Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells

Journal of Biochemical and Molecular Toxicology

Volumn 26, Issue 1, 2012, Pages 16-22

  Ohno, Marumi ^a   Ikenaka, Yoshinori ^a   Ishizuka, Mayumi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Aryl hydrocarbon receptor; Cytochrome P450; Sudan III

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A1; MESSENGER RNA; OIL SCARLET;

ARTICLE; CELL NUCLEUS; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME INDUCTION; GEL MOBILITY SHIFT ASSAY; GENE TRANSLOCATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; TRANSACTIVATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; AZO COMPOUNDS; COLORING AGENTS; CYTOCHROME P-450 CYP1A1; ENZYME INDUCTION; HEP G2 CELLS; HUMANS; PROTEIN BINDING; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RESPONSE ELEMENTS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84856400782     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20408     Document Type: Article

References (25)

1. 32P-postlabeling of DNA adducts derived from peroxidative activation of carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I). Carcinogenesis 1990;11:1843-1848.
2. An Y, Jiang L, Cao J, Gengb C, Zhong L. Sudan I induces genotoxic effects and oxidative DNA damage in HepG2 cells. Mutat Res 2007;627:164-170.
3. Nahla AG, Zein SI, Gihan GM, Sakamoto KQ, Ishizuka M, Fujita S. The induction of cytochrome P450 1A1 by Sudan dyes. J Biochem Mol Toxicol 2008;22:77-84.
4. Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M. Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue. Toxicol Sci 2010;116:79-91.
5. Lubet RA, Connolly G, Kouri RE, Nebert DW, Bigelow SW. Biological effects of the Sudan dyes: role of the Ah cytosolic receptor. Biochem Pharmacol 1983;32:3053-3058.
6. Conney AH. Enzyme induction and dietary chemicals as approaches to cancer chemoprevention. Cancer Res 2003;63:7005-7031.
7. Nebert DW. Role of genetics and drug metabolism in human cancer risk. Mutation Res 1991;247:267-281.
8. McLemore TL, Adelberg S, Liu AC, McMahon NA, Yu SJ, Hubbard WC, Czerwinski M, Wood TG, Storeng R, Lubet RA, Eggleston JC, Boyd MR, Hines RN. Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. J Natl Cancer Inst 1990;82:1333-1339.
9. Sivaraman L, Leatham MP, Yee J, Wilkens LR, Lau AF, Marchand LL. CYP1A1 genetic polymorphisms and in situ colorectal cancer. Cancer Res 1994;54:3692-3695.
10. Gillner M, Bergman J, Cambillau C, Fernström B, Gustafsson JA. Interactions of indoles with specific binding sites for 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in rat liver. Mol Pharmacol 1985;28: 357-363.
11. Hestermann EV, Brown M. Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. Mol Cell Biol 2003;23:7920-7925.
12. Yoshinari K, Yoda N, Toriyabea T, Yamazoe Y. Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region. Biochem Pharmacol 2010;79:261-269.
13. Backlund M, Johansson I, Mkrtchian S, Ingelman-Sundberg M. Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells. J Biol Chem 1997;272:31755-31763.
14. Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 1999;274:6043-6046.
15. Piechocki MP, Hines RN. Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity. Carcinogenesis 1998;19:771-780.
16. Fujita S, Suzuki M, Peisach J, Suzuki T. Induction of hepatic microsomal drug metabolism by azo compounds: a structure-activity relationship. Chem Biol Interact 1984;52:15-37.
17. Fujita S, Matsunaga T, Masubuchi Y, Suzuki T. Possible mechanism of Sudan III-induced prevention of chemical carcinogenesis in rats. Cancer Res 1988;48:254-259.
18. Elbi C, Misteli T, Hager GL. Recruitment of dioxin receptor to active transcription sites. Mol Biol Cell 2001;13:2001-2015.
19. Fallonea F, Villarda PH, Séréea E, Rimeta O, Nguyena QB, Bourgarel-Reya V, Fouchiera F, Barraa Y, Durandb A, Lacarelle B. The intersection between the aryl hydrocarbon receptor (AhR)-and retinoic acid-signaling pathways. Biochem Biophys Res Commun 2004;322:551-556.
20. Rüegg J, Swedenborg E, Wahlström D, Escande A, Balaguer P, Pettersson K, Pongratz I. The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor β-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin. Mol Endocrinol 2008;22:304-316.
21. Ross-Innes CS, Stark R, Holmes KA, Schmidt D, Spyrou C, Russell R, Massie CE, Vowler SL, Eldridge M, Carroll JS. Cooperative interaction between retinoic acid receptor-α and estrogen receptor in breast cancer. Genes Dev 2010;24:171-182.
22. Robyr D, Wolffe AP, Wahli W. Nuclear hormone receptor coregulators in action: diversity for shared tasks. Mol Endocrinol 2000;14:329-347.
23. Zaher H, Yang TJ, Gelboin HV, Fernandez-Salguero P, Gonzalez FJ. Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse. Biochem Pharmacol 1998;55:235-238.
24. Sakuma T, Ohtake M, Katsurayama Y, Jarukamjorn K, Nemoto N. Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and-nonresponsive mice. Drug Metab Dispos 1999;27:379-384.
25. Shaban Z, El-Shazly S, Ishizuka M, Kimura K, Kazusaka A, Fujita S. PPARα-dependent modulation of hepatic CYP1A by clofibric acid in rats. Arch Toxicol 2004;78:496-507.