High epitope density in a single protein molecule significantly enhances antigenicity as well as immunogenecity: A novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins

European Journal of Immunology

Volumn 35, Issue 2, 2005, Pages 505-514

  Liu, Wanli ^a   Chen, Ying Hu ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Affinity constant; B cell discrimination; Epitope density; High density epitope vaccine

Indexed keywords

ANTIGEN; EPITOPE; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; INFLUENZA VACCINE; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; PROTEIN M2;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGENICITY; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BINDING AFFINITY; BINDING KINETICS; CELL MATURATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DENSITY; HUMORAL IMMUNITY; IMMUNOGENICITY; INFECTION RESISTANCE; INFLUENZA; INFLUENZA VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; RABBIT; SURFACE PLASMON RESONANCE; TIME;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; B-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; GLUTATHIONE TRANSFERASE; KINETICS; ORTHOMYXOVIRIDAE; PROTEIN BINDING; PROTEINS; RABBITS; RECOMBINANT FUSION PROTEINS; SURFACE PLASMON RESONANCE; TIME FACTORS; VACCINES;

EID: 14744290281     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425749     Document Type: Article

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