Synthesis and molecular modeling of novel dihydroxycyclopentane- carbonitrile nor-nucleosides by bromonitrile oxide 1,3-dipolar cycloaddition

Tetrahedron

Volumn 68, Issue 7, 2012, Pages 1845-1852

  Savion, Marco ^a   Memeo, Misal Giuseppe ^a   Bovio, Bruna ^a   Grazioso, Giovanni ^b   Legnani, Laura ^a   Quadrelli, Paolo ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

1,3 Dipolar cycloaddition; Bromonitrile oxide; Molecular docking; Nor nucleosides; Thymidine kinase

Indexed keywords

5 (2 BROMOVINYL) 2' DEOXYURIDINE; ANTIVIRUS AGENT; BROMONITRILE OXIDE; CYANIDE; CYCLOPENTANE DERIVATIVE; DIHYDROXYCYCLOPENTANE; NITRILE OXIDE; NITROGEN; NUCLEOSIDE DERIVATIVE; OXYGEN; THYMIDINE KINASE; UNCLASSIFIED DRUG; URACIL;

ARTICLE; CHEMICAL BOND; CRYSTAL STRUCTURE; CYCLOADDITION; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; REDUCTION; RING OPENING; STRUCTURAL HOMOLOGY;

EID: 84856398203     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2011.12.086     Document Type: Article

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