Structure and function of human sweat glands studied with histochemistry and cytochemistry

Progress in Histochemistry and Cytochemistry

Volumn 37, Issue 4, 2002, Pages 323-386

  Saga, Kenji ^a,b  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

Anionic sites; Apocrine sweat gland; Autoradiography; Eccrine sweat gland; Enzyme histochemistry; Human sweat glands; Immunohistochemistry; Ionic mechanism of sweat secretion; Markers spefic to apocrine sweat glands; Markers to eccrine sweat glands

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALKALINE PHOSPHATASE; CARCINOEMBRYONIC ANTIGEN; CD15 ANTIGEN; CELL PROTEIN; CYTOKERATIN; EPITHELIAL MEMBRANE ANTIGEN; GROWTH FACTOR; IMMUNOGLOBULIN A; LYSOZYME; PLASMINOGEN ACTIVATOR; PROTEIN S 100; BIOLOGICAL MARKER;

APOCRINE GLAND; AUTONOMIC INNERVATION; AUTORADIOGRAPHY; CELL PROLIFERATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CYTOCHEMISTRY; FREEZING; FROZEN SECTION; HISTOCHEMISTRY; HUMAN; IN SITU HYBRIDIZATION; POTASSIUM TRANSPORT; PROTEIN LOCALIZATION; REVIEW; SECRETORY CELL; SODIUM TRANSPORT; SWEAT GLAND; SWEATING; TECHNIQUE; X RAY MICROANALYSIS; APOPTOSIS; AUTONOMIC NERVOUS SYSTEM; CELL DIVISION; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; PHYSIOLOGY; SWEAT GLAND TUMOR; ULTRASTRUCTURE;

APOCRINE GLANDS; APOPTOSIS; AUTONOMIC NERVOUS SYSTEM; BIOLOGICAL MARKERS; CELL DIVISION; ECCRINE GLANDS; HUMANS; IMMUNOHISTOCHEMISTRY; SWEAT GLAND NEOPLASMS;

EID: 0036360356     PISSN: 00796336     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0079-6336(02)80005-5     Document Type: Review

References (213)

1. Proinflammatory cytokines and their corresponding receptor proteins in eccrine sweat glands in normal and cutaneous leishmaniasis human skin
2. Neuropeptides in skin disease: Increased VIP in eczema and psoriasis but not axillary hyperhidrosis
3. A histochemical and immunohistochemical study of extra-ocular sebaceous carcinoma
4. An immunohistochemical study of lysozyme, CD-15 (Leu M1), and gross cystic disease fluid protein-15 in various skin tumors
5. A case of tubular apocrine adenoma with syringocystadenoma papilliferum
6. Bradykinin stimulates electrogenic bicarbonate secretion by the guinea pig gall bladder
7. Preservation of intercellular substances by the cationic dye alcian blue in preparative procedures for electron microscopy
8. Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction
9. The functional significance of neurotransmitter diversity
10. In situ detection of cytokine messenger RNAs in the eccrine sweat gland of normal human skin
11. The relationship between glandular kallikrein and growth factor-processing proteases of mouse submaxillary gland
12. Hypothalamic mechanisms in thermoregulation
13. A modified anaerobic method of sweat collection
14. The chemical histology of human eccrine and apocrine sweat glands
15. Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells
16. Histochemical comparison of naphthol AS-phosphate for the demonstration of phosphatases
17. The immunohistochemical localization of lysozyme in human axillary apocrine glands
18. Alterations in the distribution of alcian blue-staining fibrillar anionic sties in the glomerular basement membrane in aminonucleoside nephrosis
19. Distribution of anionic sites in glomerular basement membranes: Their possible role in filtration and attachment
20. Surface differentiation antigens of human milk fat globule
21. 125I-epidermal growth factor in human uterus
22. Frozen thin sections of fresh tissue for electron microscopy, with a description of pancreas and liver
23. Applicability of different antibodies for immunohistochemical localization of CFTR in sweat glands from healthy controls and from patients with cystic fibrosis
24. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal
25. CFTR: Development of high-affinity antibodies and localization in sweat gland
26. Cystic fibrosis: Molecular and therapeutic implications
27. Production of monoclonal antibodies against human epithelial membrane antigen for use in diagnostic immunocytochemistry
28. The formaldehyde fluorescence method for the histochemical demonstration of biogenic monoamines
29. Immunocytochemical localization of the cystic fibrosis gene product CFTR
30. Structure and function of non-enzymatically dissociated lacrimal gland acini
31. The chemical transmission of secretory impulses to the sweat glands of the cat
32. Plasminogen activators, tissue degradation, and cancer
33. Apocrine cystadenoma, apocrine hidrocystoma, and eccrine hidrocystoma: Three distinct tumors defined by expression of keratins and human milk fat globulin 1
34. Alkaline phosphatase activities in normal and denervated, slow and fast rat muscles. Bearing on the possible participation of the enzyme in the transmembrane transport phosphate ions
35. Biologically active interleukin q in human eccrine sweat: Site dependent variations in alpha/beta ratios and stress-induced increase in excretion
36. Preparation of freeze-dried cryosections for quantitative X-ray microanalysis of electrolytes in biological soft tissues
37. Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes
38. Heterodimerization and functional interaction between EGF receptor family members: A new signaling paradigm with implications for breast cancer research
39. Basolateral plasma membrane localization of ouabain-sensitive sodium transport sites in the secretory epithelium of the avian salt gland
40. Expression of anionic sites on tumour cells at different stages of tissue invasion in vivo: A comparative study by X-ray microanalysis
41. Observations on the possibilities of the cellular localization of monoamines by a fluorescence method
42. Immunocytochemical localization of ferritin in the kidney and renal tumours
43. Human sweat kallikrein: Biochemical demonstration and chromatographic separation from several other esteropeptidases in the sweat
44. Presence of epidermal cell derived thymocyte activating factor/IL-1 in normal human stratum corneum
45. Electrically silent cotransport of Na, K, and Cl in Ehrlich cells
46. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin
47. Advances in ultrarapid freezing for the preservation of cellular ultrastructure
48. Poly-L-lysine-gold complexes used at different pH are probes for differential detection of glycosaminoglycans and phosphoproteins in the predentine and dentine of rat incisor
49. Purification of plasminogen activator from Rous sarcoma virus transformed chick embryo fibroblasts treated with the tumor promoter phorbol 12-myristate 13-acetate
50. On the origin and morphology of myoepithelial cells of apocrine sweat glands
51. Alterations of glomerular basement membrane charge and structure in diabetic nephropathy
52. Detection of glomerular anionic sites post-embedded ultrathin sections using cationic colloidal gold
53. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication
54. Breast gross cystic disease fluid analysis. I. Isolation and radioimmunoassay for a major component protein
55. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms
56. Biological X-ray microanalysis
57. The localization and assay of chemical elements by microprobe methods
58. The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues
59. Protective function of proteins and lipids in human milk
60. The human alkaline phosphatases: What we know and what we don't know
61. Progression of intraepithelial Paget's disease of the vulva to invasive carcinoma
62. The ultrastructure of the skin of human embryos. I. Intraepidermal eccrine sweat duct
63. Ferritinaemia in cancer
64. Anogenital (extramammary) Paget's disease: A clinicopathological study
65. A new antigen on the epithelial membrane: Its immunoperoxidase localisation in normal and neoplastic tissues
66. A new monoclonal antibody to epithelial membrane
67. Human eccrine sweat contains tissue kallikrein and kininase II
68. Ultrastructural assessment by colloidal iron of the distribution and localization of anionic sites in human glomerulonephritides
69. Proteolytic enzymes in human eccrine sweat: A screening study
70. The distribution of cholinesterases in human skin, with special reference to eccrine and apocrine sweat glands
71. Preferential expression of a Mr 155,000 milk-fat-globule membrane glycoprotein on luminal epithelium of lobules in human breast
72. Isolation and characterization of two individual glycoprotein components from human milk-fat-globule membranes
73. Isolation and characterization of a major glycoprotein from milk-fat-globule membrane of human breast milk
74. Distinguishing tumour cells of mammary from extra-mammary Paget's disease using antibodies to two different glycoproteins from human milk-fat-globule membrane
75. Reduced secretion of IgA to skin surface of patients with atopic dermatitis
76. Immunohistochemical detection of α-fetoprotein, carcinoembryonic antigen, and ferritin in formalin-paraffin sections from hepatocellular carcinoma
77. The amino-acid sequence of S-100 protein (PAP I-b protein) and its relation to the calcium-binding proteins
78. The amino-acid sequence of the a subunit in bovine brain S-100a protein
79. Histochemistry of the cutaneous adnexa and selected adnexal neoplasms
80. Normal human sweat contains interleukin-8
81. The value of immunohistochemical studies using antibody to S100 protein in dermatopathology
82. Expression of gap junction proteins connexin 26 and 43 is modulated during differentiation of keratinocytes in newborn mouse epidermis
83. Expression of differentiation antigens in mammary and extramammary Paget's disease
84. Mislocalization of delta CFTR in cystic fibrosis sweat gland
85. Two cases of cutaneous apocrine ductal carcinoma of the axilla
86. Epidermal growth factor and transforming growth factor
87. Pharmacological actions of 6-hydroxydopamine
88. Histochemistry of hydrolytic enzymes in resting submandibular glands of rabbits
89. Subcellular and ultrastructural localization of alkaline phosphatase in lactating rat mammary glands
90. Miliaria
91. Ruthenium red and violet. II. Fine structural localization in animal tissues
92. Occurence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in certain cholinergic neurons of the cat: Evidence from combined immunohistochemistry and acetylcholinesterase staining
93. A new one step method for the cytochemical localization of ouabain-sensitive, potassium-dependent p-nitrophenyl phosphatase activity
94. The new lead citrate method for the ultracytochemical demonstration of activity of non-specific alkaline phosphatase (orthophosphoric monoester phosphohdrolase)
95. Ultracytochemical localization of ouabain-sensitive potassium-dependent p-nitrophenyl-phosphatase activity in the rat kidney
96. Immunohistochemistry of gross cystic disease fluid protein (GCDFP-15) in 65 benign sweat gland tumors of the skin
97. Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast
98. Cell kinetics of human tumors by in vitro bromodeoxyuridine labeling
99. +-pump sites in frog cell skin
100. Expression of gross cystic disease fluid protein-15/ prolactin-inducible protein in rat salivary gland
101. Comparative cytokeratin analysis of sweat gland ducts and eccrine poromas
102. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
103. Different keratin polypeptides in epidermis and other epithelia of human skin: A specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas
104. Histology and cytochemistry of human skin. IV. The eccrine sweat glands
105. Proliferating cells in human eccrine and apocrine sweat glands
106. In-vitro DNA synthesis of keratinocytes in normal human skin, psoriasis, seborrhoeic keratosis, Bowen's disease and basal cell carcinoma
107. The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7
108. The prolactin-inducible protein (PIP/GCDFP-15) gene: Cloning, structure, and regulation
109. Importance of skin temperature in the regulation of sweating
110. Peripheral modifications to the central drive for sweating
111. Mechanisms of thermal acclimation to exercise and heat
112. An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues
113. Ultrastructural localisation of anionic sites at the dermo-epidermal junction in normal human skin
114. Comparison of epidermal growth factor binding and receptor distribution in normal human epidermis and epidermal appendages
115. Immunohistochemistry of carcinoembryonic antigen in the embryo, fetus and adult
116. High-frequency pulsatile discharge of human sweat glands: Myoepithelial mechanism
117. Characteristics and functions of Na-K-Cl cotransport in epithelial transport
118. Inhibitors of complement activity in human breast-milk: A proposed hypothesis of their physiological significance
119. Identification of secretory immunoglobulin A in human sweat and sweat glands
120. Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: Assembly and analysis of a 700 kb cosmid contig spanning the region
121. Mammary and extramammary Paget's disease: An immunocytochemical and ultrastructural study
122. Epithelial membrane antigen: Partial purification, assay and properties
123. Localization of epidermal growth factor/transforming growth factor-a receptor in the human gastric mucosa
124. Kallikrein-kinin system in regulation of submandibular gland blood flow
125. Mammary plasminogen activator: Correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue
126. Antibodies to plasminogen activator inhibit human tumor metastasis
127. Immunohistological detection of interleukin-1-like molecules and tumor necrosis factor in human epidermis before and after UVB-irradiation in vivo
128. Sequence analysis of carcinoembryonic antigen: Identification of glycosylation sites and homology with the immunoglobulin supergene family
129. Carcinoembryonic antigen present in human eccrine sweat
130. Immunohistochemical demonstration of ferritin in sweat gland and sweat gland neoplasms
131. Size heterogeneity of epidermal growth factor in human body fluids
132. Growth control of myoepithelial-cell differentiation in cultures of human mammary gland
133. Immunohistochemical expression of epidermal growth factor receptors in nuclei of a subpopulation of keratinocytes and sweat gland cells
134. Transforming growth factor-b and other growth factors
135. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein
136. The type 1 (EGF-related) family of growth factor receptors and their ligands
137. Chloride impermeability in cystic fibrosis
138. Localization of Na/K-ATPase sites in the secretory and reabsorptive epithelia of perfused eccrine sweat glands: A question to the role of the enzyme in secretion
139. Anionic site and immunogold quantitation of heparan sulfate proteoglycans in glomerular basement membranes of puromycin aminonucleoside nephrotic rats
140. Differentiation of myoepithelial cells in the developing rat parotid gland
141. Immunohistochemical identification of interleukin 1α and β in human eccrine sweat-gland apparatus
142. Quantitative analysis of electrolytes in frozen dried sections
143. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
144. Apocrine sweat glands
145. Identification of the cystic fibrosis gene: Chromosomal walking and jumping
146. Activity of alkaline phosphatase in rat skeletal muscle localized along the sarcolemma and endothelial cell membranes
147. Application of cationic colloidal gold staining for the demonstration of anionic sites
148. Immunohistochemical localization of activated EGF receptor in human eccrine and apocrine sweat glands
149. Localization and characterization of anionic sites in extramammary Paget's disease with cationic colloidal gold
150. Ultrastructural localization of alkaline phosphatase activity in human eccrine and apocrine sweat glands
151. + efflux from the monkey eccrine secretory coil during the transient of stimulation with agonists
152. Electron probe X-ray micro analysis of cellular ions in the eccrine secretory coil during methacholine stimulation
153. Ultrastructural localization of ouabain-sensitive, K-dependent p-nitrophenyl phosphatase activity in monkey eccrine sweat gland
154. Demonstration of anionic sites in human eccrine and apocrine sweat glands in post-embedded ultra-thin sections using cationic colloidal gold: The effect of enzyme digestion on these anionic sites
155. Immunoelectron microscopic localization of epidermal growth factor in the eccrine and apocrine sweat glands
156. Localization of anionic sites in normal and psoriatic epidermis: The effect of enzyme digestion on these anionic sites
157. Vasoactive intestinal peptide
158. Estimation of S-phase fraction in tumor tissue sections by immunohistochemical staining of PCNA
159. Immunological determination of labelling index on human tumor tissue sections using monoclonal anti-BrdU antibody
160. In vitro BrdUrd labeling of solid tumors and immunological determination of labeling index
161. Preservation of cell cycle characteristics in solid tumors in vitro
162. cAMP-dependent C1 channel protein (CFTR) and its mRNA are expressed in the secretory portion of human eccrine sweat gland
163. Differing luminal potential difference of cystic fibrosis and control sweat secretory coils in vitro
164. Pharmacological responsiveness of the myoepithelium of the isolated human axillary apocrine sweat gland
165. The physiology, pharmacology, and biochemistry of the eccrine sweat gland
166. Sweat induction from an isolated eccrine sweat gland
167. Enzymatic basis for the active transport of sodium in the eccrine sweat gland
168. Biology of sweat glands and their disorders. I. Normal sweat gland function
169. Morphology and development of an apoeccrine sweat gland in the human axillae
170. Mechanical properties and function of the myoepithelium in the eccrine sweat gland
171. Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro
172. Effect of periglandular ionic composition and transport inhibitors on rhesus monkey eccrine sweat gland function in vitro
173. Effect of VIP on sweat secretion and cAMP accumulation in isolated simian eccrine glands
174. Interleukin-1α in human sweat is functionally active and derived from the eccrine sweat gland
175. Nonisotonicity of simian eccrine primary sweat induced in vitro
176. Pharmacologic responsiveness of isolated single eccrine sweat glands
177. +] and sweat secretion
178. Role of calcium in cholinergic and adrenergic mechanisms of eccrine sweat secretion
179. Spontaneous sweat secretion in calcium-free strontium medium
180. Sweat secretion by human axillary apoeccrine sweat gland in vitro
181. Movement of cellular ions during stimulation with isoproterenol in simian eccrine clear cells
182. The use of polyethyleneimine for demonstration of anionic sites in basement membranes and collagen fibrils
183. Histochemical demonstration of secretory activity in human eccrine sweat glands
184. Quantitative electron probe micro analysis of biological thin sections: Methods and validity
185. Differentiated microdomains on the luminal surface of the capillary endothelium. II. Partial characterization of their anionic sites
186. Cationic colloidal gold-A new probe for the detection of anionic cell surface sites by electron microscopy
187. Distribution of epithelial membrane antigen in normal and neoplastic tissues and its value in diagnostic tumor pathology
188. Bradykinin stimulates airway epithelial Cl-secretion via two second messenger pathways
189. Elemental distribution in striated muscle and the effects of hypertonicity: Electron probe analysis of cryosections
190. Eccrine sweat gland carcinoma: An histologic and immunohistochemical study of 32 cases
191. Reaction of monoclonal anti Leu M1-a myelomonocytic marker (CD15) -with normal and neoplastic epithelia
192. The distribution of substance P-, CGRP-, galanin- and ANP-like immunoreactive nerves in human sweat glands
193. Aberrant processing of alkaline phosphatase precursor caused by blocking the synthesis of glycosylphosphatidylinositol
194. Urokinase-type plasminogen activator in human eccrine and sweat
195. Intracellular ion concentrations and cell volume during cholinergic stimulation of eccrine secretory coil cells
196. Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: Production and reaction with cells in culture
197. Immunologic characteristics of keratins in extramammary Paget's disease
198. Differential characterization of carboxyl and sulphate groups in thin sections for electron microscopy
199. S-100 protein-positive cells in hidrocystomas
200. Na-K-2Cl cotransporters are present and regulated in simian eccrine clear cells
201. Electronmicroscopic localization of 5-hdroxydopamine (3,4,5,-trihydroxy-phenyl-ethylamine), a new 'false' sympathetic transmitter
202. Ultracytochemical localization of ouabain-sensitive, potassium-dependent p-nitrophenyl phosphatase activity in the lacrimal gland of the rat
203. Sympathetic innervation of the sweat glands and piloerector muscle of muscle of macaques and human beings
204. Catecholamine-containing nerve terminals of the eccrine sweat glands of macaques
205. Transport of electrolytes and water across the epithelia
206. Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the nerves of human axillary sweat glands
207. Demonstration of anionic sites on the luminal and abluminal fronts of endothelial cells with poly-L-lysine-gold complex
208. Molecular mechanism of CFTR chloride channel dysfunction in cystic fibrosis
209. Ferritin in human tissues and serum
210. Origin of periodic acid-Schiff-reactive glycoprotein in human eccrine sweat
211. Thiol-dependent aminopeptidase (350,000 mol wt) as a marker of epidermal contamination in sweat
212. Expression of mucin antigens in human cancers and its relationship with malignancy potential
213. Tissue and tumor distribution of human polymorphic epithelial mucin