Davis RB, Kerr CE, Jacobson EE, Kirsch I, Schyner RN, Nam BH, Nguyen LT, Park M, Rivers AL, McManus C, Kokkotou E, Drossman DA, Goldman P, Lembo AJ. Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. Biomed J 336: 999-1003, 2008.
15. Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, Coutifaris C, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice LC, Leppert PC, Myers ER. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med 356: 551-566, 2007.
16. MacPherson H, Altman DG, Hammerschlag R, Youping L, Taixiang W, White A, Moher D. Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): extending the CONSORT statement. PLoS Med 7: e1000261, 2010.
17. Månneras L, Cajander S, Lönn M, Stener-Victorin E. Acupuncture and exercise restore adipose tissue expression of sympathetic markers and improve ovarian morphology in rats with dihydrotestosterone-induced PCOS. Am J Physiol Regul Integr Comp Physiol 296: R1124-R1131, 2009.
18. Moran LJ, Pasquali R, Teede HJ, Hoeger KM, Norman RJ. Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertil Steril 92: 1966-1982, 2009.
19. Palomba S, Giallauria F, Falbo A, Russo T, Oppedisano R, Tolino A, Colao A, Vigorito C, Zullo F, Orio F. Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: a 24-week pilot study. Hum Reprod 23: 642-650, 2008.
20. Randeva HS, Lewandowski KC, Drzewoski J, Brooke-Wavell K, O'Callaghan C, Czupryniak L, Hillhouse EW, Prelevic GM. Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome. J Clin Endocrinol Metab 87: 4496-4501, 2002.
21. Stener-Victorin E, Fujisawa S, Kurosawa M. Ovarian blood flow responses to electroacupuncture stimulation depend on estrous cycle and on site and frequency of stimulation in anesthetized rats. J Appl Physiol 101: 84-91, 2006.
22. Stener-Victorin E, Holm G, Labrie F, Nilsson L, Janson PO, Ohlsson C. Are there any sensitive and specific sex steroid markers for polycystic ovary syndrome? J Clin Endocrinol Metab 95: 810-819, 2010.
23. Stener-Victorin E, Jedel E, Janson PO, Sverrisdottir YB. Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome. Am J Physiol Regul Integr Comp Physiol 297: R387-R395, 2009.
24. Stener-Victorin E, Jedel E, Månneras L. Acupuncture in polycystic ovary syndrome: current experimental and clinical evidence. J Neuroendocrinol 20: 290-298, 2008.
25. Stener-Victorin E, Waldenstrom U, Tägnfors U, Lundeberg T, Lindstedt G, Janson PO. Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome. Acta Obstet Gynecol Scand 79: 180-188, 2000.
26. Sverrisdottir YB, Mogren T, Kataoka J, Janson PO, Stener-Victorin E. Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth? Am J Physiol Endocrinol Metab 294: E576-E581, 2008.
27. Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH. Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study. Hum Reprod 21: 80-89, 2006.
28. The Rotterdam ESHRE/ASRM sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19: 41-47, 2004.
29. Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD. The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 93: 3373-3380, 2008.
30. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84: 3666-3672, 1999.
31. Xiaoming MO, Ding LI, Yunxing PU, Guifang XI, Xiuzhen LE, Zhimin FU. Clinical studies on the mechanism for acupuncture stimulation of ovulation. J Trad Chinese Med 13: 115-119, 1993.
32. Yildiz BO. Oral contraceptives in polycystic ovary syndrome: risk-benefit assessment. Semin Reprod Med 26: 111-120, 2008.
33. Yildiz BO, Azziz R. The adrenal and polycystic ovary syndrome. Rev Endocr Metab Disord 8: 331-342, 2007.