Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in tabby mice

Human Molecular Genetics

Volumn 10, Issue 26, 2001, Pages 2973-2981

  Srivastava, Anand K ^a   Durmowicz, Meredith C ^b   Hartung, Andrew J ^a   Hudson, Joan ^a,c   Ouzts, Lizbeth V ^a   Donovan, David M ^b   Cui, Chang Yi ^b   Schlessinger, David ^b  

^a GREENWOOD GENETIC CENTER   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c CLEMSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CELL PROTEIN; ECTODYSPLASIN A1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROTEIN; LIGAND; REAGENT; RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ECTODERMAL DYSPLASIA; GENE MUTATION; GENETIC TRANSCRIPTION; HAIR FOLLICLE; HAIR GROWTH; MALE; MOLAR TOOTH; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SKIN APPENDAGE; SWEAT GLAND; TOOTH DEVELOPMENT; TRANSGENE; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0035894745     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.26.2973     Document Type: Article

References (39)

1. A totally sex-linked gene in the house mouse
2. X-linked anhidrotic (hypohydrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein
3. The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats
4. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains
5. Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells
6. The gene defective in anhidrotic ectodermal dysplasia is expressed in the developing epithelium, neuroectoderm, thymus, and bone
7. Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein
8. Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
9. J) mutations
10. Anhidrosis and absence of sweat glands in mice hemizygous for the Tabby gene, supportive evidence for the hypothesis of homology between Tabby and human anhidrotic (hypohidrotic) ectodermal dysplasia (Christ-Siemens-Touraine syndrome)
11. Genes and genotypes affecting the teeth of the mouse
12. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors
13. The ectodermal dysplasia receptor activates the nuclear factor-κB, JNK, and cell death pathways and binds to ectodysplasin A
14. X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κ-B signaling
15. NF-κB signaling and human disease
16. Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia
17. Involvement of a novel Tnf receptor homologue in hair follicle induction
18. YAC rescue of downless locus mutations in mice
19. Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia
20. Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB
21. Limb and skin abnormalities in mice lacking IKK-α
22. IKK-α controls formation of the epidermis independently of NF-κ-B
23. Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices
24. Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A
25. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion
26. Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia
27. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
28. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure
29. Redox-sensitive transactivation of epidermal growth factor receptor by tumor necrosis factor confers the NF-κ B activation
30. Noggin is a mesenchymally derived stimulator of hair-follicle induction
31. Keratinocyte growth factor is required for hair development but not for wound healing
32. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
33. β-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
34. Essential role for Sonic Hedgehog during hair follicle morphogenesis
35. The product of the mouse nude locus, Whn, regulates the balance between epithelial growth and differentiation
36. At the roots of a never-ending cycle
37. 2+ entry channel