Combination antiretroviral therapy and chronic HIV infection affect serum retinoid concentrations: Longitudinal and cross-sectional assessments

AIDS Research and Therapy

Volumn 9, Issue , 2012, Pages

  Loignon, Maude ^a   Brodeur, Hélène ^a   Deschênes, Sonia ^a   Phaneuf, Denis ^a,b   Bhat, Pangala V ^a,b   Toma, Emil ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Chronic HIV infection; Combination antiretroviral therapy; Retinoic acids; Retinol

Indexed keywords

ANTIRETROVIRUS AGENT; C PEPTIDE; CHOLESTEROL; DIDANOSINE; EFAVIRENZ; INDINAVIR; LAMIVUDINE; NELFINAVIR; RETINOID; RITONAVIR PLUS SAQUINAVIR; STAVUDINE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; VIRUS LOAD; VITAMIN BLOOD LEVEL;

EID: 84856399475     PISSN: None     EISSN: 17426405     Source Type: Journal    
DOI: 10.1186/1742-6405-9-3     Document Type: Article

References (41)

1. Gottesman ME, Quadro L, Blaner WS. Studies of vitamin A metabolism in mouse model systems. BioEssays 2001, 23:409-419. 10.1002/bies.1059, 11340622.
2. Napoli JL. Retinoic acid: its biosynthesis and metabolism. Progr Nucleic Acid Res Mol Biol 2000, 63:139-188.
3. Duester G. Retinoic acid synthesis and signalling during early organogenesis. Cell 2008, 134:921-931. 10.1016/j.cell.2008.09.002, 2632951, 18805086.
4. Aranda A, Pascual A. Nuclear hormone receptors and gene expression. Physiol Rev 2001, 81:1269-1304.
5. Dawson MI, Xia Z. The retinoid X receptors and their ligands. Biochim Biophys Acta 2012, 1821:21-56.
6. Shulman AI, Mangelsdorf DJ. Retinoid X receptor heterodimers in the metabolic syndrome. N Engl J Med 2005, 353:604-615. 10.1056/NEJMra043590, 16093469.
7. Kane MA. Analysis, occurrence, and function of 9-cis-retinoic acid. Biochim Biophys Acta 2012, 1821:10-20.
8. Leid M, Kastner P, Chambon P. Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem Sci 1992, 17:427-433. 10.1016/0968-0004(92)90014-Z, 1333659.
9. Chambon P. The nuclear receptor superfamily: a personal retrospect on the first two decades. Mol Endocrinol 2003, 19:1418-1428.
10. Gudas LJ. Emerging roles for retinoids in regeneration and differentiation in normal and disease states. Biochim Biophys Acta 2012, 1821:213-221.
11. Sardana K, Sehgal N. Retinoids: fascinating up-and-coming scenario. J Dermatol 2003, 30:355-380.
12. Saurat JH. Side effects of systemic retinoids and their clinical management. J Am Acad Dermatol 1992, 27:S23-S28. 10.1016/S0190-9622(08)80256-3, 1460121.
13. Garcia-Silva J, Almagro M, Juega J, Pena C, Lopez-Calvo S, del Pozo J, Fonseca E. Protease inhibitor-related paronychia, ingrown toenails, desquamative cheilitis and cutaneous xerosis. AIDS 2000, 14:1289-1291. 10.1097/00002030-200006160-00035, 10894302.
14. Garcia-Silva J, Almagro M, Pena-Penabad C, Fonseca E. Indinavir-induced retinoid-like effects: incidence, clinical features and management. Drug Safety 2002, 25:993-1003. 10.2165/00002018-200225140-00002, 12408731.
15. Carr A, Samaras K, Chisholm DJ, Cooper DA. Pathogenesis of HIV-1 protease inhibitor-associated lipodystrophy, hyperlipidemia, and insulin resistance. Lancet 1998, 351:1881-1883. 10.1016/S0140-6736(98)03391-1, 9652687.
16. Lenhard JM, Weiel JE, Paulik MA, Furfine ES. Stimulation of vitamin A (1) acid signalling by the protease inhibitor indinavir. Biochem Pharmacol 2000, 59:1063-1068. 10.1016/S0006-2952(00)00246-X, 10704935.
17. Toma E, Devost D, Lan NC, Bhat PV. HIV-protease inhibitors alter retinoic acid synthesis. AIDS 2001, 15:1979-1984. 10.1097/00002030-200110190-00010, 11600826.
18. Jones CY, Tang AM, Forrester JE, Huang KM, Knox TA, Spiegelman D, Semba RD, Woods MN. Micronutrient levels and HIV disease status in HIV-infected patients on highly active antiretroviral therapy in the nutrition for healthy living cohort. J Acquir Immune Defic Syndr 2006, 43:475-482. 10.1097/01.qai.0000243096.27029.fe, 17019373.
19. Mulu A, Kassu A, Huruy K, Tegene B, Yitayaw G, Nakamori M, Van Nhien N, Bekele A, Wondimhun Y, Yamamoto S, Ota F. Vitamin A deficiency during pregnancy of HIV infected and non-infected women in tropical settings of Northwest Ethiopia. BMC Public Health 2011, 11:569-576. 10.1186/1471-2458-11-569, 3146876, 21762514.
20. McClean SW, Ruddel ME, Gross EG, DeGiovana JJ, Peck GL. Liquid-chromatography assay for retinol (vitamin A) and retinol analogs in therapeutic trials. Clin Chem 1982, 28:693-696.
21. Bhat PV. Tissue concentrations of retinol, retinyl esters, and retinoic acid in vitamin A deficient rats administered a single dose of radioactive retinol. Can J Physiol Pharmacol 1997, 75:74-77. 10.1139/y97-001, 9101068.
22. Brodeur H. Études du rôle des aldéhydes déshydrogénases de classe I dans la biosynthèse de l'acide rétinoïque. PhD Thesis 2006, Université de Montréal, Montréal, Canada.
23. Loignon M. Évaluation des rétinoïdes dans l'infection par le VIH: impact de l'infection et du traitement antirétroviral. MSc Thesis 2007, Université de Montréal, Montréal, Canada.
24. Sima A, Manolescu D-C, Bhat P. Retinoid and retinoid-metabolic genes expression in mouse adipose tissues. Biochem Cell Biol 2011, 89:578-584.
25. Vernochet C, Azoulay S, Duval D, Guedj R, Cottrez F, Vidal H, Ailhaud G, Dani C. Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines. J Biol Chem 2005, 280:2238-2243.
26. Chung H-Y, Anjos Ferreira AL, Epstein S, Paiva SAR, Castaneda-Sceppa C, Johnson EJ. Site-specific concentrations of carotenoids in adipose tissue: relations with dietary and serum carotenoid concentrations in healthy adults. Am J Clin Nutr 2009, 90:533-539. 10.3945/ajcn.2009.27712, 19587090.
27. Taimi M, Helvig C, Wisniewski J, Ramshaw H, White J, Amad M, Korczak B, Petkovich M. A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid. J Biol Chem 2004, 279:77-85.
28. Elizondo G, Corchero J, Sterneck E, Gonzales FJ. Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor α and CCAAT/enhancer-binding protein β. J Biol Chem 2000, 275:39747-39753. 10.1074/jbc.M004987200, 10995752.
29. Semba RD, Lyles CM, Margolick JB, Caiaffa WT, Farzadegan H, Cohn S, Vlahov D. Vitamin A supplementation and human immunodeficiency virus load in injection drug users. J Infect Dis 1998, 177:611-616. 10.1086/514235, 9498439.
30. Orchard K, Lang G, Harris J, Collins M, Latchman D. A palindromic element in the human immunodeficiency virus long terminal repeat binds retinoic acid receptors and can confer retinoic acid responsiveness on a heterologous promoter. J Acquir Immune Defic Syndr 1993, 6:440-445.
31. Maeda Y, Yamaguchi T, Hijikata Y, Morita Y, Tanaka M, Hirase C, Takai S, Tatsumi Y, Kanamaru A. All-trans retinoic acid attacks reverse transcriptase resulting in inhibition of HIV-1 replication. Hematology 2007, 12:263-266. 10.1080/10245330701255130, 17558705.
32. Yamakoshi Y, Fukasawa H, Yamauchi T, Waki H, Kadowaki T, Shudo K, Kagechi H. Determination of endogenous levels of retinoic acid isomers in type II diabetes mellitus patients. Possible correlation with HbA1c values. Biol Pharm Bull 2002, 25:1268-1271. 10.1248/bpb.25.1268, 12392076.
33. Nimmagadda A, Burri BJ, Neidlinger T, O'Brien WA, Goetz MB. Effect of oral β-carotene supplementation on plasma human immunodeficiency virus (HIV) RNA levels and CD4+ cell counts in HIV-infected patients. Clin Infect Dis 1998, 27:1311-1313. 10.1086/514990, 9827288.
34. Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJ, McGrath N, Mwakagile D, Antelman G, Mbise R, Herrera G, Kapiga S, Willett W, Hunter DJ. Randomized trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. The Lancet 1998, 351:1477-1482.
35. Thurnham DI, McCabe GP, Northrop-Clewes CA, Nestel P. Effects of subclinical infection on plasma retinol concentrations and assessment of prevalence of vitamin A deficiency: meta-analysis. The Lancet 2003, 362:2052-2058.
36. Villamor E, Koulinska IN, Aboud S, Murrin C, Bosch RJ, Manji KP, Fawzi WW. Effect of vitamin supplements on HIV shedding in breast milk. Am J Clin Nutr 2010, 92:881-886. 10.3945/ajcn.2010.29339, 2937587, 20739426.
37. Arsenault JE, Aboud S, Manji KP, Fawzi WW, Vilamor E. Vitamin supplementation increases risk of subclinical mastitis in HIV-infected women. J Nutr 2010, 140:1788-1792. 10.3945/jn.110.122713, 2937574, 20739447.
38. Kongnyuy EJ, Wiysonge CS, Shey MS. A systematic review of randomized controlled trials of prenatal and postnatal vitamin A supplementation of HIV-infected women. Int J Gynaecol Obstet 2009, 104:5-8. 10.1016/j.ijgo.2008.08.023, 18926534.
39. Wiysonge CS, Shey M, Kongnyuy EJ, Sterne JAC, Brocklehurst P. Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection. Cochrane database of Systematic Reviews 2005, (4). Art.No.: CD003648.DOI:10.1002/14651858.CD003648.pub2.
40. Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N. Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor α agonists in colitis. Mol Pharmacol 2007, 71:250-258.
41. Kurlandsky SB, Gamble MV, Ramakrishnan R, Blaner WS. Plasma delivery of retinoic acid to tissues in the rat. J Biol Chem 1995, 270:17850-17857. 10.1074/jbc.270.30.17850, 7629087.