A randomized controlled trial of home-based exercise for cancer-related fatigue in women during and after chemotherapy with or without radiation therapy

Cancer Nursing

Volumn 33, Issue 4, 2010, Pages 245-257

  Dodd, Marylin J ^a   Cho, Maria H ^a   Miaskowski, Christine ^a   Painter, Patricia L ^b   Paul, Steven M ^a   Cooper, Bruce A ^a   Duda, John ^c   Krasnoff, Joanne ^d   Bank, Kayee A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MIAMI   (United States)

Author keywords

Cancer related fatigue; Depression; Exercise intervention; Pain; Sleep disturbance

Indexed keywords

ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER FATIGUE; CANCER RADIOTHERAPY; CANCER THERAPY; CENTER FOR EPIDEMIOLOGICAL STUDIES DEPRESSION SCALE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; EXERCISE; FEMALE; GENERAL SLEEP DISTURBANCE SCALE; HOME CARE; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PAIN; PATIENT COMPLIANCE; PIPER FATIGUE SCALE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELF CARE; SINGLE BLIND PROCEDURE; SLEEP DISORDER; TRAINING; WORST PAIN INTENSITY SCALE; COMPLICATION; FATIGUE; FOLLOW UP; KARNOFSKY PERFORMANCE STATUS; KINESIOTHERAPY; MIDDLE AGED; NEOPLASMS; NURSING EVALUATION RESEARCH; ORGANIZATION AND MANAGEMENT; PRESCRIPTION; REGRESSION ANALYSIS; SEVERITY OF ILLNESS INDEX; SLEEP DISORDERS; TREATMENT OUTCOME; UNITED STATES;

DEPRESSION; EXERCISE THERAPY; FATIGUE; FEMALE; FOLLOW-UP STUDIES; HOME CARE SERVICES; HUMANS; KARNOFSKY PERFORMANCE STATUS; MIDDLE AGED; NEOPLASMS; NURSING EVALUATION RESEARCH; PAIN; PATIENT COMPLIANCE; PRESCRIPTIONS; REGRESSION ANALYSIS; SAN FRANCISCO; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD; SLEEP DISORDERS; TREATMENT OUTCOME;

EID: 77954142331     PISSN: 0162220X     EISSN: None     Source Type: Journal    
DOI: 10.1097/NCC.0b013e3181ddc58c     Document Type: Article

References (100)

1. Stricker CT, Drake D, Hoyer KA, Mock V. Evidence-based practice for fatigue management in adults with cancer: exercise as an intervention. Oncol Nurs Forum. 2004;31(5):963-976.
2. Conn VS, Hafdahl AR, Porock DC, McDaniel R, Nielsen PJ. A meta-analysis of exercise interventions among people treated for cancer. Support Care Cancer. 2006;14(7):699-712.
3. Courneya K, Mackey J, McKenzie D. Exercise for breast cancer survivors: research, evidence, and clinical guidelines. Phys Sportsmed. 2002;30:33-53.
4. Courneya KS. Exercise in cancer survivors: an overview of research. Med Sci Sports Exerc. 2003;35(11):1846-1852.
5. Courneya KS, Vallance JKH, McNeely ML, Karvinen KH, Peddle CJ, Mackey JR. Exercise issues in older cancer survivors. Crit Rev Oncol Hematol. 2004;51:249-261.
6. Galvao DA, Newton RU. Review of exercise intervention studies in cancer patients. J Clin Oncol. 2005;23(4):899-909.
7. Holtzman J, Schmitz K, Babes G, et al. Effectiveness of behavioral interventions to modify physical activity behaviors in general populations and cancer patients and survivors. Evid Rep Technol Assess (Summ). 2004;(102):1-8.
8. Ingram C, Courneya KS, Kingston D. The effects of exercise on body weight and composition in breast cancer survivors: an integrative systematic review. Oncol Nurs Forum. 2006;33(5):937-947; quiz 948-950.
9. Jacobsen PB, Donovan KA, Vadaparampil ST, Small BJ. Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue. Health Psychol. 2007;26(6):660-667.
10. Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G. Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol. 2005;23(16):3830-3842.
11. Markes M, Brockow T, Resch KL. Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Database Syst Rev. 2006;(4):CD005001.
12. McNeely ML, Campbell KL, Rowe BH, Klassen TP, Mackey JR, Courneya KS. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ. 2006;175(1):34-41.
13. Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R. Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2005;14(7):1588-1595.
14. Thorsen L, Courneya KS, Stevinson C, Fossa SD. A systematic review of physical activity in prostate cancer survivors: outcomes, prevalence, and determinants. Support Care Cancer. 2008;16(9):987-997.
15. MacVicar MG, Winningham ML, Nickel JL. Effects of aerobic interval training on cancer patients' functional capacity. Nurs Res. 1989;38(6):348-351.
16. Schwartz AL, Mori M, Gao R, Nail LM, King ME. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med Sci Sports Exerc. 2001;33(5):718-723. (Pubitemid 32336630)
17. Burnham TR, Wilcox A. Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exerc. 2002; 34(12):1863-1867.
18. Campbell A, Mutrie N, White F, McGuire F, Kearney N. A pilot study of a supervised group exercise program as a rehabilitation treatment for women with breast cancer receiving adjuvant treatment. Eur J Oncol Nurs. 2005;9:56-63.
19. Drouin J. Aerobic Exercise Training Effects on Physical Function, Fatigue and Mood, Immune Status, and Oxidative Stress in Subjects Undergoing Radiation Treatment for Breast Cancer. Detroit, MI: Wayne State University; 2002.
20. Courneya KS, Mackey JR, Bell GJ, Jones LW, Field CJ, Fairey AS. Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J Clin Oncol. 2003;21(9):1660-1668.
21. Crowley SA. The Effect of a Structured Exercise Program on Fatigue, Strength, Endureance, Physical Self-efficacy, and Functional Wellness in Women With Early Stage Breast Cancer. Ann Arbor, MI: University of Michigan; 2003.
22. Winningham M, MacVicar M. The effects of aerobic exercise on patient reports of nausea. Oncol Nurs Forum. 1998;15:447-450.
23. Mock V, Burke MB, Sheehan P, et al. A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy. Oncol Nurs Forum. 1994;21(5):899-907; discussion 908.
24. Mock V, Dow KH, Meares CJ, et al. Effects of exercise on fatigue, physical functioning, and emotional distress during radiation therapy for breast cancer. Oncol Nurs Forum. 1997;24(6):991-1000.
25. Mock V, Pickett M, Ropka M, et al. Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract. 2001;9(3):119-127.
26. Segal RJ, Reid RD, Courneya KS, et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol. 2003;21(9):1653-1659.
27. Schwartz AL. Cancer. In: Durstine JL, Moore GE, eds. American College of Sports Medicine's Exercise Management for Persons With Chronic Diseases and Disabilities. Champaign, IL: Human Kinetics; 2003.
28. Kolden GG, Strauman TJ, Ward A, et al. A pilot study of group exercise training (GET) for women with primary breast cancer: feasibility and health benefits. Psychooncology. 2002;11(5):447-456.
29. Dimeo FC, Stieglitz RD, Novelli-Fischer U, Fetscher S, Keul J. Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy. Cancer. 1999;85(10):2273-2277.
30. Goodwin P, Esplen MJ, Butler K, et al. Multidisciplinary weight management in locoregional breast cancer: results of a phase II study. Breast Cancer Res Treat. 1998;48(1):53-64.
31. Segar ML, Katch VL, Roth RS, et al. The effect of aerobic exercise on self-esteem and depressive and anxiety symptoms among breast cancer survivors. Oncol Nurs Forum. 1998;25(1):107-113.
32. Holley S, Borger D. Energy for living with cancer: preliminary findings of a cancer rehabilitation group intervention study. Oncol Nurs Forum. 2001; 28(9):1393-1396.
33. Durak E, Lilly PC. Preliminary results of exercise in breast cancer: a two-year follow-up survey. J Rehabil Outcomes Meas. 1999;3(4):53-60.
34. Durak EP, Lilly PC. The application of an exercise and wellness program for cancer patients: a preliminary outcomes report. J Strength Cond Res. 1998;12(1):3-6.
35. Peters C, Lotzerich H, Niemeier B, Schule K, Uhlenbruck G. Influence of a moderate exercise training on natural killer cytotoxicity and personality traits in cancer patients. Anticancer Res. 1994;14(3A):1033-1036.
36. Segal R, Evans W, Johnson D, et al. Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial. J Clin Oncol. 2001;19(3):657-665.
37. Kangas M, Bovbjerg DH, Montgomery GH. Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients. Psychol Bull. 2008;134(5):700-741.
38. Cramp F, Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2008;(2):CD006145.
39. Battaglini C, Bottaro M, Dennehy C, et al. The effects of an individualized exercise intervention on body composition in breast cancer patients undergoing treatment. Sao Paulo Med J. 2007;125(1):22-28.
40. Mock V, Frangakis C, Davidson NE, et al. Exercise manages fatigue during breast cancer treatment: a randomized controlled trial. Psychooncology. 2005;14(6):464-477.
41. Pinto BM, Frierson GM, Rabin C, Trunzo JJ, Marcus BH. Home-based physical activity intervention for breast cancer patients. J Clin Oncol. 2005;23(15):3577-3587.
42. Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Effects of supervised exercise training on cardiopulmonary function and fatigue in breast cancer survivors during and after treatment. Cancer. 2007;110(4): 918-925. (Pubitemid 47257672)
43. Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Exercise training manages cardiopulmonary function and fatigue during and following cancer treatment in male cancer survivors. Integr Cancer Ther. 2007;6(3):235-241. (Pubitemid 47301117)
44. Hanna LR, Avila PF, Meteer MA, Nicholas DR, Kaminsky LA. The effects of a comprehensive exercise program on physical function, fatigue, and mood in patients with various types of cancer. Oncol Nurs Forum. 2008; 35(3):461-469.
45. Courneya KS, Segal RJ, Mackey JR, et al. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multi-center randomized controlled trial. J Clin Oncol. 2007;25(28):4396-4404.
46. Pinto BM, Rabin C, Abdow S, Papandonatos GD. A pilot study on dissemination physical activity promotion among cancer survivors: a brief report. Psychooncology. 2008;17(5):517-521.
47. American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. Baltimore, MD: Lippincott Williams & Wilkins; 2000.
48. Humpel N, Iverson DC. Review and critique of the quality of exercise recommendations for cancer patients and survivors. Support Care Cancer. 2005;13(7):493-502.
49. American Cancer Society. Exercise to stay active. 2004. http://www.cancer. org/docroot/MIT/MIT-2-1x-ExerciseToStayActive.asp?sitearea= MIT. Accessed July 2004.
50. Schwartz AL. Physical activity. Semin Oncol Nurs. 2008;24(3):164-170.
51. Piper BF. Fatigue. In: Carrieri-Kohlman V, Lindsey AM, West C, eds. Pathophysiological Phenomena in Nursing: Human Responses to Illness. 2nd ed. Philadelphia, PA: WB Saunders; 1993:279-302.
52. Aistars J. Fatigue in the cancer patient: a conceptual approach to a clinical problem. Oncol Nurs Forum. 1987;14(6):25-30.
53. Dimeo F, Bertz H, Finke J, Fetscher S, Mertelsmann R, Keul J. An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. Bone Marrow Transplant. 1996;18(6):1157-1160.
54. Dimeo FC, Tilmann MH, Bertz H, Kanz L, Mertelsmann R, Keul J. Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation. Cancer. 1997;79(9):1717-1722.
55. Ferrell BR, Grant M, Funk B, Garcia N, Otis-Green S, Schaffner ML. Quality of life in breast cancer. Cancer Pract. 1996;4(6):331-340.
56. Messias DK, Yeager KA, Dibble SL, Dodd MJ. Patients' perspectives of fatigue while undergoing chemotherapy. Oncol Nurs Forum. 1997;24(1): 43-48.
57. Nail LM, King KB. Symptom distress. Fatigue. Semin Oncol Nurs. 1987; 3(4):257-262.
58. Nail LM, Winningham ML. Fatigue. In: Groenwald M, Frogge M, Goodman M, Yarbro C, eds. Cancer Nursing: Principles and Practice. 3rd ed. Boston, MA: Jones and Bartlett; 1993.
59. Piper B. Alterations in energy: the sensation of fatigue. In: Baird S, McCorkle R, Grant M, eds. Cancer Nursing: A Comprehensive Textbook. Philadelphia, PA: WB Saunders; 1991:894-908.
60. Winningham ML. The role of exercise in cancer therapy. In: Eisinger M, Watson R, eds. Exercise and Disease. Boca Raton, FL: CRC Press; 1992: 63-70.
61. Young-McCaughan S, Sexton DL. A retrospective investigation of the relationship between aerobic exercise and quality of life in women with breast cancer. Oncol Nurs Forum. 1991;18(4):751-757.
62. Piper BF, Lindsey AM, Dodd MJ. Fatigue mechanisms in cancer patients: developing nursing theory. Oncol Nurs Forum. 1987;14(6):17-23.
63. Piper BF, Lindsey AM, Dodd MJ, Ferketich S, Paul S, Weller S. The development of an instrument to measure the subjective dimensions of fatigue. In: Funk SG, Tournquist EM, Champagne MT, Copp LA, Weise RA, eds. Key Aspects of Comfort: Management of Pain, Fatigue and Nausea. New York: Springer; 1989:199-208.
64. Karnofsky D. Performance scale. In: Kennealey GT, Mitchell MS, eds. Factors That Influence the Therapeutic Response in Cancer: A Comprehensive Treatise. New York: Plenum Press; 1977.
65. American College of Sports Medicine. Guidelines for Exercise Testing and Prescription. 5th ed. Philadelphia, PA: Williams & Wilkins; 1995.
66. Borg G. Borg's Perceived Exertion and Pain Scales. Champaign, IL: Human Kinetics; 1998.
67. Piper BF, Dibble SL, Dodd MJ, Weiss MC, Slaughter RE, Paul SM. The revised piper fatigue scale: psychometric evaluation in women with breast cancer. Oncol Nurs Forum. 1998;25(4):677-684.
68. Dodd MJ, Miaskowski C, Paul SM. Symptom clusters and their effect on the functional status of patients with cancer. Oncol Nurs Forum. 2001;28(3):465-470.
69. Lee KA. Self-reported sleep disturbances in employed women. Sleep. 1992; 15:493-498.
70. Lee KA, Gay CL. Sleep in late pregnancy predicts length of labor and type of delivery. Am J Obstet Gynecol. 2004;191(6):2041-2046.
71. Miaskowski C, Cooper BA, Paul SM, et al. Subgroups of patients with cancer with different symptom experiences and quality-of-life outcomes: a cluster analysis. Oncol Nurs Forum. 2006;33(5):E79-E89.
72. Miaskowski C, Lee KA. Pain, fatigue, and sleep disturbances in oncology outpatients receiving radiation therapy for bone metastasis: a pilot study. J Pain Symptom Manage. 1999;17(5):320-332.
73. Pud D, Ben Ami S, Cooper BA, et al. The symptom experience of oncology outpatients has a different impact on quality-of-life outcomes. J Pain Symptom Manage. 2008;35(2):162-170.
74. Radloff L. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1(3):385-401.
75. Dodd MJ, Cho MH, Cooper BA, Miaskowski C. The effect of symptom clusters on functional status and quality of life in women with breast cancer. Eur J Oncol Nurs. 2010;14(2):101-110.
76. Jensen MP. The validity and reliability of pain measures in adults with cancer. J Pain. 2003;4(1):2-21.
77. Mor V, Laliberte L, Morris JN, Wiemann M. The Karnofsky Performance Status Scale. An examination of its reliability and validity in a research setting. Cancer. 1984;53(9):2002-2007.
78. Hyde LK, Wolf J, McCracken S, Yesner M. Natural course of inoperable lung cancer. Chest. 1973;64(3):309-312.
79. Schag CC, Heinrich RL, Ganz PA. Karnofsky performance status revisited: reliability, validity, and guidelines. J Clin Oncol. 1984;2(3):187-193.
80. Block G, Woods M, Potosky A, Clifford C. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol. 1990;43(12):1327-1335.
81. Dodd MJ, Larson P, Miaskowski C, et al. Self-care Intervention to Decrease Mucositis Morbidity RO1 CA 55555. National Institutes of Health, National Cancer Institute; 1992-1996.
82. Dodd MJ, Lovejoy N, Larson P, et al. Self-care Intervention to Decrease Chemotherapy Morbidity RO1 CA 48312. National Institutes of Health, National Cancer Institute; 1988-1992.
83. Painter P, Stewart A, Dibble S, Dodd MJ, Ascher N, Gold W. Exercise Intervention After Kidney Transplant RO1 NR 02880. National Institutes of Health, National Institute of Nursing Research; 1993-1996.
84. Dodd MJ, Painter P, Miaskowski C, et al. Exercise: A Feasibility Study of an Intervention for Fatigue in Cancer Patients: P30 Feasibility Study.Research Center for Symptom Management, University of California, San Francisco; 1996-1997.
85. Dodd MJ, Painter P, Miaskowski C, et al. Exercise: An Intervention for Fatigue in Cancer Patients. P30 Pilot Study NR 03927. National Institutes of Health, National Institute of Nursing Research; 1997-1998.
86. Dodd MJ, Dibble SL, Miaskowski C, et al. Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90(1):39-47.
87. Knowles M. The Adult Learner: A Neglected Species. Houston, TX: Gulf; 1978.
88. Dodd MJ, Miaskowski C. The Pro-self Program: a self-care intervention program for patients receiving cancer treatment. Semin Oncol Nurs. 2000;16(4):300-308; discussion 308-316.
89. SPSS 15.0 [computer program]. Chicago, IL: SPSS Inc; 2008.
90. Singer JD, Willet JB. Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence. New York: Oxford University Press; 2003.
91. Berger AM, Lockhart K, Agrawal S. Variability of patterns of fatigue and quality of life over time based on different breast cancer adjuvant chemotherapy regimens. Oncol Nurs Forum. 2009;36(5):563-570.
92. Heim ME, v.d. Malsburg E, Niklas A. Randomized controlled trial of a structured training program in breast cancer patients with tumor-related chronic fatigue. Onkologie. 2007;30(8-9):429-434.
93. Courneya K, Friedenreich C. Relationship between exercise during treatment and current quality of life among survivors of breast cancer. J Psychosoc Oncol. 1997;15:35-57. (Pubitemid 28157771)
94. Schwartz AL. Patterns of exercise and fatigue in physically active cancer survivors. Oncol Nurs Forum. 1998;25(3):485-491.
95. Courneya KS, Friedenreich CM. Relationship between exercise pattern across the cancer experience and current quality of life in colorectal cancer survivors. J Altern Complement Med. 1997;3(3):215-226.
96. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. New York, NY: Psychology Press, Taylor & Francis Group; 1988.
97. Lawrence DP, Kupelnick B, Miller K, Devine D, Lau J. Evidence report on the occurrence, assessment, and treatment of fatigue in cancer patients. J Natl Cancer Inst Monogr. 2004;(32):40-50.
98. Courneya KS, McKenzie DC, Reid RD, et al. Barriers to supervised exercise training in a randomized controlled trial of breast cancer patients receiving chemotherapy. Ann Behav Med. 2008;35(1):116-122.
99. Berger AM, Higginbotham P. Correlates of fatigue during and following adjuvant breast cancer chemotherapy: a pilot study. Oncol Nurs Forum. 2000;27(9):1443-1448.
100. Prue G, Rankin J, Allen J, Gracey J, Cramp F. Cancer-related fatigue: a critical appraisal. Eur J Cancer. 2006;42(7):846-863.